keyword
https://read.qxmd.com/read/37508320/similarity-analysis-of-klebsiella-pneumoniae-producing-carbapenemases-isolated-from-uti-and-other-infections
#21
JOURNAL ARTICLE
Agata Pruss, Paweł Kwiatkowski, Monika Sienkiewicz, Helena Masiuk, Agnieszka Łapińska, Barbara Kot, Zuzanna Kilczewska, Stefania Giedrys-Kalemba, Barbara Dołęgowska
Klebsiella pneumoniae is an important opportunistic pathogen responsible for severe infections, mainly urinary tract infections (UTIs) and pneumonia. Hospital epidemic infections caused by multiresistant strains of carbapenemase-producing K. pneumoniae are the most concerning. NDM-producing strains are resistant to a wide range of antibiotics and have become the most significant threat. Determining the natural reservoirs and routes of infections is essential to end hospital outbreaks. Understanding the relatedness of K...
July 24, 2023: Antibiotics
https://read.qxmd.com/read/37508182/screening-of-chemical-composition-antimicrobial-and-antioxidant-activities-in-pomegranate-quince-and-persimmon-leaf-peel-and-seed-valorization-of-autumn-fruits-by-products-for-a-one-health-perspective
#22
JOURNAL ARTICLE
Vanessa Silva, Adriana Silva, Jessica Ribeiro, Alfredo Aires, Rosa Carvalho, Joana S Amaral, Lillian Barros, Gilberto Igrejas, Patrícia Poeta
Antimicrobial resistance is increasing globally and is now one of the major public health problems. Therefore, there is a need to search for new antimicrobial agents. The food industry generates large amounts of by-products that are rich in bioactive compounds, such as phenolic compounds, which are known to have several health benefits, including antioxidant and antimicrobial properties. Thus, we aimed to characterize the phenolic compounds present in pomegranate, quince, and persimmon by-products, as well as their antioxidant and antimicrobial activities...
June 21, 2023: Antibiotics
https://read.qxmd.com/read/37497790/synthesis-spectroscopic-characterization-and-antibacterial-activity-of-chalcone-2e-1-3-aminophenyl-3-4-dimethylaminophenyl-prop-2-en-1-one-against-multiresistant-staphylococcus-aureus-carrier-of-efflux-pump-mechanisms-and-%C3%AE-lactamase
#23
JOURNAL ARTICLE
Larissa da Silva, Isydório Alves Donato, Suieny Rodrigues Bezerra, Hélcio Silva Dos Santos, Paulo Nogueira Bandeira, Maria Thalia Ramos do Nascimento, Jesyka Macêdo Guedes, Priscila Ramos Freitas, Ana Carolina Justino de Araújo, Thiago Sampaio de Freitas, Henrique Douglas Melo Coutinho, Yedda Maria Lobo Soares de Matos, Lígia Cláudia Castro de Oliveira, Francisco Assis Bezerra da Cunha
BACKGROUND: The bacterium Staphylococcus aureus has stood out for presenting a high adaptability, acquiring resistance to multiple drugs. The search for natural or synthetic compounds with antibacterial properties capable of reversing the resistance of S. aureus is the main challenge to be overcome today. Natural products such as chalcones are substances present in the secondary metabolism of plants, presenting important biological activities such as antitumor, antidiabetic, and antimicrobial activity...
July 27, 2023: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/37466019/do-post-surgical-multiresistant-urinary-infections-occur-in-horses-case-of-unilateral-pyelonephritis-caused-by-extended-spectrum-beta-lactamase-producing-bacteria-as-a-complication-of-cystotomy
#24
Elisa Scala, Gaby van Galen, Elin M Skärlina, Inge Durie
Pyelonephritis is a serious condition that is rarely described in horses. In contrast, urinary tract infections are common in humans and small animals, and multi-drug-resistant urinary infections are an emerging threat. In this report, we describe a horse with unilateral pyelonephritis caused by extended-spectrum beta-lactamase-producing bacteria belonging to the Enterobacter cloacae complex. [Correction added on 9 August 2023, after first online publication: The preceding sentence was corrected.] An 11-year-old Swedish warmblood gelding was diagnosed with a cystolith and a cystotomy through an open left para-inguinal approach was performed...
July 19, 2023: Veterinary Medicine and Science
https://read.qxmd.com/read/37458335/-antimicrobial-stewardship-program-in-urinary-tract-infections-due-to-multiresistant-strains-in-the-emergency-department
#25
JOURNAL ARTICLE
J Ruiz-Ramos, S Herrera-Mateo, M A Rivera-Martínez, A E Monje-López, H Hernández-Ontiveros, C S Pereia-Batista, Y M Martinez-Ysasis, M Puig-Campmany
OBJECTIVE: Urinary tract infections (UTI) are a frequent reason for attendance at emergency department (ED). The present study evaluates the impact of a multidisciplinary program for the optimization of antibiotic therapy in patients with UTI caused by multi-drug resistant bacteria treated from the hospital ED. METHODS: Descriptive study of the implementation of a program in which emergency, microbiology and pharmacy departments participated. Antibiotic treatment of the patients who consulted the ED with positive urine cultures caused by multidrug-resistant bacteria was reviewed upon discharge...
October 2023: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://read.qxmd.com/read/37453480/investigation-of-some-basil-genotypes-in-terms-of-their-effect-on-bacterial-communication-system-and-antimicrobial-activity
#26
JOURNAL ARTICLE
Gulsum Yaldiz, Mahmut Camlica, Demet Erdonmez
The exponential growth of multiresistant bacterial strains creates the need to explore new or combined strategies to combat bacterial resistance. Medicinal plant-derived compounds against pathogenic bacteria may provide new, simple approaches to developing more environmentally friendly antimicrobial agents. Many researchers focus on exploring novel or combined strategies for combating bacterial resistance. Aromatic plants containing essential oils, such as basil, are often used as therapeutic agents in the pharmaceutical industry...
July 13, 2023: Microbial Pathogenesis
https://read.qxmd.com/read/37370277/the-antimicrobial-applications-of-nanoparticles-in-veterinary-medicine-a-comprehensive-review
#27
REVIEW
Mariana Paiva Rodrigues, Priscila Natália Pinto, Raul Roque de Souza Dias, Gabriela Lago Biscoto, Lauranne Alves Salvato, Ruben Dario Sinisterra Millán, Ricardo Mathias Orlando, Kelly Moura Keller
Nanoparticles (NPs) are nanoscaled particles sized from 1-100 nm, which can be composed of inorganic or organic compounds. NPs have distinctive morphology, size, structure, and surface features, which give them specific properties. These particular attributes make them interesting for biological and medical applications. Due to these characteristics, researchers are studying the possible aptness of numerous nanoparticles in veterinary medicine, such as the capacity to act as a drug delivery system. The use of these NPs as a possible bactericidal or bacteriostatic medication has been studied against different bacteria, especially multiresistant strains and the ones that cause mastitis disease...
May 25, 2023: Antibiotics
https://read.qxmd.com/read/37306609/prophage-gifsy-1-induction-in-salmonella-enterica-serovar-typhimurium-reduces-persister-cell-formation-after-ciprofloxacin-exposure
#28
JOURNAL ARTICLE
Sebastian Braetz, Peter Schwerk, Nara Figueroa-Bossi, Karsten Tedin, Marcus Fulde
Persister cells are drug-tolerant bacteria capable of surviving antibiotic treatment despite the absence of heritable resistance mechanisms. It is generally thought that persister cells survive antibiotic exposure through the implementation of stress responses and/or energy-sparing strategies. Exposure to DNA gyrase-targeting antibiotics could be particularly detrimental for bacteria that carry prophages integrated in their genomes. Gyrase inhibitors are known to induce prophages to switch from their dormant lysogenic state into the lytic cycle, causing the lysis of their bacterial host...
June 12, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37300561/work-in-nursing-homes-and-occupational-exposure-to-endotoxin-and-bacterial-and-fungal-species
#29
JOURNAL ARTICLE
Pil Uthaug Rasmussen, Katrine Uhrbrand, Margit W Frederiksen, Anne Mette Madsen
Indoor microbial exposure may cause negative health effects. Only little is known about the occupational microbial exposure in nursing homes and the factors that influence the exposure. The exposure in nursing homes may be increased due to close contact with elderly persons who may carry infectious or antimicrobial-resistant microorganisms and due to handling of laundry, such as used clothing and bed linen. We investigated the microbial exposure in 5 nursing homes in Denmark, by use of personal bioaerosol samples from different groups of staff members taken during a typical working day, stationary bioaerosol measurements taken during various work tasks, sedimented dust samples, environmental surface swabs, and swabs from staff members' hands...
August 9, 2023: Annals of Work Exposures and Health
https://read.qxmd.com/read/37300501/synthetic-star-nanoengineered-antimicrobial-polymers-as-antibiofilm-agents-bacterial-membrane-disruption-and-cell-aggregation
#30
JOURNAL ARTICLE
Sophie Laroque, Ramón Garcia Maset, Alexia Hapeshi, Fannie Burgevin, Katherine E S Locock, Sébastien Perrier
Antimicrobial resistance has become a worldwide issue, with multiresistant bacterial strains emerging at an alarming rate. Multivalent antimicrobial polymer architectures such as bottle brush or star polymers have shown great potential, as they could lead to enhanced binding and interaction with the bacterial cell membrane. In this study, a library of amphiphilic star copolymers and their linear copolymer equivalents, based on acrylamide monomers, were synthesized via RAFT polymerization. Their monomer distribution and molecular weight were varied...
June 10, 2023: Biomacromolecules
https://read.qxmd.com/read/37260395/escherichia-coli-st2797-is-abundant-in-wastewater-and-might-be-a-novel-emerging-extended-spectrum-beta-lactamase-e-coli
#31
JOURNAL ARTICLE
Erik Paulshus, Patricia Colque, Inger Kühn, Tamanna Tauhid, Yue O O Hu, Yingshun Zhou, Kaisa Thorell, Roland Möllby, Henning Sørum, Åsa Sjöling, Enrique Joffré
The increasing prevalence of antibiotic-resistant bacteria is an emerging threat to global health. The analysis of antibiotic-resistant enterobacteria in wastewater can indicate the prevalence and spread of certain clonal groups of multiresistant bacteria. In a previous study of Escherichia coli that were isolated from a pump station in Norway over 15 months, we found a recurring E. coli clone that was resistant to trimethoprim, ampicillin, and tetracycline in 201 of 3,123 analyzed isolates (6.1%). 11 representative isolates were subjected to whole-genome sequencing and were found to belong to the MLST ST2797 E...
June 1, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37241815/the-chemical-space-of-marine-antibacterials-diphenyl-ethers-benzophenones-xanthones-and-anthraquinones
#32
JOURNAL ARTICLE
José X Soares, Inês Afonso, Adaleta Omerbasic, Daniela R P Loureiro, Madalena M M Pinto, Carlos M M Afonso
The emergence of multiresistant bacteria and the shortage of antibacterials in the drug pipeline creates the need to search for novel agents. Evolution drives the optimization of the structure of marine natural products to act as antibacterial agents. Polyketides are a vast and structurally diverse family of compounds that have been isolated from different marine microorganisms. Within the different polyketides, benzophenones, diphenyl ethers, anthraquinones, and xanthones have shown promising antibacterial activity...
May 13, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37237802/untargeted-metabolomics-for-unraveling-the-metabolic-changes-in-planktonic-and-sessile-cells-of-salmonella-enteritidis-atcc-13076-after-treatment-with-lippia-origanoides-essential-oil
#33
JOURNAL ARTICLE
Yuliany Guillín, Marlon Cáceres, Elena E Stashenko, William Hidalgo, Claudia Ortiz
Nontyphoidal Salmonella species are one of the main bacterial causes of foodborne diseases, causing a public health problem. In addition, the ability to form biofilms, multiresistance to traditional drugs, and the absence of effective therapies against these microorganisms are some of the principal reasons for the increase in bacterial diseases. In this study, the anti-biofilm activity of twenty essential oils (EOs) on Salmonella enterica serovar Enteritidis ATCC 13076 was evaluated, as well as the metabolic changes caused by Lippia origanoides thymol chemotype EO (LOT-II) on planktonic and sessile cells...
May 12, 2023: Antibiotics
https://read.qxmd.com/read/37161274/multicationic-quaternary-ammonium-compounds-a-framework-for-combating-bacterial-resistance
#34
JOURNAL ARTICLE
Mary A Seferyan, Evgeniya A Saverina, Nikita A Frolov, Elena V Detusheva, Olga A Kamanina, Vyacheslav A Arlyapov, Irina I Ostashevskaya, Valentine P Ananikov, Anatoly N Vereshchagin
During previous stages of research, high biocidal activity toward microorganism archival strains has been used as the main indicator in the development of new antiseptic formulations. Although this factor remains one of the most important characteristics of biocide efficiency, the scale of antimicrobial resistance spread causes serious concern. Therefore, focus shifts toward the development of formulations with a stable effect even in the case of prolonged contact with pathogens. Here, we introduce an original isocyanuric acid alkylation method with the use of available alkyl dichlorides, which opened access to a wide panel of multi-QACs with alkyl chains of various lengths between the nitrogen atoms of triazine and pyridine cycles...
May 10, 2023: ACS Infectious Diseases
https://read.qxmd.com/read/37107147/in-vitro-activity-of-cefiderocol-on-multiresistant-bacterial-strains-and-genomic-analysis-of-two-cefiderocol-resistant-strains
#35
JOURNAL ARTICLE
Michela Padovani, Anna Bertelli, Silvia Corbellini, Giorgio Piccinelli, Francesca Gurrieri, Maria Antonia De Francesco
Cefiderocol is a new siderophore cephalosporin that is effective against multidrug-resistant Gram-negative bacteria, including carbapenem-resistant strains. The aim of this study was to evaluate the activity of this new antimicrobial agent against a collection of pathogens using broth microdilution assays and to analyze the possible mechanism of cefiderocol resistance in two resistant Klebsiella pneumoniae isolates. One hundred and ten isolates were tested, comprising 67 Enterobacterales , two Acinetobacter baumannii , one Achromobacter xylosoxidans , 33 Pseudomonas aeruginosa and seven Stenotrophomonas maltophilia...
April 20, 2023: Antibiotics
https://read.qxmd.com/read/37107092/antibiotic-resistances-of-enterobacteriaceae-with-chromosomal-ampc-in-urine-cultures-review-and-experience-of-a-spanish-hospital
#36
JOURNAL ARTICLE
Enrique Rodríguez-Guerrero, Horacio Requena Cabello, Manuela Expósito-Ruiz, José María Navarro-Marí, José Gutiérrez-Fernández
The Enterobacteriaceae Citrobacter freundii , Enterobacter cloacae , Klebsiella aerogenes , Morganella morganii , Providencia stuartii , and Serratia marcescens (CESPM group) produce numerous urinary tract infections (UTIs) which are difficult to treat due to their high multiresistance rate. The objectives of this study were to carry out a systematic review of antibiotic resistances by UTIs and to determine changes over time in urine cultures from a reference hospital in southern Spain. The literature was searched for European data on the resistance rates of each microorganism, and a retrospective cross-sectional descriptive study was performed in samples with suspicion of UTI from patients in Virgen de las Nieves University Hospital (Granada, Spain) between 2016 and the first half of 2021...
April 8, 2023: Antibiotics
https://read.qxmd.com/read/37048403/resistance-profile-of-bovine-mastitis-isolates-presence-of-the-mec-a-gene-and-identification-of-esbl-producing-strains-from-small-rural-dairy-properties
#37
JOURNAL ARTICLE
Kawany Gabrieli Zanetti Fazoli, Laisa Marina Rosa Rey, Kariny Aparecida Jardim Rúbio, Mateus Augusto Garcia Souza, Halison Murilo da Silva Oliveira, Débora Cristina Ribeiro, Kelly Regina de Jesus Duarte Pereira, Denise Miyuki Kawamo, Thays Karollyni Amaral Gomes, Isadora Brito da Silva, Isabela Carvalho Dos Santos, Larissa Rafaela de Paula Ferreira, Isabelle Luiz Rahal, Juliana Silveira do Valle, Suelen Pereira Ruiz, Maria Graciela Iecher Faria, Zilda Cristiani Gazim, Ranunlfo Piau Junior, Daniela Dib Gonçalves
Bovine mastitis is an inflammation of the mammary gland in response to invasion by opportunistic agents. Due to the high economic importance of dairy production and the complexity related to animal health, the objective of this work was to identify and evaluate the antibacterial resistance profile of samples of mastitis milk, milking hand and milking equipment from small rural dairy farms belonging to the northwest region of the state of Paraná, Brazil. Five small, non-technical dairy farms in the municipalities of Boa Esperança, Juranda and Tapejara, all belonging to the northwest region of the state of Paraná, Brazil, were selected...
March 24, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37038293/emerging-strategies-to-combat-methicillin-resistant-staphylococcus-aureus-mrsa-natural-agents-with-high-potential
#38
JOURNAL ARTICLE
Jonata M Ueda, Catarina Milho, Sandrina A Heleno, Anton Soria-Lopez, Maria Carpena, Maria José Alves, Tânia Pires, Miguel A Prieto, Jesus Simal-Gandara, Ricardo C Calhelha, Isabel C F R Ferreira, Lillian Barros
Infectious diseases have always been a concern for human health, responsible for numerous pandemics throughout history. Even with the advancement of medicine, new infectious diseases have been discovered over the years, requiring constant effort in medical research to avoid future problems. Like the emergence of new diseases, the increase in resistance of certain bacterial strains also becomes a concern, carried out through the misuse of antibiotics, generating the adaptation of certain microorganisms. Worldwide, the resistance developed by several bacterial strains is growing exponentially, creating awareness and developing novel strategies to control their evolution a mandatory research topic...
April 10, 2023: Current Pharmaceutical Design
https://read.qxmd.com/read/36982749/a-comparative-study-of-the-inhibitory-action-of-berberine-derivatives-on-the-recombinant-protein-ftsz-of-e-coli
#39
JOURNAL ARTICLE
Angela Di Somma, Carolina Canè, Natalie Paola Rotondo, Maria Maddalena Cavalluzzi, Giovanni Lentini, Angela Duilio
Medicinal plants belonging to the genus Berberis may be considered an interesting source of drugs to counteract the problem of antimicrobial multiresistance. The important properties associated with this genus are mainly due to the presence of berberine, an alkaloid with a benzyltetrahydroisoquinoline structure. Berberine is active against both Gram-negative and Gram-positive bacteria, influencing DNA duplication, RNA transcription, protein synthesis, and the integrity of the cell surface structure. Countless studies have shown the enhancement of these beneficial effects following the synthesis of different berberine analogues...
March 16, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36978397/genomics-insight-into-cfr-mediated-linezolid-resistant-la-mrsa-in-italian-pig-holdings
#40
JOURNAL ARTICLE
Manuela Iurescia, Elena Lavinia Diaconu, Patricia Alba, Fabiola Feltrin, Carmela Buccella, Roberta Onorati, Angelo Giacomi, Andrea Caprioli, Alessia Franco, Antonio Battisti, Virginia Carfora
The cfr genes encode for a 23S rRNA methyltransferase, conferring a multiresistance phenotype to phenicol, lincosamide, oxazolidinone, pleuromutilin, and streptogramin A antibiotics. These genes have been described in staphylococci, including methicillin-resistant Staphylococcus aureus (MRSA). In this study, we retrospectively performed an in-depth genomic characterisation of three cfr -positive, multidrug-resistant (MDR) livestock-associated (LA) MRSA clonal complexes (CCs) 1 and 398 detected in different Italian pig holdings (2008-2011) during population studies on Italian livestock (2008-2014)...
March 7, 2023: Antibiotics
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