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David B Allison

Katherine M Ryan, Melanie J Zimmer-Gembeck, David L Neumann, Allison M Waters
Fear extinction studies in youth have yielded mixed results due to developmental processes and variations in design, methodology and dependent measures. This systematic review focused on studies with healthy youth between 2 and 17 years of age to identify experimental parameters of studies documenting extinction effects. Thirty-five studies met inclusion criteria and the following themes emerged (a) some studies employed parameters and task demands that are complex and require active participant involvement whereas others involved simple stimulus configurations and passive participant involvement, and (b) variation exists among dependent measures in units of measurement, timing and type of measurement...
November 20, 2018: Behaviour Research and Therapy
Nicholas Bien, Pranav Rajpurkar, Robyn L Ball, Jeremy Irvin, Allison Park, Erik Jones, Michael Bereket, Bhavik N Patel, Kristen W Yeom, Katie Shpanskaya, Safwan Halabi, Evan Zucker, Gary Fanton, Derek F Amanatullah, Christopher F Beaulieu, Geoffrey M Riley, Russell J Stewart, Francis G Blankenberg, David B Larson, Ricky H Jones, Curtis P Langlotz, Andrew Y Ng, Matthew P Lungren
BACKGROUND: Magnetic resonance imaging (MRI) of the knee is the preferred method for diagnosing knee injuries. However, interpretation of knee MRI is time-intensive and subject to diagnostic error and variability. An automated system for interpreting knee MRI could prioritize high-risk patients and assist clinicians in making diagnoses. Deep learning methods, in being able to automatically learn layers of features, are well suited for modeling the complex relationships between medical images and their interpretations...
November 2018: PLoS Medicine
Elke Platz, Allison Merz, Montane Silverman, Eldrin Lewis, John D Groarke, Aaron Waxman, David Systrom
AIMS: Dyspnoea is common in heart failure (HF) but non-specific. Lung ultrasound (LUS) could represent a non-invasive tool to detect subclinical pulmonary congestion in patients with undifferentiated dyspnoea. METHODS AND RESULTS: We assessed the feasibility of an abbreviated LUS protocol (eight and two zones) in a prospective pilot study of 25 ambulatory patients with undifferentiated dyspnoea undergoing clinically indicated invasive cardiopulmonary exercise testing (iCPET) at rest (LUS 1) and after peak exercise (LUS 2)...
November 26, 2018: ESC Heart Failure
Greg Pavela, David B Allison, Michelle I Cardel
No abstract text is available yet for this article.
January 1, 2019: Appetite
Benjamin J Matthews, Olga Dudchenko, Sarah B Kingan, Sergey Koren, Igor Antoshechkin, Jacob E Crawford, William J Glassford, Margaret Herre, Seth N Redmond, Noah H Rose, Gareth D Weedall, Yang Wu, Sanjit S Batra, Carlos A Brito-Sierra, Steven D Buckingham, Corey L Campbell, Saki Chan, Eric Cox, Benjamin R Evans, Thanyalak Fansiri, Igor Filipović, Albin Fontaine, Andrea Gloria-Soria, Richard Hall, Vinita S Joardar, Andrew K Jones, Raissa G G Kay, Vamsi K Kodali, Joyce Lee, Gareth J Lycett, Sara N Mitchell, Jill Muehling, Michael R Murphy, Arina D Omer, Frederick A Partridge, Paul Peluso, Aviva Presser Aiden, Vidya Ramasamy, Gordana Rašić, Sourav Roy, Karla Saavedra-Rodriguez, Shruti Sharan, Atashi Sharma, Melissa Laird Smith, Joe Turner, Allison M Weakley, Zhilei Zhao, Omar S Akbari, William C Black, Han Cao, Alistair C Darby, Catherine A Hill, J Spencer Johnston, Terence D Murphy, Alexander S Raikhel, David B Sattelle, Igor V Sharakhov, Bradley J White, Li Zhao, Erez Lieberman Aiden, Richard S Mann, Louis Lambrechts, Jeffrey R Powell, Maria V Sharakhova, Zhijian Tu, Hugh M Robertson, Carolyn S McBride, Alex R Hastie, Jonas Korlach, Daniel E Neafsey, Adam M Phillippy, Leslie B Vosshall
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance...
November 14, 2018: Nature
Molly B Richardson, Peng Li, Julia M Gohlke, David B Allison
OBJECTIVE: It was hypothesized that exposure to mild temperatures above the human thermoneutral zone would decrease caloric intake in a sedentary office environment. METHODS: Women (n = 25) were randomized in a crossover design to perform seated office work for 7 hours in a thermoneutral condition (control, 19°C-20°C) and a condition above the thermoneutral zone (warm, 26°C-27°C). Food intake was estimated by weight and bomb calorimetry, peripheral temperature by thermal imaging, and thermal comfort and productivity by questionnaires...
December 2018: Obesity
Elisabeth Cole, Alexandra Dreyzin, Amber D Shaffer, Allison B J Tobey, David H Chi, Tony Tarchichi
OBJECTIVES: To improve the recognition of differences in presentation amongst patients with type 1 laryngeal clefts of various ages and better understand the age dependent outcomes of injection laryngoplasty. A second aim was to analyze the discrepancies between swallow assessment modalities in various age groups with type I laryngeal clefts undergoing injection laryngoplasty. METHODS: A retrospective review of electronic medical records of patients who underwent injection laryngoplasty from 2009 through 2015 at a tertiary care children's hospital...
December 2018: International Journal of Pediatric Otorhinolaryngology
Xia Liu, Rokana Taftaf, Madoka Kawaguchi, Ya-Fang Chang, Wenjing Chen, David Entenberg, Youbin Zhang, Lorenzo Gerratana, Simo Huang, Dhwani B Patel, Elizabeth Tsui, Valery Adorno-Cruz, Steven M Chirieleison, Yue Cao, Allison S Harney, Shivani Patel, Antonia Patsialou, Yang Shen, Stefanie Avril, Hannah L Gilmore, Justin D Lathia, Derek W Abbott, Massimo Cristofanilli, John S Condeelis, Huiping Liu
Circulating tumor cells (CTCs) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less frequently detected but more metastatic than single CTCs of triple negative breast cancer patients and representative patient-derived-xenograft (PDX) models. Using intravital multiphoton microscopic imaging, we found that clustered tumor cells in migration and circulation resulted from aggregation of individual tumor cells rather than collective migration and cohesive shedding...
October 25, 2018: Cancer Discovery
Daniel L Smith, Yongbin Yang, Tim R Nagy, Amit Patki, Joseph R Vasselli, Yiying Zhang, Stephanie L Dickinson, David B Allison
OBJECTIVE: Despite the known health benefits of weight loss among persons with obesity, observational studies have reported that cycles of weight loss and regain, or weight cycling, are associated with increased mortality. To study whether weight loss must be sustained to achieve health and longevity benefits, we performed a randomized controlled feeding study of weight cycling in mice. METHODS: In early adult life, obese mice were randomized to ad libitum feeding to sustain obesity, calorie restriction to achieve a "normal" or intermediate body weight, or weight cycling (repeated episodes of calorie restriction and ad libitum refeeding)...
November 2018: Obesity
Juhua Luo, Michael Hendryx, Deepika Laddu, Lawrence S Phillips, Rowan Chlebowski, Erin S LeBlanc, David B Allison, Dorothy A Nelson, Yueyao Li, Milagros C Rosal, Marcia L Stefanick, JoAnn E Manson
OBJECTIVE: The study objective was to examine the impact of race/ethnicity on associations between anthropometric measures and diabetes risk. RESEARCH DESIGN AND METHODS: A total of 136,112 postmenopausal women aged 50-79 years participating in the Women's Health Initiative without baseline cancer or diabetes were followed for 14.6 years. BMI, waist circumference (WC), and waist-to-hip ratio (WHR) were measured in all participants, and a subset of 9,695 had assessment of whole-body fat mass, whole-body percent fat, trunk fat mass, and leg fat mass by DXA...
October 23, 2018: Diabetes Care
Wallis T Muhly, Ralph J Beltran, Alan Bielsky, Robert B Bryskin, Christopher Chinn, Dinesh K Choudhry, Giovanni Cucchiaro, Allison Fernandez, Chris D Glover, Dawit T Haile, Sabine Kost-Byerly, Gregory D Schnepper, David Zurakowski, Rita Agarwal, Tarun Bhalla, Seth Eisdorfer, Henry Huang, Lynne G Maxwell, James J Thomas, Imelda Tjia, Robert T Wilder, Joseph P Cravero
BACKGROUND: There are few comparative data on the analgesic options used to manage patients undergoing minimally invasive repair of pectus excavatum (MIRPE). The Society for Pediatric Anesthesia Improvement Network was established to investigate outcomes for procedures where there is significant management variability. For our first study, we established a multicenter observational database to characterize the analgesic strategies used to manage pediatric patients undergoing MIRPE. Outcome data from the participating centers were used to assess the association between analgesic strategy and pain outcomes...
October 19, 2018: Anesthesia and Analgesia
R Doyle Stulting, Jonathan H Lass, Mark A Terry, Beth Ann Benetz, Nathan J Cohen, Allison R Ayala, Maureen G Maguire, Christopher Croasdale, Yassine J Daoud, Steven P Dunn, Kenneth M Goins, Pankaj C Gupta, Marian S Macsai, Shahzad I Mian, Sudeep Pramanik, Jennifer Rose-Nussbaumer, Jonathan C Song, Walter J Stark, Alan Sugar, David D Verdier, Loretta B Szczotka-Flynn
PURPOSE: To identify factors related to graft rejection following Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS). DESIGN: Cohort study within a multicenter randomized clinical trial. METHODS: A total of 1330 eyes of 1090 subjects undergoing DSAEK were randomized to receive a donor cornea with preservation time (PT) of 0-7 days (n = 675) or 8-14 days (n = 655) and followed for 3 years...
December 2018: American Journal of Ophthalmology
Rachel A H Davis, Sarah E Deemer, Jonathan M Bergeron, Jason T Little, Jonathan L Warren, Gordon Fisher, Daniel L Smith, Kevin R Fontaine, Stephanie L Dickinson, David B Allison, Eric P Plaisance
The dietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases resting energy expenditure (REE) and markers of brown and white adipose thermogenesis in lean mice. The purpose of this investigation was to determine whether the ketone ester, R, S-1,3-butanediol diacetoacetate (BD-AcAc2 ), increases energy expenditure and markers of adipose tissue thermogenesis in the context of high-fat diet (HFD)-induced obesity. Thirty-five-week-old male C57BL/6J mice were placed on an ad libitum HFD (45% kcal) for 10 wk...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Neil E Rowland, Kimberly L Robertson, Dulce Minaya, Vanessa Minervini, Melissa Cervantez, Kathryn A Kaiser, David B Allison
The purpose of this study is to compare the effect of unpredictable (U) or predictable (P) food delivery on health and longevity in mice. From 2 months of age until end of life, singly-housed male C57BL/6 mice were fed a semisynthetic diet either ad libitum (AL), or as imposed meals delivered as small pellets at either P or U times, frequencies, or amounts. The total daily food consumed by all groups was the same. The AL group gained body weight faster than either P or U groups, and had ~12% shorter median life span compared with either P or U groups...
October 5, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Tapan Mehta, David B Allison
No abstract text is available yet for this article.
October 2, 2018: JAMA: the Journal of the American Medical Association
Alexander J Rodríguez, David Scott, Belal Khan, Allison Hodge, Dallas R English, Graham G Giles, B Abrahamsen, Peter R Ebeling
The risk of mortality associated with high dietary calcium is uncertain. Unlike a highly publicised study in Swedish women, high dietary calcium intake in men-not women-was associated with increased all-cause mortality. PURPOSE: The association of dietary calcium with mortality is controversial. A study of women from the Swedish Mammography Cohort (SMC) suggested higher calcium was associated with higher mortality risk, whilst a study of Australian adults from the Melbourne Collaborative Cohort Study (MCCS) suggested higher intakes were associated with lower mortality risk...
September 21, 2018: Archives of Osteoporosis
Conall OʼCleirigh, Michael J Zvolensky, Jasper A J Smits, Allison K Labbe, Jessica N Coleman, Julianne G Wilner, Amelia M Stanton, Adam Gonzalez, Lorra Garey, Kristen S Regenauer, David Rosenfield
OBJECTIVE: Among people living with HIV, cigarette smoking rates are higher than among the general population, and anxiety, depression, and their disorders are common and associated with smoking and poorer outcomes during cessation. This study evaluated the efficacy of an integrated smoking cessation intervention, developed to target anxiety, depression, and smoking cessation concurrently among people living with HIV. METHOD: Smokers living with HIV who reported at least moderate motivation to quit smoking were randomized into a novel 9-week integrated intervention (QUIT), consisting of 1 psychoeducation (prerandomization) session and 9 weekly 1-hour sessions of cognitive behavioral therapy for smoking cessation and anxiety/depression plus nicotine replacement therapy, or a 9-week enhanced standard smoking intervention (ETAU), consisting of 1 psychoeducation session (prerandomization) and 4 brief weekly check-in sessions plus nicotine replacement therapy...
October 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Allison K G Moorman, Todd F Duffield, M Ann Godkin, David F Kelton, Jeffrey Rau, Derek B Haley
Dairy cows are culled from the herd for a variety of reasons, the most common being fertility problems, low milk production, or udder problems. Disease and injury can contribute to the decision to cull either directly, or indirectly, by causing fertility or production problems, leading to culling. Disease or injury may also affect the cow's ability to handle the stress of transportation and may increase the risk for reduced welfare. The purpose of this study was to determine the general condition of culled dairy cows sold at Ontario auction markets, to quantify the frequency of culled cows in poor condition sold at these auctions, and to determine how this relates to the sale price of the cow...
November 2018: Journal of Dairy Science
Andrew W Brown, David B Allison
No abstract text is available yet for this article.
October 2018: Journal of Nursing Research: JNR
Matthew G Drake, Gregory D Scott, Emily D Blum, Katherine M Lebold, Zhenying Nie, James J Lee, Allison D Fryer, Richard W Costello, David B Jacoby
In asthma, airway nerve dysfunction leads to excessive bronchoconstriction and cough. It is well established that eosinophils alter nerve function and that airway eosinophilia is present in 50 to 60% of asthmatics. However, the effects of eosinophils on airway nerve structure have not been established. We tested whether eosinophils alter airway nerve structure and measured the physiological consequences of those changes. Our results in humans with and without eosinophilic asthma showed that airway innervation and substance P expression were increased in moderate persistent asthmatics compared to mild intermittent asthmatics and healthy subjects...
September 5, 2018: Science Translational Medicine
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