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Sexual AND Dysfunction

Michelle A Erickson, W Sandy Liang, Elizabeth G Fernandez, Kristin M Bullock, Jarl A Thysell, William A Banks
Lipopolysaccharide (LPS) is a stimulator of the innate immune system and is routinely used in animal models to study blood-brain barrier (BBB) dysfunction under inflammatory conditions. It is appreciated that both humans and mice have sexually dimorphic immune responses, which could influence the brain's response to a systemic inflammatory insult. Mouse strain is also an important factor that can contribute to pathophysiological responses to inflammatory stimuli. Therefore, we aimed to test whether BBB disruption and the associated cytokine profiles in response to LPS differed in male and female mice from two mouse strains most commonly used in blood-brain barrier studies: CD-1 and C57BL6/J (C57)...
2018: PloS One
Andrea Lamprecht, Jane Sorbello, Christina Jang, David J Torpy, Warrick J Inder
OBJECTIVE: To evaluate pituitary function, sexual function and quality of life (QoL) in patients on oral or transdermal opioids. DESIGN AND METHODS: Cross-sectional study comparing pituitary function, QoL and sexual function in people on long-term opioid therapy (n = 40) vs an age- and sex-matched control group (n = 25). Baseline pituitary function was assessed on blood samples collected prior to 0900 h. Further testing with corticotropin (250 μg IV) and metyrapone (30 mg/kg) stimulation tests was undertaken on participants with serum cortisol <250 nmol/L...
September 10, 2018: European Journal of Endocrinology
Tommaso Cai, Fabrizio Palumbo, Giovanni Liguori, Nicola Mondaini, Fabrizio Idelfonso Scroppo, Danilo Di Trapani, Andrea Cocci, Alessandro Zucchi, Paolo Verze, Andrea Salonia, Alessandro Palmieri
To investigate the efficacy, tolerability, and patient's preference of alprostadil cream for topical use administered within the urethral meatus versus the standard administration route, in erectile dysfunction (ED) treatment. Seventy-one patients (mean age 59.7 ± 9.0 years) affected by ED were analyzed in this multicenter, randomized, two-administration routes, cross-over trial. All patients received a single dose of alprostadil cream applying the dispenser to the tip of the penis (without contacting the urethral meatus) (Standard administration route or ST...
October 15, 2018: International Journal of Impotence Research
Guillermo Martín-Palomeque, Lidia Cabañes-Martínez, Gema de Blas Beorlegui, M Del Mar Moreno Galera, Jaime R López, Francisco Javier Burgos, Ignacio Regidor Bailly-Baillière
PURPOSE: The occurrence of urinary incontinence and erectile dysfunction after surgical treatment for prostate cancer is a significant and lingering problem. The aim of this study is to revise and improve older techniques of intraoperative cavernous nerve mapping already in use to improve accuracy and reliability. METHODS: We prospectively studied this technique in 12 patients suffering from prostate cancer. Inhalation or intravenous anesthetic regimen was used with nondepolarizing muscle relaxants...
October 10, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Nurse Practitioner
Line Traumer, Michael Hviid Jacobsen, Birgitte Schantz Laursen
BACKGROUND: Sexual dysfunction is common in patients diagnosed with cancer or chronic disease, having psychological, emotional and social ramifications. The consequences are ultimately significant impaired quality of life and reduced mental well-being, and it therefore requires professional attention. However, evidence suggests that sexuality is a taboo subject in the healthcare system, as healthcare professionals and patients rarely initiate conversations on this subject. AIM: Therefore, the purpose of this study was to understand how patients diagnosed with cancer or chronic disease experiencing sexual dysfunction experience sexuality as a taboo subject in the healthcare system...
October 15, 2018: Scandinavian Journal of Caring Sciences
Raymond C Rosen, Claus G Roehrborn, Michael J Manyak, Juan Manuel Palacios-Moreno, Timothy H Wilson, Zrinka Lulic, Francois Giuliano
AIMS: Five-α reductase inhibitor (5ARI) therapy has been associated with sexual dysfunction in some patients. This study assessed the impact of a fixed-dose combination of the 5ARI dutasteride 0.5 mg and the α1 -adrenoceptor antagonist tamsulosin 0.4 mg (DUT-TAM FDC) on Men's Sexual Health Questionnaire (MSHQ) domain scores in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). METHODS: This was a post hoc analysis of a double-blind, randomized, placebo-controlled, parallel-group, multicenter study in sexually active patients, aged ≥50 years, with a confirmed clinical diagnosis of BPH...
October 13, 2018: International Journal of Clinical Practice
Walaa Hassan Nazmy, Eman Abdelmonem Elbassuoni, Fatma Farrag Ali, Rehab Ahmed Rifaai
Diabetes mellitus (DM) is closely associated with male infertility and sexual dysfunction. Recent data indicate that the proinsulin C-peptide (CP) exerts important physiological effects and shows the characteristics of an endogenous peptide hormone. So, this study was done to investigate the effect of C-peptide with or without insulin treatment on testicular function and architecture in diabetic rats. Rats were divided into the following groups: control, diabetic, and diabetic groups treated with either CP alone or combined with insulin...
October 14, 2018: Journal of Cellular Physiology
Iris Palma Lopes, Victor Barbosa Ribeiro, Rosana Maria Reis, Rafael Costa Silva, Hugo Celso Dutra de Souza, Gislaine Satyko Kogure, Rui Alberto Ferriani, Lúcia Alves da Silva Lara
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common condition characterized by hyperandrogenism, anthropometric changes (increased weight and waist-to-hip ratio [WHR]), behavioral changes (sexual dysfunction, anxiety, and depression), and reduced quality of life. Physical exercise may reduce many of the adverse effects of PCOS. However, no studies have yet evaluated the effects of aerobic exercise on the sexual function of women with PCOS. AIM: To compare the effects of continuous and intermittent aerobic physical training on the sexual function and mood of women with PCOS...
October 10, 2018: Journal of Sexual Medicine
(no author information available yet)
It is the responsibility of the clinician to assess for the presence of erectile dysfunction, ejaculatory dysfunction, or diminished libido related to hypoandrogenism among men presenting with a primary complaint of infertility. Referral to a reproductive urologist or other appropriate specialist with requisite expertise in the evaluation and treatment of such conditions is often warranted.
October 2018: Fertility and Sterility
C-H Lin, S-N Chang, C-H Chen
OBJECTIVE: Hormonal changes, in either men or women experiencing chronic kidney disease, cause decreased libido, erectile dysfunction, dysmenorrhea, and ovarian dysfunction, all of which may contribute to infertility. Patients' endocrinal and sexual function could be rapidly restored after successful renal transplantation (RTx), which may assist in achieving a successful pregnancy. However, fetuses will be exposed to the immunosuppressive agents passed on from the female recipients, which may be another potential factor leading to a poor fetal outcome...
October 2018: Transplantation Proceedings
Desiree Latella, Maria Grazia Maggio, Rosaria De Luca, Giuseppa Maresca, Denise Piazzitta, Francesca Sciarrone, Luigi Carioti, Alfredo Manuli, Placido Bramanti, Rocco Salvatore Calabro
Traumatic brain injury (TBI) is any damage to the skull and/or the brain and its frameworks due to an external force. Following TBI, patients may report cognitive, physiological and psychosocial changes with a devastating impact on important aspects of the patient's life, such as sexual functioning. Although sexual dysfunction (SD) occurs at a significantly greater frequency in individuals with TBI, it is not commonly assessed in the clinical setting and little information is available on this crucial aspect of patients' quality of life...
October 9, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Konstantinos H Katsanos, Maria Saridi, Eleni Albani, George Mantzouranis, Oded Zmora, Dimitrios K Christodoulou
No abstract text is available yet for this article.
October 12, 2018: Inflammatory Bowel Diseases
Jun Mo, Lei Huang, Jianhua Peng, Umut Ocak, Jianmin Zhang, John H Zhang
Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system. We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia...
October 11, 2018: Neuroscience Bulletin
Jia Huang, Yun Wang, Jun Chen, Yanlei Zhang, Zheng Yuan, Li Yue, Josep Maria Haro, Maria Victoria Moneta, Diego Novick, Yiru Fang
Purpose: To compare treatment outcomes in patients with major depressive disorder treated with duloxetine, escitalopram, fluoxetine, paroxetine, or sertraline for up to 6 months. Patients and methods: Data were taken from a 6-month prospective, observational study that included 1,549 major depressive disorder patients without sexual dysfunction in 12 countries. We report the overall results and those from Asian countries. Depression severity was measured using the Clinical Global Impression and the 16-item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16 )...
2018: Neuropsychiatric Disease and Treatment
Cristiano Santos de Caires, Marcelo Luis Steiner, Luciano de Melo Pompei, Rodolfo Strufaldi, Cesar Eduardo Fernandes
OBJECTIVE:  The aim of the present study is to identify the association between personality traits of postmenopausal women and the occurrence of sexual dysfunction. METHODS:  A total of 43 postmenopausal women were evaluated according to their self-perception of the quality of their sexual life. They answered the following questionnaires: Sociodemographic Profile Questionnaire, Female Sexual Function Index (FSFI), Beck Depression Inventory (BDI) and Factorial Personality Inventory (FPI-II)...
October 11, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Alejandro Molina-Leyva, Luis Salvador-Rodriguez, Antonio Martinez-Lopez, Jose Carlos Ruiz-Carrascosa, Salvador Arias-Santiago
Importance: Sexual health is a major aspect of life. Increasing scientific evidence shows a potential association between psoriasis and sexual dysfunction (SD) and erectile dysfunction (ED). Objective: To evaluate the available scientific evidence regarding epidemiologic associations and treatment outcomes between psoriasis and SD and ED. Evidence Review: Information sources were MEDLINE and Embase databases, using the Scopus search engine...
October 10, 2018: JAMA Dermatology
Richardson Augusto Rosendo da Silva, Romanniny Hévillyn Silva Costa, Laísi Catharina da Silva Barbalho Braz, Indira de Araújo Lucena, Kalyane da Silva Ferreira, Fernando Hiago da Silva Duarte
OBJECTIVE: To analyze the association between nursing diagnoses and sociodemographic and clinical characteristics in people living with AIDS. METHOD: Cross-sectional study with 100 people living with AIDS in a University Hospital. Data collection took place between January and July 2015, using an interview script and physical examination. The association occurred through Pearson's Chi-Square Test and Fisher's Exact Test. RESULTS: The most prevalent nursing diagnoses were: ineffective protection, poor knowledge, lack of adherence and sexual dysfunction...
September 2018: Revista Brasileira de Enfermagem
Rosana Pinheiro Lunelli, Maria Claudia Irigoyen, Silvia Goldmeier
OBJECTIVE: to evaluate the sexual dysfunction in hypertensive patients compared to normotensive patients. METHOD: this was a cross-sectional study. Samples were composed of 54 hypertensive patients and 54 normotensive patients. The female sexual dysfunction was evaluated by the Female Sexual Function Index (FSFI). RESULTS: the average FSFI score differed highly between hypertensive and normotensive patients (22.4± 7.4 versus 26.8 ±5.4, p< 0...
September 2018: Revista Brasileira de Enfermagem
A Coppola, T Montalcini, P Gallotti, L Luzi, A Pujia, A Giustina, C Gazzaruso
BACKGROUND: Several studies suggested that abnormalities in tissue perfusion of external genitalia and vagina can lead to female sexual dysfunctions (FSDs) and can be associated to metabolic and cardiovascular risk factors. However, there are some technical difficulties in assessing these abnormalities. The measurement of oxygen partial pressure is a noninvasive method to measure oxygen partial pressure (pO2 ) at the skin surface to assess tissue perfusion. The aim of this study was to evaluate whether transmucosal oxygen tension (TmPO2 ) can be measured at the mucosal surface of clitoris and whether the measurements are reliable...
October 9, 2018: Endocrine
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