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Hiroki Abe, Kento Koyama, Shuso Kawamura, Shigenobu Koseki
Stochastic models take into account the uncertainty and variability of predictions in quantitative microbial risk assessment. However, a model that considers thermal inactivation conditions can better predict whether or not bacteria in food are alive. To this end, we describe a novel probabilistic modelling procedure for accurately predicting thermal end point, in contrast to conventional kinetic models that are based on extrapolation of the D value. We used this new model to investigate changes in the survival probability of Salmonella enterica serotype Oranienburg during thermal processing...
August 8, 2018: International Journal of Food Microbiology
Talli Hogen, Steven G Cole, Kenneth J Drobatz
OBJECTIVE: To determine whether the partial pressure of end-tidal carbon dioxide (PetCO2 ) could predict return of spontaneous circulation (ROSC) in patients with cardiopulmonary arrest (CPA) undergoing CPR. DESIGN: Prospective observational study. SETTING: Two private specialty referral hospitals. ANIMALS: Thirty-five client-owned dogs and cats in CPA in which CPR was performed and pertinent data recorded on a purpose-made form...
August 17, 2018: Journal of Veterinary Emergency and Critical Care
Pierpaolo Alongi, Ignazio Gaspare Vetrano, Elisa Fiasconaro, Valerio Alaimo, Riccardo Laudicella, Marina Bellavia, Francesca Rubino, Sergio Bagnato, Giuseppe Galardi
OBJECTIVE: Glioblastoma multiforme (GBM) represents the most common and malignant glioma, accounting for 45%-50% of all gliomas . The median survival time for patients with glioblastoma is only 12-15 months after surgical, chemioterapic and radiotherapic treatment; a correct diagnosis is naturally fundamental to establish a rapid and correct therapy. Non-invasive imaging plays a pivotal role in each phase of the diagnostic workup of patients with suspected for diagnosis. The aim of this case report was to describe the potential clinical impact of 18F-fluorocholine (FCH) PET/CT in the assessment of a cystic GBM mimicking a spontaneous hemorrhage...
August 17, 2018: Current Radiopharmaceuticals
Ting Hway Wong, Zheng Yi Lau, Whee Sze Ong, Kelvin Bryan Tan, Yu Jie Wong, Mohamad Farid, Melissa Ching Ching Teo, Alethea Chung Pheng Yee, Hai V Nguyen, Marcus Eng Hock Ong, N Gopalakrishna Iyer
BACKGROUND: Cancer patients contribute significantly to emergency department (ED) utilization. The objective of this study was to identify factors associated with patients becoming ED frequent attenders (FA) after a cancer-related hospitalization. METHODS: A retrospective cohort study was conducted using national administrative, billing, and death records of Singapore residents discharged alive from Singapore public hospitals from January 2012 to December 2015, with a primary discharge diagnosis of cancer...
August 17, 2018: Cancer Medicine
Hidde M Kroon, Wendy D van der Bol, Katherine T Tonks, Angela M Hong, George Hruby, John F Thompson
INTRODUCTION: When cervical lymph nodes are clinically positive for metastatic melanoma, surgeons may be hesitant to recommend a therapeutic complete lymph node dissection if the patient is elderly or has major comorbidities. A limited local node excision of the clinically positive nodes only, followed by adjuvant radiotherapy to the entire node field, may be an effective alternative in such patients. METHODS: All patients who had presented with a primary head and neck melanoma or an unknown primary site and had subsequently undergone limited local node excision and adjuvant radiotherapy for macroscopically involved cervical nodes between 1993 and 2010 at a tertiary referral center were selected for study...
August 16, 2018: Annals of Surgical Oncology
Anna Raciborska, Katarzyna Bilska
Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach for young patients with relapsed or refractory bone tumors. Twelve patients with refractory bone tumors (two with Ewing sarcoma, two with chondrosarcoma, and eight with osteosarcoma) received salvage treatment with sorafenib. All patients had standard tumor imaging and laboratory evaluation. All toxicities were documented...
August 16, 2018: Medical Oncology
Quirina C B S Thio, W Alexander Goudriaan, Stein J Janssen, Nuno Rui Paulino Pereira, Daniel M Sciubba, Rachel P Rosovksy, Joseph H Schwab
BACKGROUND: Skeletal metastases are a common problem in patients with cancer, and surgical decision making depends on multiple factors including life expectancy. Identification of new prognostic factors can improve survival estimation and guide healthcare providers in surgical decision making. In this study, we aim to determine the prognostic value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with bone metastasis. METHODS: One thousand and twelve patients from two tertiary referral centers between 2002 and 2014 met the inclusion criteria...
August 17, 2018: British Journal of Cancer
Michael Gabriel, Bernhard Nilica, Bernhard Kaiser, Irene J Virgolini
Peptide receptor radionuclide therapy (PRRT) has been used for more than twenty years as a systemic treatment approach in inoperable or metastatic somatostatin receptor (SSTR)-positive tumors. The purpose of this study was to analyze the long-term outcome of PRRT with regard to the most commonly used radiopharmaceuticals, 90 Y-DOTA-Tyr3-octreotide (90 Y-DOTA-TOC) and 177 Lu-DOTA-Tyr3-octreotate (177 Lu-DOTA-TATE). Methods: This retrospective clinical study included a total of 44 consecutive patients (27 men) with advanced tumors and enhanced SSTR expression...
August 16, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Cheryl Battersby, Yevgeniy Statnikov, Shalini Santhakumaran, Daniel Gray, Neena Modi, Kate Costeloe
BACKGROUND: The National Neonatal Research Database (NNRD) is a rich repository of pre-defined clinical data extracted at regular intervals from point-of-care, clinician-entered electronic patient records on all admissions to National Health Service neonatal units in England, Wales, and Scotland. We describe population coverage for England and assess data completeness and accuracy. METHODS: We determined population coverage of the NNRD in 2008-2014 through comparison with data on live births in England from the Office for National Statistics...
2018: PloS One
Umberto Cortinovis, Laura Sala, Stefano Bonomi, Gianfrancesco Gallino, Filiberto Belli, Antonino Ditto, Fabio Martinelli, Giorgio Bogani, Umberto Leone Roberti Maggiore, Francesco Raspagliesi
BACKGROUND: Several techniques for vaginal reconstruction after pelvic exenteration such as myocutaneous and myoperitoneal flaps are available. However, the use of a myofascial flap has not been previously described. Thus, the objective of this article is to present our experience of vaginal reconstruction with rectus abdominis myofascial (RAMF) flap. METHODS: Between May 2008 and March 2017, 16 patients underwent anterior, posterior, or total pelvic exenteration with RAMF flap vaginal reconstruction...
August 16, 2018: Annals of Plastic Surgery
Jordi Sánchez-Delgado, Mercedes Vergara, Salvador Machlab, Alba Lira, Carlos Gómez Zaragoza, Eva Criado, Mercè Rosinach, Lissette Batista, Beatriz Arau, Mercè Roget, Jordi Ortiz, Caridad Garcia, Pau Sort, Meritxell Casas, Blai Dalmau, Montserrat Forné, Joan Falcó, Mireia Miquel
BACKGROUND AND AIM: Drug-eluting bead transarterial chemoembolization (DEB-TACE) improves the survival of patients with hepatocellular carcinoma (HCC), intermediate stage [i.e. Barcelona Clinic Liver Cancer-B (BCLC-B)]. The aim of our study was to analyse the overall survival (OS) and prognostic factors of patients with HCC treated with DEB-TACE. PATIENTS AND METHODS: Patients' clinical course was recorded from January 2005 to July 2014. The median OS was obtained by the Kaplan-Meier method and compared using the log-rank test...
August 15, 2018: European Journal of Gastroenterology & Hepatology
C Beguin, N Jansen, C Loly
Brain metastases occur in 1 to 4 % of patients with colorectal cancer and are unique in 0.5 % of them. Because of their infrequent nature, brain imaging is not recommended in the systematic follow-up of these patients. We report here an exceptional case of a unique brain metastasis in a very unusual position. An 82-year-old patient with a colorectal cancer of the splenic angle that was treated with surgery and adjuvant chemotherapy, developed a series of neurological symptoms over four to six weeks: difficulty swallowing, loss of strength in the four limbs and balance disorders...
July 2018: Revue Médicale de Liège
Jodie B Hillen, Agnes Vitty, Gillian E Caughey
Objective: To describe medication-related quality of care (MRQOC) for Australian aged care residents. Design: Retrospective cohort using an administrative healthcare claims database. Setting: Australian residential aged care. Participants: A total of 17 672 aged care residents who were alive at 1 January 2013 and had been a permanent resident for at least 3 months. Main outcome measures: Overall, 23 evidence-based MRQOC indicators which assessed the use of appropriate medications in chronic disease, exposure to high-risk medications and access to collaborative health services...
August 3, 2018: International Journal for Quality in Health Care
Debnarayan Dutta, Sathiya Krishnamoorthy, H Sudahar, M Muthukumaran, T Ramkumar, Jayraj Govindraj
Purpose: The purpose of this study is to report CyberKnife experience in hepatocellular carcinoma (HCC) and liver metastasis (LM). Materials and Methods: Fifty liver lesions in 31 consecutive patients with liver lesion [mean age 54.5 years (range 32-81 years), 77% were male patient, GTV <10cc in 5 patients, 11-90cc in 18 & >90cc in 8 patients respectively. Eighty percentage (25/31) had prior treatment (chemotherapy 18 patient & TACE in 7 patients)...
July 2018: South Asian Journal of Cancer
Jonathan E Cohen, Feras Eleyan, Aviad Zick, Tamar Peretz, Daniela Katz
Leiomyosarcoma is the second most frequent soft-tissue sarcoma. Tumor lymphocytic infiltration (TIL) and programed cell death ligand-1 (PD-L1) have been associated with prognosis in different malignancies while DNA mismatch-repair deficiency (MMR-D) has been associated with response to check-point inhibitors. In this pilot study, we sought to examine TIL, PD-L1 and mismatch-repair (MMR) protein expression in 11 leiomyosarcoma and its association with outcome as potential biomarkers for adjuvant treatment. Eleven primary leiomyosarcoma archived-tissues were analyzed for expression of MMR proteins (MSH2, MLH1, MSH6 and PSM2), PD-L1 expression and PD-1, CD3 or CD8...
July 20, 2018: Oncotarget
Jørgen Eilenberg, Annette Bruun Jensen
The genus Strongwellsea (Entomophthorales) has a unique pathobiology. Infected adult dipteran hosts develop a large hole in their abdomens, through which conidia are actively discharged while the hosts are still alive. We analyzed the IST II region of Strongwellsea from 29 infected hosts representing 15 dipteran species from Anthomyiidae, Fanniidae, Muscidae, and Scathophagidae. Each genotype was found on only one host species or a few closely related host species. Strongwellsea genotypes infecting flies from Anthomyiidae represented a monophyletic lineage, including the species Strongwellsea castrans, while genotypes infecting Muscidae were very diverse and clustered at different places...
August 12, 2018: Journal of Invertebrate Pathology
Amanda G Bendia, Gabriel G Araujo, André A Pulschen, Bruna Contro, Rubens T D Duarte, Fábio Rodrigues, Douglas Galante, Vivian H Pellizari
Polar volcanoes harbor unique conditions of extreme temperature gradients capable of selecting different types of extremophiles. Deception Island is a marine stratovolcano located at Maritime Antarctica that is notable for its pronounced temperature gradients over very short distances, reaching values up to 100 °C in the fumaroles, and subzero temperatures next to the glaciers. Due to these characteristics, Deception can be considered an interesting analogue of extraterrestrial environments. Our main goal in this study was to isolate thermophilic and psychrophilic bacteria from sediments associated with fumaroles and glaciers from two geothermal sites in Deception Island, comprising temperatures between 0 and 98 °C, and to evaluate their survivability to desiccation and UV-C radiation...
August 14, 2018: Extremophiles: Life Under Extreme Conditions
Deneb Ortigosa, Nancy Yolimar Suárez-Mozo, Noe C Barrera, Nuno Simões
Six sediment samples weighing between 224-735 g were collected in June of 2016 from Cayo Nuevo reef, located at the Campeche Bank, southern Gulf of Mexico. Samples were collected by SCUBA diving, from were two stations at depths of 7.6 and 18.2 m. Sediment was sieved and molluscs (adults and micromolluscs ≤ 10 mm) were sorted, examined, and identified to the lowest taxonomic level. A total of 1,347 specimens was found, of which 224 shells were dead and 1,123 were alive. Thirty-four families, 53 genera, and 67 species were identified...
2018: ZooKeys
Y N Zhao, X T Wang, Q Y Xia, G P Wang, S Y Sun, L F Zhao, X J Zhou, Q Rao
Objective: To study the clinicopathologic features, immunophenotype, characteristic FISH pattern and prognosis of renal cell carcinoma (RCC) associated with chromosome X inversion harboring gene fusions involving TFE3. Methods: Ten cases of NONO-TFE3 RCC and four cases of RBM10-TFE3 RCC were investigated at Nanjing Jinling Hospital from 2009 to 2016 by clinicopathological findings, immunohistochemistry, and genetic analysis. Results: Morphologically, the distinct pattern of secretory endometrioid subnuclear vacuolization was overlapped with clear cell papillary RCC, and often accompanied by sheets of epithelial cells in NONO-TFE3 RCC...
August 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Sophie Martin, Randi Drees, Balazs Szladovits, Elsa Beltran
Objectives Feline intracranial abscessation or empyema is infrequently reported in the veterinary literature. To date, the largest study is based on a population of 19 cats with otogenic infection. The aim of this study was to review a larger population of cats with intracranial empyema from multiple aetiologies and document their signalment, imaging findings, treatment protocols (including medical and/or surgical management) and to compare outcomes. Methods Cases presenting to a single referral centre over a 10 year period with compatible history, neurological signs and imaging findings consistent with intracranial abscessation and empyema were reviewed retrospectively...
August 14, 2018: Journal of Feline Medicine and Surgery
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