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https://www.readbyqxmd.com/read/30121927/sex-related-differences-in-the-morphology-and-subpopulation-composition-of-colon-lymphocytes-in-experimental-acute-colitis
#1
Yu Gao, E A Postovalova, O V Makarova, M T Dobrynina, L P Mikhailova
Morphological manifestations of acute colitis and subpopulation composition of colon lymphocytes were studied in male and female C57Bl/6 mice with acute dextran-induced colitis. We evaluated the severity of colitis symptoms, morphological changes in the colon, and prevalence of epithelialized and non-epithelialized ulcers. The subpopulation composition of lymphocytes (CD3-CD19+ B cells, CD3+ CD4+ T helpers, CD3+ CD8+ cytotoxic T cells, and CD4+ CD25+ FOXP3+ regulatory T cells) was assessed by flow cytofluorometry in suspension of colon cells prepared by enzymatic disintegration...
August 18, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30121916/individual-differences-of-multipotent-mesenchymal-stromal-cells-manifesting-in-during-interaction-with-lymphocytes
#2
N M Kapranov, Yu O Davydova, I V Gal'tseva, N A Petinati, N V Sats, N I Drize, L A Kuz'mina, E N Parovichnikova, V G Savchenko
Analysis of changes in lymphocyte subpopulations during co-culturing with multipotent mesenchymal stromal cells (MSC) revealed two distinct MSC groups: one group (A) increased HLA-DR expression on lymphocytes during co-culturing and the other (B) did not change it in comparison with lymphocyte monoculture. In stromal cells interacting with lymphocytes, expression of HLA-DR molecules was initiated, but only in samples that induced enhanced expression on lymphocytes and irrespectively of whether allogeneic or autologous lymphocytes were used for co-culturing with MSC...
August 18, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30121197/expression-and-characterization-of-monomeric-variable-lymphocyte-receptor-b-specific-to-the-glycoprotein-of-viral-hemorrhagic-septicemia-virus-vhsv
#3
Jung Seok Lee, Jaesung Kim, Se Pyeong Im, Si Won Kim, Jae Wook Jung, Jassy Mary S Lazarte, Jeong-Ho Lee, Kim D Thompson, Tae Sung Jung
Monomeric variable lymphocyte receptor B (VLRB) is one of the smallest binding scaffold (20-25 kDa) from jawless vertebrates, hagfish and lamprey. This relatively new class of binding scaffold has various advantages: i) it has a single peptide composition, amenable to molecular engineering for enhancing its stability and affinity; ii) it has a small size, contributing better tissue penetration and easier production using microorganism expression system. Monomeric arVLRB142, which can specifically bind to the glycoprotein of viral hemorrhagic septicemia virus (VHSV), was expressed in Pichia pastoris...
August 16, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/30120894/liver-complications-following-treatment-of-hematologic-malignancy-with-anti-cd22-calicheamicin-inotuzumab-ozogamicin
#4
George B McDonald, James W Freston, James L Boyer, Laurie D DeLeve
BACKGROUND AND RATIONALE: Treatment of hematologic malignancy with antibody-drug conjugates (ADC) may cause liver injury. ADCs deliver a toxic moiety into antigen-expressing tumor cells but may also injure hepatic sinusoids (Sinusoidal Obstruction Syndrome, SOS). We studied patients who received an anti-CD22-calicheamicin conjugate (inotuzumab ozogamicin) to gain insight into mechanisms of sinusoidal injury, as there are no CD22+ cells in the normal liver but non-specific uptake of ADCs by liver sinusoidal endothelial cells...
August 18, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30120837/comparative-analysis-of-immune-cell-subsets-in-peripheral-blood-from-patients-with-periodontal-disease-and-healthy-controls
#5
Wan-Chien Cheng, Fahd Saleh, Belkais Abuaisha Karim, Francis J Hughes, Leonie S Taams
Periodontitis is a chronic inflammatory disease caused by the colonisation of teeth by the bacterial plaque biofilm and the resultant host immune responses in adjacent periodontal tissues. Disease severity can vary dramatically between patients with periodontitis, with some subjects displaying inflammation without bony destruction (gingivitis), whilst others experience chronic progressive or rapidly aggressive gingival connective tissue damage and bone loss. To determine whether peripheral immune dysregulation is associated with periodontitis, we performed extensive analysis of immune cell subsets in peripheral blood from patients with chronic or aggressive periodontitis vs...
August 18, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30119931/immunomodulatory-effects-of-mesenchymal-stem-cells-on-leukocytes-with-emphasis-on-neutrophils
#6
REVIEW
Fatemeh Salami, Amin Tavassoli, Jalil Mehrzad, Abbas Parham
Mesenchymal stem cells (MSCs) are a population of multipotent cells with the ability of expansion and plastic-adherence in vitro. MSCs can differentiate into chondrocytes, osteocytes and adipocytes; they lack co-stimulatory molecules and have small amount of MHC-I that makes no immunogenicity. These characteristics are empowering MSCs' huge in vivo applications. In addition, MSCs possess the ability of regulating the immune responses in many diseases. Many studies have shown that MSCs have immunosuppressive as well as immunoenhancing properties such as inhibition of T-lymphocytes proliferation and cytokines production which lead to the balance of Th1 and Th2...
August 6, 2018: Immunobiology
https://www.readbyqxmd.com/read/30119091/effect-of-acid-suppression-on-peripheral-t-lymphocyte-subsets-and-immunohistochemical-esophageal-mucosal-changes-in-patients-with-gastroesophageal-reflux-disease
#7
Heba Ahmed Osman, Sanaa S Aly, Hasan S Mahmoud, Eman H Ahmed, Eman M Salah Eldin, Eman A Abdelrahim, Muhammad A El Masry, Rania A Herdan, Mohammed H Hassan
BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) is a common prevalent disease. We aimed to assess the dynamic changes in the peripheral T lymphocytes and lymphocytes infiltrating the esophageal mucosa after treatment with proton-pump inhibitor (PPI) in patients with GERD. PATIENTS AND METHODS: A total of 200 patients who presented with upper GIT symptoms were included in this prospective study. All patients were subjected to full history taking, clinical examination, and complete blood count...
August 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30117603/production-of-il-35-by-bregs-is-mediated-through-binding-of-batf-irf-4-irf-8-complex-to-il12a-and-ebi3-promoter-elements
#8
Cheng-Rong Yu, Jin Kyeong Choi, Anita N Uche, Charles E Egwuagu
IL-10 and IL-35 suppress excessive immune responses and therapeutic strategies are being developed to increase their levels in autoimmune diseases. In this study, we sought to identify major cell types that produce both cytokines in-vivo and to characterize mechanisms that regulate their production. Experimental autoimmune uveitis (EAU) is a CNS autoimmune disease that serves as model of human uveitis. We induced EAU in C57BL/6J mice and investigated whether T cells, B lymphocytes, or myeloid cells are the major producers of IL-10 or IL-35 in blood, lymph nodes (LNs), spleen, and at the site of ocular inflammation, the neuroretina...
August 17, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/30116751/distinct-changes-of-btla-and-hvem-expressions-in-circulating-cd4-and-cd8-t-cells-in-hepatocellular-carcinoma-patients
#9
Jiayu Liu, Jiaqian Li, Min He, Geng-Lin Zhang, Qiyi Zhao
BTLA/HVEM (B and T lymphocyte attenuator/herpes virus entry mediator) pathways play a critical role in T cell suppression in tumor. However, its dynamic changes in different T cell subsets in peripheral blood and their clinical significance are largely unclear in cancer patients. In the current study, we showed distinct changes of BTLA and HVEM expressions on peripheral blood CD4+ and CD8+ T cells in patients with hepatocellular carcinoma (HCC); BTLA expression were significantly upregulated on circulating CD4+ but not CD8+ T cells...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30116392/preliminary-investigation-on-the-abnormal-mechanism-of-cd4-foxp3-cd25-high-regulatory-t-cells-in-pediatric-b-cell-acute-lymphoblastic-leukemia
#10
Si-Xi Liu, Hai-Rong Xiao, Guo-Bing Wang, Xiao-Wen Chen, Chang-Gang Li, Hui-Rong Mai, Xiu-Li Yuan, Guo-Sheng Liu, Fei-Qiu Wen
The current study aimed to investigate the changes and regulatory mechanism of cluster of differentiation (CD)4+ CD25high forkhead box protein 3 (Foxp3+ ) regulatory T cells (Tregs) in childhood B-cell acute lymphocytic leukemia (B-ALL). A total of 18 children with B-ALL and 15 age-matched healthy children were included. Reverse-transcription quantitative polymerase chain reaction was used to evaluate the mRNA levels of Foxp3, cytotoxic T-lymphocyte associated protein 4 (CTLA4), glucocorticoid-induced tumor necrosis factor receptor (GITR), lymphocyte activation gene 3 (LAG3), interleukin (IL)-2 receptor (R)β/γ, IL-6Rα/β, mothers against decapentaplegic homolog (Smad)3/4 and runt-related transcription factor (RUNX)1/3 in CD4-positive cells...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30116333/lap-cd4-t-cells-are-elevated-among-the-peripheral-blood-mononuclear-cells-and-tumor-tissue-of-patients-with-hepatocellular-carcinoma
#11
Xi Ou, Jing Guan, Jing-Sen Chen, Jie-Cao Ying, Xiao-Ping Liu, Pei-Kai Tian, Ji-Kui Liu, Li-Ping Nie, Yang Zhao, Guang-Yin Yu
The purpose of the present study was to investigate the role of latency-associated peptide (LAP)+ CD4+ T cells in hepatocellular carcinoma (HCC) immunity. Flow cytometric analysis was performed to detect the proportion of LAP+ CD4+ T cells among the peripheral blood mononuclear cells (PBMCs) of 30 HBV-infected HCC patients at the pre-operative and post-operative stages, as well as 30 hepatitis B virus (HBV)-infected volunteers as a control group. Furthermore, tumor tissues and peri-tumor tissues from 28 patients with HCC, as well as hepatic tissues from 28 HBV-infected patients with benign lesions were subjected to immunohistochemical analysis with double staining for LAP and CD4, and the average number of the LAP+ CD4+ T cells in each visual field was quantified...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30116026/prognostic-role-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-bone-metastases
#12
Quirina C B S Thio, W Alexander Goudriaan, Stein J Janssen, Nuno Rui Paulino Pereira, Daniel M Sciubba, Rachel P Rosovksy, Joseph H Schwab
BACKGROUND: Skeletal metastases are a common problem in patients with cancer, and surgical decision making depends on multiple factors including life expectancy. Identification of new prognostic factors can improve survival estimation and guide healthcare providers in surgical decision making. In this study, we aim to determine the prognostic value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with bone metastasis. METHODS: One thousand and twelve patients from two tertiary referral centers between 2002 and 2014 met the inclusion criteria...
August 17, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30115596/bendamustine-followed-by-obinutuzumab-and-venetoclax-in-chronic-lymphocytic-leukaemia-cll2-bag-primary-endpoint-analysis-of-a-multicentre-open-label-phase-2-trial
#13
Paula Cramer, Julia von Tresckow, Jasmin Bahlo, Sandra Robrecht, Petra Langerbeins, Othman Al-Sawaf, Anja Engelke, Anna-Maria Fink, Kirsten Fischer, Eugen Tausch, Till Seiler, Ludwig Fischer von Weikersthal, Holger Hebart, Karl-Anton Kreuzer, Sebastian Böttcher, Matthias Ritgen, Michael Kneba, Clemens-Martin Wendtner, Stephan Stilgenbauer, Barbara Eichhorst, Michael Hallek
BACKGROUND: Targeted agents such as the type II anti-CD20 antibody obinutuzumab and the B-cell lymphoma-2 antagonist venetoclax have shown impressive therapeutic activity in chronic lymphocytic leukaemia. The CLL2-BAG trial was initiated to investigate the combination of these two agents in patients with chronic lymphocytic leukaemia. METHODS: In this ongoing multicentre, open-label, investigator-initiated phase 2 trial, patients (aged ≥18 years) with chronic lymphocytic leukaemia requiring treatment according to the 2008 International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria and an Eastern Cooperative Oncology Group performance status of 0-2 were enrolled at 16 sites in Germany...
August 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30114952/analysis-of-peripheral-blood-lymphocyte-subsets-in-critical-patients-at-icu-admission-a-preliminary-investigation-of-their-role-in-the-prediction-of-sepsis-during-icu-stay
#14
Antonella Frattari, Ennio Polilli, Vanessa Primiterra, Vincenzo Savini, Tamara Ursini, Giancarlo Di Iorio, Giustino Parruti
A better knowledge of factors predicting the development of sepsis in patients hospitalized in intensive care unit (ICU) might help deploy more targeted preventive and therapeutic strategies. In addition to the known clinical and demographic predictors of septic syndromes, in this study, we investigated whether measuring T and B lymphocyte subsets upon admission in the ICU may help individualize the prediction of ensuing sepsis during ICU stay. Between May 2015 and December 2016, we performed a prospective cohort study evaluating peripheral blood lymphocyte T-CD4+ (T-helper cells), T-CD8+ (cytotoxic T-cells), T-CD56 + (natural killer cells), and T-CD19+ (B-lymphocytes), using flow cytometry on blood samples collected 2 days after admission in the ICU...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/30114695/why-is-the-immunoglobulin-heavy-chain-gene-mutation-status-a-prognostic-indicator-in-chronic-lymphocytic-leukemia
#15
REVIEW
Uri Rozovski, Michael J Keating, Zeev Estrov
The immunoglobulin heavy chain gene (IgHV) mutation status correlates with the clinical outcome of patients with chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy. Why the survival rate of patients with unmutated IgHV is worse than that of patients with mutated IgHV is unknown. CLL cells with unmutated IgHV were thought to originate from naïve B lymphocytes, whereas CLL cells with mutated IgHV were thought to arise from B cells that have undergone somatic hypermutation (SHM). Cell surface protein expression profile and gene expression studies showing that all CLL cells, regardless of their IgHV mutation status, are of postgerminal center origin, negated this hypothesis...
August 16, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/30114200/co-expression-of-cd21l-and-il17a-defines-a-subset-of-rheumatoid-synovia-characterised-by-large-lymphoid-aggregates-and-high-inflammation
#16
Kelly J McKelvey, Melanie J Millier, Terence C Doyle, Lisa K Stamp, John Highton, Paul A Hessian
OBJECTIVE: To determine whether the expression of IL17A and CD21L genes in inflamed rheumatoid synovia is associated with the neogenesis of ectopic lymphoid follicle-like structures (ELS), and if this aids the stratification of rheumatoid inflammation and thereby distinguishes patients with rheumatoid arthritis that might be responsive to specific targeted biologic therapies. METHODS: Expression of IL17A and CD21L genes was assessed by RT-PCR, qRT-PCR and dPCR in synovia from 54 patients with rheumatoid arthritis...
2018: PloS One
https://www.readbyqxmd.com/read/30113996/addition-of-anti-cd40-monoclonal-antibody-to-nonmyeloablative-conditioning-with-belatacept-abrogated-allograft-tolerance-despite-induction-of-mixed-chimerism
#17
Tetsu Oura, Kiyohiko Hotta, Ivy Rosales, Abbas Dehnadi, Kent Kawai, Hang Lee, A Benedict Cosimi, Tatsuo Kawai
BACKGROUND: We recently reported anti-CD40 monoclonal antibody and rapamycin (aCD40/rapa) to be a reliable, nontoxic, immunosuppressive regimen for combined islet and kidney transplantation (CIKTx) in nonhuman primates (NHPs). In the current study, we attempted to induce allograft tolerance through the mixed chimerism approach using a conditioning regimen with aCD40 and belatacept (Bela). METHODS: Five CIKTx or kidney transplant (KTx) recipients were treated with aCD40/rapa for 4 months...
August 15, 2018: Transplantation
https://www.readbyqxmd.com/read/30112249/longitudinal-associations-of-lymphocyte-subsets-with-clinical-outcomes-in-chronic-fatigue-syndrome
#18
Melissa L Mehalick, Karen B Schmaling, Daniel E Sabath, Dedra S Buchwald
Background: Chronic fatigue syndrome (CFS) is characterized by prolonged fatigue and other physical and neurocognitive symptoms. Some studies suggest that CFS is accompanied by disruptions in the number and function of various lymphocytes. However, it is not clear which lymphocytes might influence CFS symptoms. Purpose: To determine if patient reported fatigue symptoms and physical functioning scores significantly changed across time with lymphocyte counts as evidence of a relation among chronic fatigue symptoms and the immune response...
2018: Fatigue: Biomedicine, Health and Behavior
https://www.readbyqxmd.com/read/30112073/predictive-value-of-the-neutrophil-to-lymphocyte-ratio-and-hemoglobin-insystemic-lupus-erythematosus
#19
Haitao Yu, Lili Jiang, Liqiong Yao, Chao Gan, Xinwen Han, Ruiqi Liu, Na Su
The aim of the present study was to evaluate the association of the neutrophil-to-lymphocyte ratio (NLR) and hemoglobin levels with disease activity in patients with systemic lupus erythematosus (SLE) and to explore their clinical significance in predicting SLE. The present study included 212 patients with SLE and 201 healthy controls. All the clinical characteristics were collected from their medical records. The results revealed that the NLR was elevated and the hemoglobin level was markedly decreased in the patients with SLE compared with the healthy controls...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30111869/flt3-ligand-treatment-reduces-enterovirus-a71-lethality-in-mice-with-enhanced-b-cell-responses
#20
Yu-Wen Lin, Li-Chiu Wang, Chien-Kuo Lee, Shun-Hua Chen
Enterovirus A71 (EV-A71) infection can induce encephalitis, which causes death or long-term neurological sequelae, especially in young children. Using a murine infection model, we searched for anti-EV-A71 agents, because effective therapies are not available to control fatal infection. In EV-A71-infected mice, treatment with the hematopoietic growth factor, Fms-like tyrosine-kinase 3 ligand (Flt3 ligand) before infection reduced the lethality and tissue viral loads. Flt3 ligand failed to enhance the production of type I interferons...
August 15, 2018: Scientific Reports
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