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https://www.readbyqxmd.com/read/30552832/imbalance-of-peripheral-follicular-helper-t-lymphocyte-subsets-in-active-vitiligo
#1
Clément Jacquemin, Alain Taieb, Katia Boniface, Julien Seneschal
Vitiligo is an autoimmune disease characterized by the presence of several autoantibodies, some of which are directed against melanocyte components and have been shown to be associated with the progression of the disease. However, the mechanism involved in the production of autoantibodies remains unclear. Follicular helper CD4+ T cells (TFH) are specialized in B cell activation and antibody production, especially the TFH cell subsets type 2 and type 17. To date, TFH cell subsets have not been studied in human vitiligo...
December 15, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/30552735/effects-of-isoquinoline-alkaloids-from-macleaya-cordata-on-physiological-immunological-and-inflammatory-parameters-in-healthy-beagles-alkaloids-in-dog-nutrition
#2
B Faehnrich, A Pastor, C Heide, S Kröger, J Zentek
The aim of the study was to investigate nutritional, physiological and immunological effects of a plant-derived blend of isoquinoline alkaloids (Sangrovit® Extra) in healthy dogs. Two groups of healthy, adult beagles (N = 10) were tested in a cross-over experiment, lasting two consecutive three-week periods. The experimental group received 1.2 g additive/kg feed, according to the recommendation of 10-20 mg/kg live weight per day. The control group received the same feed without additive. Complete blood count, immunological parameters and amino acid concentrations in serum were assessed...
December 14, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/30552161/obinutuzumab-pretreatment-abrogates-tumor-lysis-risk-while-maintaining-undetectable-mrd-for-venetoclax-obinutuzumab-in-cll
#3
Arnon P Kater, Sabina Kersting, Yvette van Norden, Julie Dubois, Johan A Dobber, Clemens H Mellink, Ludo M Evers, Fransien Croon-de Boer, John Schreurs, Ellen van der Spek, Hein Visser, Cecile Idink, Shulamiet Wittebol, Mels Hoogendoorn, Sanne H Tonino, Mehrdad Mobasher, Mark-David Levin
Early data on venetoclax-containing regimens for the treatment of chronic lymphocytic leukemia (CLL) show promising results with deep remissions, but are hampered by potential risk for tumor lysis syndrome (TLS). Whether optimal duration of venetoclax treatment can be guided by minimal residual disease (MRD) is currently unknown. To study whether TLS risk can be mitigated in an unfit population by introducing preinduction, and whether MRD-guided duration of venetoclax treatment is a feasible and efficacious approach, we performed the Dutch-Belgian Cooperative Trial Group for Hemato-oncology (HOVON) 139/GIVE trial...
December 26, 2018: Blood Advances
https://www.readbyqxmd.com/read/30551501/the-applications-of-anti-cd20-antibodies-to-treat-various-b-cells-disorders
#4
REVIEW
Zahra Payandeh, Armina Alagheband Bahrami, Reyhaneh Hoseinpoor, Yousef Mortazavi, Masoumeh Rajabibazl, Azam Rahimpour, Amir Hossein Taromchi, Saeed Khalil
B-lymphocyte antigen CD20 (called CD20) is known as an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells. CD20 is involved in the regulation of trans-membrane Ca2+ conductance and also play critical roles in cell-cycle progression during human B cell proliferation and activation. The appearance of monoclonal antibody (mAb) technology provided an effective field for targeted therapy in treatment of a variety of diseases such as cancer, and autoimmune diseases. Anti-CD20 is one of important antibodies which could be employed in treatment of several diseases...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30551490/mesenchymal-stem-cell-based-therapy-of-osteoarthritis-current-knowledge-and-future-perspectives
#5
REVIEW
C Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Vladislav Volarevic
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions, meniscal damage, and synovitis. Innate immune cells (natural killer cells, macrophages, and mast cells) play the most important pathogenic role in the early inflammatory response, while cells of adaptive immunity (CD4 + Th1 lymphocytes and antibody producing B cells) significantly contribute to the development of chronic, relapsing course of inflammation in OA patients...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30551468/scutellarein-selectively-targets-multiple-myeloma-cells-by-increasing-mitochondrial-superoxide-production-and-activating-intrinsic-apoptosis-pathway
#6
Lin Shi, Yi Wu, Dian Liang Lv, Lei Feng
OBJECTIVES: Scutellarein is a flavonoid monomer found in traditional Chinese medicine such as Scutellaria barbata. This study aimed to investigate the cytotoxic effect of scutellarein treatment on multiple myeloma (MM) cells. METHODS: circulating B lymphocytes (CBL) isolated from healthy donors' peripheral blood served as control for MM.1R and IM-9 MM cells. CLB and MM cells were treated with various concentrations of scutellarein before their cell viability and apoptosis being evaluated...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30550941/microfluidic-assembly-of-hydrogel-based-immunogenic-tumor-spheroids-for-evaluation-of-anticancer-therapies-and-biomarker-release
#7
Pooja Sabhachandani, Saheli Sarkar, Seamus Mckenney, Ravi Dashnamoorthy, Andrew M Evens, Tania Konry
Diffuse large B cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin lymphoma, exhibits pathologic heterogeneity and a dynamic immunogenic tumor microenvironment (TME). However, the lack of preclinical in vitro models of DLBCL TME hinders optimal therapeutic screening. This study describes the development of an integrated droplet microfluidics-based platform for high-throughput generation of immunogenic DLBCL spheroids. The spheroids consist of three cell types (cancer, fibroblast and lymphocytes) in a novel hydrogel combination of alginate and puramatrix, which promoted cell adhesion and aggregation...
December 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30550791/organoid-modeling-of-the-tumor-immune-microenvironment
#8
James T Neal, Xingnan Li, Junjie Zhu, Valeria Giangarra, Caitlin L Grzeskowiak, Jihang Ju, Iris H Liu, Shin-Heng Chiou, Ameen A Salahudeen, Amber R Smith, Brian C Deutsch, Lillian Liao, Allison J Zemek, Fan Zhao, Kasper Karlsson, Liora M Schultz, Thomas J Metzner, Lincoln D Nadauld, Yuen-Yi Tseng, Sahar Alkhairy, Coyin Oh, Paula Keskula, Daniel Mendoza-Villanueva, Francisco M De La Vega, Pamela L Kunz, Joseph C Liao, John T Leppert, John B Sunwoo, Chiara Sabatti, Jesse S Boehm, William C Hahn, Grace X Y Zheng, Mark M Davis, Calvin J Kuo
In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly elusive. Here, an air-liquid interface (ALI) method propagated patient-derived organoids (PDOs) from >100 human biopsies or mouse tumors in syngeneic immunocompetent hosts as tumor epithelia with native embedded immune cells (T, B, NK, macrophages)...
December 13, 2018: Cell
https://www.readbyqxmd.com/read/30550623/interferon-gamma-production-in-lyme-arthritis-synovial-tissue-promotes-differentiation-of-fibroblast-like-synoviocytes-into-immune-effector-cells
#9
Robert B Lochhead, David Ordoñez, Sheila L Arvikar, John M Aversa, Luke S Oh, Benton Heyworth, Ruslan Sadreyev, Allen C Steere, Klemen Strle
Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called post-infectious LA. In this study, we phenotyped hematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Ex vivo analysis of synovial tissue revealed high abundance of IFNγ-producing T cells and NK cells...
December 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/30549985/changes-in-prealbumin-and-body-mass-index-associated-with-t-lymphocyte-subsets-and-nutritional-status-in-chronic-hepatitis-b-and-hbv-cirrhosis-patients
#10
Wen Gao, Ming Kong, Jia Yao, Fan Wang, Jing Liu, Dongmei Wang, Hongbo Ma, Lieqing Ma, Zhongping Duan
<i>Background:</i> Patient immune response is one of the main factors influencing hepatitis virus (HBV) eradication or chronicity. Our study aimed to investigate the relationship between the nutritional status and immune function, and to provide the appropriate clinical diagnosis data for treatment of patients with chronic hepatitis B virus (CHB) and cirrhosis. <i>Methods:</i> T lymphocyte subsets were tested using flow cytometry in 100 patients (48 with CHB, 52 with cirrhosis) and 26 healthy individuals...
October 31, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30547050/aav8-gene-therapy-for-crigler-najjar-syndrome-in-macaques-elicited-transgene-t-cell-responses-that-are-resident-to-the-liver
#11
Jenny A Greig, Roberto Calcedo, Leticia Kuri-Cervantes, Jayme M L Nordin, Jessica Albrecht, Erin Bote, Tamara Goode, Edward A Chroscinski, Peter Bell, Laura K Richman, Michael R Betts, James M Wilson
Systemic delivery of adeno-associated viral (AAV) vectors has been evaluated for the treatment of several liver diseases, including homozygous familial hypercholesterolemia, ornithine transcarbamylase deficiency, and hemophilia. Here, we evaluated this approach for the treatment of Crigler-Najjar syndrome. We administered wild-type rhesus macaques with 1.0 × 1013 or 2.5 × 1013 genome copies/kg of an AAV serotype 8 vector expressing a codon-optimized version of human uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) from a liver-specific promoter...
December 14, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/30546961/tgf-%C3%AE-enhances-the-cytotoxic-activity-of-v%C3%AE-2-t-cells
#12
Christian Peters, Annika Meyer, Léonce Kouakanou, Julia Feder, Tim Schricker, Marcus Lettau, Ottmar Janssen, Daniela Wesch, Dieter Kabelitz
TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, TGF-β is a driving cytokine in the differentiation of induced regulatory T cells (iTreg) but also in the polarization of interleukin-9 (IL-9) producing T helper 9 (Th9) T cells. Human Vδ2 expressing γδ T cells exert potent cytotoxicity towards a variety of solid tumor and leukemia/lymphoma target cells and thus are in the focus of current strategies to develop cell-based immunotherapies. Here we report that TGF-β unexpectedly augments the cytotoxic effector activity of short-term expanded Vδ2 T cells when purified γδ T cells are activated with specific pyrophosphate antigens and IL-2 or IL-15 in the presence of TGF-β...
2019: Oncoimmunology
https://www.readbyqxmd.com/read/30546950/b-cells-in-esophago-gastric-adenocarcinoma-are-highly-differentiated-organize-in-tertiary-lymphoid-structures-and-produce-tumor-specific-antibodies
#13
Hans A Schlößer, Martin Thelen, Axel Lechner, Kerstin Wennhold, Maria A Garcia-Marquez, Sacha I Rothschild, Elena Staib, Thomas Zander, Dirk Beutner, Birgit Gathof, Ramona Gilles, Engin Cukuroglu, Jonathan Göke, Alexander Shimabukuro-Vornhagen, Uta Drebber, Alexander Quaas, Christiane J Bruns, Arnulf H Hölscher, Michael S Von Bergwelt-Baildon
Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. This study provides a detailed analysis of TABs in gastro-esophageal adenocarcinoma (EAC). Flow cytometric analyses of single cell suspensions of tumor samples, mucosa, lymph nodes and peripheral blood mononuclear cells (PBMC) of EAC patients and healthy controls revealed a distinct B cell compartment in cancer patients...
2019: Oncoimmunology
https://www.readbyqxmd.com/read/30546949/braf-and-mek-inhibitors-differentially-affect-nivolumab-induced-t-cell-activation-by-modulating-the-tcr-and-akt-signaling-pathways
#14
Peng Yue, Taylor Harper, Silvia M Bacot, Monica Chowdhury, Shiowjen Lee, Adovi Akue, Mark A Kukuruga, Tao Wang, Gerald M Feldman
Immune checkpoint inhibitors (ICIs) such as the anti-PD-1 antibody Nivolumab, achieve remarkable clinical efficacy in patients with late stage cancers. However, only a small subset of patients benefit from this therapy. Numerous clinical trials are underway testing whether combining ICIs with other anti-cancer therapies can increase this response rate. For example, anti-PD-1/PD-L1 therapy combined with MAP kinase inhibition using BRAF inhibitors (BRAFi) and/or MEK inhibitors (MEKi) are in development for treatment of late stage melanomas...
2019: Oncoimmunology
https://www.readbyqxmd.com/read/30546948/ibrutinib-significantly-inhibited-bruton-s-tyrosine-kinase-btk-phosphorylation-in-vitro-proliferation-and-enhanced-overall-survival-in-a-preclinical-burkitt-lymphoma-bl-model
#15
Yaya Chu, Sanghoon Lee, Tishi Shah, Changhong Yin, Matthew Barth, Rodney R Miles, Janet Ayello, Erin Morris, Lauren Harrison, Carmella Van de Ven, Paul Galardy, Stanton C Goldman, Megan S Lim, Michelle Hermiston, Linda M McAllister-Lucas, Lisa Giulino-Roth, Sherrie L Perkins, Mitchell S Cairo
Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton's tyrosine kinase (BTK) is activated following B-cell receptor stimulation and in part regulates normal B-cell development. Ibrutinib, a selective and irreversible BTK inhibitor, has been efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia, and marginal zone lymphoma. In this study, we investigated the efficacy of ibrutinib alone and in selective adjuvant combinations against BL in-vitro and in a human BL xenografted immune-deficient NOD...
2019: Oncoimmunology
https://www.readbyqxmd.com/read/30546828/decreased-levels-of-regulatory-b-cells-in-patients-with-acute-pancreatitis-association-with-the-severity-of-the-disease
#16
Liannv Qiu, Yonglie Zhou, Qinghua Yu, Junde Yu, Qian Li, Renhua Sun
Early stratification of the severity of acute pancreatitis (AP) is clinically important. Regulatory B cells have been found to be associated with disease activity of autoimmune diseases. However, the role of Regulatory B cells in AP remains unknown. We investigate the dynamic longitudinal changes in circulating IL-10-producing B cells (B10) and memory CD19+ CD24hi CD27hi cells in patients with AP to evaluate their prediction utility for AP severity. B10, CD19+ CD24hi CD27hi cells, inflammatory markers and cytokines were detected in patients with AP immediately after admission to the hospital (day 1), then on the third and seventh days...
November 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/30545915/blocking-il-1%C3%AE-reverses-the-immunosuppression-in-mouse-breast-cancer-and-synergizes-with-anti-pd-1-for-tumor-abrogation
#17
Irena Kaplanov, Yaron Carmi, Rachel Kornetsky, Avishai Shemesh, Galina V Shurin, Michael R Shurin, Charles A Dinarello, Elena Voronov, Ron N Apte
Interleukin-1β (IL-1β) is abundant in the tumor microenvironment, where this cytokine can promote tumor growth, but also antitumor activities. We studied IL-1β during early tumor progression using a model of orthotopically introduced 4T1 breast cancer cells. Whereas there is tumor progression and spontaneous metastasis in wild-type (WT) mice, in IL-1β-deficient mice, tumors begin to grow but subsequently regress. This change is due to recruitment and differentiation of inflammatory monocytes in the tumor microenvironment...
December 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30545211/association-between-high-neutrophil-to-lymphocyte-ratio-and-delayed-recovery-from-bell-s-palsy
#18
Hyung-Sik Kim, Junyang Jung, Sung Hwa Dong, Sang Hoon Kim, Su Young Jung, Seung Geun Yeo
Objectives: Factors predictive of the severity of and recovery from Bell's palsy remain unclear. This study evaluated the association between neutrophil to lymphocyte ratio (NLR) and the severity of and recovery from Bell's palsy. Methods: This retrospective study included 51 patients who were hospitalized with Bell's palsy from 2015 to 2017. Degree of paralysis was assessed by House-Brackmann (H-B) grade. Patients with H-B grades 2-4 were classified as having mild to moderate palsy and patients with H-B grade 5 or 6 were classified as having severe palsy...
December 15, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30544644/dna-damage-tolerance-mechanisms-revealed-from-the-analysis-of-immunoglobulin-v-gene-diversification-in-avian-dt40-cells
#19
REVIEW
Takuya Abe, Dana Branzei, Kouji Hirota
DNA replication is an essential biochemical reaction in dividing cells that frequently stalls at damaged sites. Homologous/homeologous recombination (HR)-mediated template switch and translesion DNA synthesis (TLS)-mediated bypass processes release arrested DNA replication forks. These mechanisms are pivotal for replication fork maintenance and play critical roles in DNA damage tolerance (DDT) and gap-filling. The avian DT40 B lymphocyte cell line provides an opportunity to examine HR-mediated template switch and TLS triggered by abasic sites by sequencing the constitutively diversifying immunoglobulin light-chain variable gene ( IgV )...
December 7, 2018: Genes
https://www.readbyqxmd.com/read/30543597/immune-mediated-hemolytic-anemia-and-thrombocytopenia-in-clonal-b-cell-disorders-a-review
#20
Urshila Durani, Ronald S Go, Neil E Kay
Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and treatment of these autoimmune disorders, specifically in the setting of B-cell malignancies. AIHA and ITP are classically associated with chronic lymphocytic leukemia (CLL) but have also been reported in plasmacytic and lymphoproliferative disorders. AIHA includes both warm AIHA and cold agglutinin disease, the latter of which is strongly associated with Waldenström macroglobulinemia...
October 2018: Clinical Advances in Hematology & Oncology: H&O
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