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https://www.readbyqxmd.com/read/30317805/-effect-of-crotonaldehyde-long-term-exposure-induced-kidney-inflammatory-and-oxidative-injury-in-male-rats
#1
B Zhang, S S Li, L Li, R Han, Z H Zhang
Objective: To observe the effect of crotonaldehyde long-term exposure on kidney injury in male rats, and to explore the specific mechanism of toxic action. Methods: 32 specific pathogen free healthy adult male wistar rats were randomly divided into 4 groups with 8 rats in each group: high-, moderate-, low-dose groups and a control group. Rats were treated with 8.5, 4.5, 2.5 and 0.0 mg/kg body weight crotonaldehyde by gavage, once a day for consecutive 128 days. After the last treatment, they were sacrificed and separated bilateral kidney...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/30317798/-research-progress-in-prognostic-factors-of-hepatitis-b-virus-associated-end-stage-liver-disease
#2
X Feng, X F Shi
Hepatitis B remains a worldwide health problem with a high mortality rate associated with end-stage liver diseases. The Model for End-Stage Liver Disease and Child-Pugh score is still widely used as the prognostic model for liver cirrhosis and inflammatory reaction, B-type natriuretic peptide and portal vein thrombosis are independent risk factors. Many new models have been proposed for liver failure, including a new model HINAT ACLF. HINAT ACLF is better than its preceding models and increased neutrophil-to-lymphocyte ratio is a single factor to promote thyroid hormone, cholinesterase, and antiviral treatment response in this model...
August 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317780/-a-case-report-of-hepatitis-b-virus-reactivation-in-both-anti-hbs-hbc-positive-patients-with-chronic-lymphocytic-leukemia-after-chemotherapy
#3
Z R Yang, Q J Sheng, X Zhong, B B Kong, Y Ding, X G Dou
No abstract text is available yet for this article.
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317758/-study-on-effect-and-mechanism-of-honokiol-enhancing-tumor-necrosis-factor-related-apoptosis-inducing-ligand-against-hepatocellular-carcinoma-hepg2-cells-via-activating-jnk-signaling-pathway
#4
G Xiao, R Yang, L Dang, C L Dong
Objective: To investigate the effect and intrinsic mechanism of Honokiol (HNK) enhanced tumor necrosis factor-related apoptosis inducing ligand (TRAIL) on hepatocellular carcinoma HepG2 cells. Methods: HepG2 cells were routinely cultured. Firstly, a concentration gradient of HNK was given to observe its effect on the vitality of tumor cells. Western blot were used to detect change in the expression levels of c-jun N-terminal kinase (JNK), death receptor 4 (DR4), and DR5.Secondly, we observed the effect of combined drugs (HNK and TRAIL) on the vitality of tumor cells...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317064/metaphylactic-effect-of-minerals-on-immunological-and-antioxidant-responses-weight-gain-and-minimization-of-coccidiosis-of-newborn-lambs
#5
Chrystian J Cazarotto, Jhonatan P Boito, Roger R Gebert, João H Reis, Gustavo Machado, Nathieli B Bottari, Vera M Morsch, Maria R C Schetinger, Pedro H Doleski, Marta L R Leal, Matheus D Baldissera, Aleksandro S Da Silva
The aim of this study was to evaluate the metaphylactic effect of minerals on immunological and antioxidant responses, as well as performance and prevention of coccidiosis in newborn lambs. We divided 110 newborn lambs into two groups (55/group): control (untreated) and treated with two doses of 0.33 mL/kg of a mineral complex (zinc, copper, selenium, and manganese) on day of life (DOL) 1 and 30. Total blood was collected at DOL 1, 15, 30 and 45 to measure antioxidant enzymes, biochemical and immunology analyses, and haemogram...
September 28, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/30316899/reduced-intensity-conditioning-regimens-prior-chronic-lymphocytic-leukemia-and-graft-versus-host-disease-are-associated-with-higher-rates-of-skin-cancer-following-allogeneic-hematopoietic-stem-cell-transplantation
#6
Peggy A Wu, Robert S Stern, Victor Huang, Kevin X Liu, Chen Amy Chen, Dimitrios Tzachanis, Robin M Joyce, Roger B Davis, Vincent T Ho
No abstract text is available yet for this article.
October 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30316365/clinical-significance-of-serum-visfatin-in-renal-transplant-recipients
#7
K-H Shu, H-F Chiu, M-J Wu, C-H Chen, T-M Yu
Chronic antibody-mediated rejection is the most common cause of late graft loss in renal transplant recipients. Visfatin is a pre-B cell colony-enhancing factor secreted by activated lymphocytes. We hypothesize that visfatin may play a role in the augmentation of B cell colonies and facilitate antibody-mediated rejection. Renal transplant recipients were randomly selected for the study. Fasting blood samples were obtained for the assay of visfatin. The participants were prospectively followed up for 3 years...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316074/ketotifen-fumarate-attenuates-feline-gingivitis-related-with-gingival-microenvironment-modulation
#8
Weifeng Yuan, Shaohua Hou, Hong Jia, Zhizhao Qiu, Tao Liu, Xinsheng Chen, Hongjun Li, Yanchen Sun, Lin Liang, Xiukun Sui, Xinghui Zhao, Zhanzhong Zhao
Gingivitis is evidenced by inflammation of the free gingiva, and still reversible. If left untreated, it may then progress to periodontitis. In the present study, the therapeutical effect of ketotifen fumarate on gingivitis was explored. Domestic cats with varying degrees of gingivitis naturally were enrolled in this study. Subgroups of animals were treated twice daily for one week with or without ketotifen fumarate (5 mg/kg). Effects of ketotifen fumarate were measured on gingival index, cells accumulation, mediators release, receptor-ligand interaction, oxidative stress, MAPK and NF-κB pathways, epithelial barrier and apoptosis...
October 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30315937/peroxiredoxin-interaction-with-the-cytoskeletal-regulatory-protein-crmp2-investigation-of-a-putative-redox-relay
#9
Paul E Pace, Alexander V Peskin, Andreas Konigstorfer, Christine J Jasoni, Christine C Winterbourn, Mark B Hampton
Hydrogen peroxide (H2 O2 ) acts as a signaling molecule in cells by oxidising cysteine residues in regulatory proteins such as phosphatases, kinases and transcription factors. It is unclear exactly how many of these proteins are specifically targeted by H2 O2 because they appear too unreactive to be directly oxidised. One proposal is that peroxiredoxins (Prxs) initially react with H2 O2 and then oxidise adjacent proteins via a thiol relay mechanism. The aim of this study was to identify constitutive interaction partners of Prx2 in Jurkat T-lymphoma cells, in which thiol protein oxidation occurs at low micromolar concentrations of H2 O2 ...
October 10, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30315828/advances-in-mechanisms-of-allergic-disease-2017
#10
Chrysanthi Skevaki, Harald Renz
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; TH 2 lymphocytes; B cells; dendritic cells: microbiome and barrier function; eosinophils, mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (TH 2) as well as innate (ILC2) effector cells. New pathways of lymphocyte activation, trafficking and recruitment, and effector cell mechanisms have been discovered...
October 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30315344/prognostic-and-therapeutic-stratification-in-cll-focus-on-17p-deletion-and-p53-mutation
#11
REVIEW
Valeria Buccheri, Wolney Gois Barreto, Laura Maria Fogliatto, Marcelo Capra, Mariana Marchiani, Vanderson Rocha
Chronic lymphocytic leukemia (CLL), a disorder for which B cell heterogeneity and increased cellular proliferation play central pathogenic roles, displays several genetic abnormalities that are associated with poor prognosis and have therapeutic implications. In this review, we discuss the prognostic role and therapeutic implications of chromosome 17p deletions and TP53 mutations in CLL. Unlike other recurrent genetic abnormalities, the frequency of TP53 alterations is relatively low in newly diagnosed patients, but increases sharply with disease progression, which suggests that these alterations represent an evolutionary mechanism of resistance...
October 12, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30313065/richter-s-syndrome-of-the-central-nervous-system-diagnosed-concurrently-with-chronic-lymphocytic-leukaemia-a-case-report-and-literature-review
#12
Liye Xu, Jin Cheng Song, Xiu Hua Sun, Zi Fen Gao, Li Lv, Jie Zhu
RATIONALE: Central nervous system (CNS) infiltration of Richter's syndrome (RS) is rare and only a few cases were discussed. Of these published cases, either they were accompanied with lymph node involvement or with a history of chronic lymphocytic leukemia (CLL). To our knowledge, this is the first published case of RS of the brain and meninges diagnosed concurrently with CLL in the absence of any evidence of lymphoma outside of the CNS. PATIENT CONCERNS: A 67-year-old female presented with slurred speech, headache, and left-sided hemiparesis...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312414/low-frequency-of-opportunistic-infections-in-patients-receiving-vedolizumab-in-clinical-trials-and-post-marketing-setting
#13
Siew C Ng, Ida Normiha Hilmi, Aimee Blake, Fatima Bhayat, Shashi Adsul, Qasim Rana Khan, Deng-Chyang Wu
Background: Vedolizumab (ENTYVIO) is a humanized α4β7 integrin antagonist approved for the treatment of inflammatory bowel disease, which selectively blocks gut-specific lymphocyte trafficking. We evaluated the risk of opportunistic infections of interest in patients treated with vedolizumab. Methods: We determined the frequency of opportunistic infections and tuberculosis in patients receiving vedolizumab in phase 3 clinical trials and post-marketing settings...
October 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30312311/rates-of-immune-cell-infiltration-in-patients-with-triple-negative-breast-cancer-by-molecular-subtype
#14
Kenichi Harano, Ying Wang, Bora Lim, Robert S Seitz, Stephan W Morris, Daniel B Bailey, David R Hout, Rachel L Skelton, Brian Z Ring, Hiroko Masuda, Arvind U K Rao, Steven Van Laere, Francois Bertucci, Wendy A Woodward, James M Reuben, Savitri Krishnamurthy, Naoto T Ueno
In patients with triple-negative breast cancer (TNBC), tumor-infiltrating lymphocytes (TILs) are associated with improved survival. Lehmann et al. identified 4 molecular subtypes of TNBC [basal-like (BL) 1, BL2, mesenchymal (M), and luminal androgen receptor (LAR)], and an immunomodulatory (IM) gene expression signature indicates the presence of TILs and modifies these subtypes. The association between TNBC subtype and TILs is not known. Also, the association between inflammatory breast cancer (IBC) and the presence of TILs is not known...
2018: PloS One
https://www.readbyqxmd.com/read/30311429/s-s-peg-cooh-self-assembled-monolayer-on-gold-surface-enabled-a-combined-assay-for-serological-ebv-antibody-isotypes
#15
Hui Lv, Lei Ye, Qian Liu, Song-Guo Li, Tao Li, Na-Li Huang, Yi Gao, Li-Bin Fan, Wei-Dong Du
PURPOSE: Epstein-Barr virus (EBV) is a ubiquitous human gamma herpes virus that infects human epithelial cells and B lymphocytes. EXPERIMENTAL DESIGN: A simple antigen-probed biochip, which was modified with S-S-PEG-COOH and was used as a label-free high-throughput screening method for a combined detection of EBV capsid antigen IgM antibody, capsid antigen IgG antibody and nuclear antigen IgG antibody. RESULTS: This protein biochip had similar feasibility, sensitivity and specificity in comparison with Liaison CLIA...
October 11, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/30311254/generation-of-an-equine-biobank-to-be-used-for-functional-annotation-of-animal-genomes-project
#16
E N Burns, M H Bordbari, M J Mienaltowski, V K Affolter, M V Barro, F Gianino, G Gianino, E Giulotto, T S Kalbfleisch, S A Katzman, M Lassaline, T Leeb, M Mack, E J Müller, J N MacLeod, B Ming-Whitfield, C R Alanis, T Raudsepp, E Scott, S Vig, H Zhou, J L Petersen, R R Bellone, C J Finno
The Functional Annotation of Animal Genomes (FAANG) project aims to identify genomic regulatory elements in both sexes across multiple stages of development in domesticated animals. This study represents the first stage of the FAANG project for the horse, Equus caballus. A biobank of 80 tissue samples, two cell lines and six body fluids was created from two adult Thoroughbred mares. Ante-mortem assessments included full physical examinations, lameness, ophthalmologic and neurologic evaluations. Complete blood counts and serum biochemistries were also performed...
October 11, 2018: Animal Genetics
https://www.readbyqxmd.com/read/30310541/acute-liver-failure-secondary-to-severe-systemic-disease-from-fatal-hemophagocytic-lymphohistiocytosis-case-report-and-systematic-literature-review
#17
Mitchell S Cappell, Ismail Hader, Mitual Amin
AIM: To systematically review liver disease associated with hemophagocytic lymphohistiocytosis (HLH), propose reasonable contraindications for liver transplantation for liver failure in HLH, and report an illustrative case. METHODS: Systematic review according to PRISMA guidelines of hepatic manifestations of HLH using computerized literature search via PubMed of articles published since 1980 with keywords ("hemophagocytic lymphohistiocytosis" or "HLH") AND ("liver" or "hepatic")...
September 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/30310085/quantitative-b-lymphocyte-deficiency-and-increased-tcr%C3%AE-%C3%AE-t-lymphocytes-in-acute-infectious-spondylodiscitis
#18
Anna K Haugaard, Hanne V Marquart, Lilian Kolte, Lars Peter Ryder, Michala Kehrer, Maria Krogstrup, Ulrik B Dragsted, Benny Dahl, Ida E Gjørup, Åse B Andersen, Peter Garred, Susanne D Nielsen
Acute infectious spondylodiscitis (AIS) is a serious infection of the spine with rising incidence and a mortality of 3-6%. The role of the immune system in AIS is largely unknown. We performed extensive B and T-lymphocyte phenotyping in patients with AIS at diagnosis and after treatment cessation. In this prospective multicentre study, flow cytometric analysis of T and B-lymphocyte subsets was performed in 35 patients at diagnosis and 3 months after treatment cessation. We additionally analysed levels of immunoglobulins and IgG subclasses, serum level and genetic variants of mannose-binding lectin, and somatic hypermutation...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30309686/racial-discrimination-and-leukocyte-glucocorticoid-sensitivity-implications-for-birth-timing
#19
Shannon L Gillespie, Cindy M Anderson
RATIONALE: Psychological stress-induced cortisol elevations appear to contribute to preterm birth. Yet, some studies suggest that the biological ramifications of racial discrimination-associated stress are unique and may involve development of decreased glucocorticoid sensitivity despite normalized cortisol levels. OBJECTIVE: In this study, we examined the effects of racial discrimination on maternal cortisol output, leukocyte glucocorticoid sensitivity, and the degree of correspondence between cortisol levels and birth timing in an African American cohort...
November 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/30308033/presence-of-lymphocytic-infiltrate-cytotoxic-t-lymphocyte-cd3-cd8-and-immunoscore-as-prognostic-marker-in-patients-after-radical-cystectomy
#20
Alice Yu, Jose Joao Mansure, Shraddha Solanki, D Robert Siemens, Madhuri Koti, Ana B T Dias, Miguel M Burnier, Fadi Brimo, Wassim Kassouf
Tumor-Infiltrating Lymphocytes (TILs) has been shown to be essential to predict disease outcome in several types of cancers. Moreover, the distribution of cytotoxic T lymphocytes (CD8+) and T cells in general (CD3+) have been used to establish an Immunoscore, as a new cancer prognosticator for survival in colon and lung cancer. In bladder cancer, immune activation has been shown to be associated with genomic subtypes of muscle invasive bladder cancer (MIBC). We sought to evaluate the prognostic impact of these immune cell types in MIBC patients treated with radical cystectomy...
2018: PloS One
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