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Tomer Fekete, David B Omer, Kazunori O'Hashi, Amiram Grinvald, Cees van Leeuwen, Oren Shriki
Critical dynamics are thought to play an important role in neuronal information-processing: near critical networks exhibit neuronal avalanches, cascades of spatiotemporal activity that are scale-free, and are considered to enhance information capacity and transfer. However, the exact relationship between criticality, awareness, and information integration remains unclear. To characterize this relationship, we applied multi-scale avalanche analysis to voltage-sensitive dye imaging data collected from animals of various species under different anesthetics...
August 15, 2018: NeuroImage
Nicolas Mongardon, Matthias Kohlhauer, Fanny Lidouren, Mariana Barretto, Philippe Micheau, Clovis Adam, Gilles Dhonneur, Bijan Ghaleh, Renaud Tissier
BACKGROUND: Ischemic spinal cord injury is a devastating condition after aortic surgery. We determined whether ultrafast and short whole-body hypothermia provided by total liquid ventilation (TLV) attenuated lower limb paralysis after aortic cross-clamping with a targeted temperature management at 33°C vs 36°C. METHODS: Anesthetized rabbits were submitted to infrarenal aortic cross-clamping during 15 min. A Control group (n=7) was maintained at normothermia (38-38...
August 15, 2018: Annals of Thoracic Surgery
Wataru Ito, Howard Huang, Vanessa Brayman, Alexei Morozov
Familiarity is conveyed by social cues and determines behaviors towards conspecifics. Here we characterize a novel assay for social behaviors in mice - contacts with anesthetized conspecific - which eliminates reciprocal interactions including inter-male aggression and reveals behaviors that are independent of the demonstrator's activity. During the initial 10 minutes (phase-1), the wild-type subjects contacted the anesthetized conspecifics vigorously regardless of familiarity. During the subsequent 80 minutes (phase-2), however, they contacted more with familiar than unfamiliar conspecifics...
August 17, 2018: Genes, Brain, and Behavior
Natasa Mijailovic, Dragica Selakovic, Jovana Joksimovic, Vladimir Mihailovic, Jelena Katanic, Vladimir Jakovljevic, Tamara Nikolic, Sergey Bolevich, Vladimir Zivkovic, Milica Pantic, Gvozden Rosic
The aim of this study was to evaluate the effects of atorvastatin and simvastatin on behavioral manifestations that followed hyperhomocysteinemia induced by special dietary protocols enriched in methionine and deficient in B vitamins (B6, B9, B12) by means of alterations in anxiety levels in rats. Simultaneously, we investigated the alterations of oxidative stress markers in rat hippocampus induced by applied dietary protocols. Furthermore, considering the well-known antioxidant properties of statins, we attempted to assess their impact on major markers of oxidative stress and their possible beneficial role on anxiety-like behavior effect in rats...
August 17, 2018: Molecular and Cellular Biochemistry
Alessandro Di Rienzo, Roberto Colasanti, Valentina Liverotti, Roberta Benigni, Riccardo Paracino, Gianluca Bizzocchi, Massimo Scerrati, Maurizio Iacoangeli
The early identification and optimized treatment of wound dehiscence are a complex issue, with implications on the patient's clinical and psychological postoperative recovery and on healthcare system costs. The most widely accepted treatment is surgical debridement (also called "wash out"), performed in theater under general anesthesia (GA), followed by either wide-spectrum or targeted antibiotic therapy. Although usually effective, in some cases, such a strategy may be insufficient (generally ill, aged, or immunocompromised patients; poor tissue conditions)...
August 17, 2018: Neurosurgical Review
Carine de Freitas Souza, Sharine Descovi, Matheus Dellaméa Baldissera, Kalyne Bertolin, Adriane Erbice Bianchini, Rosa Helena Veraz Mourão, Denise Schmidt, Berta Maria Heinzmann, Alfredo Antoniazzi, Bernardo Baldisserotto, Gonzalo Martinez-Rodríguez
In teleost fish, stress initiates a hormone cascade along the hypothalamus-pituitary-interrenal (HPI) axis to provoke several physiological reactions in order to maintain homeostasis. In aquaculture, a number of factors induce stress in fish, such as handling and transport, and in order to reduce the consequences of this, the use of anesthetics has been an interesting alternative. Essential oil (EO) of Lippia alba is considered to be a good anesthetic; however, its distinct chemotypes have different side effects...
August 17, 2018: Fish Physiology and Biochemistry
Momotaro Kawai, Atsushi Tanji, Takayuki Nishijima, Koichi Tateyama, Yuhei Yoda, Ai Iizuka, Yusaku Kamata, Tadahisa Urabe
BACKGROUND: It remains unclear whether early surgical intervention can reduce mortality after surgery in hip fracture patients. The aim of this study was to investigate the association between time from injury to surgery and mortality rate within 90 days after hip fracture surgery. METHODS: We retrospectively identified 1827 patients who underwent hip fracture surgery in a tertiary care center in Japan between April 2007 and March 2017. After applying exclusion criteria (patients with spontaneous fracture, multiple fractures, revision surgery, total hip arthroplasty, or a refusal to participate), 1734 patients were included...
August 14, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Yin-Kai Chao, Kuang-Tse Pan, Chih-Tsung Wen, Hsin-Yueh Fang, Ming-Ju Hsieh
BACKGROUND: The efficacy and safety of intraoperative computed tomography (IOCT)-guided lung tumor localization and resection performed in a hybrid operating room (OR) compared with the conventional 2-stage preoperative CT (POCT)-guided approach for the treatment of small and deep solitary pulmonary nodules (SPNs) remains unknown. METHODS: We compared IOCT-guided (IOCT group) and POCT-guided (POCT group) thoracoscopic resections in 64 consecutive patients with SPNs...
July 20, 2018: Journal of Thoracic and Cardiovascular Surgery
Mansoor Aqil, Mueen Ullah Khan, Saara Mansoor, Saad Mansoor, Rashid Saeed Khokhar, Abdul Sattar Narejo
We are thankful to Dr. Deepak Gupta (Clinical Assistant Professor Anesthesiology, Wayne State University/Detroit Medical Center) for bringing to our attention a typographical error in our manuscript [1].
August 17, 2018: BMC Anesthesiology
Xinyu Xu, Xin Tian, Guolin Wang
BACKGROUND: Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction. This study aimed to evaluate the effects of sevoflurane on working memory of rats and to characterize functional connectivity between excitatory neurons in the prefrontal cortex (PFC) during working memory performance. METHODS: 18-month-old and 3-month-old male SD rats were implanted with a multielectrode array in the PFC...
July 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ki Tae Jung, Keum Young So, In Gook Jee, Sang Hun Kim
Background/aim: The number of published papers that compare the incidence of sufentanil- and remifentanil-related postoperative shivering is insufficient. We investigated the incidence of postoperative shivering after total intravenous anesthesia with either sufentanil or remifentanil in patients who underwent elective surgery. Materials and methods: Eighty-three patients, with a physical status classified as American Society of Anesthesiologists I or II, were randomly allocated to either the remifentanil–propofol (RP group, n = 40) or sufentanil–propofol (SP group, n = 43) group...
August 16, 2018: Turkish Journal of Medical Sciences
Daniele Grioni, Andrea Landi, Leonardo Fiori, Erik Pietro Sganzerla
PURPOSE: Status Epilepticus can be a serious life threatening event in epileptic patients. The definition of refractory or super-refractory Status Epilepticus was based on the therapeutic response to anti-epileptic and anesthetic drugs. Vagal Nerve Stimulation showed efficacy in treating drug-resistant epilepsy but there are only few reports on emergentplacement of Vagal Nerve Stimulator for refractory or super-refractory Status Epilepticus. METHODS: Among 49 children implanted at our Institution with Vagal Nerve Stimulation for drug-resistant epilepsy, the authors retrospectively identified those implanted for refractory or super-refractory Status Epilepticus, according with the current definitions...
August 11, 2018: Seizure: the Journal of the British Epilepsy Association
Laura K Fonken, Matthew G Frank, Heather M D'Angelo, Jared D Heinze, Linda R Watkins, Christopher A Lowry, Steven F Maier
Aging is a major risk factor for developing postoperative cognitive dysfunction. Neuroinflammatory processes, which can play a causal role in the etiology of postoperative cognitive dysfunction, are potentiated or primed as a function of aging. Here we explored whether exposure to a microorganism with immunoregulatory and anti-inflammatory properties, Mycobacterium vaccae NCTC 11659 (M. vaccae), could ameliorate age-associated neuroinflammatory priming. Aged (24 months) and adult (3 months) male F344XBN rats were immunized with heat-killed M...
July 24, 2018: Neurobiology of Aging
Hongyu Jing, Lingyun Liu, Junfeng Zhou, Hanxin Yao
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow. COPD can progress to persistent decline of pulmonary function. This study explored the effect of CXCL10 on COPD induced by cigarette smoke (CS) and its underlying mechanism. MATERIAL AND METHODS Wild-type (WT) mice were randomly assigned into 3 groups: the control group, the CS group, and the intervention group. Mice in the CS group were exposed to CS and mice in the CXCL10 group were exposed to CS and CXCL10 neutralizing antibody...
August 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Katherine Gentry, Aaron Wightman
Here we present a case of a patient in terminal respiratory failure refusing to consent to emergent tracheostomy in the setting of an anticipated difficult intubation. We examine ethical concerns that arise from deviations from the standard of care in the operative setting and the anesthesiologist's sense of culpability. Finally, we will review the ethical arguments and guidelines that support anesthesiologists' participation in palliative operative procedures when limitations on resuscitation are in place.
August 1, 2018: AMA Journal of Ethics
Mehmet Fuat Gulhan
BACKGROUND: Hypertension is described as increased blood pressure based on changed hemodynamics and associated with an increased oxidative damage to reproductive function. This work is to determine therapeutic and protective effects of apitherapy products (propolis and pollen) on reproductive functions of L-NAME-induced hypertensive male rats. METHODS: Experimental animals were indiscriminately separated into four groups of seven rats in each group: (I) Control, (II) L-NAME, (III) L-NAME+ propolis and (IV) L-NAME+ pollen...
August 17, 2018: Clinical and Experimental Hypertension: CHE
Behnood Gholami, Wassim M Haddad, James M Bailey, Beth Geist, Yukie Ueyama, William W Muir
OBJECTIVE: To evaluate and determine the performance of a partially automated as well as a fully automated closed-loop fluid resuscitation system during states of absolute and relative hypovolemia. DESIGN: Prospective experimental trial. SETTING: Research laboratory. ANIMALS: Five adult Beagle dogs. METHODS: Isoflurane anesthetized mechanically ventilated dogs were subjected to absolute hypovolemia (controlled: 2 trials; uncontrolled: 3 trials), relative hypovolemia (2 trials), and the combination of relative and absolute controlled hypovolemia (2 trials)...
August 17, 2018: Journal of Veterinary Emergency and Critical Care
Gaspar Mestres, Xavier Yugueros, Nestor Fontseré, Alejandro Fierro, Xavier Sala, Teresa Maria Derosa, Marta Burrel, Vincent Riambau
INTRODUCTION: Ambulatory surgery is associated with lower costs, but there is lack of evidence of the safety for ambulatory vascular access surgery. The objective of this study is to substantiate the safety and effectiveness of performing vascular access surgery in an ambulatory setting. METHODS: A review of our prospectively maintained database including all vascular access open surgeries (creations and repairs) performed by our Vascular Access Unit between 2013 and 2017 was compiled...
August 17, 2018: Journal of Vascular Access
Nicola Disma, James D O'Leary, Andreas W Loepke, Ansgar M Brambrink, Karin Becke, Nicola G Clausen, Jurgen C De Graaff, Fang Liu, Tom G Hansen, Mary E McCann, Cynthia F Salorio, Sulpicio Soriano, Lena S Sun, Peter Szmuk, David O Warner, Laszlo Vutskits, Andrew J Davidson
All commonly used general anesthetics have been shown to cause neurotoxicity in animal models, including nonhuman primates. Opinion, however, remains divided over how cumulative evidence from preclinical and human studies in this field should be interpreted and its translation to current practices in pediatric anesthesia and surgery. A group of international experts in laboratory and clinical sciences recently convened in Genoa, Italy, to evaluate the current state of both laboratory and clinical research and discuss future directions for basic, translational, and clinical studies in this field...
August 16, 2018: Paediatric Anaesthesia
Joel W E Chin, Grant M Stuart
Osteogenesis imperfecta is a heterogeneous genetic disorder characterized by bone fragility, with disease ranging from mild fractures to death in utero. We describe a child with autosomal recessive osteogenesis imperfecta type VIII (severe or lethal phenotype), who successfully underwent posterior spinal fusion, was extubated on postoperative day 1 and discharged home 25 days later. Recently identified recessive forms of osteogenesis imperfecta are associated with severe/lethal phenotype. Special consideration is needed in scoliosis surgery, with challenges arising from prone positioning, neurophysiology monitoring, and blood loss...
August 16, 2018: Paediatric Anaesthesia
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