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Rat inflammation

Hua-Li Huang, Guo-du Tang, Zhi-Hai Liang, Meng-Bin Qin, Xian-Mo Wang, Ren-Jie Chang, He-Ping Qin
OBJECTIVE: To clarify the protective role of Wnt/β-Catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis (AP). METHODS: AR42J cells and rats were divided into Control, Caerulein, SKL2001 + Caerulein and SKL2001 + Control groups respectively. Cell apoptosis was examined by flow cytometry. Hematoxylin-eosin (HE) staining was performed to observe pathological changes of pancreas and small intestinal tissues. Inflammatory cytokines were detected by enzyme linked immunosorbent assay (ELISA) while Wnt/β-Catenin pathway-related genes by quantitative real-time PCR (qRT-PCR)...
October 16, 2018: Canadian Journal of Physiology and Pharmacology
Maryam Ranjpour, Saima Wajid, Swatantra Kumar Jain
Identification of events leading to HCC progression is essential for understanding its pathophysiology. Present study was designed to identify differentially expressed proteins in serum of HCC-bearing rats vis-a-vis controls during cancer initiation, progression and tumorigenesis. HCC was chemically induced by administering N-Nitrosodiethylamine and 2-aminoacetylfluorine to male Wistar rats. Carcinogen administration caused inflammation leading to liver injury and HCC development. Liver inflammation was confirmed by increase in levels of IL-6 and TNF-α in carcinogen treated rats...
October 15, 2018: Anti-cancer Agents in Medicinal Chemistry
Yang Liu, Yuanhang Liu, Xuecheng Huang, Jingchang Zhang, Lihui Yang
OBJECTIVE: Coronary microembolization (CME) is a common complication during the percutaneous coronary intervention (PCI). CME-induced local myocardial inflammation and myocardial apoptosis are the primary causes of progressive cardiac dysfunction. Curcumin exerts a protective role in various cardiovascular diseases; however, its effects in CME are yet to be clarified. Therefore, the current study investigated the effects of curcumin on myocardial inflammatory responses, myocardial apoptosis, and cardiac dysfunctions induced by CME in rats...
October 15, 2018: Journal of Cellular Biochemistry
Suchada Saovieng, Jinfu Wu, Chih-Yang Huang, Chung-Lan Kao, Matthew F Higgins, Rungchai Chuanchaiyakul, Chia-Hua Kuo
Background: We have previously shown an accelerated recovery from muscle fatigue in men challenged by prolonged exercise after oral deep ocean minerals (DOM) supplementation. Here, we hypothesized a decrease in eccentric exercise-induced muscle inflammation in rats regularly consuming DOM-containing drinks (hardness 600 mg/L and fructose 11%). Methods: Forty-seven male Sprague Dawley rats were randomized into 4 groups: Control (C, N = 12), Fructose (F, N = 12), Fructose+Exercise (FE, N = 12), and Fructose+Exercise+DOM (FED, N = 11)...
2018: Frontiers in Physiology
Yasemin Sezgin, Mehtap Bilgin Çetin, Şule Bulut, Nilgün Özlem Alptekin, Pelin Börçek
BACKGROUND: Although postoperative complications occurs after periodontal plastic surgeries, an ideal treatment has not been found to overcome. AIMS: The aim of this study was evaluated the effects of topically applied Oral-norm gel on the healing of excisional wounds. STUDY DESIGN: Animal experimentation. METHODS: Excisional wounds with a 3 mm diameter were made in the center of the palatal mucosa in 63 Sprague Dawley rats...
October 16, 2018: Balkan Medical Journal
Daniela Caetano Gonçalves, Fábio Santos Lira, Alex Shimura Yamashita, Luiz Carlos Carnevali Junior, Robson Eder, Alessandro Laviano, Marília Cerqueira Leite Seelaender
BACKGROUND & AIMS: The liver is the main organ regulating metabolism. In spite of that, few studies examine liver metabolism in cachexia, a wasting syndrome associated with increased morbidity and mortality in cancer. Cachexia induces major metabolic disruption, inflammation and fat and lean mass loss. We have previously shown impairment of hepatic lipid metabolism in cancer cachexia that contributes to the aggravation of the symptoms. The present study addresses the effects of Conjugated Linoleic Acid supplementation upon liver lipid metabolism in cachectic rats...
September 25, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Jian-Zhong Zhang, Dan Chen, Li-Quan Lv, Zheng Xu, Yi-Ming Li, Jun-Yu Wang, Kai-Wei Han, Ming-Kun Yu, Cheng-Guang Huang, Li-Jun Hou
microRNAs (miRNAs) control several processes known to be involved in progression of aneurysm. Here, intracranial aneurysms (IAs) were surgically induced in Sprague-Dawley rats, and we found that miR-448-3p was downregulated and KLF5 was upregulated in IA rats. We identified Klf5 as a direct target of miR-448-3p in smooth muscle cells (SMCs). In addition, aneurysms size and the lumen area of the aneurysms were smaller 4 weeks after IA induction in the miR-448-3p-treated group. miR-448-3p treatment protected the wall thickness ratio and suppressed macrophage infiltration after IA induction...
October 12, 2018: Biochemical and Biophysical Research Communications
Cheng-Long Xie, Jun-Li Li, En-Xing Xue, Hai-Cheng Dou, Jin-Ti Lin, Kai Chen, Hong-Qiang Wu, Long Wu, Jun Xuan, Qi-Shan Huang
Excessive extracellular matrix degradation and chondrocyte apoptosis are the pathological features of osteoarthritis (OA). The ability of flavonoid compounds isolated from Chinese hawthorn leaves to exert protective effects on several diseases, via inhibition of oxidative stress and inflammation, has been demonstrated in several studies. This study explored the effects of vitexin on chondrocytes, and the underlying mechanisms thereof. Vitexin, an active ingredient in hawthorn leaf extracts, was shown to exert protective effects on chondrocytes, by inhibiting the expression of GRP78 and PDI, and an apoptotic protein (CHOP) induced by interleukin-1β...
October 15, 2018: Food & Function
Brunella Posteraro, Francesco Paroni Sterbini, Valentina Petito, Stefano Rocca, Tiziana Cubeddu, Cristina Graziani, Vincenzo Arena, Gabriele A Vassallo, Carolina Mosoni, Loris Lopetuso, Irene Lorrai, Paola Maccioni, Luca Masucci, Cecilia Martini, Antonio Gasbarrini, Maurizio Sanguinetti, Giancarlo Colombo, Giovanni Addolorato
BACKGROUND: There is strong evidence that alcoholism leads to dysbiosis in both humans and animals. However, it is unclear how changes in the intestinal microbiota (IM) relate to ethanol (EtOH)-induced disruption of gut-liver homeostasis. We investigated this issue using selectively bred Sardinian alcohol-preferring (sP) rats, a validated animal model of excessive EtOH consumption. METHODS: Independent groups of male adult sP rats were exposed to the standard, home-cage 2-bottle "EtOH (10% v/v) vs water" choice regimen with unlimited access for 24 hours/day (Group Et) for 3 (T1), 6 (T2), and 12 (T3) consecutive months...
October 15, 2018: Alcoholism, Clinical and Experimental Research
Seul Ah Lee, Bo-Ram Park, Sung-Min Moon, Seul Hee Han, Chun Sung Kim
This study evaluated the anti-inflammatory potential of a 40% prethanol extract of Trifolium pratense leaves (40% PeTP) using in vitro (RAW264.7 cells) and in vivo (carrageenan-induced inflammation model) experiments. Pretreatment with 40% PeTP significantly inhibited the LPS-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2 ), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines, including tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in RAW264...
October 15, 2018: Archives of Physiology and Biochemistry
Jorge De La Chapa, Prajjal Kanti Singha, Mckay Sallaway, Kristen Self, Ranna Nasreldin, Ramesh Dasari, Matthew Hart, Alexander Kornienko, Jeremy Just, Jason A Smith, Alex C Bissember, Cara B Gonzales
Polygodial, a drimane sesquiterpenoid dialdehyde isolated as a pungent component of the water pepper Persicaria hydropiper, exhibits antifeedant, antimicrobial, anti-inflammatory and anticancer effects. Polygodial also activates transient receptor potential vanilloid subtype 1 (TRPV1) channels. Previously, we described the synthesis of a C12-Wittig derivative of polygodial, termed P3, with significant antiproliferative effects against multiple cancer types including oral squamous cell carcinoma (OSCC). In the present study, a more potent derivative, P27, with superior anti-proliferative effects in vitro and antitumor effects in Cal-27 derived xenografts is described...
October 5, 2018: International Journal of Oncology
Qian Zhao, Hui Zhang, Junhua Huang, Huajun Yu, Jiajia Li, Qinfen Che, Yangjie Sun, Yin Jin, Jiansheng Wu
Acute pancreatitis (AP) is a serious disease characterized by the activation of trypsin, autodigestion, edemas, hemorrhages and necrosis. However, the mechanisms of regulating the apoptosis and inflammation of acinar cells in AP remain unclear. The endoplasmic reticulum (ER) stress‑related molecule, C/EBP homologous protein (CHOP), has pro‑-apoptotic and pro‑inflammatory properties, in addition to regulating ER stress responses. In the present study, a lentivirus‑mediated RNA interference (RNAi) approach was used to specifically knockdown the expression of CHOP in the pancreatic tissue of Sprague‑Dawley rats to investigate the potential role of CHOP during AP, which was induced by the retrograde injection of 5% taurocholate into the biliopancreatic duct of rats...
October 9, 2018: International Journal of Molecular Medicine
Pei-Wen Wang, Tung-Ho Wu, Tai-Long Pan, Mu-Hong Chen, Shigeru Goto, Chao-Long Chen
Acute rejection (AR) and spontaneous tolerance may occur after allograft orthotopic liver transplants (OLT) performed in certain combinations of donor and recipient rat strains, yet the underlying molecular cascades involved in these conditions remain poorly understood. Comprehensive analysis with proteomic tools revealed that ceruloplasmin was highly expressed during the tolerant period on day 63 post-OLT (POD 63) compared to the rejected samples on POD 14. Meanwhile, cytokine expression profiles implied that the inflammation was significantly stimulated in the AR subjects...
2018: Frontiers in Immunology
Wenbin Gao, Zheng Zhou, Birong Liang, Yusheng Huang, Zhongqi Yang, Yang Chen, Lu Zhang, Cui Yan, Jiajia Wang, Lu Lu, Zhaorui Wen, Shaoxiang Xian, Lingjun Wang
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy. However, the role of RAGE in pressure overload-induced HF is not well understood. We found that stimulation of RAGE triggered the death of neonatal rat ventricular myocytes (NRVMs), while cell death was alleviated by ATG5 knockdown. Using transverse aortic constriction (TAC) in mice as a model of pressure overload-induced HF, we demonstrated that RAGE knockout or RAGE blockade attenuated cardiac hypertrophy and fibrosis as well as cardiac dysfunction at 8 weeks after TAC...
2018: Frontiers in Physiology
Cheng Zheng, Jia-Feng Lin, Zhong-Hao Lin, Wei-Qian Lin, Saroj Thapa, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Xiao-Wei Li
With the chronic ischemia persisting after acute myocardial infarction, the accompanying low-degree inflammation and subsequent fibrosis result in progression of cardiac remodeling and heart failure. Recently, Sodium Houttuyfonate (SH), a pure compound extracted from Houttuynia cordata , has been confirmed exerting anti-inflammatory and anti-fibrotic effects under diseased situations. Here, we aimed to investigate whether SH could reverse the cardiac remodeling post-myocardial infarction by alleviating cardiac inflammation and fibrosis...
2018: Frontiers in Pharmacology
Shenandoah Robinson, Fatu S Conteh, Akosua Y Oppong, Tracylyn R Yellowhair, Jessie C Newville, Nagat El Demerdash, Christine L Shrock, Jessie R Maxwell, Stephen Jett, Frances J Northington, Lauren L Jantzie
Posthemorrhagic hydrocephalus of prematurity (PHHP) remains a global challenge. Early preterm infants (<32 weeks gestation), particularly those exposed to chorioamnionitis (CAM), are prone to intraventricular hemorrhage (IVH) and PHHP. We established an age-appropriate, preclinical model of PHHP with progressive macrocephaly and ventriculomegaly to test whether non-surgical neonatal treatment could modulate PHHP. We combined prenatal CAM and postnatal day 1 (P1, equivalent to 30 weeks human gestation) IVH in rats, and administered systemic erythropoietin (EPO) plus melatonin (MLT), or vehicle, from P2 to P10...
2018: Frontiers in Cellular Neuroscience
Youakim Saliba, Victor Jebara, Joelle Hajal, Richard Maroun, Stéphanie Chacar, Viviane Smayra, Joel Abramowitz, Lutz Birnbaumer, Nassim Fares
AIMS: Cardiac fibroblasts (CFs) are emerging as major contributors to myocardial fibrosis (MF), a final common pathway of many etiologies of heart disease. Here, we studied the functional relevance of transient receptor potential canonical 3 (TRPC3) channels and nuclear factor of activated T-cells c3 (NFATc3) signaling in rodent and human ventricular CFs, and whether their modulation would limit MF. RESULTS: A positive-feedback loop between TRPC3 and NFATc3 drove a rat ventricular CF fibrotic phenotype...
October 15, 2018: Antioxidants & Redox Signaling
Serena B Gumusoglu, Hanna E Stevens
Early disruptions to neurodevelopment are highly relevant to understanding both psychiatric risk and underlying pathophysiology that can be targeted by new treatments. Much convergent evidence from the human literature associates inflammation during pregnancy with later neuropsychiatric disorders in offspring. Preclinical models of prenatal inflammation have been developed to examine the causal maternal physiological and offspring neural mechanisms underlying these findings. Here we review the strengths and limitations of preclinical models used for these purposes and describe selected studies that have shown maternal immune impacts on the brain and behavior of offspring...
August 27, 2018: Biological Psychiatry
B Tutun, H Elbe, N Vardi, H Parlakpinar, A Polat, M Gunaltili, M M Guclu, E N Yasar
Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress contributes to the development of diabetic complications. Dexpanthenol (Dxp) is the biological active form of pantothenic acid. We investigated whether Dxp administration could decrease oxidative stress as a way to treat renal complications of diabetes mellitus (DM). Thirty-two male Wistar albino rats were divided into four groups: control, Dxp, DM and DM + Dxp. Experimental diabetes was induced by a single dose of streptozotocin (STZ)...
October 15, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Ali Abbas, Syed Saeed-Ul Hassan, Ali Sharif, Shoaib Ahmed
The whole plant, Tricholepis chaetolepis, powder was investigated using proximate and fluorescence analysis along with determining the extractive values. Total phenolics, flavonoids and total protein contents of n-hexane, chloroform and methanolic extracts of the whole plant were also determined. The anti-diabetic activity of all the three extracts of the plant was determined by in vitro alpha-amylase inhibition assay. The anti-oxidant potential was evaluated using Phosophomolybdenum and DPPH methods. The anti-inflammatory potential of all extracts were determined by carrageenan-induced rat paw oedema model...
October 15, 2018: Natural Product Research
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