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Rat inflammation

O V Payushina, N N Butorina, O N Sheveleva, E I Domaratskaya
We studied the effect of mesenchymal stromal cells and conditioned media on healing of full-thickness skin wound in rats. Cell transplantation to the wound bed did not accelerate wound closing and had no effect on the severity of inflammation, but increased vasculariza - tion of the granulation tissue in 14 days after injury. After injection of conditioned medium to the wound, less pronounced inflammation or enhanced epithelialization was observed. The angiogenic effect was observed only after repeated administration of conditioned medium and was associated with slower regeneration, probably due to skin traumatization by repeated injections...
August 18, 2018: Bulletin of Experimental Biology and Medicine
Maria Lavinia Bartolucci, Ida Marini, Francesco Bortolotti, Daniela Impellizzeri, Rosanna Di Paola, Giuseppe Bruschetta, Rosalia Crupi, Marco Portelli, Angela Militi, Giacomo Oteri, Emanuela Esposito, Salvatore Cuzzocrea
OBJECTIVE AND DESIGN: Temporomandibular disorder (TMD) is a common painful condition in the temporomandibular joint (TMJ). Joint inflammation is believed to be a chief cause of pain in patients with TMD, through the release of pro-inflammatory cytokines that induce peripheral sensitization of nerve terminals followed by microglial stimulation. MATERIALS AND SUBJECT: TMJ was induced in rats with the injection of complete Freund's adjuvant (CFA) emulsion into the left TMJ capsule...
August 18, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Atilla Çifci, Cüneyt Tayman, Halil İbrahim Yakut, Halit Halil, Esra Çakır, Ufuk Çakır, Salih Aydemir
Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonary dysplasia (BPD) in premature infants. We aimed to ascertain the beneficial effects of ginger ( Zingiber officinale ) on rat pups exposed to hyperoxia and inflammation. Materials and methods: Thirty-six newborn Wistar rats were randomly divided into 3 groups as the hyperoxia (95% O 2 ) + lipopolysaccharide (LPS) group, the hyperoxia + LPS + ginger-treated group, and the control/no treatment group (21% O 2 )...
August 16, 2018: Turkish Journal of Medical Sciences
Amanda C Kentner, Stephanie Scalia, Junyoung Shin, Mattia M Migliore, Alejandro N Rondón-Ortiz
Both basic and clinical research support the use of tactile stimulation to rescue several neurobiobehavioral consequences that follow early life stress including. Here, using a translational rodent model of the neonatal intensive care unit (NICU), we tested the individual prophylactic potential of a variety of sensory interventions including tactile (brushing pups with a paint brush to mimic maternal licking), auditory (a simulated lactating rat dam heart beat), and olfactory (a series of aroma therapy scents) stimulation...
July 30, 2018: Psychoneuroendocrinology
Ichiro Tamaki, Koichiro Hata, Yusuke Okamura, Yermek Nigmet, Hirofumi Hirao, Toyonari Kubota, Osamu Inamoto, Jiro Kusakabe, Toru Goto, Tetsuya Tajima, Junichi Yoshikawa, Hirokazu Tanaka, Tatsuaki Tsuruyama, Rene H Tolba, Shinji Uemoto
Cold storage (CS) remains the gold standard for organ preservation worldwide, though it is inevitably associated with cold-ischemia/warm-reperfusion injury (IRI). Molecular hydrogen (H2 ) is well-known to have anti-oxidative properties, however, its unfavorable features, i.e. inflammability, low solubility, and high tissue/substance permeability, have hampered its clinical application. To overcome such obstacles, we developed a novel reconditioning method for donor organs, named HyFACS (hydrogen flush after cold storage), just an end-ischemic H2 -flush directly to donor organs ex vivo, and herein report its therapeutic impact against hepatic IRI...
August 18, 2018: Liver Transplantation
Z V Bakaeva, N V Ermakova, O V Mankaeva, D S Sveshnikov, A E Severin, A N Sinel'nikova, Yu P Starshinov, I V Radysh, V I Torshin, D A Frolov, I G Kozlov
We studied the effect of collagen fragments (PGP and AcPGP) on serum content of epinephrine, corticosterone, and IL-1β in rats subjected to water-immersion stress. The degree of local inflammation accompanying ulceration was assessed by IL-1β production by ln. gastricus caudalis cells. In 1 h, the sharp increase in hormone concentrations in the blood of stressed animals reflected the high stress intensity. Intranasal administration of PGP reduced the area of stress-induced ulcers by 63%, prevented the increase in the levels of stress hormones and the main proinflammatory cytokine in rat blood...
August 18, 2018: Bulletin of Experimental Biology and Medicine
Masanobu Yamazato, Akio Ishida, Yoriko Yamazato, Takuto Nakamura, Yusuke Ohya
Bone marrow-derived cells exert anti-inflammatory actions and can migrate into the brain. However, their role in the development of neurogenic hypertension remains unclear. A hyperactive renin-angiotensin system and inflammation in the brain are mechanisms that contribute to angiotensin II-initiated neurogenic hypertension. We hypothesized that bone marrow-derived cells in the brain attenuate the overactive brain renin-angiotensin system and inflammation, thereby reducing neurogenic hypertension. We cultured plastic-adherent bone marrow-derived cells for 3 weeks...
August 17, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
A Vysakh, Kuriakose Jayesh, Lal Raisa Helen, Mathew Jyothis, M S Latha
BACKGROUND: The plant Rotula aquatica Lour. was traditionally well known due to its large number of pharmacological action and medicinal uses. The plant is a necessary component of many Ayurvedic drug preparations since historical times. It is widely used as a crucial ancient drug for kidney and bladder stones. OBJECTIVES: The main objective of the study was to evaluate the acute toxicity and anti inflammatory efficacy of methanolic extract of R.aquatica Lour. in in vivo models...
August 14, 2018: Journal of Ayurveda and Integrative Medicine
Dannielle Zierath, Theresa Olmstead, Astiana Stults, Angela Shen, Allison Kunze, Kyra J Becker
BACKGROUND: A robust adrenergic response following stroke impairs lymphocyte function, which may prevent the development of autoimmune responses to brain antigens. We tested whether inhibition of the sympathetic response after stroke would increase the propensity for developing autoimmune responses to brain antigens. METHODS: Male Lewis rats were treated with 6-hydroxydopamine (OHDA) prior to middle cerebral artery occlusion (MCAO), labetalol after MCAO, or appropriate controls...
August 14, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Ying-Nan Ju, Jing Gong, Xue-Ting Wang, Jing-Li Zhu, Wei Gao
BACKGROUND: Mechanical ventilation (MV) can cause ventilator-induced lung injury (VILI). AIM OF THE STUDY: This study investigated whether endothelial colony-forming cells (ECFC) could inhibit VILI in a rat model of acute respiratory distress syndrome (ARDS). METHODS: Male Wistar rats received the femoral artery and venous cannulation (sham group) or were injected intravenously with 500 μg/kg lipopolysaccharide to induce ARDS. The ARDS rats were subjected to MV...
August 14, 2018: Archives of Medical Research
Vishesh Dubey, Azeem Ahmad, Rajwinder Singh, Deanna L Wolfson, Purusotam Basnet, Ganesh Acharya, Dalip Singh Mehta, Balpreet Singh Ahluwalia
Total internal reflection fluorescence (TIRF) microscopy benefits from high-sensitivity, low background noise, low photo-toxicity and high-contrast imaging of sub-cellular structures close to the membrane surface. Although, TIRF microscopy provides high-contrast imaging it does not provide quantitative information about morphological features of the biological cells. Here, we propose an integrated waveguide chip-based TIRF microscopy and label-free quantitative phase imaging (QPI). The evanescent field present on top of a waveguide surface is used to excite the fluorescence and an upright microscope is used to collect the signal...
August 6, 2018: Optics Express
Yanbo Yu, Mengye Zhu, Yong Zhao, Mu Xu, Mizhen Qiu
OBJECTIVE: The aim of this study was to investigate the mechanisms of TUSC7/miR-449a/PPAR-γ axis on the inflammation induced by microglia activation. METHODS: A compressive spinal cord injury (SCI) model was established. The expressions of TUSC7, miR-449a PPAR-γ, TNF-α and IL-1β in spinal cord tissues of SCI rats and HAPI cells were determined. The interaction of TUSC7 and miR-449a was tested by RIP and RNA pull-down assays. The regulatory relationship between miR-449a and PPAR-γ was tested by dual luciferase reporter gene assay...
September 5, 2018: Biochemical and Biophysical Research Communications
Zeynab Mohamadi Yarijani, Aliashraf Godini, Seyed Hamid Madani, Houshang Najafi
BACKGROUND: Cisplatin is widely used in the chemotherapy of solid organ cancers. However, its application is associated with serious side effects in various organs including the kidneys and liver. OBJECTIVES: The aim of this study was to investigate the effects of mallow extract on the side effects of cisplatin in the kidneys and liver. METHODS: Hydroalcoholic extract of mallow, at doses of 200, 400, and 600 mg/kg BW, was administered to the animals for seven days intraperitoneally (ip)...
July 31, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kaan Demiroren, Mehmet Turan Basunlu, Remzi Erten, Erdem Cokluk
This study investigated the effects of thymoquinone, silymarin, and N-acetylcysteine in a rat model with carbon tetrachloride (CCl4 )-induced hepatotoxicity. Although numerous similar studies are available, we aimed to compare the efficacy of these agents by considering N-acetylcysteine as a reference compound. A total of 50 male Wistar albino rats were randomly designated as 5 groups: Group I, CCl4 ; group II, thymoquinone and CCl4 ; group III, silymarin and CCl4 ; group IV, N-acetylcysteine and CCl4 ; group V, control group...
July 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Rui Xin, Xuhong Sun, Ziying Wang, Wendan Yuan, Weidong Jiang, Lin Wang, Yanxiao Xiang, Hongqin Zhang, Xiaoyan Li, Yun Hou, Wangnan Sun, Pengchao Du
AIMS: In this animal study, we tried to test the hypothesis that apocynin could play an anti-inflammation role by inhibiting NLRP3/X-linked inhibitor of apoptosis protein (XIAP) signalling and have an effect on antifibrosis in rats with diabetic nephropathy. MAIN METHODS: Diabetic nephropathy rats were induced by tail-vein injection of streptozotocin at 60 mg/kg body weight in sodium citrate buffer (0.01 M, pH 4.5) with unrestricted access to food/water for 12 weeks, and rats with blood glucose levels above 18...
July 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yanan Cao, Yue Yang, Lu Wang, Longyan Li, Junjie Zhang, Xiaowei Gao, Sisi Dai, Yanrong Zhang, Qulian Guo, Yong Gang Peng, E Wang
We investigated the changes in expression profile and potential roles of long noncoding RNAs (lncRNAs) in right ventricle (RV) myocardium of pulmonary arterial hypertension (PAH) rats with RV failure induced by acute inflammation. Sprague-Dawley rats were given monocrotaline to establish a PAH model and acute heart failure was induced by an injection of lipopolysaccharide. The RV failure was confirmed by echocardiography data. The expression profiles of lncRNAs and messenger RNAs (mRNAs) in RV tissues were obtained by RNA sequencing...
July 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Wei Zhang, Yangyang Zhang, Keke Ding, Hengbing Zhang, Qian Zhao, Zheng Liu, Yawei Xu
JNK1/2 and NF-κB signal are essential signaling pathways that mediate a variety of cellular processes, including cell survival, apoptosis, inflammation and angiogenesis. JNK1/2 activation and NF-κBp65 nuclear translocation have been found in ischemia/reperfusion (I/R)-induced injury. However, the regulation of JNK1/2-NF-κBp65 signaling pathway remains unclear. To examine the function and possible mechanism of HMGB2 in I/R-induced cell injury, human AC16 cardiomyocytes transfected with pLVX-Puro-HMGB2 were treated with SP600125 (JNK1/2 inhibitor) or PDTC (NF-κB inhibitor) and that following I/R injury were transfected with HMGB2-shRNA...
July 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Faisal Imam, Naif O Al-Harbi, Mohammad Matar Al-Harbi, Mushtaq Ahmad Ansari, Abdullah F Al-Asmari, Mohd Nazam Ansari, Wael A Al-Anazi, Saleh Bahashwan, Mashal M Almutairi, Musaad Alshammari, Mohammad Rashid Khan, Abdulaziz Mohammed Alsaad, Moureq Rashed Alotaibi
BACKGROUND: Doxorubicin is an effective, potent and commonly used anthracycline-related anticancer drug; however, cardiotoxicity compromises its therapeutic potential. Apremilast, a novel phosphodiesterase type 4-inhibitor, reported to have anti-inflammatory effects and modulating many inflammatory mediators. METHODS: The present study investigated the influence of apremilast against doxorubicin-induced cardiotoxicity in male Wistar rats. A total, 24 animals were divided into four groups of six animal each...
March 29, 2018: Pharmacological Reports: PR
Omnyah A El-Kharashi, Dalia Alaa El-Din Aly El-Waseef, Enas S Nabih, Doaa I Mohamed
BACKGROUND: NLRP3 inflammasome is described in many pathological conditions and is also involved in drug induced liver injury. AIM OF THE WORK: To investigate the role of NLRP3 inflammasome in liver injury induced by chronic alcohol and/or atorvastatin ingestion. MATERIALS AND METHODS: Sixty male Wistar rats were used. They were divided into 5 groups: (I) control naïve (II) Alcoholic: given ethanol 8 g/kg/day, p.o (III) Atorvastatin: given atorvastatin 10 mg/kg/day, p...
August 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yang Zhang, Zhen Su, Hai-Lin Liu, Lin Li, Meng Wei, Dong-Jian Ge, Zhi-Jie Zhang
MicroRNA are emerging as significant regulators of neuropathic pain progression. In addition, neuroinflammation contributes a lot to neuropathic pain. miR-26a-5p has been identified as an inflammation-associated miRNA in multiple pathological processes. However, little is known about the biological role of miR-26a-5p in neuroinflammation and neuropathic pain development. Therefore, we aimed to investigate the function of miR-26a-5p in neuropathic pain by establishing a rat model using chronic sciatic nerve injury (CCI)...
August 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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