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María F González Fleitas, Marcos L Aranda, Hernán H Dieguez, Julian D Devouassoux, Mónica S Chianelli, Damian Dorfman, Ruth E Rosenstein
Retinal ischemia is a condition associated with several degenerative diseases leading to visual impairment and blindness worldwide. Currently, there is no highly effective therapy for ischemic retinopathies. This study was designed to determine possible benefits of pre-exposure to enriched environment against retinal damage induced by acute ischemia. For this purpose, adult male Wistar rats were randomly assigned to a pre-ischemic standard environment or a pre-ischemic enriched environment for 3 weeks, followed by unilateral ischemia induced by increasing intraocular pressure above 120 mm Hg for 40 min and reperfusion for 1 or 2 weeks in standard environment...
October 13, 2018: Experimental Eye Research
Hernán Guillermo Hernández, Adrián Gabriel Sandoval-Hernández, Pablo Garrido-Gil, José Luis Labandeira-Garcia, María Victoria Zelaya, Gustavo F Bayon, Agustín F Fernández, Mario F Fraga, Gonzalo Arboleda, Humberto Arboleda
OBJECTIVE: To study DNA methylation patterns of cortical pyramidal layers susceptible to late-onset Alzheimer's disease (LOAD) neurodegeneration. METHODS: Laser-assisted microdissection to select pyramidal layers' cells in frontal cortex of 32 human brains (18 LOAD) and Infinium DNA Methylation 450K analysis were performed to find differential methylated positions and regions, in addition to the corresponding gene set functional enrichment analyses. RESULTS: Differential hypermethylation in several genomic regions and genes mainly in HOXA3, GSTP1, CXXC1-3 and BIN1...
October 16, 2018: Epigenomics
Laura Lema Perez, Jose Garcia-Tirado, Carlos Builes-Montaño, Hernan Alvarez
The stomach is a segment of the gastrointestinal (GI) tract which receives food from the esophagus, mixes it, breaks it down, and then passes it on to the small intestine in smaller portions. In the stomach, the main secretory functions and digestion process begin. However, the most critical and important function of the stomach in digestive physiology is perhaps gastric motility. In this way, the functions of the stomach are mainly three: (i) the storage of large quantities of food to be further processed in the duodenum, and lower intestinal tract, (ii) the mixing of this food with gastric secretions to form a semi-fluid mixture, and (iii) to slow down the emptying of that semi-fluid mixture into the small intestine at a rate suitable for proper digestion and absorption...
October 10, 2018: Journal of Theoretical Biology
Agostina Giacobino, Adriana Pacini, Ana Molineri, Graciela Rodríguez, Paola Crisanti, Natalia Bulacio Cagnolo, Julieta Merke, Emanuel Orellano, Ezequiel Bertozzi, Hernán Pietronave, Marcelo Signorini
The presence of Varroa destructor in colonies of Apis mellifera is explained by the interaction among a number of factors including beekeeping practices and surrounding environment features. The aim of this study was to evaluate the relative impact of environment geographical region and beekeeping management on Varroa infestation levels throughout a year. A monitoring study was carried out during 2015 in north-central regions from Argentina, consisting of three sampling dates: 1) autumn survey before autumn acaricide treatment; 2) autumn survey after autumn acaricide treatment and 3) spring survey...
November 1, 2018: Preventive Veterinary Medicine
Gustavo Citera, Fernando Dal Pra, Christian A Waimann, Hernan Maldonado Ficco, Teresita Alvarellos, Luciana A Mas, Osvaldo L Cerda, Sergio Paira, Antonio Catalán Pellet, Anastasia Secco, Lucila Marino, María Martire, Josefina Marcos, Mercedes A García, Adrián Salas, Alberto Berman, Horacio Berman, Oscar L Rillo, Liliana Vargas, Edson Velozo, Ricardo Vicente Juarez, María Elena Crespo Espindola
Patients with rheumatoid arthritis (RA) or undifferentiated arthritis (UA) in the CONAART database (Argentine Consortium for Early Arthritis) were assessed for genetic risk factors for RA, specifically for HLA-DRB1 alleles and the PTPN22 rs2476601 polymorphism associated with progression to RA. This is a case-control study. Blood samples were obtained to determine HLA-DRB1 genotypes by PCR-SSO Luminex and PTPN22 (rs2476601) polymorphism by allelic discrimination. A control group of individuals from the general Argentinian population were obtained from the national register of cadaveric organ donors...
October 10, 2018: Clinical Rheumatology
Hernán Cortés, Néstor Mendoza-Muñoz, Francisco A Galván-Gil, Jonathan J Magaña, Enrique Lima, Maykel González-Torres, Gerardo Leyva-Gómez
BACKGROUND: Previous studies analyzed a series of representative anatomical regions in the human body; however, there is a wide structural and cellular variability in the constitution of the skin. Our objective was to perform a comprehensive assessment of human skin hydration throughout the largest possible area. MATERIALS AND METHODS: Hydration was registered by Corneometer® CM825 probe in 23 anatomical regions of five healthy men. Each zone was analyzed by 2-cm segments in the supine, prone, and lateral positions...
October 10, 2018: Skin Research and Technology
Laura Michalovic, Luke Currin, Karina Gutierrez, Anne-Marie Bellefleur, Werner G Glanzner, Yasmin Schuermann, Mariana P de Macedo, Rodrigo C Bohrer, Naomi Dicks, Rosalba Lopez, Milena Taibi, Ejimedo Madogwe, Audrey St-Yves, Rafael G Mondadori, Jim Gourdon, Christian Vigneault, Hernan Baldassarre, Vilceu Bordignon
Oocytes collected from prepubertal animals are known to be less developmentally competent than those from adult animals. There is evidence suggesting that acquisition of developmental competence in bovine oocytes may be linked to the expression profile of genes in the granulosa cells (GCs). Cumulus-oocyte-complexes (COC) and GCs were collected from 12 Holstein heifers between 2-6 months of age (9 FSH-treated and 3 untreated) and 8 FSH-treated cows. The COCs from prepubertal animals were matured, fertilized and cultured in vitro to assess development to the blastocyst stage...
October 9, 2018: Molecular Reproduction and Development
A A Khan, I Hernan, J A Adamthwaite, K W D Ramsey
BACKGROUND: Breast cancer-related lymphoedema (BCRL) presents a significant healthcare burden and adversely affects quality of life of breast cancer survivors. A prospective feasibility study was performed on lymphaticovenous anastomosis (LVA) for the treatment of BCRL. METHODS: Patients with BCRL underwent near-infrared spectroscopy with indocyanine green lymphatic mapping to identify suitable lymphatic channels for LVA. End-to-end anastomoses to subdermal venules were performed and patients recommenced compression garment therapy (CGT) after surgery...
October 8, 2018: British Journal of Surgery
María Paula Russo, María Florencia Grande Ratti, Diego Hernán Giunta, Cristina María Elizondo
INTRODUCTION: The study objective was to estimate during post-discharge follow-up the incidence of diabetes and to ascertain mortality in hospitalized patients, classified during follow-up as having stress hyperglycemia (SH) or normoglycemia (NG) based on blood glucose levels. MATERIAL AND METHODS: A retrospective cohort of non-diabetic adults with SH (> 140mg/dl and HbA1c <6.5%) or NG (all blood glucose values ≤ 140mg/dl) was used. RESULTS: There were 3981 patients with NG and 884 with SH...
October 4, 2018: Endocrinología, Diabetes y Nutrición
Claudia Patricia Acosta, Francesc Codony, Mariana Fittipaldi, Carlos Hernán Sierra-Torres, Jordi Morató
Helicobacter pylori infection is a risk factor for chronic active gastritis, peptic ulcers, gastric carcinoma and lymphoma. Although the infection may be acquired through different transmission routes, the presence and viability of H. pylori in water sources are not well known. Therefore, the aim of our study was to analyse the viability of H. pylori cells in urban surface waters collected at the Vallparadís public park in Terrassa, Barcelona, Spain. The water samples were analysed by viability quantitative polymerase chain reaction (qPCR) using propidium monoazide and specific primers for the H...
October 2018: Journal of Water and Health
Alejandro Ruiz-Patiño, Christian David Castro, Luisa María Ricaurte, Andrés F Cardona, Leonardo Rojas, Zyanya Lucia Zatarain-Barrón, Beatriz Wills, Noemí Reguart, Hernán Carranza, Carlos Vargas, Jorge Otero, Luis Corrales, Claudio Martín, Pilar Archila, July Rodriguez, Jenny Avila, Melissa Bravo, Luis Eduardo Pino, Rafael Rosell, Oscar Arrieta
BACKGROUND: Non-small cell lung cancer (NSCLC) has a 5-year survival of 5-16%. Epidermal growth factor receptor (EGFR) mutations, in most cases, confer sensitivity to EGFR tyrosine kinase inhibitor (TKI) therapy. Nonetheless, it is still unclear why clinical outcomes vary among patients with identical EGFR mutations. The amplification of the EGFR gene (EGFRamp) may play a significant role. OBJECTIVE: Compare the complete (CR) and partial response (PR) rates, overall survival (OS), and progression-free survival (PFS) in Hispanic patients with lung adenocarcinoma treated with erlotinib with EGFR mutations (L858R or exon 19 deletion [Del19]) with and without concomitant EGFRamp...
October 2018: Targeted Oncology
Lincoln J Pac, Hernan A Rossi, Kalamaushika V Theyagarajan, Teodora J Monoski, Max J Louzon, Melora C Riveira, John R Hess
No abstract text is available yet for this article.
October 4, 2018: Transfusion
Martín Hernán Di Marco, Sabrina Ferraris, Martín Langsam
In the context of social and demographic studies of sexual and reproductive health, this paper discusses the situation of young people in Argentina, emphasizing the problems revolving around Sexually Transmitted Diseases (STDs) and the compliance with sexual rights. This work aims to study the calendars and characteristics of the onset of sexual life in young Argentinean people and to describe the current situation of knowledge, practices, and access related to sexual life. Based on data from the National Survey on Sexual and Reproductive Health ( 2013) we worked with the universe of young people between 15 and 29 years of age (n = 2,084 women, n = 1,872 men, without weighting) and analyzed the differences in the calendars of the onset of sexual life, as well as the knowledge and prevention of STDs by gender sex, age groups, household income and geographical regions...
September 2018: Ciência & Saúde Coletiva
Jean Bertoldo, Hernán Terenzi, Stefan Hüttelmaier, Gonçalo J L Bernardes
The field of chemical site-selective modification of proteins has progressed extensively in recent decades to enable protein functionaliza-tion for imaging, drug-delivery and functional studies. In this perspective, we provide a detailed insight into an alternative use of site-selective protein chemistry to probe the role(s) of unpaired Cys residues in the structure and function of disease relevant proteins. Phos-phatases are important players in the successful infection of pathogenic bacteria, which represent a significant health burden, particularly in multi-drug-resistant strains...
October 3, 2018: Biochemistry
Hernán F Peñaloza, Loreani P Noguera, Claudia A Riedel, Susan M Bueno
Interleukin-10 (IL-10) is one of the most important anti-inflammatory cytokine produced during bacterial infection. Two related phenomena explain the importance of IL-10 production in this context: first, the wide range of cells able to produce this cytokine and second, the wide effects that it causes on target cells. In a previous report we described opposing roles of IL-10 production during bacterial infection. Overall, during infections caused by intracellular bacteria or by pathogens that modulate the inflammatory response, IL-10 production facilitates bacterial persistence and dissemination within the host...
2018: Frontiers in Microbiology
Todd Schwedt, Uwe Reuter, Stewart Tepper, Messoud Ashina, David Kudrow, Gregor Broessner, Guy P Boudreau, Peter McAllister, Thuy Vu, Feng Zhang, Sunfa Cheng, Hernan Picard, Shihua Wen, Joseph Kahn, Jan Klatt, Daniel Mikol
BACKGROUND: Subcutaneous erenumab reduced monthly migraine days and increased the likelihood of achieving a ≥ 50% reduction at all monthly assessment points tested in 2 pivotal trials in episodic migraine (EM) and chronic migraine (CM). Early efficacy of migraine preventive medications is an important treatment characteristic to patients. Delays in achievement of efficacy can result in failed adherence. The objective of these post-hoc analyses were to evaluate efficacy in the first 4 weeks after initial subcutaneous administration of erenumab 70 mg, erenumab 140 mg, or placebo...
October 1, 2018: Journal of Headache and Pain
Mariana P de Macedo, Werner G Glanzner, Vitor B Rissi, Karina Gutierrez, Luke Currin, Hernan Baldassarre, Vilceu Bordignon
Oocyte activation is physiologically triggered by the sperm during fertilization, however, production of porcine embryos by somatic cell nuclear transfer (SCNT), intracytoplasmic sperm injection (ICSI) or parthenogenetic activation (PA) requires artificial oocyte activation. Although effective protocols for artificial oocyte activation have been developed, current protocols require long exposures to non-specific inhibitors, which do not mimic the physiological process and may have detrimental consequences for embryo development...
September 24, 2018: Theriogenology
Kerollos Nashat Wanis, Arin L Madenci, M Katherine Dokus, Koji Tomiyama, Bandar M Al-Judaibi, Miguel A Hernán, Roberto Hernandez-Alejandro
BACKGROUND: The opioid abuse epidemic and the deaths of otherwise healthy individuals due to drug overdose in the United States has major implications for transplantation. The current extent and safety of utilization of liver and kidney grafts from donation after cardiac death (DCD) donors who died in the context of opioid overdose is unknown. METHODS: Using national data from 2006 to 2016, we estimated the cumulative incidence of graft failure for recipients of DCD grafts, comparing the risk amongst recipients of organs from donors who died of anoxic drug overdose and recipients of organs from donors who died of other causes...
September 28, 2018: Transplantation
Paola Andrea Ortiz Salas, Camila Olarte Parra, Carlos Eduardo Pinzon Florez, Lina Maria Goez, Alberto Velez-van-Meerbeke, Jesus Hernan Rodriguez
OBJECTIVES: To compare the liver safety profile of interferon β (IFN β) and teriflunomide in patients with multiple sclerosis. METHODS: A network meta-analysis was carried out following the Cochrane Collaboration methodology. All trials comparing all types of IFN β with teriflunomide, or disease-modifying drugs, or placebo in RRMS were included. An indirect comparison network meta-analysis within a Bayesian framework with STATA (version 13.0) was done for this study...
September 22, 2018: Multiple Sclerosis and related Disorders
Carlos Sobrino Armas, Mariano Hernán García, Rafael Cofiño
"Community health" is a widely used term in our context. Although interest in the concept has gradually increased over the past decade, we believe the term is still vague. Therefore, we think a better working definition is required. We conducted a review of the specialized literature on the topic. This was later contrasted with the professional backgrounds of the authors, as well as with the results of field work consisting of interviews with individuals with recognized experience and intellectual authority in the area...
September 25, 2018: Gaceta Sanitaria
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