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https://www.readbyqxmd.com/read/30532543/activation-of-erk-creb-bdnf-pathway-involved-in-abnormal-behavior-of-neonatally-borna-virus-infected-rats
#1
Chenmeng Li, Xiaoyan Xu, Xiong Zhang, Ke Cheng, Yujie Guo, Jie Jie, Hua Guo, Yong He, Chanjuan Zhou, Siwen Gui, Xiaogang Zhong, Haiyang Wang, Peng Xie
Background: Neuropsychiatric disorders are devastating illnesses worldwide; however, the potential involvement of viruses in the pathophysiological mechanisms of psychiatric diseases have not been clearly elucidated. Borna disease virus (BDV) is a neurotropic, noncytopathic RNA virus. Materials and methods: In this study, we infected neonatal rats intracranially with BDV Hu-H1 and Strain V within 24 hours of birth. Psychological phenotypes were assessed using sucrose preference test, open field test, elevated plus maze test, and forced swim test...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30529370/non-aids-related-comorbidities-in-people-living-with-hiv-1-aged-50-and-older-the-aging-positive-study
#2
Rosário Serrão, Carmela Piñero, Jorge Velez, Daniela Coutinho, Fernando Maltez, Sara Lino, Rui Sarmento E Castro, Ana Paula Tares, Patrícia Pacheco, Maria João Lopes, Kamal Mansinho, Ana Cláudia Miranda, Isabel Neves, Ricardo Correia de Abreu, Joana Almeida, Leonor Pássaro
OBJECTIVES: To characterize the profile of NARC in older HIV-1-infected population and explore the factors associated with multiple NARC. METHODS: Multicenter, cross-sectional study including HIV-1-infected patients ≥50 years, virologically suppressed and on a stable ART regimen for at least 6 months. Multiple regression model explored the association of demographic and clinical variables with the number of NARC. RESULTS: Overall, 401 patients were enrolled...
October 25, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/30517589/association-of-preoperative-anxiety-and-depression-symptoms-with-postoperative-complications-of-cardiac-surgeries
#3
Hélen Francine Rodrigues, Rejane Kiyoma Furuya, Rosana Aparecida Spadoti Dantas, Alfredo José Rodrigues, Carina Aparecida Marosti Dessotte
OBJECTIVE: to investigate the associations of preoperative anxiety and depression symptoms with postoperative complications and with sociodemographic and clinical characteristics of patients submitted to the first coronary artery bypass graft. METHOD: observational, analytical and longitudinal study. A consecutive non-probabilistic sample consisted of patients submitted to coronary artery bypass graft. To evaluate the symptoms, the Hospital Anxiety and Depression Scale was used...
November 29, 2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/30514138/pectoralis-major-myocutaneous-flap-in-salvage-reconstruction-following-free-flap-failure-in-head-and-neck-cancer-surgery
#4
Wei Wei, Yongsheng Qiu, Qigen Fang, Yingping Jia
OBJECTIVE: This study aimed to compare the results of the pectoralis major myocutaneous (PMM) flap in primary and salvage head and neck cancer surgery. METHODS: A total of 160 patients were enrolled in this study. The salvage group consisted of 30 patients who received immediate PMM flap surgery following free flap failure. In the primary group, the PMM flap was primarily chosen for 130 patients. Related information was collected and analysed. The University of Washington (UW)-Quality of Life questionnaire, version 4, was mailed to every patient...
December 5, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30509706/a-systematic-review-of-the-content-and-delivery-of-education-in-pulmonary-rehabilitation-programmes
#5
REVIEW
N J Roberts, L Kidd, K Kirkwood, J Cross, M R Partridge
INTRODUCTION: Pulmonary rehabilitation (PR) is a core component of Chronic Obstructive Pulmonary Disease (COPD) management with well recognized benefits. While suggestions for educational content within pulmonary rehabilitation have been detailed in clinical guidance, it is unclear what educational content is delivered as part of pulmonary rehabilitation, who delivers it, and how it is delivered. METHODS: A systematic review was conducted to identify what educational content is delivered as part of pulmonary rehabilitation, how is this delivered and who delivers it...
December 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/30508227/abstracts
#6
A D Irvine, A P Jones, P Beattie, S Baron, F Browne, F Ashoor, L O'Neill, A Rosala-Hallas, T Sach, C Spowart, L Taams, C Walker, M Wan, N Webb, P Williamson, C Flohr
Atopic eczema is a skin disease affecting around 20% of UK children, 16% of whom have moderate to severe disease. Severe atopic eczema can cause sleep disturbance, poor school attendance and social withdrawal, as well as attention-deficit hyperactivity disorder, anxiety and clinical depression. Skin can become infected and this can be a reason for hospital admission. Although most cases of atopic eczema can be treated with emollients, topical anti-inflammatory treatments and/or ultraviolet (UV) therapy, around 2% of children require oral (taken by mouth) immuno-suppressive treatment...
December 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30472482/brain-grey-matter-volume-reduction-and-anxiety-like-behavior-in-lipopolysaccharide-induced-chronic-pulmonary-inflammation-rats-a-structural-mri-study-with-histological-validation
#7
Ji Chen, Ya Yan, Fengjuan Yuan, Jianbo Cao, Shanhua Li, Simon B Eickhoff, Jiaxing Zhang
While there have been multiple fMRI studies into the brain functional changes after acutely stimulated peripheral infection, knowledge for the effect of chronic peripheral infection on whole brain morphology is still quite limited. The present study was designed to investigate the brain structural and emotional changes after peripheral local infection initiated chronic systemic inflammation and the relationship between circulating inflammatory markers and brain grey matter. Specifically, in-vivo T2-weighted MRI was performed on rats with lipopolysaccharide (LPS)-induced chronic pulmonary inflammation (CPI) for 4 months and those without...
November 22, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/30469423/prenatal-programming-of-neuroendocrine-system-development-by-lipopolysaccharide-long-term-effects
#8
REVIEW
Marina Izvolskaia, Viktoria Sharova, Liudmila Zakharova
Various stress factors during critical periods of fetal development modulate the epigenetic mechanisms controlling specific genes, which can affect the structure and function of physiological systems. Maternal immune stress by bacterial infection simulated by lipopolysaccharide (LPS) in an experiment is considered to be a powerful programming factor of fetal development. Studies of the molecular mechanisms controlling the formation and functioning of physiological systems are in the pilot stage. LPSs are the most potent natural inflammation factors...
November 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30460729/multi-professional-simulation-and-risk-perception-of-health-care-workers-caring-for-ebola-infected-patients
#9
Eva Carvalho, Pedro Castro, Esther León, Ana Del Río, Félix Crespo, Laura Trigo, Sara Fernández, Antoni Trilla, Pilar Varela, Jose Maria Nicolás
INTRODUCTION: Treatment of infections that require high-level isolation can cause anxiety and fear among health care workers. Adequate and complete multi-professional simulation-based training could reduce those feelings and improve patient care. OBJECTIVE: The purpose of this study was to assess the impact of multi-professional simulation-based training on the risk perception and preparedness of health care workers (registered nurses, doctors and ancillary staff) who care for patients assessed to be at risk or confirmed to have Ebola, level 3-4 biohazard...
November 20, 2018: Nursing in Critical Care
https://www.readbyqxmd.com/read/30459012/predicting-the-occurrence-of-complications-following-corrective-cervical-deformity-surgery-analysis-of-a-prospective-multicenter-database-using-predictive-analytics
#10
Peter G Passias, Cheongeun Oh, Samantha R Horn, Han Jo Kim, D Kojo Hamilton, Daniel M Sciubba, Brian J Neuman, Aaron J Buckland, Gregory W Poorman, Frank A Segreto, Cole A Bortz, Avery E Brown, Themistocles S Protopsaltis, Eric O Klineberg, Christopher Ames, Justin S Smith, Virginie Lafage
We developed a predictive model to describe risk factors for complications in cervical deformity surgeries. Cervical deformity (CD) surgical patients are growing in number, but remain under-studied in the literature. CD was defined as at least one of the following: C2-C7 Cobb >10°, CL >10°, cSVA >4 cm, CBVA >25°. Patient demographics and clinical data were assessed as risk factors for medical/surgical complications using multivariate regression models. 123 patients underwent CD surgery (60...
November 17, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30450213/effects-of-high-intensity-interval-training-on-exercise-capacity-in-people-with-cystic-fibrosis-study-protocol-for-a-randomised-controlled-trial
#11
Abbey Sawyer, Vinicius Cavalheri, Sue Jenkins, Jamie Wood, Nola Cecins, Bhajan Singh, Kylie Hill
Background: In people with cystic fibrosis (CF), higher exercise capacity is associated with better health-related quality of life (HRQoL), reduced risk of hospitalisation for a respiratory infection and survival. Therefore, optimisation of exercise capacity is an important treatment goal. The Australian and New Zealand clinical practice guidelines recommend that people with CF complete 30 to 60 min of moderate intensity aerobic exercise on most days of the week. This recommendation can be difficult to achieve by people with CF because of time constraints, and intolerable breathlessness and muscle fatigue during continuous exercise...
2018: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/30444755/the-need-and-desire-for-mental-health-and-substance-use-related-services-among-clients-of-publicly-funded-sexually-transmitted-infection-clinics-in-vancouver-canada
#12
Travis Salway, Olivier Ferlatte, Jean Shoveller, Aaron Purdie, Troy Grennan, Darrell H S Tan, Theodora Consolacion, Ashleigh J Rich, Naomi Dove, Hasina Samji, Kai Scott, Everett Blackwell, Dean Mirau, Natalie Holgerson, Jason Wong, Mark Gilbert
CONTEXT: Sexually transmitted infections (STI) and mental health and substance use (MHSU) disorders all occur at elevated rates in sexual and gender minorities. These overlapping epidemics, or syndemics, are exacerbated by challenges these same populations face in accessing sexual/gender minority-affirming services. Many publicly funded STI clinics are a low barrier and provide sexual minority-competent care. These sites therefore may be uniquely situated to address clients' MHSU-related needs...
November 15, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/30429181/what-are-the-most-common-conditions-in-primary-care-systematic-review
#13
Caitlin R Finley, Derek S Chan, Scott Garrison, Christina Korownyk, Michael R Kolber, Sandra Campbell, Dean T Eurich, Adrienne J Lindblad, Ben Vandermeer, G Michael Allan
OBJECTIVE: To identify the most commonly presenting conditions in primary care globally, and to compare common reasons for visits (RFVs) as reported by clinicians and patients, as well as among countries of different economic classifications. DATA SOURCES: Twelve scientific databases were searched up to January 2016, and a dual independent review was performed to select primary care studies. STUDY SELECTION: Studies were included if they contained 20 000 visits or more (or equivalent volume by patient-clinician interactions) and listed 10 or more RFVs...
November 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/30381161/gabapentin-or-pregabalin-induced-myoclonus-a-case-series-and-literature-review
#14
REVIEW
Aaron Desai, Yazan Kherallah, Cheryl Szabo, Rohit Marawar
Gabapentin (GBP) and pregabalin (PGB) are FDA approved for adjunctive treatment of partial seizures and for treatment of post-herpetic neuralgia. Both drugs are primarily eliminated by renal excretion. However, PGB or GBP induced myoclonus has only been reported infrequently in case reports/series. It is not discussed with patients and its sudden occurrence can lead to anxiety because of "seizure-like" nature. In addition, first-contact physicians might treat it as seizures, leading to unnecessary tests and aggressive management...
October 28, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30376641/associations-between-parental-psychopathology-and-sexual-behavior-in-an-outpatient-psychiatric-sample
#15
Sarah R Black, Ilana Seager, Molly R Meers, L Eugene Arnold, Boris Birmaher, Robert L Findling, Sarah M Horwitz, Eric A Youngstrom, Mary A Fristad
Early age of sexual debut is associated with an increase in negative outcomes, including higher incidence of nonconsensual sexual experiences, higher rates of sexually transmitted infections, and risky sexual practices. Little research has examined the role of parental psychopathology as a predictor of adolescent sexual activity, however. The current study aims to close this gap by examining the relationship between parental psychopathology and sexual activity in a longitudinal sample of youth. Participants were 685 adolescents from the Longitudinal Assessment of Manic Symptoms study, the majority of whom were male (67%) and White (65%)...
October 30, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/30371952/heliox-for-croup-in-children
#16
REVIEW
Irene Moraa, Nancy Sturman, Treasure M McGuire, Mieke L van Driel
BACKGROUND: Croup is an acute viral respiratory infection with upper airway mucosal inflammation that may cause respiratory distress. Most cases are mild. Moderate to severe croup may require treatment with corticosteroids (from which benefits are often delayed) and nebulised epinephrine (adrenaline) (which may be short-lived and can cause dose-related adverse effects including tachycardia, arrhythmias, and hypertension). Rarely, croup results in respiratory failure necessitating emergency intubation and ventilation...
October 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30368620/physical-activity-intensity-is-associated-with-symptom-distress-in-the-cnics-cohort
#17
Allison R Webel, Amanda L Willig, Wei Liu, Abdus Sattar, Stephen Boswell, Heidi M Crane, Peter Hunt, Mari Kitahata, W Christopher Matthews, Michael S Saag, Michael M Lederman, Benigno Rodriguez
Symptom distress remains a challenging aspect of living with HIV. Physical activity is a promising symptom management strategy, but its effect on symptom distress has not been examined in a large, longitudinal HIV-infected cohort. We hypothesized that higher physical activity intensity would be associated with reduced symptom distress. We included 5370 people living with HIV (PLHIV) who completed patient-reported assessments of symptom distress, physical activity, alcohol and substance use, and HIV medication adherence between 2005 and 2016...
October 27, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/30366345/imipramine-treatment-reverses-depressive-and-anxiety-like-behaviors-normalize-adrenocorticotropic-hormone-and-reduces-interleukin-1%C3%AE-in-the-brain-of-rats-subjected-to-experimental-periapical-lesion
#18
Lutiana R Simões, Soraia Netto, Jaqueline S Generoso, Renan A Ceretta, Rodrigo F Valim, Diogo Dominguini, Monique Michels, Gislaine Z Réus, Samira S Valvassori, Felipe Dal-Pizzol, Tatiana Barichello
BACKGROUND: A periodontal lesion is a consequence of chronic inflammatory processes, itself triggered by a bacterial infection of the pulpal and endodontic microenvironment. Evidence suggests that periodontal lesion induction could alter inflammatory cytokines leading to behavior changes. These effects in the context of anxiety and depressive behavior have been not full investigated. We aimed to observe anxiety- and depressive-like behavioral in rodent subjected to periapical dental lesions...
August 8, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/30357305/screening-for-intimate-partner-violence-elder-abuse-and-abuse-of-vulnerable-adults-us-preventive-services-task-force-final-recommendation-statement
#19
Susan J Curry, Alex H Krist, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, David C Grossman, Alex R Kemper, Martha Kubik, Ann Kurth, C Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng, John B Wong
Importance: Intimate partner violence (IPV) and abuse of older or vulnerable adults are common in the United States but often remain undetected. In addition to the immediate effects of IPV, such as injury and death, there are other health consequences, many with long-term effects, including development of mental health conditions such as depression, posttraumatic stress disorder, anxiety disorders, substance abuse, and suicidal behavior; sexually transmitted infections; unintended pregnancy; and chronic pain and other disabilities...
October 23, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/30337264/somatic-symptoms-and-fatigue-in-a-norwegian-population-with-high-exposure-to-ticks
#20
Erik Thomas Thortveit, Åslaug Rudjord Lorentzen, Unn Ljøstad, Åse Mygland
BACKGROUND: It is heavily debated whether tick-borne infections cause chronic subjective health complaints. If the hypothesis of a major causal connection is true, one would expect to find more subjective health complaints in a population with high exposure to ticks than in a population with less exposure. In the current study we aimed to assess somatic symptoms and fatigue in a Norwegian population with high exposure to ticks, compare our findings to normative data, and assess predictors of somatic symptom load...
January 2019: Ticks and Tick-borne Diseases
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