Yadira Pastor, Olivier Reynard, Mathieu Iampietro, Mathieu Surenaud, Florence Picard, Nora El Jahrani, Cécile Lefebvre, Adele Hammoudi, Léa Dupaty, Élise Brisebard, Stéphanie Reynard, Élodie Moureaux, Marie Moroso, Stéphanie Durand, Claudia Gonzalez, Lucia Amurri, Anne-Sophie Gallouët, Romain Marlin, Sylvain Baize, Eve Chevillard, Hervé Raoul, Hakim Hocini, Mireille Centlivre, Rodolphe Thiébaut, Branka Horvat, Véronique Godot, Yves Lévy, Sylvain Cardinaud
Nipah virus (NiV) has been recently ranked by the World Health Organization as being among the top eight emerging pathogens likely to cause major epidemics, whereas no therapeutics or vaccines have yet been approved. We report a method to deliver immunogenic epitopes from NiV through the targeting of the CD40 receptor of antigen-presenting cells by fusing a selected humanized anti-CD40 monoclonal antibody to the Nipah glycoprotein with conserved NiV fusion and nucleocapsid peptides. In the African green monkey model, CD40...
March 7, 2024: Cell reports medicine