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Fahad S Al-Jasser, Randa M Nouh, Randa M Youssef
BACKGROUND: MERS-CoV emerged as a zoonotic disease in Saudi Arabia with 1437 cases as of July 2016. This study aimed at describing the epidemiology of MERS-CoV infection, clinical aspects of the disease and the determinants of survival. METHODS: The medical records of Prince Mohamed Bin Abdulaziz Hospital were reviewed between April 2014 and December 2015 to identify admission and discharge with MERS-CoV. Patient's characteristics, epidemiologic and clinical data and laboratory results were extracted and described...
October 16, 2018: Journal of Infection and Public Health
Roland Christian Schelker, Wolfgang Herr, Albrecht Reichle, Martin Vogelhuber
BACKGROUND: Rituximab plus combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is broadly accepted as standard for the treatment of diffuse large B-cell lymphoma (DLBCL). Nevertheless, there is sparsely data concerning the management of elderly patients. METHODS: We performed a retrospective study of treatment with rituximab and low-dose trofosfamide in elderly patients (≥ 75 years) with DLBCL who were not suitable for R-CHOP or R-CHOP-like regimens or who did not consent to aggressive treatment...
October 19, 2018: BMC Cancer
Sati Akbaba, Kristin Lang, Thomas Held, Olcay Cem Bulut, Matthias Mattke, Matthias Uhl, Alexandra Jensen, Peter Plinkert, Stefan Rieken, Klaus Herfarth, Juergen Debus, Sebastian Adeberg
(1) Background: The authors present the first results of active raster-scanned carbon ion radiotherapy (CIRT) for radioresistant laryngeal malignancies regarding efficacy and toxicity. (2) Methods: 15 patients with laryngeal adenoid cystic carcinoma (ACC; n = 8; 53.3%) or chondrosarcoma (CS; n = 7; 46.7%) who underwent radiotherapy with carbon ions (C12) at the Heidelberg Ion Beam Therapy Center (HIT) between 2013 and 2018 were identified retrospectively and analyzed for local control (LC), overall survival (OS), and distant progression-free survival using the Kaplan⁻Meier method...
October 18, 2018: Cancers
Dorian Patzkéwitsch, Michael Erhard, Janina Kickstein, Shana Bergmann, Sandrina Klein
OBJECTIVE: The aim of this field study was to examine the loose farrowing system in view of practicability, particularly to monitor piglet losses and their causes, on a farm proceeding in accordance with the BIO AUSTRIA production guidelines from summer 2015 until summer 2017. The so-called "Ethobox" (HAKA, Josef Häufele GmbH & Co. KG, Erbach-Dellmensingen, Germany) had been installed into two cold barns with access to outdoor areas. MATERIAL AND METHODS: The reproductive rate was recorded routinely on charts...
October 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
Freja Stæhr Holm, Pradeesh Sivapalan, Niels Seersholm, Theis Skovsgaard Itenov, Per Hjort Christensen, Jens-Ulrik Stæhr Jensen
BACKGROUND: Gelsolin is an actin-scavenger controlling the tissue damage from actin in the blood. Gelsolin levels in circulation drops when tissue damage and corresponding actin release is pronounced due to catabolic conditions. The purpose of this study was to determine if low plasma gelsolin independently predicts a reduced chance of weaning from ventilator-demanding respiratory failure in critically ill patients within 28 days from admission. RESULTS: This cohort study included 746 critically ill patients with ventilator-demanding respiratory failure from the randomized clinical trial, "Procalcitonin And Survival Study"...
October 18, 2018: Shock
Maximilian Körner, Malgorzata Roos, Valeria S Meier, Alena Soukup, Simona Cancedda, Magdalena M Parys, Michelle Turek, Carla Rohrer Bley
Objectives The aim of this study was to evaluate the outcome of cats with intracranial tumours presenting with neurological signs treated with radiation therapy. Methods This study comprised a retrospective multi-centre case series. Medical records of a total of 22 cats with intracranial space-occupying lesions, presenting with neurological signs and/or epileptic seizures and treated with external beam radiation therapy, were reviewed. In the treated cats, patient-, tumour- and treatment-related variables were investigated, including age, sex, tumour location, tumour volume, total radiation dose, equivalent dose in 2 Gy fractions (EQD2 ), corticosteroid dose, overall treatment time and institution for influence on local tumour control and survival...
October 19, 2018: Journal of Feline Medicine and Surgery
Clayton Mowrer, Brian R Lee, Rakesh Goyal, Rangaraj Selvarangan, Jennifer E Schuster
Rhinoviruses are commonly detected in symptomatic and asymptomatic children prior to HCT. Unlike pre-HCT detection of other respiratory viruses, it is not known whether RV detection, with or without clinical symptoms, is associated with worse outcomes in children post-HCT. In a retrospective study of children undergoing allogeneic HCT from January 2009 to February 2015, 91 children underwent allogeneic HCT, and 62 children had RPP testing within 30 days pre-HCT. Fifty-six (90%) children had either no pathogen (n = 34, 55%) or single RV detection (n = 22, 35%), which was the most common pathogen identified...
October 19, 2018: Pediatric Transplantation
Mithun Vinod Shah, Rima M Saliba, Gabriela Rondon, Julianne Chen, Doris Soebbing, Ioana Rus, Amin Alousi, Betul Oran, Partow Kebriaei, Muzaffar Qazilbash, Simrit Parmar, Chitra Hosing, Issa F Khouri, Uday R Popat, Richard E Champlin, Stefan O Ciurea
Allogeneic SCT for older patients remains challenging at least in part due to graft-versus-host disease (GVHD) and higher non-relapse mortality (NRM). We conducted a prospective pilot study primarily for older patients undergoing matched unrelated donor (MUD) SCT using a reduced-intensity (RIC) melphalan-based conditioning and post-transplant cyclophosphamide (PTCy)-based GVHD prophylaxis with tacrolimus and mycophenolate mofetil. Twenty-two patients (median age 64, IQR 58, 66) underwent RIC MUD SCT for high-risk hematological malignancies including AML/MDS (73%), CML/MPD (18%), and other (10%)...
October 18, 2018: Bone Marrow Transplantation
V Bourinet, K Thiam, J Guinde, S Laroumagne, H Dutau, P Astoul
INTRODUCTION: Benign laryngotracheal stenosis is a rare pathology with multiple etiologies, the management of which is complex. This is because of the configuration and proximity of the larynx and the difficulty with surgical approaches, which are potentially mutilating, especially for the management of a benign disease. When surgery is challenging, iterative dilatations of the stricture or the fashioning of a definitive tracheotomy are therapeutic alternatives. Advances in rigid bronchoscopy and the evolution of prosthetic silicone material allow a new approach in the management of benign laryngotracheal stenosis, by placing flexible silicone prostheses which cover all the stenosis from the arytenoids to the trachea...
October 15, 2018: Revue des Maladies Respiratoires
Fredric Parenmark, Göran Karlström, Thomas Nolin, Mats Fredrikson, Sten M Walther
PURPOSE: Discharge from an intensive care unit (ICU) during the night is an independent risk factor for adverse outcomes. A quality improvement project was conducted with the aim of reducing the incidence and the associated mortality after night-time discharge. MATERIALS AND METHODS: ICUs that submitted data to the Swedish Intensive Care Registry (SIR) agreed to appoint night-time discharge as a national quality indicator with detailed public display on the internet of various discharge proportions and outcomes...
September 19, 2018: Journal of Critical Care
Isabel Barroeta-Espar, Laura D Weinstock, Beatriz G Perez-Nievas, Avery C Meltzer, Michael Siao Tick-Chong, Ana C Amaral, Melissa E Murray, Krista L Moulder, John C Morris, Nigel J Cairns, Joseph E Parisi, Val J Lowe, Ronald C Petersen, Julia Kofler, Milos D Ikonomovic, Oscar López, William E Klunk, Richard P Mayeux, Matthew P Frosch, Levi B Wood, Teresa Gomez-Isla
Our group has previously studied the brains of some unique individuals who are able to tolerate robust amounts of Alzheimer's pathological lesions (amyloid plaques and neurofibrillary tangles) without experiencing dementia while alive. These rare resilient cases do not demonstrate the patterns of neuronal/synaptic loss that are normally found in the brains of typical demented Alzheimer's patients. Moreover, they exhibit decreased astrocyte and microglial activation markers GFAP and CD68, suggesting that a suppressed neuroinflammatory response may be implicated in human brain resilience to Alzheimer's pathology...
October 15, 2018: Neurobiology of Disease
Vivek N Iyer, Behnam Saberi, Julie K Heimbach, Joseph J Larson, Suresh Raghavaiah, Ivo Ditah, Karen Swanson, Patrick S Kamath, K D Watt, Timucin Taner, Michael J Krowka, Michael D Leise
INTRODUCTION: Liver arteriovenous malformations (AVM) in Hereditary Hemorrhagic Telangiectasia (HHT) can necessitate liver transplantation. There is limited data on HHT patients undergoing LT in the United States. METHODS: Two sources of data were utilized: (1) Scientific Registry of Transplant Recipients (SRTR) database (1998-2016) (2) Single center liver transplant database (Mayo Clinic Rochester, MN). The aims of this study were (1) To determine trends in LT for HHT related liver involvement in the US using the SRTR database (2) To identify clinical characteristics, indications, and outcomes for LT in HHT...
October 16, 2018: Transplantation
Kristina Granger
No abstract text is available yet for this article.
October 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Dong Hyun Kim, Eunae Cho, Sung Bum Cho, Sung Kyu Choi, Sunmin Kim, Jieun Yu, Young-Il Koh, Da Woon Sim, Chung Hwan Jun
RATIONALE: Hepatocellular carcinomas (HCCs) with metastases to the right atrium (RA) and lungs are rare, with a poor prognosis. Furthermore, the treatment outcomes in patients with advanced HCCs remain unsatisfactory. PATIENT CONCERNS: A 46-year-old man presented to our hospital for dyspnea on exertion and abdominal pain. DIAGNOSES: HCC and extra-hepatic metastases to the lung and RA. INTERVENTIONS: Multidisciplinary treatment including radiotherapy (RT), transarterial chemoembolization (TACE), and sorafenib...
October 2018: Medicine (Baltimore)
Janek Senaratne, Thiloththama Thisaranie Herath, Diane Beaudette, Marleen Irwin, Sajad Gulamhusein, Manohara Piyasiri Senaratne
BACKGROUND: The DANPACE study suggested implanting dual-pacing dual-sensing dual-response rate-adaptive (DDDR) pacemakers in patients with sick sinus syndrome, even though 90.7% of their atrial-pacing atrial-sensing inhibited-response rate-adaptive (AAIR) group did not require upgrade. Most centers implant DDDR pacemakers due to risk of future atrioventricular (AV) block. Given that AAIR pacemakers are less expensive, have one less lead with potentially one less point of complication, we question whether DDDR pacemakers are superior to AAIR pacemakers...
October 2018: Medicine (Baltimore)
Yizhou Jiang, Shaoyi Zhou, Gang Shen, Hua Jiang, Jing Zhang
The present study is to evaluate the feasibility and efficacy of microwave ablation (MWA) combined with transcatheter arterial chemoembolization (TACE) in the treatment for unresectable hepatoblastoma in infants and children. A total of 17 patients with PRETEXT stage III and IV hepatoblastoma that was unresectable by conventional resection were included in the present study. The patients were treated with TACE, MWA, and chemotherapy. All cases were diagnosed by computed tomography (CT) and liver tumor biopsy before TACE procedure...
October 2018: Medicine (Baltimore)
Nicole A Carreau, Anna C Pavlick
As recently as 10 years ago, a diagnosis of metastatic melanoma was considered fatal, with a prognosis of typically 6 months or less from diagnosis. The development of checkpoint inhibitors, such as ipilimumab and nivolumab, which modulate the effects of the CTLA-4 and PD-1, respectively, has revolutionized outcomes for these patients. Monotherapy improves metastatic disease survival, but dual therapy provides greater benefit with 58% of patients alive at 3 years. Combination immunotherapy is even active in brain metastases...
October 18, 2018: Future Oncology
Michael V Ortiz, Shannon Fernandez-Ledon, Kavitha Ramaswamy, Christopher J Forlenza, Neerav N Shukla, Rachel Kobos, Todd E Heaton, Michael P LaQuaglia, Peter G Steinherz
From 2009 to 2018, 10 consecutive patients with Wilms tumors and bilateral nephroblastomatosis, who had completed standard therapy, were provided a maintenance chemotherapy regimen consisting of vincristine and dactinomycin every 3 months for 12 months in order to prevent an early metachronous Wilms tumor. One patient (10%) with Beckwith-Wiedemann syndrome developed a new tumor, without anaplasia. There were no significant toxicities reported during maintenance. All patients are currently alive with no evidence of disease...
October 18, 2018: Pediatric Blood & Cancer
Krisztián Kállay, Judit Csomor, Emma Ádám, Csaba Bödör, Csaba Kassa, Réka Simon, Gábor Kovács, György Péter, Gábor Ottóffy, Katalin Bartyik, Csongor Kiss, Péter Masát, Marienn Réti, Blanka Tóth, Gergely Kriván
INTRODUCTION: Acquired bone marrow failures are rare but fatal diseases in childhood. Since 2013, Hungary has been participating as a full member in the work of the European Working Group on uniform diagnostics and therapy in patients with acquired bone marrow failure syndromes. Hypocellular refractory cytopenia of childhood has been emphasized as a frequent entity, transplanted by reduced intensity conditioning with excellent outcomes. AIM: To analyse and compare the results of treatment before and after our joining...
October 2018: Orvosi Hetilap
Vaishnavi Pochineni, Helbert Rondon-Berrios
Kidney transplantation is the current treatment of choice for patients with end-stage renal disease. Innovations in transplantation and immunosuppression regimens have greatly improved the renal allograft survival. Based on recently published data from the Scientific Registry of Transplant recipients, prevalence of kidney transplants is steadily rising in the United States. Over 210,000 kidney transplant recipients were alive with a functioning graft in mid-2016, which is nearly twice as many as in 2005. While successful renal transplantation corrects most of the electrolyte and mineral abnormalities seen in advanced renal failure, the abnormalities seen in the post-transplant period are surprisingly different from those seen in chronic kidney disease...
2018: Frontiers in Medicine
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