Shuzhen Sun, Linan Xu, Yunli Bi, Jing Wang, Zhiqing Zhang, Xiaoshan Tang, Qi Cao, Yihui Zhai, Jing Chen, Xiaoyan Fang, Jialu Liu, Ye Fang, Tianchao Xiang, Yanyan Qian, Bingbing Wu, Huijun Wang, Wenhao Zhou, Jian Shen, Kuiran Dong, Xiaorong Liu, Bixia Zheng, Aihua Zhang, Xiaowen Wang, Yubing Wu, Duan Ma, Qian Shen, Jia Rao, Hong Xu
BACKGROUND: WT1 mutations cause a wide spectrum of renal and extrarenal manifestations concerning urogenital development and the development of tumors. METHODS: We retrospectively collected the information on the genotype and phenotype of WT1 nephropathy from the multicenter registry since 2014 to 2019. All patients were stratified by renal function decline status or by sequence timing. Rapid progressive group was defined as rapidly developing into ERSD within 12 months since disease onset...
November 2020: European Journal of Medical Genetics