Jonathan T Reeder, Zhaoqian Xie, Quansan Yang, Min-Ho Seo, Ying Yan, Yujun Deng, Katherine R Jinkins, Siddharth R Krishnan, Claire Liu, Shannon McKay, Emily Patnaude, Alexandra Johnson, Zichen Zhao, Moon Joo Kim, Yameng Xu, Ivy Huang, Raudel Avila, Christopher Felicelli, Emily Ray, Xu Guo, Wilson Z Ray, Yonggang Huang, Matthew R MacEwan, John A Rogers
Implantable devices capable of targeted and reversible blocking of peripheral nerve activity may provide alternatives to opioids for treating pain. Local cooling represents an attractive means for on-demand elimination of pain signals, but traditional technologies are limited by rigid, bulky form factors; imprecise cooling; and requirements for extraction surgeries. Here, we introduce soft, bioresorbable, microfluidic devices that enable delivery of focused, minimally invasive cooling power at arbitrary depths in living tissues with real-time temperature feedback control...
July 2022: Science