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Severe allergic asthma

Sara Rojas-Dotor, Adriana González-Hernández, Francisco Humberto León-Aguilar, Víctor Juárez-Téllez, Patricia Gómez de León Cruces
Entamoeba histolytica produces, in axenic culture, the monocytes locomotion inhibitory factor (MLIF), a oligopeptide with selective anti-inflammatory properties. We evaluated the effect of MLIF on the expression of pro- and anti-inflammatory cytokines in CD4+ T lymphocytes from children with asthma and allergic rhinitis. Twelve children with severe asthma, 12 children with allergic rhinitis and 6 healthy controls were recruited for this study between May and December 2016. CD4+ T cells were cultured for 24 h at 37°C, 5% CO2 in the presence of MLIF, 1-phorbol 12-myristate 13-acetate (PMA), MLIF+PMA or RPMI...
August 12, 2018: Iranian Journal of Allergy, Asthma, and Immunology
T Sinai, M R Goldberg, L Nachshon, R Amitzur-Levy, T Yichie, Y Katz, E Monsonego-Ornan, A Elizur
BACKGROUND: Growth impairment was previously described in milk-allergic children but was not examined in adults upon reaching final height. OBJECTIVES: To investigate the dietary intake and final stature of young adults with IgE-mediated cow's milk-allergy (IgE-CMA) as compared to non-allergic controls. METHODS: 87 IgE-CMA patients, median age 19.5 years (IQR, 17.3-22.7) and 36 control participants without food allergies, median age 22.7 years (IQR, 18...
December 6, 2018: Journal of Allergy and Clinical Immunology in Practice
Mary Clare McGregor, James G Krings, Parameswaran Nair, Mario Castro
Patients with severe uncontrolled asthma have disproportionally high morbidity and health care utilization as compared to their peers with well-controlled disease. While treatment options for these patients were previously limited with unacceptable side effects, the emergence of biologic therapies for the treatment of asthma has provided promising targeted therapy for these patients. Biologic therapies target specific inflammatory pathways involved in the pathogenesis of asthma, particularly in patients with an endotype driven by type 2 (T2) inflammation...
December 10, 2018: American Journal of Respiratory and Critical Care Medicine
Sasawan Chinratanapisit, Narissara Suratannon, Punchama Pacharn, Paskorn Sritipsukho, Pakit Vichyanond
BACKGROUND: Allergic rhinitis (AR) is a disease with a high global disease burden and significant morbidity and expense. Risk factors are not well understood. OBJECTIVE: The objective of our project is to study the prevalence and risk factors of AR in children living in the Bangkok area. METHODS: A cross-sectional, multi-center survey using new GAN core questionnaires on current AR and risk factors was completed by 3,074 parents of children aged 6-7 years and by 3,217 children aged 13-14 years, directly...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Joyce A M Emons, Roy Gerth van Wijk
Purpose of review: To describe and understand the links and interactions between food allergy and asthma. Recent findings: Food allergy and asthma are characterized by an increasing prevalence. Moreover, food allergy and asthma often coexist. Both conditions are associated with each other in different ways. It has been shown that food allergy is a risk factor of developing asthma. Atopic dermatitis appears to be the common denominator in this interaction. Loss-of-function variants of the filaggrin mutation result in an impaired epidermal barrier function and have been shown to be a risk factor for the development of atopic dermatitis, allergies, and asthma...
2018: Current Treatment Options in Allergy
Prafull Bandopant Ninave, Savita Dattatray Patil
Zizyphus jujuba Mill, a famous oriental traditional medicine, has been reported to exhibit diverse activities in biological systems including the respiratory system. However, a little information is available on its antiasthmatic activity. Jujuboside B (JB) is a natural saponin and one of the active constituent of fruits of Zizyphus jujuba. In the present investigation, JB was isolated from ethanolic extracts of fruits of Zizyphus jujuba (EZJF). EZJF and JB were then evaluated for anti-asthmatic activity using various screening methods...
December 3, 2018: Respiratory Physiology & Neurobiology
Anne-Charlotte Jonckheere, Dominique M A Bullens, Sven F Seys
PURPOSE OF REVIEW: The current review describes the role of different types of innate lymphoid cells (ILCs) in the pathogenesis of asthma inflammatory phenotypes by linking findings from murine asthma models with human studies. Novel treatment options are needed for patients with steroid-insensitive asthma. Strategies targeting ILCs, or their upstream or downstream molecules are emerging and discussed in this review. RECENT FINDINGS: In eosinophilic asthma, ILCs, and especially type 2 ILCs (ILC2s), are activated by alarmins such as IL-33 upon allergen triggering of the airway epithelium...
December 3, 2018: Current Opinion in Allergy and Clinical Immunology
Giancarlo Marone, Maria Rosaria Galdiero, Antonio Pecoraro, Valentina Pucino, Gjada Criscuolo, Maria Triassi, Gilda Varricchi
Prostaglandin D2 (PGD2 ) is a major cyclooxygenase mediator that is synthesized by activated human mast cells and other immune cells. The biological effects of PGD2 are mediated by D-prostanoid (DP1 ), DP2 (CRTH2) and thromboxane prostanoid (TP) receptors that are expressed on several immune and non-immune cells involved in allergic inflammation. PGD2 exerts various proinflammatory effects relevant to the pathophysiology of allergic disorders. Several selective, orally active, DP2 receptor antagonists and a small number of DP1 receptor antagonists are being developed for the treatment of allergic disorders...
January 2019: Expert Opinion on Investigational Drugs
M M Folqué, J Lozano, C Riggioni, M Piquer, M Álvaro, A Machinena, M T Giner, O Domínguez, R M Jiménez-Feijoo, M Dias da Costa, A M Plaza
INTRODUCTION AND OBJECTIVES: Omalizumab is present in international guidelines for the control of severe asthma, but data on the long-term effects in children are limited. Our objective was to perform a 'real-life' long-term trial of omalizumab in children with allergic asthma. MATERIALS AND METHODS: An observational single center 'real-life' study was performed. Data for treatment, lung function, side effect, asthma exacerbations and hospitalizations were recorded at six months and annually...
November 30, 2018: Allergologia et Immunopathologia
Oliver Pfaar, Claus Bachert, Piotr Kuna, Peter Panzner, Mária Džupinová, Ludger Klimek, Maroesja J van Nimwegen, Johan D Boot, Donghui Yu, Dirk Jan E Opstelten, Pieter-Jan de Kam
BACKGROUND: Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both clinical efficacious and safe. However, in line with the current regulatory guidance from the European Medicines Agency, allergen immunotherapy (AIT) products must demonstrate their efficacy and safety in pivotal, phase III trials for registration. OBJECTIVE: To investigate the efficacy and safety of sublingual high-dose liquid birch pollen extract (40,000 AUN/ml) in birch pollen allergic adult patients...
November 30, 2018: Journal of Allergy and Clinical Immunology
Hanako Tajima, Ruby Pawankar
PURPOSE OF REVIEW: The prevalence of obesity and allergic diseases, such as asthma and allergic rhinitis, is increasing worldwide not only in adults, but also in children. Experimental and clinical studies have demonstrated the effect of obesity not only on asthma, but also on other allergic diseases. RECENT FINDINGS: Allergic diseases, such as asthma and allergic rhinitis, are common chronic inflammatory diseases of the airways. Obesity is an increasingly common pediatric disease and is a risk factor for the development of asthma in that obese patients with asthma tend to have more severe asthma that does not respond well to standard asthma therapy...
November 29, 2018: Current Opinion in Allergy and Clinical Immunology
Hua Zhou, Yanming Lu, Bin Wu, Datian Che
OBJECTIVE: The addition of omalizumab to standard therapy has proven to be efficacious in children with severe allergic asthma. The goal of this study was to assess the cost-effectiveness of adding omalizumab to standard treatment for asthma in Chinese pediatric patients. METHODS: A Markov model was constructed to project the health and economic outcomes in pediatric patients with severe allergic asthma. Model inputs were obtained from the literature. Cost and quality-adjusted life-years (QALYs) were measured over a five-year time horizon...
December 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Olga Danov, Sharon Melissa Jiménez Delgado, Helena Obernolte, Sophie Seehase, Susann Dehmel, Peter Braubach, Hans-Gerd Fieguth, Gabriele Matschiner, Mary Fitzgerald, Danny Jonigk, Sascha Knauf, Olaf Pfennig, Gregor Warnecke, Judy Wichmann, Armin Braun, Katherina Sewald
Subgroups of patients with severe asthma are insensitive to inhaled corticosteroids and require novel therapies on top of standard medical care. IL-13 is considered one of the key cytokines in the asthma pathogenesis, however, the effect of IL-13 was mostly studied in rodents. This study aimed to assess IL-13 effect in human lung tissue for the development of targeted therapy approaches such as inhibition of soluble IL-13 or its receptor IL-4Rα subunit. Precision-cut lung slices (PCLS) were prepared from lungs of rodents, non-human primates (NHP) and humans...
2018: PloS One
Yanran Huang, Yuan Zhang, Luo Zhang
Background: Most epidemiologic studies reporting prevalence of allergic rhinitis (AR) and nonallergic rhinitis (NAR) have assessed solely self-reported prevalence, without confirmation by objective measures. Furthermore, reports of prevalence of NAR in Chinese subjects are scarce. Thus, we aimed to explore the prevalence and risk factors of AR and NAR in a Chinese, based on both clinical manifestation and allergic status. Methods: We conducted a population-based cross-sectional survey, involving 1084 local residents from a rural area of Beijing, China...
2018: Allergy, Asthma, and Clinical Immunology
Min Hye Kim, Sang Heon Kim, So Young Park, Ga Young Ban, Joo Hee Kim, Jae Woo Jung, Ji Yong Moon, Woo Jung Song, Hyouk Soo Kwon, Jae Woo Kwon, Jae Hyun Lee, Hye Ryun Kang, Jong Sook Park, Tae Bum Kim, Heung Woo Park, Kwang Ha Yoo, Yeon Mok Oh, Young Il Koh, An Soo Jang, Byung Jae Lee, Young Joo Cho, Sang Heon Cho, Hae Sim Park, Choon Sik Park, Ho Joo Yoon, You Sook Cho
PURPOSE: Although mild to moderate asthma is much more common, the morbidity and mortality of severe asthma are much higher. This study was performed to identify and analyze the clinical characteristics of severe asthma in Korea. METHODS: We registered patients with severe refractory asthma into the Severe Asthma Registry supported by the Severe Asthma Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology. Patients were enrolled since 2010 from the 15 university hospitals nationwide in Korea...
January 2019: Allergy, Asthma & Immunology Research
Chloé Beuraud, Vincent Lombardi, Sonia Luce, Stéphane Horiot, Emmanuel Naline, Catherine Neukirch, Sabi Airouche, Thibaut Perchet, Rachel Golub, Philippe Devillier, Sylvie Chollet-Martin, Véronique Baron-Bodo, Emmanuel Nony, Michel Aubier, Laurent Mascarell, Philippe Moingeon
BACKGROUND: We previously showed that patients with severe allergic asthma have high numbers of circulating ILC2s expressing CCR10. METHOD: Herein, CCR10+ ILC2s were further analyzed in the blood of healthy individuals or patients with allergic and non-allergic asthma. Characteristics of human CCR10+ and CCR10- ILC2s were assessed by flow cytometry as well as single-cell multiplex RT-qPCR. The role of CCR10+ ILC2s in asthma pathophysiology was studied in allergen-treated mice...
November 26, 2018: Allergy
Ahmed Al-Digheari, Bassam Mahboub, Hesham Tarraf, Taskin Yucel, Isabella Annesi-Maesano, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz, Abdelkader El Hasnaoui
Background: The SNAPSHOT program provides current data on the allergic rhinitis burden in the adult general population of five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia and the United Arab Emirates, the latter three grouped into a Gulf cluster). Methods: A multi-country, cross-sectional, epidemiological program conducted by telephone in a random sample of the adult general population; quotas were defined per country demographics. Subjects were screened for allergic rhinitis using the Score For Allergic Rhinitis questionnaire...
2018: Allergy, Asthma, and Clinical Immunology
Chang Hoon Han, Jae Ho Chung
OBJECTIVES: Adolescent asthma can be the cause of social and psychological problems. We investigated the association between asthma with other allergic diseases and suicidal risk behavior among South Korean adolescents using nationally representative data. METHODS: Web-based self-report data from the Korean Youth Risk Behavior Web-Based Survey were used in this study (N = 237,022). Complex sample logistic regression was used to define the relationship between suicidal behavior and asthma (n = 7177), with other allergic diseases [asthma with allergic rhinitis (AR) or asthma with atopic dermatitis (AD) (n = 9720), asthma with AD and AR (n = 4971)]...
December 2018: Journal of Psychosomatic Research
Antonietta Rossi, Fiorentina Roviezzo, Rosalinda Sorrentino, Maria A Riemma, Ida Cerqua, Rossella Bilancia, Giuseppe Spaziano, Fabiana Troisi, Simona Pace, Aldo Pinto, Bruno D'Agostino, Oliver Werz, Giuseppe Cirino
The incidence and severity of asthma preponderate in women versus men. Leukotrienes (LTs) are lipid mediators involved in asthma pathogenesis, and sex disparities in LT biosynthesis and anti-LT pharmacology in inflammation have recently emerged. Here, we report on sex dimorphism in LT production during allergen sensitization and its correlation to lung function. While high plasma levels of IgE, as sensitization index, were elevated in both sexes, LT levels increased only in lungs of female ovalbumin-sensitized BALB/c mice...
November 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Ignacio Esteban-Gorgojo, Darío Antolín-Amérigo, Javier Domínguez-Ortega, Santiago Quirce
Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma phenotype, its importance cannot be underestimated. NEA is characterized by airway inflammation with the absence of eosinophils, subsequent to activation of non-predominant type 2 immunologic pathways. This phenotype, which possibly includes several not well-defined subphenotypes, is defined by an eosinophil count <2% in sputum. NEA has been associated with environmental and/or host factors, such as smoking cigarettes, pollution, work-related agents, infections, and obesity...
2018: Journal of Asthma and Allergy
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