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https://www.readbyqxmd.com/read/30321518/dysphagia-requiring-nasogastric-feeding-following-orthognathic-surgery-an-unusual-complication-case-report-literature-review-and-recommendations
#1
Bryant A Salmon, Ali Dawlatly, Joseph E Van Sickels
Orthognathic surgery has several known complications, including neurosensory disturbances, postoperative nausea and vomiting, relapse, malocclusion, nonunion, infection, and depression. Persistent dysphagia after orthognathic surgery is an uncommon complication. Complete dysphagia requiring placement of a nasogastric feeding tube is a rare complication, with only 2 cases reported in the English-language literature. This report describes 2 additional cases with prolonged dysphagia requiring nasogastric feeding, reviews the pathophysiology associated with this entity, and makes recommendations for its management...
September 20, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30318370/hiv-exposure-and-formula-feeding-predict-under-2-mortality-in-hiv-uninfected-children-botswana
#2
Gbolahan Ajibola, Jean Leidner, Gloria K Mayondi, Erik van Widenfelt, Tebogo Madidimalo, Chipo Petlo, Sikhulile Moyo, Mompati Mmalane, Paige L Williams, Adam R Cassidy, Roger Shapiro, Betsy Kammerer, Shahin Lockman
OBJECTIVES: To prospectively assess rates and detailed predictors of morbidity and mortality among HIV-exposed uninfected children and HIV-unexposed children in Botswana in a more recent era. STUDY DESIGN: We enrolled HIV-infected and HIV-uninfected mothers and their children in the prospective observational Tshipidi study at 2 sites (1 city and 1 village) in Botswana from May 2010-July 2012. Live-born children and their mothers were followed for 24 months postpartum...
October 11, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30316944/functional-characterization-of-a-matrix-metalloproteinase-2-gene-in-litopenaeus-vannamei
#3
Yu-Ying Lian, Hong-Hui He, Chao-Zheng Zhang, Xin-Cang Li, Yi-Hong Chen
Matrix metalloproteinases (MMPs) contribute to both normal and pathological tissue remodeling. They act as regulatory molecules by working in enzyme cascades as well as processing matrix proteins, cytokines, growth factors and adhesion molecules to generate fragments with biological effects. So MMPs could play distrinct roles in the process of pathogen infection. In present study, we cloned a MMP-2 (LvMMP-2) gene from Litopenaeus vannamei. LvMMP-2, highly expressed in epidermis, located to endoplasmic reticulum in S2 cells...
October 11, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/30314584/posttraumatic-growth-among-people-living-with-hiv-a-systematic-review
#4
REVIEW
Marcin Rzeszutek, Ewa Gruszczyńska
OBJECTIVES: The aim of this systematic review was to analyse, synthesise and review existing results on posttraumatic growth (PTG) among PLWH. In particular, we investigated the relationship of PTG with sociodemographic, HIV-related clinical variables, positive and negative psychological correlates as well as HIV-related social issues among PLWH. METHOD: A literature search was performed on Web of Science, PsyARTICLES, MedLine, Proquest and Scopus databases using appropriate descriptors for positive changes among PLWH...
November 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/30310281/restriction-of-h1n1-influenza-virus-infection-by-selenium-nanoparticles-loaded-with-ribavirin-via-resisting-caspase-3-apoptotic-pathway
#5
Zhengfang Lin, Yinghua Li, Guifang Gong, Yu Xia, Changbing Wang, Yi Chen, Liang Hua, Jiayu Zhong, Ying Tang, Xiaomin Liu, Bing Zhu
Introduction: Ribavirin (RBV) is a broad-spectrum antiviral drug. Selenium nanoparticles (SeNPs) attract much attention in the biomedical field and are used as carriers of drugs in current research studies. In this study, SeNPs were decorated by RBV, and the novel nanoparticle system was well characterized. Madin-Darby Canine Kidney cells were infected with H1N1 influenza virus before treatment with RBV, SeNPs, and SeNPs loaded with RBV (Se@RBV). Methods and results: MTT assay showed that Se@RBV nanoparticles protect cells during H1N1 infection in vitro...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30304947/mental-health-in-south-african-adolescents-living-with-hiv
#6
Nora West, Sheree Schwartz, Mutsa Mudavanhu, Colleen Hanrahan, Holly France, Jeremy Nel, Lillian Mutunga, Shelley Bernhardt, Jean Bassett, Annelies Van Rie
We examined the prevalence of mental health conditions, social support, and associated factors among adolescents living with HIV. We conducted a cross-sectional analysis with adolescents (ages 9-19) attending a primary care clinic in Johannesburg, South Africa. We analyzed the results of four self-report tools: Children's Depression Inventory-Short, Revised Manifest Anxiety Scale, Child Post-Traumatic Stress Disorder (PTSD) Checklist, and a modified version of the Medical Outcomes Study Social Support Scale...
October 10, 2018: AIDS Care
https://www.readbyqxmd.com/read/30304890/combination-of-berberine-with-ciprofloxacin-reduce-a-multi-resistant-salmonella-strain-biofilm-formation-by-depressing-mrna-expressions-of-luxs-rpoe-and-ompr
#7
Chenxi Shi, Minmin Li, Ishfaq Muhammad, Xin Ma, Yicong Chang, Rui Li, Changwen Li, Jingshan He, Fangping Liu
Bacterial biofilms have been demonstrated to be closely related to clinical infections and mainly contribute to drug resistance. Berberine, which is the main component of Coptis chinensis , has been reported to have efficient antibacterial activity. This study aimed to investigate the potential effect of combination of berberine with ciprofloxacin (CIP) to inhibit Salmonella biofilm formation and the effect on the related genes ( rpoE , luxS , ompR ) expressions. The fractional inhibitory concentration index of the combination of berberine with CIP is 0...
October 8, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/30303841/immunotherapy-with-antiprogrammed-cell-death-1-antibody-improves-outcome-in-a-mouse-model-of-spinal-cord-injury-followed-by-staphylococcus-aureus-pneumonia
#8
Tiphaine Ruggeri, Cédric Jacqueline, Xavier Ambrosi, Alexis Broquet, Juliette Desfrançois, Antoine Roquilly, Frédéric Altare, Karim Asehnoune
OBJECTIVES: In patients with spinal cord injury, spinal cord injury-immune depression syndrome induces pneumonia. We aimed to develop a new spinal cord injury-immune depression syndrome mouse model and to test antiprogrammed cell death 1 therapy. DESIGN: Experimental study. SETTING: Research laboratory. SUBJECTS: RjOrl: SWISS and BALB/cJ mice. INTERVENTIONS: Mouse model of spinal cord injury-immune depression syndrome followed by a methicillin-susceptible Staphylococcus aureus pneumonia...
October 9, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/30302093/a-very-rare-complication-of-hepatitis-a-infection-acute-myocarditis-a-case-report-with-literature-review
#9
Olivia Allen, Ahmed Edhi, Adam Hafeez, Alexandra Halalau
Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain-Barre syndrome, and pleural or pericardial effusion...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/30301874/impact-of-decision-aids-used-during-clinical-encounters-on-clinician-outcomes-and-consultation-length-a-systematic-review
#10
Claudia Caroline Dobler, Manuel Sanchez, Michael R Gionfriddo, Neri A Alvarez-Villalobos, Naykky Singh Ospina, Gabriela Spencer-Bonilla, Bjorg Thorsteinsdottir, Raed Benkhadra, Patricia J Erwin, Colin P West, Juan P Brito, Mohammad Hassan Murad, Victor M Montori
BACKGROUND: Clinicians' satisfaction with encounter decision aids is an important component in facilitating implementation of these tools. We aimed to determine the impact of decision aids supporting shared decision making (SDM) during the clinical encounter on clinician outcomes. METHODS: We searched nine databases from inception to June 2017. Randomised clinical trials (RCTs) of decision aids used during clinical encounters with an unaided control group were eligible for inclusion...
October 9, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/30300395/impact-of-successful-treatment-with-direct-acting-antiviral-agents-on-health-related-quality-of-life-in-chronic-hepatitis-c-patients
#11
Regina Juanbeltz, Iván Martínez-Baz, Ramón San Miguel, Silvia Goñi-Esarte, Juan Manuel Cabasés, Jesús Castilla
BACKGROUND: Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim to assess the change in health-related quality of life (HRQoL) among patients successfully treated, and to identify predictors of this variation. METHODS: In a prospective observational study, patients with chronic hepatitis C who started DAA therapy between May 2016 and April 2017 completed the EQ-5D-5L questionnaire at baseline and 12 weeks after the end of therapy before knowing the virological result...
2018: PloS One
https://www.readbyqxmd.com/read/30300297/the-mysteries-of-menopause-and-urogynecologic-health-clinical-and-scientific-gaps
#12
Marianna Alperin, Lindsey Burnett, Emily Lukacz, Linda Brubaker
OBJECTIVES: A significant body of knowledge implicates menopausal estrogen levels in the pathogenesis of the common pelvic floor disorders (PFDs). These health conditions substantially decrease quality of life, increase depression, social isolation, caregiver burden, and economic costs to the individuals and society. METHODS: This review summarizes the epidemiology of the individual PFDs with particular attention to the understanding of the relationship between each PFD and menopausal estrogen levels, and the gaps in science and clinical care that affect menopausal women...
October 8, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30298536/inbreeding-shapes-tuberculosis-progression-in-female-adult-badgers-meles-meles
#13
João Queirós, Joaquín Vicente
In Focus: Beton, C. H., Delahay, R. J., Smith, F. A. P., Robertson, A., McDonald, R. A., Young, A. J., Burke T. A., & Hodgson, D. (2018). Inbreeding intensifies sex- and age-dependent disease in a wild mammal. Journal of Animal Ecology, 87, 1497-1499. https://doi.org/10.1111/1365-2656.12878 Increasing crossbreeding of relatives promotes inbreeding which, in turn, can cause a reduction in fitness and the emergence of a phenomenon known as inbreeding depression. Benton et al., used the badger (Meles meles)-Mycobacterium bovis model system to study the relationship between inbreeding, disease, ageing and sex...
November 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/30296575/postoperative-complications-in-adult-spinal-deformity-patients-with-a-mental-illness-undergoing-reconstructive-thoracic-or-thoracolumbar-spine-surgery
#14
Ishan Shah, Christopher Wang, Nick Jain, Blake Formanek, Zorica Buser, Jeffrey Wang
BACKGROUND CONTEXT: Previous studies have found an association between mental illness and poor outcomes in spine surgery, but little is known about the effects of depression and/or anxiety on the adult spinal deformity population. In addition, most relevant studies exclusively focused on the lumbar spine and had relatively small patient sizes. PURPOSE: The aim of this study was to investigate whether adult spinal deformity patients with depression and/or anxiety have an increased risk of postoperative complications and reoperation following posterior thoracolumbar spinal surgery...
October 5, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/30295215/drug-drug-interactions-and-clinical-considerations-with-co-administration-of-antiretrovirals-and-psychotropic-drugs
#15
Kellie J Goodlet, Monika T Zmarlicka, Alyssa M Peckham
Psychotropic medications are frequently co-prescribed with antiretroviral therapy (ART), owing to a high prevalence of psychiatric illness within the population living with HIV, as well as a 7-fold increased risk of HIV infection among patients with psychiatric illness. While ART has been notoriously associated with a multitude of pharmacokinetic drug interactions involving the cytochrome P450 enzyme system, the magnitude and clinical impact of these interactions with psychotropics may range from negligible effects on plasma concentrations to life-threatening torsades de pointes or respiratory depression...
October 8, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/30289374/building-resilient-families-developing-family-interventions-for-preventing-adolescent-depression-and-hiv-in-low-resource-settings
#16
Caroline Kuo, Ashleigh LoVette, Dan J Stein, Lucie D Cluver, Larry K Brown, Millicent Atujuna, Tracy R G Gladstone, Jacqueline Martin, William Beardslee
Depression contributes significantly to the global burden of disease in low- and middle-income countries. In South Africa, individuals may be at elevated risk for depression due to HIV and AIDS, violence, and poverty. For adolescents, resilience-focused prevention strategies have the potential to reduce onset of depression. Involving families in promoting adolescent mental health is developmentally appropriate, but few existing interventions take a family approach to prevention of adolescent depression. We conducted a qualitative investigation from 2013-2015 to inform the development of a family intervention to prevent adolescent depression in South Africa among families infected or at risk for HIV...
October 5, 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/30288287/post-infectious-ibs-defining-its-clinical-features-and-prognosis-using-an-internet-based-survey
#17
Tim Card, Paul Enck, Giovanni Barbara, Guy Ee Boeckxstaens, Javier Santos, Fernando Azpiroz, Fermin Mearin, Qasim Aziz, John Marshall, Robin Spiller
Background: Gastrointestinal infection is an important risk factor for developing irritable bowel syndrome (IBS). Our aim was to characterise post-infectious IBS (PI-IBS) compared to other IBS patients. Methods: An internet survey of IBS patients using Rome III diagnostic questionnaire, Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-12 Somatic Symptom (PHQ12-SS) scale score documenting the mode of onset was conducted. Results: A total of 7811 participants (63...
October 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/30282828/mucosal-associated-invariant-and-%C3%AE-%C3%AE-t-cell-subsets-respond-to-initial-mycobacterium-tuberculosis-infection
#18
Charles Kyriakos Vorkas, Matthew F Wipperman, Kelin Li, James Bean, Shakti K Bhattarai, Matthew Adamow, Phillip Wong, Jeffrey Aubé, Marc Antoine Jean Juste, Vanni Bucci, Daniel W Fitzgerald, Michael S Glickman
Innate immune responses that control early Mtb infection are poorly understood, but understanding these responses may inform vaccination and immunotherapy strategies. Innate T cells that respond to conserved bacterial ligands such as mucosal-associated invariant T (MAIT) and γδ T cells are prime candidates to mediate these early innate responses but have not been examined in subjects who have been recently exposed to Mtb. We recruited a cohort living in the same household with an active tuberculosis (TB) case and examined the abundance and functional phenotypes of 3 innate T cell populations reactive to M...
October 4, 2018: JCI Insight
https://www.readbyqxmd.com/read/30282363/frontotemporal-dementia-misdiagnosed-for-post-treatment-lyme-disease-syndrome-or-vice-versa-a-treviso-dementia-tredem-registry-case-report
#19
Maria Elena Di Battista, Carola Dell'Acqua, Luciana Baroni, Chiara Fenoglio, Daniela Galimberti, Maurizio Gallucci
We describe the case of a 61-year-old woman diagnosed with Borreliosis at the age of 57. Subsequently, the patient developed depression, anxiety, and behavioral disturbances. A lumbar puncture excluded the condition of Neuroborreliosis. The diagnostic workup included: an MRI scan, a 18F-FDG PET, a 123I-ioflupane-SPECT, an amyloid-β PET, a specific genetic analysis, and a neuropsychological evaluation. Based on our investigation, the patient was diagnosed with probable behavioral-frontotemporal dementia (bvFTD), whereas in the previous years, the patient had been considered firstly as a case of Post-Treatment-Lyme Disease and, secondly, a psychiatric patient...
September 28, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/30278525/epigenetic-differences-of-chronic-hepatitis-b-in-different-tcm-syndromes-protocol-for-a-case-control-non-interventional-observational-clinical-study
#20
COMPARATIVE STUDY
Li Ma, Xiuli Zheng, Yu Yang, Jian Wang, Youli Xu, Baojia Wang
INTRODUCTION: Chronic hepatitis B is a serious disease causing serious harm to the human health. Chinese medicine has its unique advantages in the clinical prevention and treatment, while the syndrome of Chinese medicine lacks the understanding at the micro level. There are some theoretical commonalities between the epigenetics and traditional Chinese medicine (TCM) syndromes. The biological basis of chronic hepatitis B (CHB) syndrome differentiation from the perspective of epigenetics is of great significance to diagnose and prevent the diseases...
September 2018: Medicine (Baltimore)
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