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Stem Cell banking

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https://www.readbyqxmd.com/read/30341674/the-influence-of-p02-be-bb-parameters-of-perinatally-obtained-cord-blood-on-quantity-of-obtained-cells-and-focus-on-the-perfect-donor-criteria
#1
Cecylia Jendyk, Agnieszka Drosdzol-Cop, Agnieszka Nowak-Brzezińska, Marcin Sadłocha, Rafał Stojko, Żaneta Jastrzȩbska-Stojko
The aim of the study was to analyze the influence of oxygene partial pressure (p02), base excess (BE) and buffer base (BB) parameters of cord blood obtained perinatally on quantity of obtained cells and focus on the perfect donor criteria. The study included 50 pregnant women aged between 18 and 38 years in which spontaneous labors and elective cesarean sections were performed. Umbilical cord blood was collected immediately after the women were delivered of newborns. The cells were analyzed in the Polish Stem Cells Bank in Warsaw...
October 19, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/30326618/nanometric-bio-banked-msc-derived-exosome-nanobiome-as-a-novel-approach-to-regenerative-medicine
#2
REVIEW
Bruna Codispoti, Massimo Marrelli, Francesco Paduano, Marco Tatullo
Mesenchymal stem cells (MSCs) are well known for their great potential in clinical applications. In fact, MSCs can differentiate into several cell lineages and show paracrine behavior by releasing endogenous factors that stimulate tissue repair and modulate local immune response. Each MSC type is affected by specific biobanking issues-technical issues as well as regulatory and ethical concerns-thus making it quite tricky to safely and commonly use MSC banking for swift regenerative applications. Extracellular vesicles (EVs) include a group of 150⁻1000 nm vesicles that are released by budding from the plasma membrane into biological fluids and/or in the culture medium from varied and heterogenic cell types...
October 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30323827/effect-of-cold-stress-on-photosynthetic-traits-carbohydrates-morphology-and-anatomy-in-nine-cultivars-of-stevia-rebaudiana
#3
Shokoofeh Hajihashemi, Fariba Noedoost, Jan M C Geuns, Ivica Djalovic, Kadambot H M Siddique
Stevia rebaudiana Bertoni is a sweet medicinal herb that is cultivated worldwide. This study aimed to identify the genotypic responses and function of nine cultivars of S. rebaudiana (accession numbers 1-9 from the EUSTAS Stevia Gene Bank) to low temperature. Plants were grown in vitro and incubated under controlled conditions at 5° or 25°C for 1 month. Cold stress significantly decreased the maximum quantum yield of photosystem II (Fv /Fm ) in all cultivars, which was more pronounced in cultivars 5, 6, 8, and 9...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30307450/magnetothermal-heating-facilitates-the-cryogenic-recovery-of-stem-cell-laden-alginate-fe-3-o-4-nanocomposite-hydrogels
#4
Xiaozhang Zhang, Gang Zhao, Yuan Cao, Zeeshan Haider, Meng Wang, Jianping Fu
Constructs of magnetic nanocomposite hydrogels microencapsulated with stem cells are of great interest as smart materials for tissue engineering and regenerative medicine. Due to the short shelf life of such biocomposites at an ambient temperature, their long-term storage and banking at cryogenic temperatures are essential for the "off-the-shelf" availability of such biocomposites for widespread clinical applications. However, high-quality cryogenic recovery of stem cell-nanocomposite hydrogel constructs has not yet been achieved due to the damage to cells and/or microstructures of hydrogel constructs caused by ice formation, particularly during warming from cryogenic temperatures...
October 11, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30305548/-immunotherapy-using-t-cells-for-treating-viral-infections
#5
Satoshi Takahashi
Recipients of hematopoietic stem cell transplantation suffering from severe immunosuppression and immune dysregulation because of GVHD or other causes are at higher risk of viral infection. Often, cytomegalovirus and EB virus are reactivated from their latent state in these patients ; viral infections thus remain a primary cause of severe morbidity and mortality. Since the 1990s, virus-specific T cells have been generated by different methods using immunogenic epitope peptides or EBV-LCL from transplant donors, and studies have demonstrated the efficacy of these methods...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/30305052/parents-knowledge-awareness-and-attitudes-of-cord-blood-donation-and-banking-options-an-integrative-review
#6
Lisa Peberdy, Jeanine Young, Debbie Louise Massey, Lauren Kearney
BACKGROUND: For over 25 years cord blood has been used as an alternative to bone marrow for therapeutic use in conditions of the blood, immune system and metabolic disorders. Parents can decide if they would like to privately store their infant's cord blood for later use if needed or to publicly donate it. Parents need to be aware of the options that exist for their infant's cord blood and have access to the relevant information to inform their choice. The aim of this paper is to identify parent's knowledge and awareness of cord blood donation, private banking options and stem cell use, and parent sources and preferred sources of this information...
October 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/30290185/application-of-induced-pluripotent-stem-cell-transplants-autologous-or-allogeneic
#7
REVIEW
Chenxu Li, Shubin Chen, Yulai Zhou, Yifan Zhao, Pengfei Liu, Jinglei Cai
The development of induced pluripotent stem cells (iPS cells) has raised the prospect of patient-specific treatments for various diseases. Theoretically, iPS cell technology avoids the limitations of human embryonic stem cells (ES cells), including poor establishment, ethical issues, and immune rejection of allogeneic transplantation. However, the immunogenicity of iPS cells has attracted the attention of researchers, and it remains unclear whether iPS cells and their derivatives will be recognized as a patient's own cells...
October 2, 2018: Life Sciences
https://www.readbyqxmd.com/read/30289343/corporate-profile-roosterbio-inc
#8
Timothy R Olsen, Jon A Rowley
RoosterBio, Inc. (MD, USA) is a privately held stem cell tools and technology company focused on accelerating the development of a sustainable regenerative medicine industry, one customer at a time. RoosterBio's products are high-volume and well-characterized adult human mesenchymal stem/stromal cells (hMSCs) paired with highly engineered media systems. RoosterBio has aimed to simplify and standardize how stem cells are purchased, expanded and used in the development of regenerative medicine products. To this end, RoosterBio supplies off-the-shelf cGMP hMSC working cell banks with bioprocess media that mimic the format and formulation of the research grade counterparts, radically simplifying and shortening product development and clinical translation...
October 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/30263133/strategies-for-screening-cord-blood-for-a-public-cord-blood-bank-in-high-hiv-prevalence-regions
#9
REVIEW
M Meissner-Roloff, L Gaggia, M Vermeulen, A F H Mazanderani, N M du Plessis, H C Steel, M S Pepper
The probability of a Black African finding a matched unrelated donor for a hematopoietic stem cell transplant is minimal due to the high degree of genetic diversity amongst individuals of African origin. This problem could be resolved in part by the establishment of a public cord blood (CB) stem cell bank. The high prevalence of human immunodeficiency virus (HIV) amongst women attending antenatal clinics in sub-Saharan Africa together with the risk of mother-to-child transmission increases the risk of transplant transmissible infection...
2018: Global health, epidemiology and genomics
https://www.readbyqxmd.com/read/30257956/reconstitution-of-the-gut-microbiota-of-antibiotic-treated-patients-by-autologous-fecal-microbiota-transplant
#10
Ying Taur, Katharine Coyte, Jonas Schluter, Elizabeth Robilotti, Cesar Figueroa, Mergim Gjonbalaj, Eric R Littmann, Lilan Ling, Liza Miller, Yangtsho Gyaltshen, Emily Fontana, Sejal Morjaria, Boglarka Gyurkocza, Miguel-Angel Perales, Hugo Castro-Malaspina, Roni Tamari, Doris Ponce, Guenther Koehne, Juliet Barker, Ann Jakubowski, Esperanza Papadopoulos, Parastoo Dahi, Craig Sauter, Brian Shaffer, James W Young, Jonathan Peled, Richard C Meagher, Robert R Jenq, Marcel R M van den Brink, Sergio A Giralt, Eric G Pamer, Joao B Xavier
Antibiotic treatment can deplete the commensal bacteria of a patient's gut microbiota and, paradoxically, increase their risk of subsequent infections. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), antibiotic administration is essential for optimal clinical outcomes but significantly disrupts intestinal microbiota diversity, leading to loss of many beneficial microbes. Although gut microbiota diversity loss during allo-HSCT is associated with increased mortality, approaches to reestablish depleted commensal bacteria have yet to be developed...
September 26, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/30248919/non-inherited-maternal-antigens-identify-acceptable-hla-mismatches-a-new-policy-for-the-hellenic-cord-blood-bank
#11
Effrosyni Panagouli, Amalia Dinou, Panagiotis Mallis, Efstathios Michalopoulos, Andreas Papassavas, Maria Spyropoulou-Vlachou, John Meletis, Maria Angelopoulou, Kostas Konstantopoulos, Theodoros Vassilakopoulos, Catherine Stavropoulos-Giokas
BACKGROUND: During pregnancy, the maternal-fetal contact may lead to the development of tolerance against the maternal human leukocyte antigen (HLA) that is not inherited by the fetus. These non-inherited maternal antigens (NIMAs) define acceptable HLA mismatches; therefore, the number of HLA phenotypes that are suitable matches for patients who need a hematopoietic stem cell transplant could be increased. Cord blood unit (CBU) transplantations to patients mismatched for a HLA loci, but similar to the ΝΙΜAs of the CBU, have a prognosis similar to 6/6-matched ones...
September 21, 2018: Bioengineering
https://www.readbyqxmd.com/read/30247478/defined-xeno-free-and-feeder-free-culture-conditions-for-the-generation-of-human-ipsc-derived-retinal-cell-models
#12
Amélie Slembrouck-Brec, Céline Nanteau, José-Alain Sahel, Olivier Goureau, Sacha Reichman
The production of specialized cells from pluripotent stem cells provides a powerful tool to develop new approaches for regenerative medicine. The use of human-induced pluripotent stem cells (iPSCs) is particularly attractive for neurodegenerative disease studies, including retinal dystrophies, where iPSC-derived retinal cell models mark a major step forward to understand and fight blindness. In this paper, we describe a simple and scalable protocol to generate, mature, and cryopreserve retinal organoids. Based on medium changing, the main advantage of this method is to avoid multiple and time-consuming steps commonly required in a guided differentiation of iPSCs...
September 6, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30229475/human-leucocyte-antigen-hla-a-b-c-drb1-and-dqb1-haplotype-frequencies-from-2491-cord-blood-units-from-tamil-speaking-population-from-tamil-nadu-india
#13
Saranya Narayan, Martin Maiers, Mike Halagan, Arunadevi Sathishkannan, Chandramouleeswaran Naganathan, Abeer Madbouly, Srinivasan Periathiruvadi
The Public Cord Blood Bank of Jeevan Stem Cell Foundation was established in 2008 to harvest cord blood units and make them available to treat multiple blood disorders through Hematopoietic Stem Cell Transplants. We studied Human Leucocyte Antigen (HLA)-A, -B, -C, -DRB1 and -DQB1 allele and haplotype diversity in a sample of 2491 unrelated cord-blood units from Jeevan's Public Cord Blood Bank (part of Be The Cure Registry) in the Tamil Nadu state in the Indian Peninsula.
September 18, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30228821/integrated-genome-wide-analysis-of-gene-expression-and-dna-copy-number-variations-highlights-stem-cell-related-pathways-in-small-cell-esophageal-carcinoma
#14
Di Liu, Xinyan Xu, Junmiao Wen, Liyi Xie, Junhua Zhang, Yuxin Shen, Guoliang Jiang, Jiayan Chen, Min Fan
Purpose / Objectives . Primary small cell esophageal carcinoma (SCEC) represents a rare and aggressive malignancy without any prospective clinical trial or established treatment strategy at present. Although previous studies have indicated similarities between SCEC and small cell lung cancer (SCLC) in terms of their clinical manifestations, pathology, and morphology, very little genetic information is available on this highly malignant tumor. At present, patients with SCEC are staged and treated according to the guidelines established for SCLC...
2018: Stem Cells International
https://www.readbyqxmd.com/read/30194383/mapping-molecular-landmarks-of-human-skeletal-ontogeny-and-pluripotent-stem-cell-derived-articular-chondrocytes
#15
Gabriel B Ferguson, Ben Van Handel, Maxwell Bay, Petko Fiziev, Tonis Org, Siyoung Lee, Ruzanna Shkhyan, Nicholas W Banks, Mila Scheinberg, Ling Wu, Biagio Saitta, Joseph Elphingstone, A Noelle Larson, Scott M Riester, April D Pyle, Nicholas M Bernthal, Hanna Ka Mikkola, Jason Ernst, Andre J van Wijnen, Michael Bonaguidi, Denis Evseenko
Tissue-specific gene expression defines cellular identity and function, but knowledge of early human development is limited, hampering application of cell-based therapies. Here we profiled 5 distinct cell types at a single fetal stage, as well as chondrocytes at 4 stages in vivo and 2 stages during in vitro differentiation. Network analysis delineated five tissue-specific gene modules; these modules and chromatin state analysis defined broad similarities in gene expression during cartilage specification and maturation in vitro and in vivo, including early expression and progressive silencing of muscle- and bone-specific genes...
September 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/30183752/generation-and-selection-of-pluripotent-stem-cells-for-robust-differentiation-to-insulin-secreting-cells-capable-of-reversing-diabetes-in-rodents
#16
Sheryl M Southard, Rama P Kotipatruni, William L Rust
Induced pluripotent stem cell (iPSC) technology enables the creation and selection of pluripotent cells with specific genetic traits. This report describes a pluripotent cell line created specifically to form replacement pancreatic cells as a therapy for insulin-dependent diabetes. Beginning with primary pancreatic tissue acquired through organ donation, cells were isolated, re-programmed using non-integrating vectors and exposed to a four day differentiation protocol to generate definitive endoderm, a developmental precursor to pancreas...
2018: PloS One
https://www.readbyqxmd.com/read/30172015/establishment-and-operation-of-a-third-party-virus-specific-t-cell-bank-within-an-allogeneic-stem-cell-transplant-program
#17
Barbara Withers, Leighton Clancy, Jane Burgess, Renee Simms, Rebecca Brown, Kenneth Micklethwaite, Emily Blyth, David Gottlieb
Hematopoietic stem cell transplantation (HSCT) donor-generated virus-specific T cells (VSTs) can provide effective treatment for viral infection post-HSCT but are not readily accessible to all patients. Off-the-shelf cryopreserved VSTs suitable for treatment of multiple patients are an attractive alternative. We generated a bank of 17 cytomegalovirus (CMV)-, 14 Epstein-Barr virus (EBV)-, and 15 adenovirus (AdV)-specific T cell products from 30 third-party donors. Donors were selected for expression of 6 core HLA antigens expressed at high frequency in the local transplant population...
August 29, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30133035/clinical-applications-of-carbon-nanomaterials-in-diagnostics-and-therapy
#18
REVIEW
Kian Ping Loh, Dean Ho, Gigi Ngar Chee Chiu, David Tai Leong, Giorgia Pastorin, Edward Kai-Hua Chow
Nanomaterials have the potential to improve how patients are clinically treated and diagnosed. While there are a number of nanomaterials that can be used toward improved drug delivery and imaging, how these nanomaterials confer an advantage over other nanomaterials, as well as current clinical approaches is often application or disease specific. How the unique properties of carbon nanomaterials, such as nanodiamonds, carbon nanotubes, carbon nanofibers, graphene, and graphene oxides, make them promising nanomaterials for a wide range of clinical applications are discussed herein, including treating chemoresistant cancer, enhancing magnetic resonance imaging, and improving tissue regeneration and stem cell banking, among others...
August 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30087600/hippocampal-mechanisms-underlying-impairment-in-spatial-learning-long-after-establishment-of-noise-induced-hearing-loss-in-cba-mice
#19
Lijie Liu, Chuanying Xuan, Pei Shen, Tingting He, Ying Chang, Lijuan Shi, Shan Tao, Zhiping Yu, Richard E Brown, Jian Wang
Sensorineural hearing loss (SNHL) has been demonstrated in many clinical reports as a risk factor that promotes the development of cognitive impairment. However, the underlying neurological mechanisms are not clear. Noise exposure is one of the most common causes of SNHL. Although noise exposure causes relatively less damage to general health as compared with other methods for creating hearing loss (such as ototoxicity), it does impair cognitive function. Many studies have shown that the noise-induced cognitive impairment occur via the oxidative stress induced by the noise...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/30078320/intracellular-delivery-of-trehalose-for-cell-banking
#20
Samantha Stewart, Xiaoming He
Advances in stem cell technology and regenerative medicine have underscored the need for effective banking of living cells. Cryopreservation, using very low temperatures to achieve suspended animation, is widely used to store or bank cells for later use. This process requires the use of cryoprotective agents (CPAs) to protect cells against damage caused by the cooling and warming process. However, current popular CPAs like DMSO can be toxic to cells and must be thoroughly removed from cells before they can be used for research or clinical applications...
August 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
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