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Infection depression

Meike Dirks, Kim Haag, Henning Pflugrad, Anita Blanka Tryc, Ramona Schuppner, Heiner Wedemeyer, Andrej Potthoff, Hans Ludger Tillmann, Kajetan Sandorski, Hans Worthmann, Xiaoqi Ding, Karin Weissenborn
Chronic fatigue, mood alterations and cognitive impairment are frequent accessory symptoms of HCV-infection. Fatigue and mood alterations have also been observed in autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC), but not in hepatitis B virus (HBV)-infection, thus indicating an autoimmune response as possible cause of HCV-infection associated encephalopathy. Data, however, are sparse. This study aims to prove that HCV patients feature similar to those with autoimmune liver disease but contrary to HBV patients regarding neuropsychiatric symptoms...
August 18, 2018: Journal of Viral Hepatitis
Sophie Khadr, Venetia Clarke, Kaye Wellings, Laia Villalta, Andrea Goddard, Jan Welch, Susan Bewley, Tami Kramer, Russell Viner
BACKGROUND: Young people are disproportionately affected by sexual assault, yet longitudinal data are sparse. This paper examines the characteristics of adolescents presenting to sexual assault services and mental and sexual health outcomes after an assault. METHODS: This was a prospective cohort study in adolescents aged 13-17 years attending the Sexual Assault Referral Centres serving Greater London, UK, over 2 years. Baseline interviews (T0) were done less than 6 weeks after an assault to collect data on sociodemographic and assault characteristics and psychological symptoms, with follow-up interviews (T1) at 4-5 months after the assault...
September 2018: Lancet Child & Adolescent Health
Benjamin A Neely, Katherine Prager, Alison M Bland, Christine Fontaine, Frances M Gulland, Michael G Janech
Urinary markers for the assessment of kidney diseases in wild animals are limited, in part, due to the lack of urinary proteome data, especially for marine mammals. One of the most prevalent kidney diseases in marine mammals is caused by Leptospira interrogans, which is the second most common etiology linked to stranding of California sea lions (Zalophus californianus). Urine proteins from eleven sea lions with leptospirosis kidney disease and eight sea lions without leptospirosis or kidney disease were analyzed using shotgun proteomics...
August 16, 2018: Journal of Proteome Research
Getinet Ayano, Melat Solomon, Mebratu Abraha
BACKGROUND: Depression is the most prevalent psychiatric disorder among people living with HIV (PLWHIV) and is associated with poor quality of life, additional comorbidities, disability, unemployment, poorer therapeutic outcomes and risky behaviors. The present systematic review and meta-analysis aims to systematically summarize empirical evidence and to formulate recommendations for future research. METHODS: We searched PubMed, EMBASE, SCOPUS, and relevant literature for possible studies to include...
August 15, 2018: BMC Psychiatry
Wei-Ti Chen, Chengshi Shiu, Joyce P Yang, Kerong Wang, Lin Zhang, Jing Zhang, Nancy R Reynolds, Holly Powell Kennedy, Kaveh Khoshnood, Li-Chen Chen, Meijuan Bao, Hongxin Zhao, Hongzhou Lu
China is experiencing a rapid increase in the number of HIV-infected women. In this study, we describe the development and preliminary evaluation of an intervention tailored for Chinese HIV-infected women and caregivers to improve their self- and family management, with goals of enhancing their physical quality of life (QOL) and decreasing their depressive symptomatology. Forty-one HIV-infected women and their caregivers were recruited from two premier Chinese hospitals from July 2014 through March 2016. Participants were randomized to either the control or intervention arm for the Self- and Family Management Intervention (SAFMI)...
August 15, 2018: AIDS Care
Kimberly Stanford, Alyssa Cappetta, Roy Ahn, Wendy Macias-Konstantopoulos
Trafficking of adults and children for both sex and labor is a human rights violation occurring with alarming frequency throughout the world, and resulting in profound harm to close-knit communities and severe health consequences for victims. Certain areas, such as the country of Paraguay, are at a higher risk for trafficking due to unique economic, cultural, and geographic factors. Thousands of people, especially children, are trafficked within Paraguay's borders, and many eventually are transported to neighboring countries and sometimes to Europe and elsewhere...
August 11, 2018: Journal of Interpersonal Violence
Timothy G Heckman, John C Markowitz, Bernadette D Heckman, Henok Woldu, Timothy Anderson, Travis I Lovejoy, Ye Shen, Mark Sutton, William Yarber
Background: Rural areas account for 5% to 7% of all HIV infections in the USA, and rural people living with HIV (PLHIV) are 1.3 times more likely to receive a depression diagnosis than their urban counterparts. A previous analysis from our randomized clinical trial found that nine weekly sessions of telephone-administered interpersonal psychotherapy (tele-IPT) reduced depressive symptoms and interpersonal problems in rural PLHIV from preintervention through postintervention significantly more than standard care but did not increase perceived social support compared to standard care...
March 15, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
M Acebo García-Guerrero, Pedro Sánchez Gómez, Javier Peña Lasa, Joseba Portu Zapirain, Edorta Elizagárate Zabala, Victoria Gorria Bernal, Natalia Ojeda Del Pozo
OBJECTIVES: Reduced performance in several cognitive domains has been repeatedly related to Hepatitis C Virus (HCV). Nevertheless, there is no consensus about the severity or cognitive profile. Moreover, other possible influential variables are scarcely controlled. The aim of this study is to define the specific cognitive profile in HCV after controlling for confounding variables. METHODS: Forty-two HCV patients were distributed in two groups according to the presence of co-infection with Human Immunodeficiency Virus (HIV); a third group with 22 healthy controls was also included...
August 3, 2018: Revista de Psiquiatrí́a y Salud Mental
Kenneth A Field, Brent J Sewall, Jenni M Prokkola, Gregory G Turner, Marianne Gagnon, Thomas M Lilley, J Paul White, Joseph S Johnson, Christopher L Hauer, DeeAnn M Reeder
Hibernation, the use of prolonged torpor to depress metabolism, is employed by mammals to conserve resources during extended periods of extreme temperatures and/or resource limitation. Mammalian hibernators arouse to euthermy periodically during torpor for reasons that are not well understood and these arousals may facilitate immune processes. To determine if arousals enable host responses to pathogens, we used dual RNA-Seq and a paired sampling approach to examine gene expression in a hibernating bat, the little brown myotis (Myotis lucifugus)...
August 6, 2018: Molecular Ecology
R B Bassey, S N Chapman, M Pessu, A Jayam-Trouth, M C Gondré-Lewis
Background: Human immunodeficiency virus (HIV) infection remains a serious immunological disease with new infections in the U.S. disproportionately reported in minority populations. For many years, the District of Columbia (DC) has reported the highest HIV infection rate in the nation. Drug abuse and addiction is also prevalent in DC and has traditionally been linked to HIV/AIDS because of the likelihood for opportunistic infections. Despite this data, the relationship between HIV status, drugs of abuse, and the incidence of neurological disorders are scarcely reported for minority populations...
2018: Journal of Neurology and Neuroscience
Tracy-Leigh McIntyre, Diane Elkonin, Margo de Kooker, Jessica F Magidson
Despite the recent growth of mindfulness research worldwide, there remains little research examining the application of mindfulness-based interventions in resource-limited, international settings. This study examined the application of Mindfulness Based Stress Reduction (MBSR) for HIV-infected individuals in South Africa, where rates of HIV are highest in the world. Mixed methods were used to examine the following over a three-month follow up: (1) feasibility, acceptability, and preliminary adaptation of MBSR for this new context; and (2) effects of MBSR on immune functioning, self-reported mindfulness (MAAS, FFMQ), depression, anxiety, and stress (DASS-21)...
June 2018: Mindfulness
E Morales-Raveendran, E Goodman, E West, J E Cone, C Katz, J Weiss, J M Feldman, D Harrison, S Markowitz, Alex Federman, J P Wisnivesky
OBJECTIVE: There is limited information regarding asthma triggers in World Trade Center (WTC) rescue and recovery workers or how mental health conditions affect the perception of triggers. METHODS: We included 372 WTC workers with asthma. The Asthma Trigger Inventory (ATI) assessed triggers along five domains: psychological, allergens, physical activity, infection, and pollution. We administered the Structured Clinical Interview to diagnose post-traumatic stress disorder (PTSD), major depression and panic disorder (PD)...
August 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Sadayuki Hashioka, Ken Inoue, Maiko Hayashida, Rei Wake, Arata Oh-Nishi, Tsuyoshi Miyaoka
Increasing evidence suggests that infection and persistent low-grade inflammation in peripheral tissues are important pathogenic factors in major depression. Major depression is frequently comorbid with systemic inflammatory diseases/conditions such as rheumatoid arthritis, allergies of different types, multiple sclerosis, cardiovascular disease, inflammatory bowel disease, chronic liver disease, diabetes, and cancer, in which pro-inflammatory cytokines are overexpressed. A number of animal studies demonstrate that systemic inflammation induced by peripheral administration of lipopolysaccharide increases the expression of pro-inflammatory cytokines in both the periphery and brain and causes abnormal behavior similar to major depression...
2018: Frontiers in Neuroscience
Trent M Gause, John J Nunnery, Abhinav B Chhabra, Brian C Werner
BACKGROUND: The goals of the study were to: (1) evaluate trends in preoperative and prolonged postoperative narcotic use in carpal tunnel release (CTR); (2) characterize risks for prolonged narcotic use; and (3) evaluate narcotic use as an independent risk factor for complications following CTR. METHODS: A query of a large insurance database from 2007-2016 was conducted. Patients undergoing open or endoscopic CTR were included. Revision surgeries or patients undergoing median nerve repair at the forearm, upper extremity fasciotomies, or with distal radius fractures were excluded...
August 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
Paul Sator
Biologic therapies like adalimumab are the gold standard for psoriasis treatment with efficacy and safety profiles allowing for long-term treatment. However, adalimumab cannot be used in all patients and may cause adverse drug reactions. This study reviews conditions that might limit the use of adalimumab under real-life conditions. Local injection site reactions affect 12-37% of patients but rarely require specific therapy. Dermatological adverse events (AEs) include the paradoxical psoriasis and tend to respond to adequate therapy without adalimumab discontinuation...
August 2018: Therapeutic Advances in Chronic Disease
Luigi Ferrucci, Elisa Fabbri
Most older individuals develop inflammageing, a condition characterized by elevated levels of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability, frailty, and premature death. Potential mechanisms of inflammageing include genetic susceptibility, central obesity, increased gut permeability, changes to microbiota composition, cellular senescence, NLRP3 inflammasome activation, oxidative stress caused by dysfunctional mitochondria, immune cell dysregulation, and chronic infections...
September 2018: Nature Reviews. Cardiology
Giovanni Paolino, Chiara Panetta, Dario Didona, Michele Donati, Pietro Donati
Cutaneous sarcoidosis is not an uncommon disorder, and the skin can be the sole manifestation in about 10% of patients. However, when the involved anatomical area of the cutaneous sarcoidosis is the scalp and it presents as a scarring alopecia, there is an increased risk of a systemic disease (1,2). A 79-year-old Caucasian male patient presented to our Institute with annular and painless plaques of the scalp, with variable diameter, showing a reddish and yellowish color (Figure 1, a). Furthermore, a scleroderma-like atrophy of the skin with an exposure of the underlying vasculature was present (Figure 1, b)...
December 2017: Acta Dermatovenerologica Croatica: ADC
Ruiwen Cao, Yongliang Liu, Qing Wang, Qianqian Zhang, Dinglong Yang, Hui Liu, Yi Qu, Jianmin Zhao
Seawater acidification (OA) and cadmium (Cd) has the potential to lead to immunosuppression effect on marine bivalves. However, the interaction between these two environmental stressors on immune system of marine bivalves has received limited attention. In order to evaluate the defense responses of oysters under the combined exposure to OA and cadmium, the oysters Crassostrea gigas were exposed to 10 μg/L Cd at three pH levels (8.1, 7.8 and 7.6) for 31 days. Results showed that OA exposure alone led to increased DNA damage, apoptosis rate and ROS production of hemocytes...
July 29, 2018: Fish & Shellfish Immunology
Samuel J Pellock, Benjamin C Creekmore, William G Walton, Naimee Mehta, Kristen A Biernat, Andrew P Cesmat, Yamuna Ariyarathna, Zachary D Dunn, Bo Li, Jian Jin, Lindsey I James, Matthew R Redinbo
Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biology, mass spectrometry, and cell-based assays, we establish that piperazine-containing GUS inhibitors intercept the glycosyl-enzyme catalytic intermediate of these retaining glycosyl hydrolases. We demonstrate that piperazine-based compounds are substrate-dependent GUS inhibitors that bind to the GUS-GlcA catalytic intermediate as a piperazine-linked glucuronide (GlcA, glucuronic acid)...
July 25, 2018: ACS Central Science
Jaroslav Flegr, Marek Preiss, Pavla Balátová
Several recent studies have demonstrated the association of cat-related injuries with major depression and with depressiveness in the general population. It was suggested that cat-scratch disease, the infection with the bacterium Bartonella henselae , can be responsible for the observed association. However, no direct evidence for the role of the Bartonella infection in this association has been published until now. In this preregistered case-controls study performed on 250 healthy subjects tested earlier for the presence of anti- Toxoplasma IgG antibodies, we searched for the positive association between presence of anamnestic anti- Bartonella IgG antibodies and depressiveness measured with Beck II inventory, depression subscale of neuroticism measured with N-70 questionnaire, and self-reported health problems...
2018: Frontiers in Psychiatry
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