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Domenico Penna, Terra L Lasho, Christy M Finke, Rangit R Vallapureddy, Curtis A Hanson, Rhett P Ketterling, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
In the last decade, several prognostic models for primary myelofibrosis (PMF) have been introduced and shown to be effective in predicting overall survival. The main objective for this study was to identify clinical and genetic markers of very long (20+ years) survival in PMF. A total of 1282 patients with PMF were considered (median age 65 years, range 19-92; 63% males); 26 (2%) patients (median age 51 years, range 28-71; 38% males) survived their disease for at least 20 years (long-lived patients) and 626 (49%) patients (median age 68 years, range 27-92; 66% males) died within 5 years of their diagnosis (short-lived patients)...
December 5, 2018: American Journal of Hematology
Iñigo Ojanguren, Ferran Morell, María-Antonia Ramón, Ana Villar, Christian Romero, María-Jesús Cruz, Xavier Muñoz
INTRODUCTION: The objective of this study was to analyze mortality, possible predictors of long-term survival and health-related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample. METHODS: Longitudinal study in patients diagnosed with CHP during 2004-2013, followed for at least one year. Patients remaining alive and consenting to participate had a follow-up visit during 2015, including a complete pulmonary function study and the EuroQol-5D and Beck Depression and Anxiety Inventories...
December 4, 2018: Allergy
Aleksandra Napieralska, Iwona Brąclik, Michał Radwan, Marek Mandera, Sławomir Blamek
PURPOSE: To assess the results and tolerance of radiosurgery/hypofractionated stereotactic radiotherapy performed after craniospinal irradiation for recurrent tumor. METHODS: Fourteen patients aged 3-46 years, diagnosed with medulloblastoma (10), anaplastic ependymoma (3), and primitive neuroectodermal tumor (1). All patients had craniospinal irradiation (CSI) with the total dose of 30.6-36 Gy and boost to 53.9-60 Gy either during primary or during second-line treatment...
December 4, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Andrei S Morgan, Laurence Foix L'Helias, Caroline Diguisto, Laetitia Marchand-Martin, Monique Kaminski, Babak Khoshnood, Jennifer Zeitlin, Gérard Bréart, Xavier Durrmeyer, François Goffinet, Pierre-Yves Ancel
BACKGROUND: Emerging evidence suggests intensity of perinatal care influences survival for extremely preterm babies. We evaluated the effect of differences in perinatal care intensity between centres on sensorimotor morbidity at 2 years of age. We hypothesised that hospitals with a higher intensity of perinatal care would have improved survival without increased disability. METHODS: Foetuses alive at maternal admission to a level 3 hospital in France in 2011, subsequently delivered between 22 and 26 weeks gestational age (GA) and included in the EPIPAGE-2 national prospective observational cohort study formed the baseline population...
December 5, 2018: BMC Medicine
Misumi Hata, Mustafa Soylu, Satoru Izumi, Toru Abe, Takuo Suganuma
Nowadays, due to the widespread usage of mobile devices and wireless network technologies, we can use various ICT services almost anytime, anywhere even if we are changing our location at that moment. Therefore, mobility management technology have been attracting attention. This technology is to keep communication alive even when a mobile node (MN), which is communicating with the server or some nodes, moves to another network domain. Software Defined Networking (SDN) is used for mobility management to realize effective intra-domain routing that optimizes routes when an MN moves inside an SDN domain...
December 2, 2018: Sensors
Isabelle Catherine Pitzen, Lucia Anna Otten, Till Dresbach, Christoph Boesecke, Jan-Christian Wasmuth, Andreas Mueller, Ulrich Gembruch, Waltraut M Merz, Christian P Strassburg, Annette Haberl, Juergen K Rockstroh, Silvia Poralla, Carolynne Schwarze-Zander
INTRODUCTION: Worldwide, 37 million people are infected with HIV; more than 50% are women. Currently, MTCT (mother-to-child transmission) can be reduced to<1%. The intention of the present study was to analyze the development of (1) the course of pregnancy of HIV-infected women, (2) the mode of delivery and (3) the post-exposure prophylaxis of the newborn over the last decade. METHODOLOGY: In this retrospective study, data from HIV-infected women who between 2005 and 2016 received care at the HIV outpatient department and gave birth at the Department of Obstetrics at University Hospital Bonn was analyzed...
December 4, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
Tatsuya Suwabe, Yoshifumi Ubara, Noriko Hayami, Masayuki Yamanouchi, Rikako Hiramatsu, Keiichi Sumida, Naoki Sawa, Akinari Sekine, Masahiro Kawada, Eiko Hasegawa, Junichi Hoshino, Kenmei Takaichi
BACKGROUND: Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often difficult to treat. However, the factors influencing cyst infection are still unknown. Therefore, we investigated clinical factors related to the duration of hospitalization and death due to cyst infection. METHODS: All ADPKD patients undergoing cyst drainage or nephrectomy or partial hepatectomy at Toranomon Hospital from January 2004 to March 2016, in whom cyst fluid analysis showed bacteria or neutrophils indicating definite cyst infection, were reviewed retrospectively...
December 4, 2018: Nephron
Gregory M Videtic, Rebecca Paulus, Anurag K Singh, Joe Y Chang, William Parker, Kenneth R Olivier, Robert D Timmerman, Ritsuko R Komaki, James J Urbanic, Kevin L Stephans, Sue S Yom, Clifford G Robinson, Chandra P Belani, Puneeth Iyengar, Munther I Ajlouni, Darindra D Gopaul, Shashikant B Lele, Ronald C McGarry, Hak Choy, Jeffrey D Bradley
PURPOSE/OBJECTIVE(S): To present long-term results of XXXX, a randomized lung stereotactic body radiotherapy (SBRT) trial of 34 Gy in 1 fraction versus 48 Gy in 4 fractions. MATERIALS/METHODS: This was a phase II multicenter study of medically inoperable non-small cell lung cancer patients with biopsy-proven peripheral T1 or T2 N0M0 tumors, with 1-year toxicity rates as primary endpoint and selected failure and survival outcomes as secondary endpoints. The study opened in September 2009 and closed in March 2011...
December 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Jiaofang Huang, Suying Liu, Chen Zhang, Xinyu Wang, Jiahua Pu, Fang Ba, Shuai Xue, Haifeng Ye, Tianxin Zhao, Ke Li, Yanyi Wang, Jicong Zhang, Lihua Wang, Chunhai Fan, Timothy K Lu, Chao Zhong
Bacterial biofilms can be programmed to produce living materials with self-healing and evolvable functionalities. However, the wider use of artificial biofilms has been hindered by limitations on processability and functional protein secretion capacity. We describe a highly flexible and tunable living functional materials platform based on the TasA amyloid machinery of the bacterium Bacillus subtilis. We demonstrate that genetically programmable TasA fusion proteins harboring diverse functional proteins or domains can be secreted and can assemble into diverse extracellular nano-architectures with tunable physicochemical properties...
December 3, 2018: Nature Chemical Biology
Raffaele Longo, Oana Balasanu, Mathilde Chastenet de Castaing, Eric Chatelain, Mohammed Yacoubi, Marco Campitiello, Nathalie Marcon, Francesca Plastino
BACKGROUND Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine tumor frequently associated with Merkel cell polyomavirus infection. Despite its aggressiveness, a few reports of spontaneous MCC regression have been described in the literature, most of them following incisional biopsy supporting a hypothetical role of surgery-induced inflammation in the process of regression. CASE REPORT We report a case of 69-year-old Caucasian male who was followed for an idiopathic hyper-eosinophilic syndrome...
December 4, 2018: American Journal of Case Reports
Giovanni E Cacciamani, Vincenzo De Marco, Marco Sebben, Riccardo Rizzetto, Maria A Cerruto, Antonio B Porcaro, Inderbir S Gill, Walter Artibani
BACKGROUND: The Vescica Ileale Padovana (VIP) was first described in 1989 as a technique for total bladder replacement, and gained popularity due to technical simplicity and functional advantages. OBJECTIVE: To report preliminary results and a detailed step-by-step surgical technique description of robot-assisted VIP (ra-VIP) that replicates the open technique principles. DESIGN, SETTING, AND PARTICIPANTS: We report the data of 15 consecutive patients who underwent robot-assisted radical cystectomy (RARC) and totally intracorporeal ra-VIP at our institution from April 2015 to March 2017...
November 30, 2018: European Urology
A Vallard, P Diao, M-A Garcia, G Pigné, N Vial, F Forest, M Peoc'h, J Langrand-Escure, N Magné
PURPOSE: There is paucity of data on rectal cancer with uncommon histologic types. The objective was to describe managements of care and outcomes in patients with rectal cancer of histologic types other than adenocarcinoma. MATERIAL AND METHODS: This monoinstitutional retrospective study included all patients with rectal cancer undergoing rectal radiotherapy. RESULTS: From 2004 to 2015, 744 patients were treated for rectal cancer, and ten had a histologic type other than adenocarcinoma...
November 30, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Anna Mäkinen, Ali Nawaz, Antti Mäkitie, Jukka H Meurman
PURPOSE: This study examined the prevalence of Candida species in the saliva of oral squamous cell carcinoma patients and its effect on the mortality rate. MATERIALS AND METHODS: One hundred patients with oral cavity squamous cell carcinoma undergoing protocol treatment at Helsinki University Hospital were recruited into the study from March 2011 through 2014. For comparison, 75 age-matched controls with no current or previously treated oral cancer were recruited...
December 2018: Journal of Oral and Maxillofacial Surgery
M Augugliaro, G Marvaso, D Ciardo, D Zerini, G Riva, E Rondi, S Vigorito, S Comi, O De Cobelli, R Orecchia, B Alicja Jereczek-Fossa
The aim of our study was to retrospectively report on radiotherapy (RT) in the oligometastastic recurrence of bladder cancer. Thirteen patients treated for low-volume metastatic transitional cell urinary bladder carcinoma (TCC) were reviewed. The primary endpoint was to evaluate the safety and efficacy of RT, proposed as an alternative to systemic treatment and/or to defer the start of a systemic therapy. Inclusion criteria for our retrospective study were as follows: patients that received RT (without other local/systemic therapy) for oligometastatic TCC with lymph node, bone, lung lesions or local recurrence...
September 4, 2018: Neoplasma
Cara L Sedney, Uzer Khan, Patricia Dekeseredy
CONTEXT: Medicaid has been linked to worse outcomes in a variety of diagnoses such as lung cancer, uterine cancer, and cardiac valve procedures. It has furthermore been linked to the reduced health-related quality of life outcomes after traumatic injuries when compared to other insurance groups. In spinal cord injury (SCI), the care provided in the subacute setting may vary based upon payor status, which may have implications on outcomes and cost of care. DESIGN: A retrospective review utilizing the institutional trauma databank was performed for all adult patients with spinal cord injury since 2009...
December 3, 2018: Journal of Spinal Cord Medicine
Afshin Nikkhoo, Narges Rostami, Mohammad Hojjat-Farsangi, Gholamreza Azizi, Bahman Yousefi, Ghasem Ghalamfarsa, Farhad Jadidi-Niaragh
Breast cancer is the most prevalent cancer in women. Despite improvements in treatment, the rate of breast cancer-related deaths is still high, and this issue needs further, accurate investigations. Although several treatment options are available, none of them are efficient for complete remission, particularly in advanced stages of the disease. It is known that cancerous cells have dysregulated apoptosis-related pathways, by which they can remain alive for a long time, expand freely, and escape from apoptosis-inducing drugs or antitumor immune responses...
December 3, 2018: Journal of Cellular Biochemistry
Lingquan Wang, Wei Xu, Xuexin Yao, Chao Yan, Chen Li, Zhenggang Zhu, Wentao Liu, Min Yan
OBJECTIVE: To investigate the clinical characteristics and prognostic factors of reoperation patients with postoperative recurrence or metastasis of gastrointestinal stromal tumor (GIST). METHODS: A retrospective case-control study was performed on the clinical data of 31 patients with GIST who had recurrence or metastasis after the first surgery and underwent one or more operations again from February 2003 to January 2016 at Ruijin Hospital, Shanghai Jiaotong University School of Medicine...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Philipp Horvath, Can Yurttas, Philipp Birk, Florian Struller, Alfred Königsrainer
PURPOSE: Documentation of cellularity in Pseudomyxoma peritonei (PMP) is not performed on a regular basis in everyday clinical practice, but is recommended by the PSOGI (Peritoneal Surface Oncology Group International). We investigated the impact of cellularity in PMP following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on recurrence-free survival. METHODS: Data from 25 patients with low-grade (American Joint Committee on Cancer grade G1) PMP were retrospectively evaluated...
December 1, 2018: Langenbeck's Archives of Surgery
Mahmoud Ismail, Dania Nachira, Elisa Meacci, Gian Maria Ferretti, Marc Swierzy, Julianna Paulina Englisch, Ramin Raul Ossami Saidy, Svea Faber, Maria Teresa Congedo, Marco Chiappetta, Leonardo Petracca Ciavarella, Stefano Margaritora, Jens C Rueckert
Background: The efficacy of video-assisted thoracic surgery (VATS) in the treatment of pleural empyema has recently been proven. Till today, very few works evaluated the role of uniportal-VATS (U-VATS) approach in the treatment of pleural empyema even if it currently represents the most innovative and less invasive thoracoscopic approach. We report our experience with U-VATS in the treatment of pleural empyema. Methods: A retrospective bicentric analysis of 35 consecutive patients who underwent surgical treatment of stage II and stage III pleural empyema was performed, from January 2015 to May 2017...
November 2018: Journal of Thoracic Disease
Dania Nachira, Elisa Meacci, Maria Giovanna Mastromarino, Luca Pogliani, Edoardo Zanfrini, Amedeo Iaffaldano, Leonardo Petracca-Ciavarella, Marco Chiappetta, Maria Teresa Congedo, Maria Letizia Vita, Venanzio Porziella, Stefano Margaritora
Background: Multiportal thoracoscopic approach is already a well standardized procedure for minimally invasive esophagectomy (MIE); conversely very few reports have been published about uniportal video-assisted thoracic surgery (VATS) technique till now. We present our preliminary experience with uniportal VATS esophagectomy, evaluating short-term outcomes as perioperative mortality, complications, oncological radicality, postoperative pain and cosmetic results. Methods: From December 2016 to November 2017, the prospectively collected clinical data of 12 patients, who underwent uniportal VATS esophagectomy and reconstruction with a stomach conduit, according to McKeown technique, were reviewed and outcomes evaluated...
November 2018: Journal of Thoracic Disease
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