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David B Allison

R Doyle Stulting, Jonathan H Lass, Mark A Terry, Beth Ann Benetz, Nathan Cohen, Allison R Ayala, Maureen G Maguire, Christopher Croasdale, Yassine J Daoud, Steven P Dunn, Kenneth M Goins, Pankaj C Gupta, Marian S Macsai, Shahzad I Mian, Sudeep Pramanik, Jennifer Rose-Nussbaumer, Jonathan C Song, Walter J Stark, Alan Sugar, David D Verdier, Loretta B Szczotka-Flynn
PURPOSE: To identify factors related to graft rejection following Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS). DESIGN: Cohort study within a multicenter randomized clinical trial. METHODS: 1330 eyes of 1090 subjects undergoing DSAEK were randomized to receive a donor cornea with preservation time (PT) of 0-7 days (N=675) or 8-14 days (N=655) and followed for three years. Central endothelial cell density (ECD) was determined by a central image analysis reading center...
October 8, 2018: American Journal of Ophthalmology
Rachel A H Davis, Sarah E Deemer, Jonathan M Bergeron, Jason T Little, Jonathan L Warren, Gordon Fisher, Daniel L Smith, Kevin R Fontaine, Stephanie L Dickinson, David B Allison, Eric P Plaisance
The dietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases resting energy expenditure (REE) and markers of brown and white adipose thermogenesis in lean mice. The purpose of this investigation was to determine whether the ketone ester, R, S-1,3-butanediol diacetoacetate (BD-AcAc2 ), increases energy expenditure and markers of adipose tissue thermogenesis in the context of high-fat diet (HFD)-induced obesity. Thirty-five-week-old male C57BL/6J mice were placed on an ad libitum HFD (45% kcal) for 10 wk...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Neil E Rowland, Kimberly L Robertson, Dulce Minaya, Vanessa Minervini, Melissa Cervantez, Kathryn A Kaiser, David B Allison
The purpose of this study is to compare the effect of unpredictable (U) or predictable (P) food delivery on health and longevity in mice. From 2 months of age until end of life, singly-housed male C57BL/6 mice were fed a semisynthetic diet either ad libitum (AL), or as imposed meals delivered as small pellets at either P or U times, frequencies, or amounts. The total daily food consumed by all groups was the same. The AL group gained body weight faster than either P or U groups, and had ~12% shorter median life span compared with either P or U groups...
October 5, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Tapan Mehta, David B Allison
No abstract text is available yet for this article.
October 2, 2018: JAMA: the Journal of the American Medical Association
Alexander J Rodríguez, David Scott, Belal Khan, Allison Hodge, Dallas R English, Graham G Giles, B Abrahamsen, Peter R Ebeling
The risk of mortality associated with high dietary calcium is uncertain. Unlike a highly publicised study in Swedish women, high dietary calcium intake in men-not women-was associated with increased all-cause mortality. PURPOSE: The association of dietary calcium with mortality is controversial. A study of women from the Swedish Mammography Cohort (SMC) suggested higher calcium was associated with higher mortality risk, whilst a study of Australian adults from the Melbourne Collaborative Cohort Study (MCCS) suggested higher intakes were associated with lower mortality risk...
September 21, 2018: Archives of Osteoporosis
Conall OʼCleirigh, Michael J Zvolensky, Jasper A J Smits, Allison K Labbe, Jessica N Coleman, Julianne G Wilner, Amelia M Stanton, Adam Gonzalez, Lorra Garey, Kristen S Regenauer, David Rosenfield
OBJECTIVE: Among people living with HIV, cigarette smoking rates are higher than among the general population, and anxiety, depression, and their disorders are common and associated with smoking and poorer outcomes during cessation. This study evaluated the efficacy of an integrated smoking cessation intervention, developed to target anxiety, depression, and smoking cessation concurrently among people living with HIV. METHOD: Smokers living with HIV who reported at least moderate motivation to quit smoking were randomized into a novel 9-week integrated intervention (QUIT), consisting of 1 psychoeducation (prerandomization) session and 9 weekly 1-hour sessions of cognitive behavioral therapy for smoking cessation and anxiety/depression plus nicotine replacement therapy, or a 9-week enhanced standard smoking intervention (ETAU), consisting of 1 psychoeducation session (prerandomization) and 4 brief weekly check-in sessions plus nicotine replacement therapy...
October 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Allison K G Moorman, Todd F Duffield, M Ann Godkin, David F Kelton, Jeffrey Rau, Derek B Haley
Dairy cows are culled from the herd for a variety of reasons, the most common being fertility problems, low milk production, or udder problems. Disease and injury can contribute to the decision to cull either directly, or indirectly, by causing fertility or production problems, leading to culling. Disease or injury may also affect the cow's ability to handle the stress of transportation and may increase the risk for reduced welfare. The purpose of this study was to determine the general condition of culled dairy cows sold at Ontario auction markets, to quantify the frequency of culled cows in poor condition sold at these auctions, and to determine how this relates to the sale price of the cow...
September 6, 2018: Journal of Dairy Science
Andrew W Brown, David B Allison
No abstract text is available yet for this article.
October 2018: Journal of Nursing Research: JNR
Matthew G Drake, Gregory D Scott, Emily D Blum, Katherine M Lebold, Zhenying Nie, James J Lee, Allison D Fryer, Richard W Costello, David B Jacoby
In asthma, airway nerve dysfunction leads to excessive bronchoconstriction and cough. It is well established that eosinophils alter nerve function and that airway eosinophilia is present in 50 to 60% of asthmatics. However, the effects of eosinophils on airway nerve structure have not been established. We tested whether eosinophils alter airway nerve structure and measured the physiological consequences of those changes. Our results in humans with and without eosinophilic asthma showed that airway innervation and substance P expression were increased in moderate persistent asthmatics compared to mild intermittent asthmatics and healthy subjects...
September 5, 2018: Science Translational Medicine
Allison P Boss, Robert A Freeborn, David M Duriancik, Rebekah C Kennedy, Elizabeth M Gardner, Cheryl E Rockwell
Tert-butylhydroquinone (tBHQ) is a commonly used food preservative with known immunomodulatory activity; however, there is little information regarding its role on natural killer (NK) cell activation and function. tBHQ is a known activator of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which results in induction of cytoprotective genes. Activation of Nrf2 has been shown to modulate immune responses in a number of different models. In addition, studies in our laboratory have shown that tBHQ inhibits numerous early events following T cell activation...
August 30, 2018: Food and Chemical Toxicology
Bridget A Hannon, Diana M Thomas, Cynthia Siu, David B Allison
No abstract text is available yet for this article.
October 2018: British Journal of Nutrition
Shiriki K Kumanyika, Knashawn H Morales, Kelly C Allison, A Russell Localio, David B Sarwer, Etienne Phipps, Jennifer E Fassbender, Adam G Tsai, Thomas A Wadden
OBJECTIVE: Think Health! ¡Vive Saludable! evaluated a moderate-intensity, lifestyle behavior-change weight-loss program in primary care over 2 years of treatment. Final analyses examined weight-change trajectories by treatment group and attendance. METHODS: Adult primary care patients (n = 261; 84% female; 65% black; 16% Hispanic) were randomly assigned to Basic Plus (moderate intensity; counseling by primary care clinician and a lifestyle coach) or Basic (clinician counseling only)...
September 2018: Obesity
Sarah A Buchan, Hannah Chung, Timothy Karnauchow, J Dayre McNally, Michael A Campitelli, Jonathan B Gubbay, Kevin Katz, Allison J McGeer, David C Richardson, Susan E Richardson, Andrew Simor, Marek Smieja, George Zahariadis, Dat Tran, Natasha S Crowcroft, Laura C Rosella, Jeffrey C Kwong
BACKGROUND: Respiratory illnesses are a major contributor to pediatric hospitalizations, with influenza and respiratory syncytial virus (RSV) causing substantial morbidity and cost each season. We compared the characteristics and outcomes of children 0-59 months of age who were hospitalized with laboratory-confirmed influenza or RSV between 2009 and 2014 in Ontario, Canada. METHODS: We included hospitalized children who were tested for influenza A, influenza B, and RSV, and were positive for a single virus...
August 27, 2018: Pediatric Infectious Disease Journal
Allison Tam, Shan Chen, Evan Schauer, Ingo Grafe, Venkata Bandi, Jay R Shapiro, Robert D Steiner, Peter A Smith, Michael B Bober, Tracy Hart, David Cuthbertson, Jeffrey Krischer, Mary Mullins, Peter H Byers, Robert A Sandhaus, Michaela Durigova, Francis H Glorieux, Frank Rauch, Vernon Reid Sutton, Brendan Lee, Eric T Rush, Sandesh C S Nagamani
Pulmonary complications are a significant cause for morbidity and mortality in osteogenesis imperfecta (OI). However, to date, there have been few studies that have systematically evaluated pulmonary function in individuals with OI. We analyzed spirometry measurements, including forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1 ), in a large cohort of individuals with OI (n = 217) enrolled in a multicenter, observational study. We show that individuals with the more severe form of the disease, OI type III, have significantly reduced FVC and FEV1 which do not follow the expected trends of the normal population...
August 26, 2018: Clinical Genetics
Mark Misener, David T Starr, Allison J Scaccia, Vibhuti Arya
Individuals exposed to spores of B. anthracis must take a course of antibiotics as postexposure prophylaxis (PEP) to prevent inhalation anthrax. During an anthrax event, public health authorities are responsible for conducting dispensing operations to offer PEP to exposed individuals. Jurisdictions have developed antibiotic PEP screening algorithms to determine which antibiotic is appropriate for each individual. Variability exists with regard to screening questions and dispensing decisions based on responses to those questions...
July 2018: Health Security
Allison B Simler, Margaret R Metz, Kerri M Frangioso, Ross K Meentemeyer, David M Rizzo
Human-altered ecological disturbances may challenge system resilience and disrupt biological legacies maintaining ecosystem recovery. Yet, the extent to which novel regimes challenge these legacies varies. This may be partially explained by differences in the vulnerability of life history strategies to disturbance characteristics. In the fire-prone, resprouter-dominated coast redwood forests of California, the introduced disease sudden oak death (SOD) alters fuel profiles, fire behavior, and aboveground tree mortality; however, this system is dominated by resprouting trees that are well-adapted to aboveground damage, and belowground survival of individuals may represent the principal biological legacy connecting pre- and post-fire communities...
October 2018: Ecology
Allison Barz Leahy, Caitlin W Elgarten, Stephan A Grupp, Shannon L Maude, David T Teachey
Cure rates for pediatric and young adult patients with refractory or recurrently relapsed acute lymphoblastic leukemia (ALL) are dismal. Survival from time of relapse is typically measured in weeks to months, and standard chemotherapy and currently approved targeted therapy achieve remission in less than a third of affected patients. To date, the only definitive curative therapy has been allogeneic hematopoietic stem cell transplant (HSCT). Advances in immunotherapy, with the introduction of chimeric antigen receptor T-cell therapies and the development of tisagenlecleucel, have changed the landscape...
October 2018: Expert Review of Anticancer Therapy
Michelle L Hernandez, Radhika Dhingra, Allison J Burbank, Krista Todorich, Ceila E Loughlin, Marcia Frye, Kelly Duncan, Carole Robinette, Katherine Mills, Robert B Devlin, David B Peden, David Diaz-Sanchez
No abstract text is available yet for this article.
August 10, 2018: Journal of Allergy and Clinical Immunology
Mark A Terry, Anthony J Aldave, Loretta B Szczotka-Flynn, Wendi Liang, Allison R Ayala, Maureen G Maguire, Christopher Croasdale, Yassine J Daoud, Steven P Dunn, Caroline K Hoover, Marian S Macsai, Thomas F Mauger, Sudeep Pramanik, George O D Rosenwasser, Jennifer Rose-Nussbaumer, R Doyle Stulting, Alan Sugar, Elmer Y Tu, David D Verdier, Sonia H Yoo, Jonathan H Lass
PURPOSE: To associate donor, recipient, and operative factors with graft success 3 years after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS). DESIGN: Cohort study within a multicenter, double-masked, randomized clinical trial. PARTICIPANTS: One thousand ninety individuals (1330 study eyes) with a median age of 70 years undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphakic corneal edema (PACE; 6% of eyes)...
August 9, 2018: Ophthalmology
Amy Bartlett, Stephen J Kolb, Allison Kingsley, Kathryn J Swoboda, Sandra P Reyna, Ai Sakonju, Basil T Darras, Richard Shell, Nancy Kuntz, Diana Castro, Susan T Iannaccone, Julie Parsons, Anne M Connolly, Claudia A Chiriboga, Craig McDonald, W Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B Shieh, Erika Finanger, Christopher S Coffey, Jon W Yankey, Merit E Cudkowicz, Michelle M McGovern, D Elizabeth McNeil, W David Arnold, John T Kissel
Background/Aims: Recruitment and retention of research participants are challenging and critical components of successful clinical trials and natural history studies. Infants with spinal muscular atrophy (SMA) have been a particularly challenging population to study due to their fragile and complex medical issues, poor prognosis and, until 2016, a lack of effective therapies. Recruitment of healthy infants into clinical trials and natural history studies is also challenging and sometimes assumed to not be feasible...
September 2018: Contemporary Clinical Trials Communications
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