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EDITORIAL
Arthur Lupia, David B Allison, Kathleen Hall Jamieson, Jennifer Heimberg, Magdalena Skipper, Susan M Wolf
In recent years, many questions have been raised about whether public confidence in science is changing. To clarify recent trends in the public's confidence and factors that are associated with these feelings, an effort initiated by the National Academies' Strategic Council for Research Excellence, Integrity, and Trust (the Strategic Council) analyzed findings from multiple survey research organizations. The Strategic Council's effort, which began in 2022, found that U.S. public confidence in science, the scientific community, and leaders of scientific communities is high relative to other civic, cultural, and governmental institutions for which researchers regularly collect such data...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
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JOURNAL ARTICLE
Jennifer DeCuir, Amanda B Payne, Wesley H Self, Elizabeth A K Rowley, Kristin Dascomb, Malini B DeSilva, Stephanie A Irving, Shaun J Grannis, Toan C Ong, Nicola P Klein, Zachary A Weber, Sarah E Reese, Sarah W Ball, Michelle A Barron, Allison L Naleway, Brian E Dixon, Inih Essien, Daniel Bride, Karthik Natarajan, Bruce Fireman, Ami B Shah, Erica Okwuazi, Ryan Wiegand, Yuwei Zhu, Adam S Lauring, Emily T Martin, Manjusha Gaglani, Ithan D Peltan, Samuel M Brown, Adit A Ginde, Nicholas M Mohr, Kevin W Gibbs, David N Hager, Matthew Prekker, Amira Mohamed, Vasisht Srinivasan, Jay S Steingrub, Akram Khan, Laurence W Busse, Abhijit Duggal, Jennifer G Wilson, Steven Y Chang, Christopher Mallow, Jennie H Kwon, Matthew C Exline, Cristie Columbus, Ivana A Vaughn, Basmah Safdar, Jarrod M Mosier, Estelle S Harris, Jonathan D Casey, James D Chappell, Carlos G Grijalva, Sydney A Swan, Cassandra Johnson, Nathaniel M Lewis, Sascha Ellington, Katherine Adams, Mark W Tenforde, Clinton R Paden, Fatimah S Dawood, Katherine E Fleming-Dutra, Diya Surie, Ruth Link-Gelles
In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5) COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19, including severe disease. However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available. This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged ≥18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks...
February 29, 2024: MMWR. Morbidity and Mortality Weekly Report
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JOURNAL ARTICLE
Edward A Frongillo, Hilary J Bethancourt, Andrea Norcini Pala, Sigal Maya, Katherine C Wu, Jorge R Kizer, Phyllis C Tien, Mirjam-Colette Kempf, David B Hanna, Allison A Appleton, Daniel Merenstein, Gypsyamber D'Souza, Igho Ofotokun, Deborah Konkle-Parker, Erin D Michos, Sarah Krier, Valentina Stosor, Bulent Turan, Sheri D Weiser
BACKGROUND: Social unacceptability of food access is part of the lived experience of food insecurity but is not assessed as part of the U.S. Household Food Security Survey Module (HFSSM). OBJECTIVE: The objectives were to 1) determine the psychometric properties of two additional items on social unacceptability in relation to the HFSSM items and 2) test whether these two items provided added predictive accuracy to that of the HFSSM items for mental health outcomes...
February 24, 2024: Journal of Nutrition
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JOURNAL ARTICLE
Waaqo Daddacha, Dominique Monroe, Ashley J Schlafstein, Allison E Withers, Elizabeth B Thompson, Diana Danelia, Nho C Luong, Fatmata Sesay, Sandip K Rath, Edidiong R Usoro, Mark E Essien, Andrew T Jung, Jinmeng G Jiang, Jiaxuan Hu, Bijan Mahboubi, Arilyn Williams, Julia E Steinbeck, Xiaofeng Yang, Zachary S Buchwald, William S Dynan, Jeffrey M Switchenko, Baek Kim, Mohammad K Khan, David L Jaye, David S Yu
Diffuse large B-cell lymphoma (DLBCL) is a commonly diagnosed, aggressive non-Hodgkin's lymphoma. While R-CHOP chemoimmunotherapy is potentially curative, about 40% of DLBCL patients will fail, highlighting the need to identify biomarkers to optimize management. SAMHD1 has a dNTPase-independent role in promoting resection to facilitate DNA double-strand break (DSB) repair by homologous recombination. We evaluated the relationship of SAMHD1 levels with sensitivity to DSB-sensitizing agents in DLBCL cells and the association of SAMHD1 expression with clinical outcomes in 79 DLBCL patients treated with definitive therapy and an independent cohort dataset of 234 DLBCL patients...
March 2024: NAR cancer
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JOURNAL ARTICLE
Hannah Chung, Michael A Campitelli, Sarah A Buchan, Aaron Campigotto, Natasha S Crowcroft, Jonathan B Gubbay, James Kh Jung, Timothy Karnauchow, Kevin Katz, Allison J McGeer, J Dayre McNally, David C Richardson, Susan E Richardson, Laura C Rosella, Margaret L Russell, Kevin L Schwartz, Andrew Simor, Marek Smieja, Maria E Sundaram, Bryna F Warshawsky, George Zahariadis, Jeffrey C Kwong
BackgroundWaning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals are subject to biases.AimWe examined the association between time since vaccination and laboratory-confirmed influenza to assess the change in influenza vaccine protection over time.MethodsUsing linked laboratory and health administrative databases in Ontario, Canada, we identified community-dwelling individuals aged ≥ 6 months who received an influenza vaccine before being tested for influenza by RT-PCR during the 2010/11 to 2018/19 influenza seasons...
February 2024: Euro Surveillance
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JOURNAL ARTICLE
Hussain Syed Iqbal, Mihili P Gunaratne, Talia A Loeb, Amrose Pradeep, Allison M McFall, Aylur K Srikrishnan, Mark Anderson, Mary A Rodgers, David D Celentano, Shruti H Mehta, Gavin A Clohertly, Sunil S Solomon
People living with HIV (PWH) have been shown to bear a higher burden of hepatitis B virus (HBV) due to shared routes and risk factors for transmission. Populations such as men who have sex with men (MSM) are at an increased risk of both being infected with HBV and HIV, that places them at higher risk of hepatocellular carcinoma. Using weighted and adjusted multilevel logistic regression, we characterized the prevalence and correlates of hepatitis B surface antigen (HBsAg) among MSM living with HIV across 12 Indian cities from 2012 to 2013...
February 22, 2024: Journal of Viral Hepatitis
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JOURNAL ARTICLE
Siru Liu, Allison B McCoy, Josh F Peterson, Thomas A Lasko, Dean F Sittig, Scott D Nelson, Jennifer Andrews, Lorraine Patterson, Cheryl M Cobb, David Mulherin, Colleen T Morton, Adam Wright
OBJECTIVE: To develop and evaluate a data-driven process to generate suggestions for improving alert criteria using explainable artificial intelligence (XAI) approaches. METHODS: We extracted data on alerts generated from January 1, 2019 to December 31, 2020, at Vanderbilt University Medical Center. We developed machine learning models to predict user responses to alerts. We applied XAI techniques to generate global explanations and local explanations. We evaluated the generated suggestions by comparing with alert's historical change logs and stakeholder interviews...
February 22, 2024: Journal of the American Medical Informatics Association: JAMIA
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JOURNAL ARTICLE
Melissa M Garrido, Allison Dorneo, Michael Adelberg, David Biko, Paul R Shafer, Austin B Frakt
OBJECTIVES: Counseling and education on Medicare coverage options are available through the federal State Health Insurance Assistance Program (SHIP), but little is known about the population that SHIP reaches. STUDY DESIGN: Cross-sectional study. METHODS: Using a novel data source on SHIP counseling site locations, we characterized the availability of in-person SHIP counseling by zip code tabulation area (ZCTA) and used linear regression and t tests to evaluate whether SHIP counseling sites are disproportionately located in higher-income communities...
February 1, 2024: American Journal of Managed Care
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JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#30
JOURNAL ARTICLE
Stephen A Schworer, Alan L Hinderliter, Melissa C Caughey, Carole Robinette, Kelly D Chason, Haolin Li, Haibo Zhou, Amika K Sood, Allison J Burbank, David B Peden, Michelle L Hernandez
OBJECTIVE: The gram-negative bacterial cell wall component endotoxin (lipopolysaccharide, LPS) is a key component of particulate matter (PM). PM exposure is associated with cardiovascular morbidity and mortality. However, the contribution of individual components of PM to acute and chronic cardiovascular measures is not clear. This study examines whether systemic inflammation induced by LPS inhalation causes acute changes in cardiovascular physiology measures. MATERIALS AND METHODS: In this double blinded, placebo-controlled crossover study, fifteen adult volunteers underwent inhalation exposure to 20,000 EU Clinical Center Reference Endotoxin (CCRE)...
February 18, 2024: Inhalation Toxicology
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JOURNAL ARTICLE
Allison Kirkegaard, Esther M Friedman, Sarah Edgington, David Kennedy
OBJECTIVES: Previous research links increased care provision to worse wellbeing among family and friend caregivers, both before and during the COVID-19 pandemic. We expand on this by incorporating data on caregivers' social networks and exploring the relationships between own and network changes in care during the pandemic and caregiver wellbeing. METHODS: We use nationally representative data from 1,876 family and friend caregivers in the first wave of our Care Network Connections over Time study (fielded 12/17/2020-1/4/2021) who had provided care continuously since before the COVID-19 pandemic began...
February 14, 2024: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
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JOURNAL ARTICLE
Edo Dongelmans, Nicole Erler, Rene Adam, Silvio Nadalin, Vincent Karam, Sezai Yilmaz, Claire Kelly, Jacques Pirenne, Koray Acarli, Michael Allison, Abdul Hakeem, Dhakshinamoorthy Vijayanand, Dzmitry Fedaruk, Oleg Rummo, Murat Kilic, Arno Nordin, Lutz Fischer, Alessandro Parente, Darius Mirza, William Bennet, Yaman Tokat, Francois Faitot, Barbara B Antonelli, Gabriela Berlakovich, David Patch, Frederik Berrevoet, Marija Ribnikar, Theophile Gerster, Eric Savier, Salvatore Gruttadauria, Bo-Göran Ericzon, Andrés Valdivieso, Valentin Cuervas-Mons, Baltasar Perez Saborido, Roland S Croner, Luciano De Carlis, Giulia Magini, Roberta Rossi, Irinel Popescu, Laze Razvan, Stefan Schneeberger, Hans Blokzijl, Laura Llado, Miguel Angel Gomez Bravo, Christophe Duvoux, Vladimír Mezjlík, Gabriel C Oniscu, Kelsey Pearson, Murat Dayangac, Valerio Lucidi, Olivier Detry, Fernando Rotellar, Caroline den Hoed, Wojciech G Polak, Sarwa Darwish Murad
BACKGROUND AND AIMS: Management of Budd-Chiari Syndrome (BCS) has improved over the last decades. The main aim was to evaluate the contemporary post-liver transplant (LT) outcomes in Europe. APPROACH AND RESULTS: Data from all transplanted patients from 1976-2020 was obtained from the European Liver Transplantation Registry (ELTR). Patients<16yrs, with secondary BCS or hepatocellular carcinoma were excluded. Patient- (PS) and graft survival (GS) before and after 2000 were compared...
February 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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JOURNAL ARTICLE
Charlotte S Walmsley, Philip Jonsson, Michael L Cheng, Sean McBride, Christopher Kaeser, Herbert Alberto Vargas, Vincent Laudone, Barry S Taylor, Rajya Kappagantula, Priscilla Baez, Allison L Richards, Anne Marie Noronha, Dilmi Perera, Michael Berger, David B Solit, Christine A Iacobuzio-Donahue, Howard I Scher, Mark T A Donoghue, Wassim Abida, Alison M Schram
Reversion mutations that restore wild-type function of the BRCA gene have been described as a key mechanism of resistance to Poly(ADP-ribose) polymerase (PARP) inhibitor therapy in BRCA-associated cancers. Here, we report a case of a patient with metastatic castration-resistant prostate cancer (mCRPC) with a germline BRCA2 mutation who developed acquired resistance to PARP inhibition. Extensive genomic interrogation of cell-free DNA (cfDNA) and tissue at baseline, post-progression, and postmortem revealed ten unique BRCA2 reversion mutations across ten sites...
February 14, 2024: NPJ Precision Oncology
#34
JOURNAL ARTICLE
Thayne A Munce, Allison D Peplowski, Thomas G Bowman, Patricia M Kelshaw, Thomas R Campbell, Sean B Ahonen, Verle D Valentine, David X Cifu, Jacob E Resch
PURPOSE: We investigated time to reach concussion diagnosis and recovery milestones in collegiate athletes relative to their schools' National Collegiate Athletic Association (NCAA) classification. METHODS: We retrospectively examined 849 (43.1% female) concussion cases from 11 NCAA institutions (Division I Power 5 [ n = 4], Division I Non-Power 5 [ n = 4], and Division II/III [ n = 3]) from the 2015-16 to 2019-20 athletic seasons...
February 9, 2024: Brain Injury
#35
JOURNAL ARTICLE
Joshua F E Koenig, Niels Peter H Knudsen, Allyssa Phelps, Kelly Bruton, Ilka Hoof, Gitte Lund, Danielle Della Libera, Anders Lund, Lars Harder Christensen, David R Glass, Tina D Walker, Allison Fang, Susan Waserman, Manel Jordana, Peter S Andersen
Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we report a population of type 2-polarized MBCs defined as CD23hi , IL-4Rαhi , and CD32low at both the transcriptional and surface protein levels. These MBC2s are enriched in IgG1- and IgG4-expressing cells while constitutively expressing germline transcripts for IgE...
February 7, 2024: Science Translational Medicine
#36
JOURNAL ARTICLE
Giangela Stokes, Zhuowei Li, Nicole Talaba, William Genthe, Maria B Brix, Betty Pham, Mark D Wienhold, Gracia Sandok, Rebecca Hernan, Julia Wynn, Haiyang Tang, Diana M Tabima, Allison Rodgers, Timothy A Hacker, Naomi C Chesler, Pan Zhang, Rabi Murad, Jason X-J Yuan, Yufeng Shen, Wendy K Chung, David J McCulley
A major barrier to the impact of genomic diagnosis in patients with congenital malformations is the lack of understanding regarding how sequence variants contribute to disease pathogenesis and whether this information could be used to generate patient-specific therapies. Congenital diaphragmatic hernia (CDH) is among the most common and severe of all structural malformations; however, its underlying mechanisms are unclear. We identified loss-of-function sequence variants in the epigenomic regulator gene SIN3A in two patients with complex CDH...
January 31, 2024: Science Translational Medicine
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REVIEW
Natalia Smirnova, Allison V Lange, Amanda Glickman, Kristen Desanto, Cara L McDermott, Donald R Sullivan, David B Bekelman, Dio Kavalieratos
CONTEXT: Use of palliative care interventions in chronic obstructive pulmonary disease (COPD) has increased in recent years and inclusion criteria used to identify patients with COPD appropriate for palliative care vary widely. We evaluated the inclusion criteria to identify ways to improve enrollment opportunities for patients with COPD. OBJECTIVES: To determine inclusion criteria used to select patients with COPD for palliative care trials. METHODS: A systematic review was conducted to determine criteria used to select patients with COPD for palliative care randomized controlled trials...
January 26, 2024: Journal of Pain and Symptom Management
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JOURNAL ARTICLE
Julie A Wolfson, Allison C Grimes, Michelle Nuno, Charlotte L Kerber, Subhash Ramakrishnan, Melissa Beauchemin, David Dickens, Jennifer M Levine, Michael E Roth, Michele Scialla, Wendy Woods, Sarah Vargas, Koh B Boayue, George J Chang, Wendy Stock, Dawn Hershman, Emily Curran, Anjali Advani, Kristen O'Dwyer, Selina Luger, Jane Jijun Liu, David R Freyer, Lillian Sung, Susan K Parsons
PURPOSE: Individuals diagnosed with cancer between 15 and 39 years (adolescent and young adult [AYA]) face unique vulnerability. Detail is lacking about care delivery for these patients, especially those with ALL. We address these knowledge gaps by describing AYA ALL care delivery details at National Cancer Institute Community Oncology Research Program (NCORP) (sub)affiliates by model of care. METHODS: Participating institutions treated at least one AYA with ALL from 2012 to 2016...
January 22, 2024: JCO oncology practice
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JOURNAL ARTICLE
Hanna J McLennan, Shauna L Heinrich, Megan P Inge, Samuel J Wallace, Adam J Blanch, Llewelyn Hails, John P O'Connor, Michael B Waite, Stephen McIlfatrick, Mark B Nottle, Kylie R Dunning, David K Gardner, Jeremy G Thompson, Allison K Love
PURPOSE: Intracytoplasmic sperm injection (ICSI) imparts physical stress on the oolemma of the oocyte and remains among the most technically demanding skills to master, with success rates related to experience and expertise. ICSI is also time-consuming and requires workflow management in the laboratory. This study presents a device designed to reduce the pressure on the oocyte during injection and investigates if this improves embryo development in a porcine model. The impact of this device on laboratory workflow was also assessed...
January 18, 2024: Journal of Assisted Reproduction and Genetics
#40
JOURNAL ARTICLE
Aung M Tun, Yucai Wang, Seth Maliske, Ivana Micallef, David J Inwards, Thomas M Habermann, Luis Porrata, Jonas Paludo, Jose Villasboas Bisneto, Allison Rosenthal, Mohamed A Kharfan-Dabaja, Stephen M Ansell, Grzegorz S Nowakowski, Umar Farooq, Patrick B Johnston
Chimeric antigen receptor T-cell (CAR-T) therapy is the new standard of care in fit patients with refractory or early relapsed diffuse large B-cell lymphoma (DLBCL). However, there may still be a role for salvage chemotherapy (ST) and autologous stem cell transplant (ASCT) in certain circumstances (eg, lack of CAR-T resources, chemosensitive relapses, etc). We retrospectively studied 230 patients with refractory or early relapsed DLBCL who underwent ST and ASCT. Median line of ST was 1 (range 1-3). Best response before ASCT was complete response (CR) in 106 (46%) and partial response (PR) in 124 (54%) patients...
January 18, 2024: Haematologica
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