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Infection anxiety

Kate B Carey, Kate M Guthrie, Carla M Rich, Naomi H Krieger, Alyssa L Norris, Clair Kaplan, Michael P Carey
Alcohol use and sexual behavior co-occur frequently in young women, increasing risk for HIV and other sexually transmitted infections. To inform preventive interventions, we used qualitative methods to better understand how women think about the contribution of alcohol use to sexual risk-taking. Young women (N = 25; M = 22.8 years; 64% White) were recruited from a community-based reproductive health clinic to attend focus groups; a semi-structured agenda was used to investigate both a priori explanatory mechanisms as well as participant-driven explanations for the alcohol-sex association...
October 12, 2018: AIDS and Behavior
Sin How Lim, Shan-Estelle Brown, Stacey A Shaw, Adeeba Kamarulzaman, Frederick L Altice, Chris Beyrer
Malay-Muslim men who have sex with men (MSM) are marginalized and hidden in Malaysia, a predominantly Muslim country in southeast Asia. We explored the policy, network, community, and individual factors related to HIV infection among Malay-Muslim MSM through 26 in-depth interviews and one focus group discussion (n = 5) conducted in Kuala Lumpur and Kota Bharu between October 2013 and January 2014. As religion plays an important role in their lives, participants viewed homosexuality as a sin. Low risk perception and misconceptions about HIV/AIDS were common, and most participants expressed reluctance to consult a doctor unless they had symptoms...
October 11, 2018: Journal of Homosexuality
Nora West, Sheree Schwartz, Mutsa Mudavanhu, Colleen Hanrahan, Holly France, Jeremy Nel, Lillian Mutunga, Shelley Bernhardt, Jean Bassett, Annelies Van Rie
We examined the prevalence of mental health conditions, social support, and associated factors among adolescents living with HIV. We conducted a cross-sectional analysis with adolescents (ages 9-19) attending a primary care clinic in Johannesburg, South Africa. We analyzed the results of four self-report tools: Children's Depression Inventory-Short, Revised Manifest Anxiety Scale, Child Post-Traumatic Stress Disorder (PTSD) Checklist, and a modified version of the Medical Outcomes Study Social Support Scale...
October 10, 2018: AIDS Care
Regina Juanbeltz, Iván Martínez-Baz, Ramón San Miguel, Silvia Goñi-Esarte, Juan Manuel Cabasés, Jesús Castilla
BACKGROUND: Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim to assess the change in health-related quality of life (HRQoL) among patients successfully treated, and to identify predictors of this variation. METHODS: In a prospective observational study, patients with chronic hepatitis C who started DAA therapy between May 2016 and April 2017 completed the EQ-5D-5L questionnaire at baseline and 12 weeks after the end of therapy before knowing the virological result...
2018: PloS One
Ishan Shah, Christopher Wang, Nick Jain, Blake Formanek, Zorica Buser, Jeffrey Wang
BACKGROUND CONTEXT: Previous studies have found an association between mental illness and poor outcomes in spine surgery, but little is known about the effects of depression and/or anxiety on the adult spinal deformity population. In addition, most relevant studies exclusively focused on the lumbar spine and had relatively small patient sizes. PURPOSE: The aim of this study was to investigate whether adult spinal deformity patients with depression and/or anxiety have an increased risk of postoperative complications and reoperation following posterior thoracolumbar spinal surgery...
October 5, 2018: Spine Journal: Official Journal of the North American Spine Society
Jacqueline A Richmond, Jeanne Ellard, Jack Wallace, Rachel Thorpe, Peter Higgs, Margaret Hellard, Alexander Thompson
Background: Universal access to the hepatitis C direct acting antiviral (DAAs) regimens presents a unique opportunity to eliminate hepatitis C in Australia. Large numbers of Australians have already been cured using these treatments, however, the numbers presenting for treatment have begun to plateau. This study explored how people experienced and understood being cured of hepatitis C, with the aim of informing interventions to increase uptake of DAA treatment among people with hepatitis C...
2018: Hepatology, Medicine and Policy
Tim Card, Paul Enck, Giovanni Barbara, Guy Ee Boeckxstaens, Javier Santos, Fernando Azpiroz, Fermin Mearin, Qasim Aziz, John Marshall, Robin Spiller
Background: Gastrointestinal infection is an important risk factor for developing irritable bowel syndrome (IBS). Our aim was to characterise post-infectious IBS (PI-IBS) compared to other IBS patients. Methods: An internet survey of IBS patients using Rome III diagnostic questionnaire, Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-12 Somatic Symptom (PHQ12-SS) scale score documenting the mode of onset was conducted. Results: A total of 7811 participants (63...
October 2018: United European Gastroenterology Journal
Maria Elena Di Battista, Carola Dell'Acqua, Luciana Baroni, Chiara Fenoglio, Daniela Galimberti, Maurizio Gallucci
We describe the case of a 61-year-old woman diagnosed with Borreliosis at the age of 57. Subsequently, the patient developed depression, anxiety, and behavioral disturbances. A lumbar puncture excluded the condition of Neuroborreliosis. The diagnostic workup included: an MRI scan, a 18F-FDG PET, a 123I-ioflupane-SPECT, an amyloid-β PET, a specific genetic analysis, and a neuropsychological evaluation. Based on our investigation, the patient was diagnosed with probable behavioral-frontotemporal dementia (bvFTD), whereas in the previous years, the patient had been considered firstly as a case of Post-Treatment-Lyme Disease and, secondly, a psychiatric patient...
September 28, 2018: Journal of Alzheimer's Disease: JAD
Greta Tam
ABSTRACTSince the first human A/H7N9 infection in Hong Kong, there has been an ongoing threat of human-to-human transmission, potentially causing a pandemic. Because there is no vaccine for A/H7N9, the individual preventive measures become all the more important for reducing transmission. However, due to the ongoing threat of numerous avian influenza viruses, the public may suffer from pandemic-media-fatigue. This study was done to assess the need for a targeted A/H7N9 health promotion campaign. Steven and Gillam's framework using epidemiological, comparative, and corporate approaches was used to assess the need for a targeted A/H7N9 health promotion campaign...
October 2, 2018: Disaster Medicine and Public Health Preparedness
Mary Warrell, David A Warrell, Arnaud Tarantola
The aim of this review is to guide clinicians in the practical management of patients suffering from rabies encephalomyelitis. This condition is eminently preventable by modern post-exposure vaccination, but is virtually always fatal in unvaccinated people. In the absence of any proven effective antiviral or other treatment, palliative care is an imperative to minimise suffering. Suspicion of rabies encephalomyelitis depends on recognising the classic symptomatology and eliciting a history of exposure to a possibly rabid mammal...
October 4, 2017: Tropical Medicine and Infectious Disease
Kerstin J Olbrich, Dirk Müller, Sarah Schumacher, Ekkehard Beck, Kinga Meszaros, Florian Koerber
INTRODUCTION: Invasive meningococcal disease (IMD, septicaemia and/or meningitis) has a severe acute and long-term burden: 5-10% of patients die within 48 h, and long-term sequelae have been reported in 10-20% of survivors. Health-related quality of life (HRQoL) is increasingly but inconsistently assessed. METHODS: A systematic literature review on Neisseria meningitidis IMD sequelae and HRQoL in survivors of all ages and their caregivers, including family, was conducted for high-income countries from 2001 to 2016 (in Medline and Embase, following Cochrane and PRISMA guidelines)...
September 28, 2018: Infectious Diseases and Therapy
Maria Pedersen, Tarjei Tørre Asprusten, Kristin Godang, Truls Michael Leegaard, Liv Toril Osnes, Eva Skovlund, Trygve Tjade, Merete Glenne Øie, Vegard Bruun Bratholm Wyller
INTRODUCTION: Acute Epstein-Barr virus (EBV) infection is a trigger of chronic fatigue and Chronic Fatigue Syndrome (CFS). This study investigated baseline predictors of chronic fatigue six months after an acute EBV infection. MATERIALS AND METHODS: A total of 200 adolescents (12-20 years old) with acute EBV infection were assessed for 149 possible baseline predictors and followed prospectively. We performed linear regression to assess possible associations between baseline predictors and fatigue (Chalder Fatigue Questionnaire total score) six months after the acute EBV infection...
September 25, 2018: Brain, Behavior, and Immunity
Ashley N Rubin, Eduardo D Espiridion, Nhu-Hac Truong, Daniel H Lofgren
The number of cases of late and late latent syphilis in the United States is on the rise. This diagnosis is often forgotten when an elderly patient is being worked up for altered mental status. Rarely does a 70-year-old male with neurosyphilis present simply with anxiety. Due to the decreased severity of the presentation, this patient was sent home from the emergency department multiple times until the anxiety progressed to psychosis. He was finally admitted with delirium, suicidal ideation, and paranoia. A routine Treponema pallidum antibody test returned positive and a further workup of confirmatory lab work, a thorough neurological exam, and magnetic resonance imaging (MRI) revealed a chronic syphilis infection...
July 22, 2018: Curēus
Elise C Cope, Maya Opendak, Elizabeth A LaMarca, Sahana Murthy, Christin Y Park, Lyra B Olson, Susana Martinez, Jacqueline M Leung, Andrea L Graham, Elizabeth Gould
The hippocampus of rodents undergoes a substantial amount of structural remodeling throughout adulthood, including the addition of entirely new neurons. Adult neurogenesis is sensitive to living conditions, including environmental enrichment and stress. Microglia, the brain's resident immune cells, are involved in adult neurogenesis by engulfing dying new neurons. While previous studies using laboratory environmental enrichment have investigated alterations in brain structure and function, they do not provide an adequate reflection of living in the wild, in which stress and environmental instability are common...
September 25, 2018: Hippocampus
Hye-Young Wang, Hyunil Kim, Kwang Hwa Park
OBJECTIVES: Pap smear and high-risk human papillomavirus (HR-HPV) DNA testing are the most widely applied methods for cervical cancer screening, but both methods are limited by their low specificity and lack of association with the patients' prognoses. The aim of the study was to compare the clinical and prognostic significance of HPV E6/E7 mRNA as an early biomarker with cytology and HPV DNA detection in cervical cancer screening. METHODS: In this study, we evaluated the performance of the OPTIMYGENE® HR-HPV RT-qDx assay, which is a HPV E6/E7 mRNA-based assay, to detect 16 HR-HPV subtypes (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, and 69)...
September 21, 2018: International Journal of Infectious Diseases: IJID
Eytan M Stein, Min Yang, Annie Guerin, Wei Gao, Philip Galebach, Cheryl Q Xiang, Subrata Bhattacharyya, Gaetano Bonifacio, George J Joseph
BACKGROUND: Preference valuations of health status are essential in health technology and economic appraisal. This study estimated utilities for treatment-related health states of acute myeloid leukemia (AML) and disutilities of severe adverse events (SAEs) using a representative sample of adults from the general population in the United States (US). METHODS: Treatment-related AML health states, defined based on literature and interviews with clinicians, included complete remission (CR), no CR, relapse, stem cell transplant (SCT), and post SCT short-term recovery...
September 21, 2018: Health and Quality of Life Outcomes
Gurpreet Kaur, Gaurav Prakash, Pankaj Malhotra, Sandhya Ghai, Sukhpal Kaur, Mahender Singh, Kulbeer Kaur
Background: Yoga is proven beneficial in improving quality of life among breast cancer survivors receiving chemotherapy, but its effectiveness in lymphoma patients needs to be explored. As chemotherapy-induced neutropenia is very common among lymphoma patients, they are much prone to infections from the environment. Furthermore, trained yoga instructors are not available in every setting, so there is a need to develop home-based yoga program modules for lymphoma patients receiving chemotherapy...
September 2018: International Journal of Yoga
Stella O Odedina, IkeOluwapo O Ajayi, Adenike Adeniji-Sofoluwe, Imran O Morhason-Bello, Dezheng Huo, Olufunmilayo I Olopade, Oladosu A Ojengbede
BACKGROUND: Breast disorders cause great anxiety for women especially when they occur in pregnancy because breast cancer is the most common cause of cancer related deaths in women. Majority of the disorders are Benign Breast Diseases (BBD) with various degrees of associated breast cancer risks. With increasing breast cancer awareness in Nigeria, we sought to determine the prevalence and characteristics of breast disorders among a cohort of pregnant women. METHODS: A longitudinal study of 1248 pregnant women recruited in their first trimester- till 26 weeks gestational age consecutively from selected antenatal clinics (ANCs), in Ibadan, Southwest Nigeria...
September 19, 2018: BMC Women's Health
Andrew Stevenson, Kim Kavanagh, Jiafeng Pan, Lynne Stevenson, Heather Griffin, John Doorbar, Evelyn Scott, Miriam Deeny, Kate Cuschieri, Sheila V Graham
BACKGROUND: While human papillomavirus (HPV) DNA testing offers high sensitivity for the detection of significant cervical disease, its specificity is suboptimal given the high prevalence of transient HPV infections (CIN1 or less). Biomarkers to identify those suffering from low grade disease from those with high grade disease could save healthcare costs and reduce patient anxiety. OBJECTIVE: The objective of the present work was to develop and test an immunohistochemistry (IHC)-based dual viral and cellular biomarker strategy which was applicable to liquid based cytology (LBC) samples...
August 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Xiaojie Huang, Kathrine Meyers, Xinchao Liu, Xia Li, Tong Zhang, Wei Xia, Jiahua Hou, Aixin Song, Haolan He, Chongxi Li, Shenghua He, Weiping Cai, Huolin Zhong, Chengyu Huang, Shuiqing Liu, Hui Wang, Xuemei Ling, Ping Ma, Rongxia Ye, Gang Xiao, Taisheng Li, Ding Ding, Kristine Yaffe, Hui Chen, Yaokai Chen, Hao Wu
Background: Anxiety and depression continue to be significant comorbidities for people with HIV infection. We investigated the prevalence of and factors associated with anxiety and depression among adult HIV-infected patients across China. Methods: In this cross-sectional study, we described clinical and psychosocial variables related to depression and anxiety in 4103 HIV-infected persons. Doctors assessed anxiety and depression by asking patients whether they had experienced anxiety or depression in the prior month...
2018: Frontiers in Psychiatry
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