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Merin Sara Thomas, Prasanth K S Pillai, Marisa Faria, Nereida Cordeiro, Hernane Barud, Sabu Thomas, Laly A Pothen
Fabricating novel materials for biomedical applications mostly require the use of biodegradable materials. In this work biodegradable materials like polylactic acid (PLA) and chitosan (CHS) were used for designing electrospun mats. This work reports the physical and chemical characterization of the PLA-CHS composite, prepared by the electrospinning technique using a mixed solvent system. The addition of chitosan into PLA, offered decrease in fiber diameter in the composites with uniformity in the distribution of fibers with an optimum at 0...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Pauline W Ondachi, Chad M Kormos, Scott P Runyon, James B Thomas, S Wayne Mascarella, Ann M Decker, Hernán A Navarro, Timothy Raymond Fennell, Rodney W Snyder, F Ivy Carroll
Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clinical development. In this study, we present a structural activity relationship (SAR) study of a recently discovered new class of tetrahydroisoquinoline κ opioid receptor antagonists which led to (3R)-7-hydroxy-N-{(1S)-2-methyl-1-[(-4-methylpiperidine-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (12) (4-Me-PDTic). Compound 12 had a Ke = 0...
August 17, 2018: Journal of Medicinal Chemistry
Hernan Hernandez, Sara A Myers, Molly Schieber, Duy M Ha, Sarah Baker, Panagiotis Koutakis, Kyung-Soo Kim, Constance Mietus, George P Casale, Iraklis I Pipinos
OBJECTIVES: Claudication is the most common manifestation of peripheral artery disease (PAD), producing significant ambulatory compromise. Limited information exists on the routine physical activity of claudicating patients. Our objective was to record the intensity/time profiles of physical activity and the timing and duration of sedentary behavior of a sample of community-dwelling claudicating patients. METHODS: Forty-four claudicating patients referred to our vascular clinic were recruited...
August 13, 2018: Annals of Vascular Surgery
Hernan Biava, Toni Schreiber, Sagie Katz, Jan-Stefan Völler, Michael Stolarski, Claudia Schulz, Norbert Michael, Nediljko Budisa, Jacek Arthur Kozuch, Tillmann Utesch, Peter Hildebrandt
Electrostatic interactions are essential for controlling protein structure and function. Whereas so far experimental and theoretical efforts focused on the effect of local electrostatics, this work aims at elucidating the long-range modulation of electric fields in proteins upon binding to charged surfaces. The study is based on cytochrome c (Cytc) variants carrying nitrile reporters for the vibrational Stark effect that are incorporated into the protein via genetic engineering and chemical modification. The Cytc variants were thoroughly characterized with respect to possible structural perturbations due to labeling...
August 15, 2018: Journal of Physical Chemistry. B
Andrés Babino, Hernán A Makse, Rafael DiTella, Mariano Sigman
The coexistence of cooperation and selfish instincts is a remarkable characteristic of humans. Psychological research has unveiled the cognitive mechanisms behind self-deception. Two important findings are that a higher ambiguity about others' social preferences leads to a higher likelihood of acting selfishly and that agents acting selfishly will increase their belief that others are also selfish. In this work, we posit a mathematical model of these mechanisms and explain their impact on the undermining of a global cooperative society...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Arjun Sekar, Taranpreet Kaur, Joseph V Nally, Hernan Rincon-Choles, Stacey Jolly, Georges N Nakhoul
In caring for patients with chronic kidney disease, it is important to prevent and treat hyperphosphatemia with a combination of dietary restrictions and phosphorus binders. This review describes the pathophysiology and control of hyperphosphatemia and the different classes of phosphorus binders with respect to their availability, cost, side effects, and scenarios in which one class of binder may be more beneficial than another.
August 2018: Cleveland Clinic Journal of Medicine
Cameron Schlegel, Lynne A Lapierre, Victoria G Weis, Janice A Williams, Izumi Kaji, Carolina Pinzon-Guzman, Nripesh Prasad, Braden Boone, Angela Jones, Hernan Correa, Shawn E Levy, Xianlin Han, Miao Wang, Kelly Thomsen, Sari Acra, James R Goldenring
Deficiency in diacylglycerol acyltransferase (DGAT1) is a rare cause of neonatal diarrhea, without a known mechanism or in vitro model. METHODS AND RESULTS: A patient presenting at our institution at 7 weeks of life with failure to thrive and diarrhea was found by whole-exome sequencing to have a homozygous DGAT1 truncation mutation. Duodenal biopsies showed loss of DGAT1 and deficits in apical membrane transporters and junctional proteins in enterocytes. When placed on a very low-fat diet, the patient's diarrhea resolved with normalization of brush border transporter localization in endoscopic biopsies...
August 10, 2018: Traffic
Javier Escaned, Nicola Ryan, Hernán Mejía-Rentería, Christopher M Cook, Hakim-Moulay Dehbi, Eduardo Alegria-Barrero, Ali Alghamdi, Rasha Al-Lamee, John Altman, Alphonse Ambrosia, Sérgio B Baptista, Maria Bertilsson, Ravinay Bhindi, Mats Birgander, Waldemar Bojara, Salvatore Brugaletta, Christopher Buller, Fredrik Calais, Pedro Canas Silva, Jörg Carlsson, Evald H Christiansen, Mikael Danielewicz, Carlo Di Mario, Joon-Hyung Doh, Andrejs Erglis, David Erlinge, Robert T Gerber, Olaf Going, Ingibjörg Gudmundsdottir, Tobias Härle, Dario Hauer, Farrel Hellig, Ciro Indolfi, Lars Jakobsen, Luc Janssens, Jens Jensen, Allen Jeremias, Amra Kåregren, Ann-Charlotte Karlsson, Rajesh K Kharbanda, Ahmed Khashaba, Yuetsu Kikuta, Florian Krackhardt, Bon-Kwon Koo, Sasha Koul, Mika Laine, Sam J Lehman, Pontus Lindroos, Iqbal S Malik, Michael Maeng, Hitoshi Matsuo, Martijn Meuwissen, Chang-Wook Nam, Giampaolo Niccoli, Sukhjinder S Nijjer, Hans Olsson, Sven-Erik Olsson, Elmir Omerovic, Georgios Panayi, Ricardo Petraco, Jan J Piek, Flavo Ribichini, Habib Samady, Bruce Samuels, Lennart Sandhall, James Sapontis, Sayan Sen, Arnold H Seto, Murat Sezer, Andrew S P Sharp, Eun-Seok Shin, Jasvindar Singh, Hiroaki Takashima, Suneel Talwar, Nobuhiro Tanaka, Kare Tang, Eric Van Belle, Niels van Royen, Christoph Varenhorst, Hugo Vinhas, Christiaan J Vrints, Darren Walters, Hiroyoshi Yokoi, Ole Fröbert, Manesh R Patel, Patrick Serruys, Justin E Davies, Matthias Götberg
OBJECTIVES: The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND: Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the need for myocardial revascularization. METHODS: The safety of deferral of coronary revascularization in the pooled per-protocol population (n = 4,486) of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) and iFR-SWEDEHEART (Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve in Patients With Stable Angina Pectoris or Acute Coronary Syndrome) randomized clinical trials was investigated...
August 13, 2018: JACC. Cardiovascular Interventions
Javier Escaned, Hernán Mejía-Rentería
No abstract text is available yet for this article.
August 13, 2018: JACC. Cardiovascular Interventions
Arega D Alene, Tahirou Abdoulaye, Joseph Rusike, Ricardo Labarta, Bernardo Creamer, Martha Del Río, Hernan Ceballos, Luis Augusto Becerra
It is widely recognized that increasing agricultural production to the levels needed to feed an expanding world population requires sharply increased public investment in research and development and widespread adoption of new technologies, but funding for national and international agricultural research has rather declined in recent years. In this situation, priority setting has become increasingly important for allocating scarce research resources among competing needs to achieve greater impacts. Using partial equilibrium economic surplus models and poverty impact simulations, this paper assesses cassava research priorities in Africa, Latin America and Caribbean, and Asia based on the potential economic and poverty reduction impacts of alternative research and technology options...
2018: PloS One
Dawn C Buse, Richard B Lipton, Yngve Hallström, Uwe Reuter, Stewart J Tepper, Feng Zhang, Sandhya Sapra, Hernan Picard, Daniel D Mikol, Robert A Lenz
Background We evaluated the effect of erenumab, a fully human monoclonal antibody that inhibits the canonical calcitonin gene-related peptide receptor, on migraine-related disability, impact, and health-related quality of life among patients with episodic migraine. Methods Patients enrolled in a phase 3, 6-month, double-blind, placebo-controlled study of once-monthly erenumab 70 and 140 mg for migraine prevention (STRIVE) used an eDiary during the baseline and double-blind treatment phases to complete validated, specific questionnaires, including the modified (monthly) Migraine Disability Assessment Questionnaire; Headache Impact Test; and Migraine-Specific Quality of Life Questionnaire-role function-restrictive (MSQ-RFR), -role function-preventive (MSQ-RFP), and -emotional function (MSQ-EF)...
August 7, 2018: Cephalalgia: An International Journal of Headache
Gino Del Ferraro, Andrea Moreno, Byungjoon Min, Flaviano Morone, Úrsula Pérez-Ramírez, Laura Pérez-Cervera, Lucas C Parra, Andrei Holodny, Santiago Canals, Hernán A Makse
The original version of this Article contained an error in the last sentence of the first paragraph of the Introduction, which incorrectly read 'Correlation of brain activity is typically measured using functional magnetic resonance imaging (fMRI), and the correlation structure is often referred to as "fu'. The correct version states 'referred to as "functional connectivity"2-6 ' in place of 'referred to as "fu'. This has been corrected in both the PDF and HTML versions of the Article.
August 3, 2018: Nature Communications
Valentina Squicciarini, Raul Riquelme, Kathryn Wilsterman, George E Bentley, Hernan Lara
RFamide-related peptide (RFRP-3), is a regulator of GnRH secretion from the brain, but it can also act in human ovary to influence steroidogenesis. We aimed to study the putative local role of RFRP-3 in the ovary and its potential participation in the development of a polycystic ovary phenotype induced by chronic sympathetic stress (cold stress). We used adult Sprague-Dawley rats divided into control and stressed groups. In both groups we studied the effect of intraovarian exposure to RFRP-3 on follicular development and plasma ovarian steroid concentrations...
August 2, 2018: Journal of Endocrinology
Rocío Casañas, Victoria-Mailen Arfuch, Pere Castellví, Juan-José Gil, Maria Torres, Angela Pujol, Gemma Castells, Mercè Teixidó, Maria Teresa San-Emeterio, Hernán María Sampietro, Aleix Caussa, Jordi Alonso, Lluís Lalucat-Jo
BACKGROUND: One half of adults who develop any mental disorder do so during adolescence. Previous literature showed that Mental Health Literacy (MHL) interventions impact mental health knowledge, reduce the associated stigma, and promote help-seeking among the adolescent population. However, evidence for the effectiveness and cost-effectiveness of these programmes remains inconclusive. The aim of this paper is to present a study protocol that evaluates the effectiveness of the " EspaiJove...
July 31, 2018: BMC Public Health
Joaquín Pérez, Gabriel Adrián Novoa, Andrés Pierobon, Santiago Soliño, Melina Calvo Delfino, Malka Eugenia Sajfar, Candela Carmody, Tomas Vuoto, Javier Hernán Dorado, Sandra Salzberg
INTRODUCTION: The simultaneous rupture of anterior cruciate ligament (ACL) and patellar ligament (PL) is an infrequent condition. Each isolated injury has surgical techniques and rehabilitation protocols that differ widely among each other. Nonetheless, there is no established physical rehabilitation approach when both injuries are associated. OBJECTIVE: The aim of this report is to describe the rehabilitation and the outcomes obtained in the postoperative period of simultaneous rupture of ACL and PL and the follow-up period...
July 29, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
Hernan G Garcia, Dirk Benzinger, Marc Rullan, Andreas Milias-Argeitis, Mustafa Khammash, Adam M Deutschbauer, Erin M Langdon, Amy S Gladfelter
This month: two examples of door-opening, innovative microscopy (Garcia and also Benzinger et al.), expanding our functional knowledge of bacteria by over 10,000 genes (Deutschbauer), and probing how RNA structure dictates inclusion in liquid-like droplets in vivo (Langdon and Gladfelter).
July 25, 2018: Cell Systems
Aydee Meza, Carina Caldeira, Anthony Valverde, César Ordóñez, Enrique Ampuero, Hernán Cucho, Carles Soler
Semen analysis is a key factor when determining the fertility ability in males. South American camelids, and in particular the alpaca, have been studied very little when compared with other farm animals. The aim of this work was to perform the kinematic characterisation of alpaca spermatozoa collected directly from the deferent duct by using CASA-Mot (Computer Assisted Semen Analysis for Motility) technology. Samples were obtained every three days throughout the reproductive season during two periods and with a break of seven days in the middle...
July 25, 2018: Reproduction in Domestic Animals, Zuchthygiene
Hernan Polo Friz, Valentina Pezzetti, Annalisa Orenti, Alessandro Caleffi, Valeria Corno, Chiara Crivellari, Francesco Petri, Melisa Polo Friz, Veronica Punzi, Daniela Teruzzi, Luca Cavalieri d'Oro, Cristina Giannattasio, Giuseppe Vighi, Claudio Cimminiello, Patrizia Boracchi
INTRODUCTION: The prognostic accuracy of D-dimer for risk assessment in acute Pulmonary Embolism (APE) patients may be hampered by comorbidities. We investigated the impact of comorbidity burden (CB) by using the Charlson Comorbidity Index (CCI), on the prognostic ability of D-dimer to predict 30 and 90-day mortality in hemodynamically stable elderly patients with APE. METHODS: All patients aged >65 years with normotensive APE, consecutively evaluated in the Emergency Department since 2010 through 2014 were included in this retrospective cohort study...
July 18, 2018: American Journal of Emergency Medicine
Valeria Villalobos, Angel Leiva, Hernan E Ríos, Jorge Enrique Pavez, Carlos Silva, Mohammed Ahmar, Yves Queneau, Jenny M Blamey, Francisco P Chávez, Marcela D Urzúa
Inhibiting pathogenic bacterial adherence on surfaces is an ongoing challenge to prevent the development of biofilms. Multilayer polyelectrolyte films are feasible antibacterial materials. Here we have designed new films made of carbohydrate polyelectrolytes to obtain antibacterial coatings that prevent biofilm formation. The polyelectrolyte films were constructed from poly(maleic anhydride-alt-styrene) functionalized with glucofuranose derivatives and quaternized poly(4-vinylpyridine) N-alkyl. These films prevent Pseudomonas aeruginosa and Salmonella Typhimurium, two important bacterial contaminants in clinical environments, from adhering to surfaces...
July 23, 2018: ACS Applied Materials & Interfaces
Hernan Roca, Laurie K McCauley
No abstract text is available yet for this article.
May 2018: Oncoscience
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