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Nina Zech, Milena Seemann, Timo F Seyfried, Max Lange, Juergen Schlaier, Ernil Hansen
BACKGROUND: Sedatives and opioids used during deep brain stimulation (DBS) surgery interfere with optimal target localization and add to side effects and risks, and thus should be minimized. OBJECTIVE: To retrospectively test the actual need for sedatives and opioids when cranial nerve blocks and specific therapeutic communication are applied. METHODS: In a case series, 64 consecutive patients treated with a strong rapport, constant contact, non-verbal communication and hypnotic suggestions, such as dissociation to a "safe place," reframing of disturbing noises and self-confirmation, were compared to 22 preceding patients under standard general anaesthesia or conscious sedation...
December 5, 2018: Stereotactic and Functional Neurosurgery
Eileen R Chasens, Charles W Atwood, Lora E Burke, Mary Korytkowski, Robert Stansbury, Patrick J Strollo, Susan M Sereika
The Diabetes Sleep Treatment Trial (DSTT) is a multi-site, double-blinded, randomized, sham-controlled trial. The study objective is to test whether treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) treatment results in improved glycemic control and diabetes self-management behavior compared to participants on a sham-CPAP (sub-therapeutic) device in participants with type 2 diabetes mellitus (T2DM) and co-morbid OSA. The purpose of this paper is to describe the premise for the DSTT, the study design, and the methodology used in this on-going trial...
December 2, 2018: Contemporary Clinical Trials
Valentino Bianco, Emanuele Locatelli, Paolo Malgaretti
We study the dynamics and conformation of polymers composed by active monomers. By means of Brownian dynamics simulations we show that, when the direction of the self-propulsion of each monomer is aligned with the backbone, the polymer undergoes a coil-to-globulelike transition, highlighted by a marked change of the scaling exponent of the gyration radius. Concurrently, the diffusion coefficient of the center of mass of the polymer becomes essentially independent of the polymer size for sufficiently long polymers or large magnitudes of the self-propulsion...
November 23, 2018: Physical Review Letters
Mikaël Ghadimi Nassiri, Etienne Brasselet
We report on a programmable liquid crystal spatial light modulator enabling independent orbital angular momentum state control on multiple spectral channels. This is done by using electrically controllable "topological pixels" that independently behave as geometric phase micro-optical elements relying on self-engineered liquid crystal defects. These results open interesting opportunities in optical manipulation, sensing, imaging, and communications, as well as information processing. In particular, spectral vortex modulation allows considering singular spatiotemporal shaping of ultrashort pulses which may find applications in many areas such as material processing, spectroscopy, or elementary particles acceleration...
November 23, 2018: Physical Review Letters
Lauren E O'Connor, Sarah L Biberstine, Douglas Paddon-Jones, A J Schwichtenberg, Wayne W Campbell
Background: Reducing red meat intake is commonly recommended. Limited observational studies suggest that healthy eating patterns with red meat are associated with improved quality of life. Objective: The secondary objectives of this randomized crossover controlled-feeding trial were to assess the effects of following a Mediterranean-style eating pattern (Med-Pattern) with different amounts of red meat on indexes of personal well-being (i.e., perceived quality of life, mood, and sleep) in overweight or obese adults...
December 1, 2018: Journal of Nutrition
Michael T Spooner, John E Alex, Joy A Greer, Donald R Delorey, Rebecca A Kiser, Carl Petersen, Travis Polk, Kim Gunzelman
Introduction: A standardized training curriculum designed for general medical officers (GMO) titled Simulation Training for Operational Medicine Providers (STOMP) was recently developed to educate and improve GMOs' procedural skills through directed feedback prior to assuming duties in an operational environment. This study aimed to determine the impact this novel curriculum had on GMOs'confidence levels in 21 core privileges covering eight different subspecialties while stationed at Naval Medical Center Portsmouth (NMCP)...
December 4, 2018: Military Medicine
Lucja T Bundy, Regine Haardörfer, Michelle C Kegler, Shadé Owolabi, Carla J Berg, Cam Escoffery, Tess Thompson, Patricia Dolan Mullen, Rebecca Williams, Mel Hovell, Tanya Kahl, Dayanne Harvey, Adrianne Price, Donnie House, Becky W Booker, Matthew W Kreuter
Introduction: Given homes are now a primary source of secondhand smoke exposure (SHS) in the US, research-tested interventions that promote smoke-free homes should be evaluated in real-world settings to build the evidence-base for dissemination. This study describes outcome evaluation results from a dissemination and implementation study of a research-tested program to increase smoke-free home rules through US 2-1-1 helplines. Methods: Five 2-1-1 organizations, chosen through a competitive application process, were awarded grants of up to $70,000...
December 5, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Simoni Urbano da Silva, Laura Augusta Barufaldi, Silvânia Suely Caribé de Araújo Andrade, Maria Aline Siqueira Santos, Rafael Moreira Claro
INTRODUCTION: This study aimed to analyze the association between nutritional status, body image perception, and extreme weight control behaviors among adolescents. METHODS: This is an analytical cross-sectional study conducted in Brazil based on the National Adolescent Student Health Survey (Pesquisa Nacional de Saúde do Escolar - PeNSE) of 2015, with adolescents aged 13 to 17 years. Nutritional status and body image perception were the independent variables. The two dependent variables were vomiting or laxative use and use of medicines and other formulas for weight control in the 30 days prior to data collection...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Vivian Gehm Seballos, Mirela Sangoi Barreto, Ricardo Abreu da Rosa, Eduardo Machado, Luiz Felipe Valandro, Osvaldo Bazzan Kaizer
The aim of this study was to evaluate the effect of post-space irrigation with NaOCl and CaOCl at different concentrations on the bond strength of posts cemented with a self-adhesive resin cement. Eighty premolars were sectioned 14 mm from the apex, and endodontically treated. The root canal filling was partially removed. Specimens were randomly assigned into 8 groups (n=10), according to the irrigant for post-space irrigation: SS - 0.9% saline solution (control group); CHX - 2% chlorhexidine; 1% NaOCl - 1% sodium hypochlorite; 2...
September 2018: Brazilian Dental Journal
Maria de Lourdes Barbosa Negrão, Patrícia Costa Dos Santos da Silva, Camila Maria Silva Paraizo, Roberta Garcia Gomes, Eliza Maria Rezende Dázio, Eliane Garcia Rezende, Zélia Marilda Rodrigues Resck, Silvana Maria Coelho Leite Fava
OBJECTIVE: To analyze the meanings assigned by people with systemic arterial hypertension to health education actions in the waiting room. METHOD: This is an analytical qualitative study, held in 2016 with 19 people with arterial hypertension from a health unit. The data were collected in households, through a semi-structured interview and field notes, recorded on audio, transcribed and organized by thematic analysis, being analyzed considering Vygostky's Cultural-Historical Learning Theory...
November 2018: Revista Brasileira de Enfermagem
Takashi Kido, Shigeru Miyagawa, Takasumi Goto, Katsuto Tamai, Takayoshi Ueno, Koichi Toda, Toru Kuratani, Yoshiki Sawa
OBJECTIVES: We hypothesized that systemic administration of high-mobility group box 1 fragment attenuates the progression of myocardial fibrosis and cardiac dysfunction in a hamster model of dilated cardiomyopathy by recruiting bone marrow mesenchymal stem cells thus causing enhancement of a self-regeneration system. METHODS: Twenty-week-old J2N-k hamsters, which are δ-sarcoglycan-deficient, were treated with systemic injection of high-mobility group box 1 fragment (HMGB1, n = 15) or phosphate buffered saline (control, n = 11)...
2018: PloS One
Francesca Accioni, Noelia Caballero-Casero, Diego García-Gómez, Soledad Rubio
In this work, a restricted access volatile supramolecular solvent (RAM-VOL-SUPRAS) directly synthesized in milk is proposed for the first time for the simultaneous extraction and cleanup of benzimidazole anthelmintic drugs in milk meant for human consumption. The RAM-VOL-SUPRAS was formed by the self-assembly and coacervation of hexanol in tetrahydrofuran induced by the water content in milk. Benzimidazoles legislated by the European Union were quantitatively extracted (80-110%) Proteins were precipitated by the action of THF and the amphiphile, extraction of carbohydrates was avoided by a size exclusion mechanism and lipids were removed during hexanol evaporation...
December 5, 2018: Journal of Agricultural and Food Chemistry
Seher Unver, Semra Eyi, Zeynep Kizilcik Ozkan
Pain during negative pressure wound therapy (NPWT) has been reported in the literature. PURPOSE: The study was conducted to describe patients' pain experience, pain-coping skills, and the effect of NPWT-related pain on daily life activities following abdominal surgery. METHOD: Using a descriptive, qualitative design, semi-structured face-to-face interviews were conducted between April 3, 2016 and December 26, 2016, in the surgical ward of a university hospital in Edirne, Turkey...
December 2018: Ostomy/wound Management
Hannah Doucette, Charlene Collibee, Erik Hood, Daniel Ian Gittins Stone, Brett DeJesus, Christie Jade Rizzo
Electronic intrusiveness is a form of cyber dating abuse that includes monitoring a partners' location, whom a partner is talking to, and other private information via technology and social networking sites. The aim of this study was to further explore the prevalence of electronic intrusiveness, as well as to assess how electronic intrusiveness relates to in-person dating violence while controlling for known risk factors for in-person dating violence, namely, depression, emotion regulation, and acceptance of couple violence...
December 5, 2018: Journal of Interpersonal Violence
Hyo-Jin Park, Sung-Hwan Choi, Yoon Jeong Choi, Young-Bum Park, Kwang-Mahn Kim, Hyung-Seog Yu
OBJECTIVES: To determine whether the success rate and primary stability of surface-treated miniscrews differ from those of nontreated miniscrews. MATERIALS AND METHODS: Patients who required one or more miniscrews for the same reason in each quadrant were recruited into a single-blinded, split-mouth, randomized, controlled trial with a 1:1 allocation ratio. Self-drilling miniscrews with two surface types were used: those with no surface treatment, and those with an acid-etched surface treatment...
December 5, 2018: Angle Orthodontist
Subhadeep Saha, Björn Holzapfel, Yen-Ting Chen, Kai Terlinden, Pascal Lill, Christos Gatsogiannis, Heinz Rehage, Guido H Clever
Self-assembled, porous coordination cages with a functional interior find application in controlled guest inclu-sion/release, drug delivery, separation processes, and catalysis. However, only few studies exist that describe their utilization for the development of self-assembled materials based on their 3-dimensional shape and external functional-ization. Here, dodecyl chain-containing, acridone-based ligands (LA) and shape-complementary phenanthrene-derived ligands (LB) are shown to self-assemble to heteroleptic coordination cages cis-[Pd2(LA)2(LB)2]4+ acting as a gemini amphiphile (CGA-1; Cage-based Gemini Amphiphile-1)...
December 5, 2018: Journal of the American Chemical Society
Weixin Zheng, Haoyi Wu, Guifang Ju, Zhong Mo, Huafeng Dong, Yihua Hu, Yahong Jin
In this paper, a new color tunable long persistent phosphor (Ca, Sr)Ga4O7:Mn2+,Bi3+ has been successfully synthesized via a high-temperature solid-state reaction. Crystal field modulation and band gap engineering controlled by Sr2+ substitution for Ca2+ realizes the color tunable Mn2+ emission from 580 to 556 nm. Guided by the tailoring of traps distribution, the long persistence luminescence (LPL) performance of CaGa4O7:Mn2+ is greatly enhanced to 33 times higher brightness and much longer persistent time through Bi3+ co-doping...
December 5, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
David Welch, Kim N Dirks, Daniel Shepherd, David McBride
Introduction: The aim of the study was to determine whether those who are noise sensitive are more adversely affected by airport noise than those who are not noise sensitive. Participants and Methods: One area was very close to Wellington International Airport and the other was distant from the airport and any other major sources of noise such as motorways and railways. Noise sensitivity was self-rated on a three-point scale as follows: non-noise sensitive, moderately noise sensitive, or highly noise sensitive...
September 2018: Noise & Health
Benjamin Mesure, Patrick Menu, Jagadeesh Kumar Venkatesan, Magali Cucchiarini, Émilie Velot
Musculoskeletal pathologies, especially those affecting bones and joints, remain a challenge for regenerative medicine. The main difficulties affecting bone tissue engineering are the size of the defects, the need for blood vessels and the synthesis of appropriate matrix elements in the engineered tissue. Indeed, the cartilage is an avascular tissue and consequently has limited regenerative abilities. Thanks to their self-renewal, plasticity and immunomodulatory properties, mesenchymal stem cells (MSCs) became a central player in tissue engineering, and have already been shown to be able to differentiate towards chondrogenic or osteogenic phenotypes...
December 5, 2018: Current Stem Cell Research & Therapy
Ian T Hoffecker, Sijie Chen, Andreas Gådin, Alessandro Bosco, Ana I Teixeira, Björn Högberg
Self-assembled DNA origami nanostructures have a high degree of programmable spatial control that enables nanoscale molecular manipulations. A surface-tethered, flexible DNA nanomesh is reported herein which spontaneously undergoes sharp, dynamic conformational transitions under physiological conditions. The transitions occur between two major macrostates: a spread state dominated by the interaction between the DNA nanomesh and the BSA/streptavidin surface and a surface-avoiding contracted state. Due to a slow rate of stochastic transition events on the order of tens of minutes, the dynamic conformations of individual structures can be detected in situ with DNA PAINT microscopy...
December 5, 2018: Small
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