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David B Allison

Michelle L Hernandez, Radhika Dhingra, Allison J Burbank, Krista Todorich, Ceila E Loughlin, Marcia Frye, Kelly Duncan, Carole Robinette, Katherine Mills, Robert B Devlin, David B Peden, David Diaz-Sanchez
In a cohort of African American adolescents with persistent asthma on guidelines-based daily controller therapies, short-term elevation of low ozone levels below the National Ambient Air Quality Standard of 70 ppb were associated with lung function decrements and elevated lipid levels.
August 10, 2018: Journal of Allergy and Clinical Immunology
Mark A Terry, Anthony J Aldave, Loretta B Szczotka-Flynn, Wendi Liang, Allison R Ayala, Maureen G Maguire, Christopher Croasdale, Yassine J Daoud, Steven P Dunn, Caroline K Hoover, Marian S Macsai, Thomas F Mauger, Sudeep Pramanik, George Od Rosenwasser, Jennifer Rose-Nussbaumer, R Doyle Stulting, Alan Sugar, Elmer Y Tu, David D Verdier, Sonia H Yoo, Jonathan H Lass
PURPOSE: To associate donor, recipient, and operative factors with graft success 3 years after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS). DESIGN: Cohort study within a multi-center, double-masked, randomized clinical trial. PARTICIPANTS: 1,090 individuals (1,330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic/aphakic corneal edema (PACE, 6% of eyes)...
August 8, 2018: Ophthalmology
Amy Bartlett, Stephen J Kolb, Allison Kingsley, Kathryn J Swoboda, Sandra P Reyna, Ai Sakonju, Basil T Darras, Richard Shell, Nancy Kuntz, Diana Castro, Susan T Iannaccone, Julie Parsons, Anne M Connolly, Claudia A Chiriboga, Craig McDonald, W Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B Shieh, Erika Finanger, Christopher S Coffey, Jon W Yankey, Merit E Cudkowicz, Michelle M McGovern, D Elizabeth McNeil, W David Arnold, John T Kissel
Background/Aims: Recruitment and retention of research participants are challenging and critical components of successful clinical trials and natural history studies. Infants with spinal muscular atrophy (SMA) have been a particularly challenging population to study due to their fragile and complex medical issues, poor prognosis and, until 2016, a lack of effective therapies. Recruitment of healthy infants into clinical trials and natural history studies is also challenging and sometimes assumed to not be feasible...
September 2018: Contemporary Clinical Trials Communications
Nadeeja N Wijayatunga, Bridget Ironuma, John A Dawson, Bailey Rusinovich, Candice A Myers, Michelle Cardel, Gregory Pavela, Corby K Martin, David B Allison, Emily J Dhurandhar
OBJECTIVES: Subjective social status (SSS) is known to be inversely associated with obesity. Our objective was to determine if SSS is associated with eating behaviors that would predispose to weight gain, specifically, with inadequate compensation for excess energy consumed during a single large meal. Therefore, we conducted a pilot study to determine the association of SSS with 24-h energy balance, 24-h and post-lunch energy intake, changes in body composition and changes in adjusted resting energy expenditure on days when a high-energy lunch was consumed in free-living human subjects...
July 27, 2018: Appetite
Annie Yang, Susan Chimonas, Peter B Bach, David J Taylor, Allison Lipitz-Snyderman
PURPOSE: Access to comparative information on hospitals' quality of cancer care is limited. Patients' interest in using this information when selecting a hospital for cancer surgery and the specific data they would desire are unknown. This study gauges patients' demand for comparative information on hospitals' quality of cancer surgery. METHODS: We conducted a cross-sectional, national survey of 3,334 US residents who had received cancer surgery. The outcomes were patients' reported likelihood of using a list of best hospitals for cancer surgery and patients' reported interest in information about specific clinical outcomes, including 4-year survival after surgery, 30-day mortality after surgery, and rate of complications from surgery...
July 30, 2018: Journal of Oncology Practice
Moonseong Heo, Singh R Nair, Judith Wylie-Rosett, Myles S Faith, Angelo Pietrobelli, Nancy R Glassman, Sarah N Martin, Stephanie Dickinson, David B Allison
Objective: To evaluate whether clustering effects, often quantified by the intracluster correlation coefficient (ICC), were appropriately accounted for in design and analysis of school-based trials. Methods: We searched PubMed and extracted variables concerning study characteristics, power analysis, ICC use for power analysis, applied statistical models, and the report of the ICC estimated from the observed data. Results: N =263 papers were identified, and N =121 papers were included for evaluation...
2018: Journal of Obesity
Sangwoo T Han, Andras Rab, Matthew J Pellicore, Emily F Davis, Allison F McCague, Taylor A Evans, Anya T Joynt, Zhongzhou Lu, Zhiwei Cai, Karen S Raraigh, Jeong S Hong, David N Sheppard, Eric J Sorscher, Garry R Cutting
Treatment of individuals with cystic fibrosis (CF) has been transformed by small molecule therapies that target select pathogenic variants in the CF transmembrane conductance regulator (CFTR). To expand treatment eligibility, we stably expressed 43 rare missense CFTR variants associated with moderate CF from a single site in the genome of human CF bronchial epithelial (CFBE41o-) cells. The magnitude of drug response was highly correlated with residual CFTR function for the potentiator ivacaftor, the corrector lumacaftor, and ivacaftor-lumacaftor combination therapy...
July 25, 2018: JCI Insight
Theresa Barberi, Allison Martin, Rahul Suresh, David J Barakat, Sarah Harris-Bookman, Charles G Drake, Michael Lim, Alan D Friedman
High-grade gliomas harbor abundant myeloid cells that suppress anti-tumor immunity and support tumor growth. Targeting transcription factors, such as NF-κB p50, that mediate suppressive myeloid M2 polarization may prove therapeutic. GL261-Luc glioblastoma cells were inoculated into wild-type and p50-/- mice, followed by analysis of tumor growth, survival, tumor myeloid cells, and T cells. The absence of host p50 slows tumor growth and enables regression in 30% of recipients, leading to prolonged survival. Tumors developing in p50-/- mice possess a greater concentration of tumor-infiltrating myeloid cells (TIMs) than those in wild-type mice...
July 21, 2018: Cancer Immunology, Immunotherapy: CII
Anton Tamtögl, Davide Campi, Martin Bremholm, Ellen M J Hedegaard, Bo B Iversen, Marco Bianchi, Philip Hofmann, Nicola Marzari, Giorgio Benedek, John Ellis, William Allison
We present a combined experimental and theoretical study of the surface vibrational modes of the topological insulator Bi2Te3. Using high-resolution helium-3 spin-echo spectroscopy we are able to resolve the acoustic phonon modes of Bi2Te3(111). The low energy region of the lattice vibrations is mainly dominated by the Rayleigh mode which has been claimed to be absent in previous experimental studies. The appearance of the Rayleigh mode is consistent with previous bulk lattice dynamics studies as well as theoretical predictions of the surface phonon modes...
August 2, 2018: Nanoscale
Roxane Ridolfo, Benjamin C Ede, Paraskevi Diamanti, Paul B White, Adam W Perriman, Jan C M van Hest, Allison Blair, David S Williams
The stabilization and transport of low-solubility drugs, by encapsulation in nanoscopic delivery vectors (nanovectors), is a key paradigm in nanomedicine. However, the problems of carrier toxicity, specificity, and producibility create a bottleneck in the development of new nanomedical technologies. Copolymeric nanoparticles are an excellent platform for nanovector engineering due to their structural versatility; however, conventional fabrication processes rely upon harmful chemicals that necessitate purification...
July 12, 2018: Small
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser, Jennifer L Onken, Kurt O Johnson, Grace C Verzosa, Larissa G P Langhi, Moritz Weigl, Nino Giorgadze, Nathan K LeBrasseur, Jordan D Miller, Diana Jurk, Ravinder J Singh, David B Allison, Keisuke Ejima, Gene B Hubbard, Yuji Ikeno, Hajrunisa Cubro, Vesna D Garovic, Xiaonan Hou, S John Weroha, Paul D Robbins, Laura J Niedernhofer, Sundeep Khosla, Tamara Tchkonia, James L Kirkland
Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear. Here we demonstrate that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues...
July 9, 2018: Nature Medicine
William G Kronenberger, Shirley C Henning, Allison M Ditmars, David B Pisoni
OBJECTIVE: Verbal working memory (WM) is more strongly correlated with spoken language skills in prelingually deaf, early-implanted cochlear implant (CI) users than in normal-hearing (NH) peers, suggesting that CI users access WM in order to support and compensate for their slower, more effortful spoken language processing. This pilot study tested the feasibility and validity of a dual-task method for establishing the causal role of WM in basic language processing (lexical access speed) in samples of 9 CI users (ages 8-26 years) and 9 NH peers...
July 5, 2018: Cochlear Implants International
Mahim Jain, Allison Tam, Jay R Shapiro, Robert D Steiner, Peter A Smith, Michael B Bober, Tracy Hart, David Cuthbertson, Jeff Krischer, Mary Mullins, Sunil Bellur, Peter H Byers, Melanie Pepin, Michaela Durigova, Francis H Glorieux, Frank Rauch, Brendan Lee, V Reid Sutton, Sandesh C S Nagamani
PURPOSE: Osteogenesis imperfecta (OI) predisposes people to recurrent fractures, bone deformities, and short stature. There is a lack of large-scale systematic studies that have investigated growth parameters in OI. METHODS: Using data from the Linked Clinical Research Centers, we compared height, growth velocity, weight, and body mass index (BMI) in 552 individuals with OI. Height, weight, and BMI were plotted on Centers for Disease Control and Prevention normative curves...
July 4, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Ming He, Qianyi Yang, Allison B Norvil, David Sherris, Humaira Gowher
Discovery of inhibitors for endothelial-related transcription factors can contribute to the development of anti-angiogenic therapies that treat various diseases, including cancer. The role of transcription factor Vezf1 in vascular development and regulation of angiogenesis has been defined by several earlier studies. Through construction of a computational model for Vezf1, work here has identified a novel small molecule drug capable of inhibiting Vezf1 from binding to its cognate DNA binding site. Using structure-based design and virtual screening of the NCI Diversity Compound Library, 12 shortlisted compounds were tested for their ability to interfere with the binding of Vezf1 to DNA using electrophoretic gel mobility shift assays...
July 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Malika Sharma, Allison Chris, Arlene Chan, David C Knox, James Wilton, Owen McEwen, Sharmistha Mishra, Daniel Grace, Tim Rogers, Ahmed M Bayoumi, John Maxwell, Rita Shahin, Isaac Bogoch, Mark Gilbert, Darrell H S Tan
BACKGROUND: Gay, bisexual and other men who have sex with men (gbMSM) in Canada continue to experience high rates of incident HIV. Pre-exposure prophylaxis (PrEP, the regular use of anti-HIV medication) reduces HIV acquisition and could reduce incidence. However, there are too few physicians with expertise in HIV care to meet the projected demand for PrEP. To meet demand and achieve greater public health impact, PrEP delivery could be 'decentralized' by incorporating it into front-line prevention services provided by family physicians (FPs) and sexual health clinic nurses...
July 3, 2018: BMC Health Services Research
Shuying Xu, Marianela Feliu, Allison K Lord, Daniel P Lukason, Paige E Negoro, Nida S Khan, Zeina Dagher, Michael B Feldman, Jennifer L Reedy, Samantha N Steiger, Jenny M Tam, Alexander A Soukas, David B Sykes, Michael K Mansour
Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a challenge. In this study, we investigate the therapeutic potential of metformin, a biguanide with well-established action for diabetes, as an antifungal agent against C. glabrata. Both wild type and antifungal-resistant isolates of C. glabrata were subjected to biguanide and biguanide-antifungal combination treatment...
July 2, 2018: Virulence
David B Abrams, Allison M Glasser, Andrea C Villanti, Jennifer L Pearson, Shyanika Rose, Raymond S Niaura
Tobacco control has made strides in prevention and cessation, but deaths will not decline rapidly without massive behavior change. Currently, inhaled smoke from combusting tobacco is chiefly responsible for prematurely killing 7.2 million people worldwide and 530,000 in the United States annually. An array of noncombustible nicotine products (NNPs) has emerged and has disrupted the marketplace. Saving lives more speedily will require societal acceptance of locating a "sweet spot" within a three-dimensional framework where NNPs are simultaneously: 1...
June 23, 2018: Preventive Medicine
Rumi Nakamura, Ali Varsani, Kevin J Genestreti, Olivier Le Contel, Takuma Nakamura, Wolfgang Baumjohann, Tsugunobu Nagai, Anton Artemyev, Joachim Birn, Victor A Sergeev, Sergey Apatenkov, Robert E Ergun, Stephen A Fuselier, Daniel J Gershman, Barbara J Giles, Yuri V Khotyaintsev, Per-Arne Lindqvist, Werner Magnes, Barry Mauk, Anatoli Petrukovich, Christopher T Russell, Julia Stawarz, Robert J Strangeway, Brian Anderson, James L Burch, Ken R Bromund, Ian Cohen, David Fischer, Allison Jaynes, Laurence Kepko, Guan Le, Ferdinand Plaschke, Geoff Reeves, Howard J Singer, James A Slavin, Roy B Torbert, Drew L Turner
We present characteristics of current layers in the off-equatorial near-Earth plasma sheet boundary observed with high time-resolution measurements from the Magnetospheric Multiscale mission during an intense substorm associated with multiple dipolarizations. The four Magnetospheric Multiscale spacecraft, separated by distances of about 50 km, were located in the southern hemisphere in the dusk portion of a substorm current wedge. They observed fast flow disturbances (up to about 500 km/s), most intense in the dawn-dusk direction...
February 2018: Journal of Geophysical Research. Space Physics
Alex R Dopp, Anita Saranga Coen, Allison B Smith, Jessica Reno, David H Bernstein, Suzanne E U Kerns, Deborah Altschul
Several states have made considerable investments into large-scale implementation of evidence-based treatments (EBTs), yet little is known about key success indicators for these implementation efforts such as cost and sustainability. To that end, the present study examined the economic impact of statewide implementation of multisystemic therapy (MST; Henggeler, Schoenwald, Borduin, Rowland, & Cuningham, 2009), a family- and community-based behavioral EBT for serious juvenile offenders in New Mexico. Participants were 1,869 youth who received MST across 23 teams during the study period...
July 2018: Behavior Therapy
Walter H B Demczuk, Irene Martin, Shalini Desai, Averil Griffith, Laurence Caron-Poulin, Brigitte Lefebvre, Allison McGeer, Gregory J Tyrrell, George G Zhanel, Jonathan Gubbay, Linda Hoang, Paul N Levett, Paul Van Caeseele, Rita Raafat Gad, David Haldane, George Zahariadis, Gregory German, Jennifer Daley Bernier, Lori Strudwick, Michael R Mulvey
The 13-valent conjugate vaccine (PCV13) was recommended for childhood immunization programs in 2010 in Canada and has decreased the incidence of invasive pneumococcal disease (IPD) in children and changed the epidemiology of IPD in adults. This study investigated the epidemiology of IPD in adults 65 years of age and older in Canada. A total of 7282 invasive S. pneumoniae isolated from adults ≥65 years old were serotyped from 2010 to 2016 and antimicrobial susceptibility was performed on 2527 isolates...
July 25, 2018: Vaccine
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