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https://www.readbyqxmd.com/read/28330421/the-proteinopathy-of-d169g-and-k263e-mutants-at-the-rna-recognition-motif-rrm-domain-of-tar-dna-binding-protein-tdp43-causing-neurological-disorders-a-computational-study
#1
Vishwambhar Vishnu Bhandare, Amutha Ramaswamy
One of the multitasking proteins, transactive response DNA-binding protein 43 (tdp43) plays a key role in RNA regulation and the two pathogenic mutations such as D169G and K263E, located at the RNA Recognition Motif (RRM) of tdp43, are reported to cause neurological disorders such as Amyotrophic Lateral Sclerosis (ALS) and Fronto Temporal Lobar Degeneration (FTLD). As the exploration of the proteinopathy demands both structural and functional characterization of mutants, a comparative analysis on the wild type and mutant tdp43 (D169G and K263E) and their complexes with RNA have been performed using computational approaches...
March 22, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28326021/abnormalities-in-structural-covariance-of-cortical-gyrification-in-parkinson-s-disease
#2
Jinping Xu, Jiuquan Zhang, Jinlei Zhang, Yue Wang, Yanling Zhang, Jian Wang, Guanglin Li, Qingmao Hu, Yuanchao Zhang
Although abnormal cortical morphology and connectivity between brain regions (structural covariance) have been reported in Parkinson's disease (PD), the topological organizations of large-scale structural brain networks are still poorly understood. In this study, we investigated large-scale structural brain networks in a sample of 37 PD patients and 34 healthy controls (HC) by assessing the structural covariance of cortical gyrification with local gyrification index (lGI). We demonstrated prominent small-world properties of the structural brain networks for both groups...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28323166/neural-foundations-of-overt-and-covert-actions
#3
Panagiotis G Simos, Eleftherios Kavroulakis, Thomas Maris, Efrosini Papadaki, Themistoklis Boursianis, Giorgos Kalaitzakis, Helen E Savaki
We used fMRI to assess the human brain areas activated for execution, observation and 1(st) person motor imagery of a visually guided tracing task with the index finger. Voxel-level conjunction analysis revealed several cortical areas activated in common across all three motor conditions, namely, the upper limb representation of the primary motor and somatosensory cortices, the dorsal and ventral premotor, the superior and inferior parietal cortices as well as the posterior part of the superior and middle temporal gyrus including the temporo-parietal junction (TPj) and the extrastriate body area (EBA)...
March 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28302454/craniofacial-fibrous-dysplasia-a-10-case-series
#4
A Couturier, O Aumaître, L Gilain, B Jean, T Mom, M André
OBJECTIVES: Fibrous dysplasia of bone is a rare sporadic benign congenital condition in which normal cancellous bone is replaced by fibro-osseous tissue with immature osteogenesis. Sarcomatous transformation is exceptional. Lesions may involve one bone (monostotic) or several (polyostotic). Fibrous dysplasia may be associated with café-au-lait skin macules and endocrinopathy in McCune-Albright syndrome, or with myxoma in Mazabraud's syndrome. METHODS: We report ten cases of patients followed up for craniofacial fibrous dysplasia in our center between 2010 and 2015...
March 14, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28291690/social-cognitive-brain-function-and-connectivity-during-visual-perspective-taking-in-autism-and-schizophrenia
#5
Shaun M Eack, Jessica A Wojtalik, Matcheri S Keshavan, Nancy J Minshew
BACKGROUND: Autism spectrum disorder (ASD) and schizophrenia are neurodevelopmental conditions that are characterized by significant social impairment. Emerging genomic and neurobiological evidence has increasingly pointed to shared pathophysiologic mechanisms in the two disorders. Overlap in social impairment may reflect similar underlying neural dysfunction in social-cognitive brain networks, yet few studies have directly compared brain function and communication between those with ASD and schizophrenia...
March 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28290071/structural-connectivity-in-spatial-attention-network-reconstruction-from-left-hemispatial-neglect
#6
Takaaki Hattori, Kenji Ito, Chika Nakazawa, Yoshiyuki Numasawa, Mayumi Watanabe, Shigeki Aoki, Hidehiro Mizusawa, Sumio Ishiai, Takanori Yokota
Left hemispatial neglect (neglect) is an impaired state of spatial attention. We aimed to reconstruct structural connectivity in the spatial attention network and to identify disconnection patterns underlying neglect. We enrolled 59 right-handed patients who had their first-ever infarction in the right hemisphere and classified them into neglect group (34 patients with neglect) and control group (25 patients without neglect). The neglect group was further subcategorized into 6 subgroups based on infarcted vascular territories...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28284798/interactions-between-the-anterior-cingulate-insula-network-and-the-fronto-parietal-network-during-perceptual-decision-making
#7
Ganesh B Chand, Mukesh Dhamala
Information processing in the human brain during cognitively demanding goal-directed tasks is thought to involve several large-scale brain networks, including the anterior cingulate-insula network (aCIN) and the fronto-parietal network (FPN). Recent functional MRI (fMRI) studies have provided clues that the aCIN initiates activity changes in the FPN. However, when and how often these networks interact remains largely unknown to date. Here, we systematically examined the oscillatory interactions between the aCIN and the FPN by using the spectral Granger causality analysis of reconstructed brain source signals from the scalp electroencephalography (EEG) recorded from human participants performing a face-house perceptual categorization task...
March 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28283114/the-varieties-of-psychosis-in-multiple-sclerosis-a-systematic-review-of-cases
#8
REVIEW
Carlos R Camara-Lemarroy, Beatriz E Ibarra-Yruegas, Rene Rodriguez-Gutierrez, Idanis Berrios-Morales, Carolina Ionete, Peter Riskind
OBJECTIVES: Multiple Sclerosis (MS) is known to be associated with a wide range of psychiatric symptoms, particularly with affective disorders. However, a link to psychotic disorders has not been fully established. METHODS: A systematic review of the PubMed/MEDLINE database was performed to identify cases of MS presenting with psychotic symptoms. Variables analyzed included patient demographics, clinical presentation, imaging characteristics and treatment. RESULTS: Ninety-one cases were identified...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28277283/toward-a-functional-neuroanatomy-of-semantic-aphasia-a-history-and-ten-new-cases
#9
Olga Dragoy, Yulia Akinina, Nina Dronkers
Almost 70 years ago, Alexander Luria incorporated semantic aphasia among his aphasia classifications by demonstrating that deficits in linking the logical relationships of words in a sentence could co-occur with non-linguistic disorders of calculation, spatial gnosis and praxis deficits. In line with his comprehensive approach to the assessment of language and other cognitive functions, he argued that deficits in understanding semantically reversible sentences and prepositional phrases, for example, were in line with a single neuropsychological factor of impaired spatial analysis and synthesis, since understanding such grammatical relationships would also draw on their spatial relationships...
October 6, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28275366/white-matter-correlates-of-auditory-comprehension-outcomes-in-chronic-post-stroke-aphasia
#10
Shihui Xing, Elizabeth H Lacey, Laura M Skipper-Kallal, Jinsheng Zeng, Peter E Turkeltaub
Neuroimaging studies have shown that speech comprehension involves a number of widely distributed regions within the frontal and temporal lobes. We aimed to examine the differential contributions of white matter connectivity to auditory word and sentence comprehension in chronic post-stroke aphasia. Structural and diffusion MRI data were acquired on 40 patients with chronic post-stroke aphasia. A battery of auditory word and sentence comprehension tests were administered to all the patients. Tract-based spatial statistics were used to identify areas in which white matter integrity related to specific comprehension deficits...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28269497/reconstructing-multivariate-causal-structure-between-functional-brain-networks-through-a-laguerre-volterra-based-granger-causality-approach
#11
Andrea Duggento, Gaetano Valenza, Luca Passamonti, Maria Guerrisi, Riccardo Barbieri, Nicola Toschi
Classical multivariate approaches based on Granger causality (GC) which estimate functional connectivity in the brain are almost exclusively based on autoregressive models. Nevertheless, information available from past samples is limited due to both signal autocorrelation and necessarily low model orders. Consequently, multiple time-scales interactions are usually unaccounted for. To overcome these limitations, in this study we propose the use of discrete-time orthogonal Laguerre basis functions within a Wiener-Volterra decomposition of the BOLD signals to perform effective GC assessments of brain functional connectivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268521/creation-of-a-whole-brain-short-association-bundle-atlas-using-a-hybrid-approach
#12
M Guevara, C Roman, J Houenou, D Duclap, C Poupon, J-F Mangin, P Guevara
The Human brain connection map is far from being complete. In particular the study of the superficial white matter (SWM) is an unachieved task. Its description is essential for the understanding of human brain function and the study of pathogenesis triggered by abnormal connectivity. In this work we expanded a previously developed method for the automatic creation of a whole brain SWM bundle atlas. The method is based on a hybrid approach. First a cortical parcellation is used to extract fibers connecting two regions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267656/a-prospective-study-of-diffusion-weighted-magnetic-resonance-imaging-abnormalities-in-patients-with-cluster-of-seizures-and-status-epilepticus
#13
S A Jabeen, Pavankumar Cherukuri, Rukmini Mridula, K R Harshavardhana, Padmaja Gaddamanugu, Sailaja Sarva, A K Meena, Rupam Borgohain, Y Jyotsna Rani
OBJECTIVE: To study the frequency, imaging characteristics, and clinical predictors for development of periictal diffusion weighted MRI abnormalities. METHODS: We prospectively analyzed electro clinical and imaging characteristic of adult patients with cluster of seizures or status epilepticus between November 2013 and November 2015, in whom the diffusion weighted imaging was done within 24h after the end of last seizure (clinical or electrographic). RESULTS: There were thirty patients who fulfilled the inclusion and exclusion criteria...
February 24, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28266344/epilepsy-at-the-prodromal-stages-of-neurodegenerative-diseases
#14
Benjamin Cretin, Nathalie Philippi, Laure Dibitonto, Frédéric Blanc
This review provides a clinically grounded description of the links between epilepsy and early common neurodegenerative diseases (i.e. Alzheimer's disease, Lewy body disease, vascular cognitive impairment, fronto-temporal lobar degeneration). It shows that epilepsy does not only concern demented patients displaying convulsive seizures (whether focal or generalized) and obvious atrophy on brain imaging. On the contrary, unprovoked seizures and epilepsy - commonly involving the temporal lobe - are now reported at the prodromal stages of these diseases, when cognitive complaints are mild or even minimal and brain imaging inconstantly abnormal...
March 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28243761/neural-pathways-subserving-face-based-mentalizing
#15
Yordanka Nikolova Yordanova, Hugues Duffau, Guillaume Herbet
Over the past few years, considerable progress has been done in clarifying the neural networks underlying mentalizing. However, although the cortical architecture of this function is relatively well understood, the white matter pathways that may be involved in conveying neural signals within the mentalizing network remain to be elucidated. To gain insight into this matter, a detailed stimulation mapping of face-based mentalizing was performed in 27 patients undergoing awake surgery for a right-sided diffuse low-grade glioma (DLGG)...
February 27, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28242315/individual-differences-and-time-varying-features-of-modular-brain-architecture
#16
Xuhong Liao, Miao Cao, Mingrui Xia, Yong He
Recent studies have suggested that human brain functional networks are topologically organized into functionally specialized but inter-connected modules to facilitate efficient information processing and highly flexible cognitive function. However, these studies have mainly focused on group-level network modularity analyses using "static" functional connectivity approaches. How these extraordinary modular brain structures vary across individuals and spontaneously reconfigure over time remain largely unknown...
February 24, 2017: NeuroImage
https://www.readbyqxmd.com/read/28239343/neural-markers-associated-with-the-temporal-deployment-of-attention-a-systematic-review-of-non-motor-psychophysical-measures-post-stroke
#17
REVIEW
Essie Low, Robin Laycock, Sheila Crewther
In recent years, evidence has emerged to suggest abnormal temporal dynamics of attentional processing in stroke patients, especially those presenting with neglect symptoms. However, there has been little profiling of the nature and extent of such temporal anomalies. In addition, many paradigms currently used to measure the time required to deploy visual attention in stroke require a psychomotor response, and may therefore confound performance outcomes. Thus, the aim of this systematic review was to identify and evaluate studies that have employed non-motor psychophysical paradigms to characterize the temporal deployment of visual attention in space...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28230585/decompressive-craniectomy-with-bifrontal-coronal-incision-in-the-management-of-fronto-temporal-contusion-and-laceration-for-early-cranioplasty
#18
Zhong Wang, Ning Su, Ri-Le Wu, Yi-Song Zhang, Xiao-Jun Zhang, Jian-Jun Qi, Wei-Ping Zhao, Zhong Zhang, Jun-Qing Wang
The present study aims to explore the effectiveness of decompressive craniectomy with bifrontal coronal incision in the management of severe contusion and laceration of bilateral fronto-temporal lobes, as well as the outcomes of early cranioplasty. The authors performed the bifrontal decompressive craniectomy on 56 patients with contusion and laceration of bilateral frontal and temporal lobes, and their follow-up treatment outcomes were tracked within 6 months using Glasgow Outcome Scale. The results showed that 33 patients (out of 56, 58...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28227749/reconstructing-multivariate-causal-structure-between-functional-brain-networks-through-a-laguerre-volterra-based-granger-causality-approach
#19
Andrea Duggento, Gaetano Valenza, Luca Passamonti, Maria Guerrisi, Riccardo Barbieri, Nicola Toschi, Andrea Duggento, Gaetano Valenza, Luca Passamonti, Maria Guerrisi, Riccardo Barbieri, Nicola Toschi, Andrea Duggento, Nicola Toschi, Maria Guerrisi, Luca Passamonti, Riccardo Barbieri, Gaetano Valenza
Classical multivariate approaches based on Granger causality (GC) which estimate functional connectivity in the brain are almost exclusively based on autoregressive models. Nevertheless, information available from past samples is limited due to both signal autocorrelation and necessarily low model orders. Consequently, multiple time-scales interactions are usually unaccounted for. To overcome these limitations, in this study we propose the use of discrete-time orthogonal Laguerre basis functions within a Wiener-Volterra decomposition of the BOLD signals to perform effective GC assessments of brain functional connectivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226695/creation-of-a-whole-brain-short-association-bundle-atlas-using-a-hybrid-approach
#20
M Guevara, C Roman, J Houenou, D Duclap, C Poupon, J-F Mangin, P Guevara, M Guevara, C Roman, J Houenou, D Duclap, C Poupon, J-F Mangin, P Guevara, J-F Mangin, C Roman, D Duclap, C Poupon, J Houenou, P Guevara, M Guevara
The Human brain connection map is far from being complete. In particular the study of the superficial white matter (SWM) is an unachieved task. Its description is essential for the understanding of human brain function and the study of pathogenesis triggered by abnormal connectivity. In this work we expanded a previously developed method for the automatic creation of a whole brain SWM bundle atlas. The method is based on a hybrid approach. First a cortical parcellation is used to extract fibers connecting two regions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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