keyword
https://read.qxmd.com/read/38434489/the-evolution-of-circulating-biomarkers-for-use-in-acetaminophen-paracetamol-induced-liver-injury-in-humans-a-scoping-review
#1
JOURNAL ARTICLE
Mitchell R McGill, Steven C Curry
Acetaminophen (APAP) is a widely used drug, but overdose can cause severe acute liver injury. The first reports of APAP hepatotoxicity in humans were published in 1966, shortly after the development of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as the first biomarkers of liver injury as opposed to liver function. Thus, the field of liver injury biomarkers has evolved alongside the growth in APAP hepatotoxicity incidence. Numerous biomarkers have been proposed for use in the management of APAP overdose patients in the intervening years...
December 2023: Livers
https://read.qxmd.com/read/38421361/risk-factors-for-deliberate-self-poisoning-among-children-and-adolescents-in-the-netherlands
#2
JOURNAL ARTICLE
Ilze M J Thoonen, Saskia J Rietjens, Agnes G van Velzen, Dylan W de Lange, Arjen Koppen
INTRODUCTION: In the past decade, the number of deliberate self-poisonings involving young people has increased strongly worldwide. This study aimed to gain insight into risk factors associated with deliberate self-poisonings among children and adolescents reported to the Dutch Poisons Information Center. METHODS: A study was performed between 1 February 2022 and 31 January 2023 involving those aged 8-17 years of age with deliberate self-poisoning. Data were collected on patient characteristics (age, gender, body mass index and living situation) and exposure characteristics (type of toxicant, way of acquiring toxicant and day of exposure)...
January 2024: Clinical Toxicology
https://read.qxmd.com/read/38396643/inhibition-of-adult-neurogenesis-in-male-mice-after-repeated-exposure-to-paracetamol-overdose
#3
JOURNAL ARTICLE
Juan Suárez, Marialuisa de Ceglia, Miguel Rodríguez-Pozo, Antonio Vargas, Ignacio Santos, Sonia Melgar-Locatelli, Adriana Castro-Zavala, Estela Castilla-Ortega, Fernando Rodríguez de Fonseca, Juan Decara, Patricia Rivera
Paracetamol, or acetaminophen (N-acetyl-para-aminophenol, APAP), is an analgesic and antipyretic drug that is commonly used worldwide, implicated in numerous intoxications due to overdose, and causes serious liver damage. APAP can cross the blood-brain barrier and affects brain function in numerous ways, including pain signals, temperature regulation, neuroimmune response, and emotional behavior; however, its effect on adult neurogenesis has not been thoroughly investigated. We analyze, in a mouse model of hepatotoxicity, the effect of APAP overdose (750 mg/kg/day) for 3 and 4 consecutive days and after the cessation of APAP administration for 6 and 15 days on cell proliferation and survival in two relevant neurogenic zones: the subgranular zone of the dentate gyrus and the hypothalamus...
February 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38374310/-drug-induced-autoimmune-like-liver-injury
#4
REVIEW
Sabine Weber
Drug-induced liver injury (DILI) is a rare yet potentially life-threatening disease. Besides intrinsic DILI, which is mainly caused by paracetamol overdosing and which is dose-dependent and predictable, there is idiosyncratic DILI-an unpredictable and dose-independent injury of the liver caused by certain medications that only occurs in a minority of patients taking this drug. The reason why some patients react with DILI towards a specific drug is still unknown. However, the immune system plays a central role, which is underlined by the association of certain human leukocyte antigen (HLA) polymorphisms and DILI caused by specific drug classes...
February 19, 2024: Inn Med (Heidelb)
https://read.qxmd.com/read/38257189/flaxseed-lignan-alleviates-the-paracetamol-induced-hepatotoxicity-associated-with-regulation-of-gut-microbiota-and-serum-metabolome
#5
JOURNAL ARTICLE
Yongyan Ren, Zhenxia Xu, Zhixian Qiao, Xu Wang, Chen Yang
This study examined the protective effect of flaxseed lignans on liver damage caused by an overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d flaxseed lignan prior to PAM significantly decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBi) levels, while it increased liver superoxide dismutase (SOD) and glutathione (GSH) levels in mice. Flaxseed lignan renovated the gut microbiota dysbiosis induced by PAM by promoting the proliferation of sulfonolipid (SL) producing bacteria such as Alistipes and lignan-deglycosolating bacteria such as Ruminococcus while inhibiting the growth of opportunistic pathogen bacteria such as Acinetobacter and Clostridium ...
January 18, 2024: Nutrients
https://read.qxmd.com/read/38249636/clinical-profile-and-outcomes-of-children-with-acute-liver-failure-in-a-tertiary-care-center-in-south-india-a-retrospective-study
#6
JOURNAL ARTICLE
Anitha Abimannane, Bobbity Deepthi, Rohit Bhowmick, Narayanan Parameswaran
PURPOSE: In this study, we investigated the clinical profile, survival at discharge, and proportion of children with acute liver failure (ALF) meeting the criteria for, yet surviving without, liver transplantation (LT). METHODS: Medical case records of children aged >28 days to ≤15 years over a period of 7 years, identified from pediatric admission and discharge registers, were screened. Children satisfying the criteria for ALF were included in this study...
January 2024: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/38233098/medication-errors-involving-intravenous-paracetamol-in-children-experience-from-enquiries-to-the-national-poisons-information-service
#7
JOURNAL ARTICLE
Florence Vincent, John Thompson, Laurence Gray, Sally Bradberry, Euan Sandilands, Ruben Thanacoody, David Tuthill
INTRODUCTION: Children are at higher risk of medication errors due to the complexity of drug prescribing and administration in this patient group. Intravenous (IV) paracetamol overdose differs from overdose by ingestion as there is no enteral absorptive buffering. We provide the first national UK data focusing on paediatric IV paracetamol poisoning. METHODS: All telephone enquiries to the National Poisons Information Service between 2008 and 2021 regarding children less than 18 years old in the UK concerning IV paracetamol overdose were extracted from the UK Poisons Information Database (UKPID)...
January 17, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38197864/fifty-years-of-paracetamol-acetaminophen-poisoning-the-development-of-risk-assessment-and-treatment-1973-2023-with-particular-focus-on-contributions-published-from-edinburgh-and-denver
#8
REVIEW
D Nicholas Bateman, Richard C Dart, James W Dear, Laurie F Prescott, Barry H Rumack
INTRODUCTION: Fifty years ago, basic scientific studies and the availability of assay methods made the assessment of risk in paracetamol (acetaminophen) poisoning possible. The use of the antidote acetylcysteine linked to new methods of risk assessment transformed the treatment of this poisoning. This review will describe the way in which risk assessment and treatments have developed over the last 50 years and highlight the remaining areas of uncertainty. METHODS: A search of PubMed and its subsidiary databases revealed 1,166 references published in the period 1963-2023 using the combined terms "paracetamol", "poisoning", and "acetylcysteine"...
January 10, 2024: Clinical Toxicology
https://read.qxmd.com/read/38149309/intestinal-injury-in-paracetamol-overdose-atom-8
#9
JOURNAL ARTICLE
Varan Perananthan, Fathima Shihana, Angela Chiew, Jacob George, Andrew Dawson, Nicholas A Buckley
BACKGROUND AND AIM: Paracetamol, a widely used medication, is known for its delayed hepatotoxicity in cases of overdose. However, the potential for intestinal toxicity resulting from very high paracetamol concentrations during absorption is not well explored. This study aims to investigate the presence of intestinal toxicity and its correlation with observations in early and late paracetamol toxicity. METHODS: Serial samples of 30 patients with acute paracetamol overdose (> 10 g or 200 mg/kg) were prospectively tested...
December 27, 2023: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38112311/an-international-survey-of-the-treatment-of-massive-paracetamol-overdose-in-2023
#10
JOURNAL ARTICLE
Sanjay Mohan, Joshua Bloom, Samantha Kerester, Robert S Hoffman, Mark K Su
INTRODUCTION: Changes in the commercialization of nonprescription drugs have made large quantities of paracetamol available to individuals, resulting in larger overdoses than previously observed. Although most patients with paracetamol overdose can be managed with acetylcysteine, patients with a massive overdose may become critically ill earlier and fail standard antidotal therapy. Several strategies are proposed for the management of these patients, including using increased doses of acetylcysteine, extracorporeal removal, and fomepizole...
November 2023: Clinical Toxicology
https://read.qxmd.com/read/38090101/potentiometric-planar-platforms-modified-with-a-multiwalled-carbon-nanotube-polyaniline-nanocomposite-and-based-on-imprinted-polymers-for-erythromycin-assessment
#11
JOURNAL ARTICLE
Abdulrahman A Almehizia, Ahmed M Naglah, Mashael G Alanazi, Abdel El-Galil E Amr, Ayman H Kamel
A screen-printed potentiometric sensor for the erythromycin macrolide antibiotic (ERY) that is affordable, highly selective, and sensitive is made, described, and used for drug monitoring. Two circular carbon dots with a diameter of 4 mm make up the sensor. Multiwalled carbon nanotubes and polyaniline (f-MWCNTs/PANi) nanocomposites are used to change one carbon spot, which is then used as an ion-to-electron transfer material. Ag/AgCl is applied to the other spot, which is then used as a reference electrode...
December 8, 2023: RSC Advances
https://read.qxmd.com/read/38085531/an-intravenous-paracetamol-overdose-in-an-eight-day-old-neonate
#12
JOURNAL ARTICLE
Arjen Koppen, Cecile H J Bekkers, Gordon H P R Slabbers, Dylan W de Lange, Robbert B T Verkooijen
No abstract text is available yet for this article.
December 12, 2023: Clinical Toxicology
https://read.qxmd.com/read/38001256/non-canonical-bim-regulated-energy-metabolism-determines-drug-induced-liver-necrosis
#13
JOURNAL ARTICLE
Rebekka Lambrecht, Franziska Rudolf, Anna-Katharina Ückert, Valentina C Sladky, Truong San Phan, Jasmin Jansen, Samara Naim, Thomas Kaufmann, Adrian Keogh, Susanne Kirschnek, Aswin Mangerich, Florian Stengel, Marcel Leist, Andreas Villunger, Thomas Brunner
Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality. Here, we studied this switch of cell death modes and demonstrate a non-canonical role of the apoptosis-regulating BCL-2 homolog BIM/Bcl2l11 in promoting necrosis by regulating cellular bioenergetics. BIM deficiency enhanced total ATP production and shifted the bioenergetic profile towards glycolysis, resulting in persistent protection from APAP-induced liver injury...
November 24, 2023: Cell Death and Differentiation
https://read.qxmd.com/read/37999416/antioxidative-and-anti-inflammatory-protective-effects-of-fucoxanthin-against-paracetamol-induced-hepatotoxicity-in-rats
#14
JOURNAL ARTICLE
Maimonah Fuad Koshak, Mahmoud Zaki El-Readi, Mohamed Elzubier Elzubier, Bassem Refaat, Riyad Adnan Almaimani, Shakir Idris, Mohammad Althubiti, Hiba Saeed Al-Amodi, Safaa Yehia Eid
Paracetamol or acetaminophen (PAC) is a commonly used analgesic and antipyretic drug. It has been shown that overdoses beyond the therapeutic range can cause hepatotoxicity and acute liver injury. The most common cause of drug-induced liver injury (DILI) in Saudi Arabia and worldwide is paracetamol overdose. Fucoxanthin (FUC) is an allenic carotenoid that is found in edible brown seaweeds, and it has antioxidant and anti-inflammatory effects. Several studies have shown the potential therapeutic effects of FUC in diabetes, cancers, and inflammatory disorders...
November 14, 2023: Marine Drugs
https://read.qxmd.com/read/37951015/high-resolution-mass-spectrometry-identifies-delayed-biomarkers-for-improved-precision-in-acetaminophen-paracetamol-human-biomonitoring
#15
JOURNAL ARTICLE
Eva Gorrochategui, Marc Le Vee, Habiba Selmi, Anne Gérard, Jade Chaker, Annette M Krais, Christian Lindh, Olivier Fardel, Cécile Chevrier, Pierre Le Cann, Gary W Miller, Robert Barouki, Bernard Jégou, Thomas Gicquel, David M Kristensen, Arthur David
Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) is a top selling analgesic used in more than 600 prescription and non-prescription pharmaceuticals. To study efficiently some of the potential undesirable effects associated with increasing APAP consumption (e.g., developmental disorders, drug-induced liver injury), there is a need to improve current APAP biomonitoring methods that are limited by APAP short half-life. Here, we demonstrate using high-resolution mass spectrometry (HRMS) in several human studies that APAP thiomethyl metabolite conjugates (S-methyl-3-thioacetaminophen sulfate and S-methyl-3-thioacetaminophen sulphoxide sulfate) are stable biomarkers with delayed excretion rates compared to conventional APAP metabolites, that could provide a more reliable history of APAP ingestion in epidemiological studies...
October 31, 2023: Environment International
https://read.qxmd.com/read/37937337/immunomodulatory-protective-effects-of-nigella-sativa-and-lactuca-sativa-oils-on-liver-intoxication-in-experimental-animals
#16
JOURNAL ARTICLE
Elsayed Hamed Ali Bakr, Reema Abdulrahman Saad Alyamani
<b>Background and Objective:</b> The liver plays an important role in transforming and clearing chemicals in human body. Hepatic injury is usually caused by numerous toxic chemicals such as carbon tetrachloride, thioacetamide, galactosamine and drugs including paracetamol as overdoses consumption. This investigation aimed to study the immunomodulatory protective effects of black seed (<i>Nigella sativa</i> L.) oil and lettuce (<i>Lactuca sativa</i> L...
July 2023: Pakistan Journal of Biological Sciences: PJBS
https://read.qxmd.com/read/37923574/root-cause-analysis-of-medication-errors-of-the-most-frequently-involved-active-substances-in-paediatric-patients
#17
JOURNAL ARTICLE
Nikica Mirosevic Skvrce, Lana Omrcen, Morana Pavicic, Iva Mucalo
BACKGROUND: Use of medicinal products in paediatric patients is identified as a risk factor for the occurrence of medication errors. OBJECTIVES: To describe and identify root causes of medication errors in children and adolescents spontaneously reported to Agency for Medicinal Products and Medical Devices of Croatia (Agency). METHOD: Agency's adverse drug reaction database was searched by using the Standardised MedDRA Query: medication errors (Broad) with data lock point set at 30th June 2022...
October 18, 2023: Research in Social & Administrative Pharmacy: RSAP
https://read.qxmd.com/read/37893532/the-protective-potential-of-petroselinum-crispum-mill-fuss-on-paracetamol-induced-hepatio-renal-toxicity-and-antiproteinuric-effect-a-biochemical-hematological-and-histopathological-study
#18
JOURNAL ARTICLE
Ghizlane Nouioura, Tayeb Kettani, Meryem Tourabi, Layla Tahiri Elousrouti, Omkulthom Al Kamaly, Samar Zuhair Alshawwa, Abdelaaty A Shahat, Abdulsalam Alhalmi, Badiaa Lyoussi, Elhoussine Derwich
Background and Objectives: Paracetamol overdose is a significant global issue due to its widespread use, which can lead to a lack of awareness regarding its potential side effects. Paracetamol can harm the liver, possibly resulting in liver failure. Conversely, this study employed extracts from Petroselinum crispum (PC), known for its rich content of bioactive compounds, with demonstrated antioxidant properties shown in previous research as well as protective effects against various diseases. The primary objective of this study was to investigate the potential protective effects of Petroselinum crispum on altered hematological and biochemical parameters in the blood of rats exposed to paracetamol...
October 12, 2023: Medicina
https://read.qxmd.com/read/37837969/acute-liver-failure-in-low-income-and-middle-income-countries
#19
REVIEW
Sandro Vento, Francesca Cainelli
Acute liver failure is a rare condition involving the rapid development, progression, and worsening of liver dysfunction, characterised by coagulopathy and encephalopathy, and has a high mortality unless liver transplantation is performed. Population-based studies are scarce, and most published data are from high-income countries, where the main cause of acute liver failure is paracetamol overdose. This Review provides an overview of the scanty literature on acute liver failure in low-income and middle-income countries, where patients are often admitted to primary care hospitals and viral hepatitis (especially hepatitis E), tropical infections (eg, dengue), traditional medicines, and drugs (especially anti-tuberculosis drugs) have an important role...
November 2023: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/37767912/novel-biomarkers-for-drug-induced-liver-injury
#20
JOURNAL ARTICLE
Christopher Humphries, James W Dear
INTRODUCTION: Liver toxicity due to medicines (drug-induced liver injury) is a challenge for clinicians and drug developers. There are well-established biomarkers of drug-induced liver injury, which are widely used and validated by decades of clinical experience. These include alanine aminotransferase and bilirubin. Limitations of the current biomarkers are well described, and this has resulted in global efforts to identify and develop new candidates. This process has been aided by regulatory pathways being established for biomarker qualification...
August 2023: Clinical Toxicology
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