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https://www.readbyqxmd.com/read/28951797/earlier-intervention-with-deep-brain-stimulation-for-parkinson-s-disease
#1
REVIEW
Gerson Suarez-Cedeno, Jessika Suescun, Mya C Schiess
Neuromodulation of subcortical areas of the brain as therapy to reduce Parkinsonian motor symptoms was developed in the mid-twentieth century and went through many technical and scientific advances that established specific targets and stimulation parameters. Deep Brain Stimulation (DBS) was approved by the FDA in 2002 as neuromodulation therapy for advanced Parkinson's disease, prompting several randomized controlled trials that confirmed its safety and effectiveness. The implantation of tens of thousands of patients in North America and Europe ignited research into its potential role in early disease stages and the therapeutic benefit of DBS compared to best medical therapy...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28735132/asleep-robot-assisted-surgery-for-the-implantation-of-subthalamic-electrodes-provides-the-same-clinical-improvement-and-therapeutic-window-as-awake-surgery
#2
COMPARATIVE STUDY
Michel Lefranc, Yassine Zouitina, Mélissa Tir, Philippe Merle, Martial Ouendo, Jean-Marc Constans, Olivier Godefroy, Johann Peltier, Pierre Krystkowiak
OBJECTIVE: To study the impact of not performing awake clinical evaluation during the robot-assisted implantation of subthalamic nucleus deep brain stimulation (STN-DBS) electrodes on the stimulation parameters and clinical outcomes in patients with Parkinson disease (PD). METHODS: A total of 23 patients with PD underwent robot-assisted surgery for the bilateral implantation of STN-DBS electrodes. Thirteen patients received general anesthesia (GA) and a limited intraoperative evaluation (side effects only), and the other 10 patients received local anesthesia (LA) and a full evaluation...
October 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28669542/opposite-effects-of-l-dopa-and-dbs-stn-on-saccadic-eye-movements-in-advanced-parkinson-s-disease
#3
Małgorzata Dec-Ćwiek, Marcin Tutaj, Jean-Michel Gracies, Jens Volkmann, Monika Rudzińska, Agnieszka Słowik, Andrzej Szczudlik
OBJECTIVE: To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD). METHODS: Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their "med-off" (OFF) and "med-on" (ON) status, whereas 20 DBS-STN treated patients were assessed in their "med-off, stim-off" (OFF) and "med-off, stim-on" (ON) status...
September 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28528805/acute-response-of-non-motor-symptoms-to-subthalamic-deep-brain-stimulation-in-parkinson-s-disease
#4
Margherita Fabbri, Miguel Coelho, Leonor Correia Guedes, Mario M Rosa, Daisy Abreu, Nilza Gonçalves, Angelo Antonini, Joaquim J Ferreira
BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) is an established treatment for the motor complications of Parkinson's disease (PD) and may have beneficial effects on non-motor symptoms (NMS). However, the acute effect of STN stimulation on NMS has only been explored in small PD cohorts with short post-surgical follow-up. OBJECTIVE: To study NMS response to an acute stimulation challenge in an STN-DBS PD population with a medium/long-term post-surgical follow-up...
August 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28298702/fixed-versus-mixed-rsa-%C3%A2-explaining-visual-representations-by-fixed-and-mixed-feature-sets-from-shallow-and-deep-computational-models
#5
Seyed-Mahdi Khaligh-Razavi, Linda Henriksson, Kendrick Kay, Nikolaus Kriegeskorte
Studies of the primate visual system have begun to test a wide range of complex computational object-vision models. Realistic models have many parameters, which in practice cannot be fitted using the limited amounts of brain-activity data typically available. Task performance optimization (e.g. using backpropagation to train neural networks) provides major constraints for fitting parameters and discovering nonlinear representational features appropriate for the task (e.g. object classification). Model representations can be compared to brain representations in terms of the representational dissimilarities they predict for an image set...
February 2017: Journal of Mathematical Psychology
https://www.readbyqxmd.com/read/27766724/effect-of-high-frequency-subthalamic-neurostimulation-on-gait-and-freezing-of-gait-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
C Schlenstedt, A Shalash, M Muthuraman, D Falk, K Witt, G Deuschl
The aim of this meta-analysis was to summarize the short- and long-term effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on gait and freezing of gait (FOG) in Parkinson's disease and to detect predictors of post-stimulation outcome. A comprehensive review of the literature was conducted up to October 2015 using Medline Ovid databases for studies analyzing the effect of bilateral STN-DBS on FOG and/or gait. Sixteen studies with available data for the gait item (no. 29) of the Unified Parkinson's Disease Rating Scale (UPDRS) and six studies with the FOG item (no...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27491538/does-the-use-of-intraoperative-microelectrode-recording-influence-the-final-location-of-lead-implants-in-the-ventral-intermediate-nucleus-for-deep-brain-stimulation
#7
Sujan Reddy, Albert Fenoy, Erin Furr-Stimming, Mya Schiess, Raja Mehanna
To determine if the use of intraoperative microelectrode recording (MER) influences the final location of lead implant in deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM), and to evaluate the incidence of associated complications. The usefulness of intraoperative MER in DBS is debated, some centers suggesting it increases complications without additional benefit. We conducted a retrospective chart review of all patients who underwent VIM DBS with MER at the University of Texas Health Science Center in Houston from June 1, 2009 to October 1, 2013...
April 2017: Cerebellum
https://www.readbyqxmd.com/read/27399413/134%C3%A2-vantage-trial-three-year-outcomes-of-a-prospective-multicenter-trial-evaluating-deep-brain-stimulation-with-a-new-multiple-source-constant-current-rechargeable-system-in-parkinson-disease
#8
Lars Timmermann, Roshini Jain, Lilly Chen, Thomas Brucke, Fernando Seijo, Esther Suarez San Martin, Claire Haegelen, Marc Verin, Veerle Visser-Vandewalle, Michael T Barbe, Steven Gill, Alan Whone, Mauro Porta, Domenico Servello, Francois Alesch
INTRODUCTION: Deep brain stimulation (DBS) has been demonstrated to be effective for Parkinson disease (PD) symptom relief. We sought to characterize the benefit of subthalamic nucleus (STN) DBS for PD patients using a recently CE-marked multiple-source, constant-current system that permits a well-defined distribution of applied current. We report the 3-year results of the first clinical trial using multiple independent current control (MICC) DBS in the management of symptoms of PD. METHODS: VANTAGE is a monitored, prospective, multicenter, nonrandomized, open-label interventional trial sponsored by Boston Scientific Corporation...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/26195164/chronic-deep-brain-stimulation-of-the-medial-forebrain-bundle-reverses-depressive-like-behavior-in-a-hemiparkinsonian-rodent-model
#9
Luciano L Furlanetti, Volker A Coenen, Iñigo A Aranda, Máté D Döbrössy
Preclinical and clinical evidence suggests that depression might be associated with a dysfunction in the reward/motivation circuitry. Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (MFB) has been shown in a recent clinical trial to provide a prompt and consistent improvement of depressive symptoms in treatment-resistant patients. In order to better understand the underlying mechanisms of neuromodulation in the context of depression, the effects of chronic bilateral MFB-DBS were assessed in a combined rodent model of depression and Parkinson's disease...
November 2015: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/26156511/effects-of-subthalamic-nucleus-stimulation-on-motor-cortex-plasticity-in-parkinson-disease
#10
Sang Jin Kim, Kaviraja Udupa, Zhen Ni, Elena Moro, Carolyn Gunraj, Filomena Mazzella, Andres M Lozano, Mojgan Hodaie, Anthony E Lang, Robert Chen
OBJECTIVE: We hypothesized that subthalamic nucleus (STN) deep brain stimulation (DBS) will improve long-term potentiation (LTP)-like plasticity in motor cortex in Parkinson disease (PD). METHODS: We studied 8 patients with PD treated with STN-DBS and 9 age-matched healthy controls. Patients with PD were studied in 4 sessions in medication (Med) OFF/stimulator (Stim) OFF, Med-OFF/Stim-ON, Med-ON/Stim-OFF, and Med-ON/Stim-ON states in random order. Motor evoked potential amplitude and cortical silent period duration were measured at baseline before paired associated stimulation (PAS) and at 3 different time intervals (T0, T30, T60) up to 60 minutes after PAS in the abductor pollicis brevis and abductor digiti minimi muscles...
August 4, 2015: Neurology
https://www.readbyqxmd.com/read/26001501/voice-tremor-in-patients-with-essential-tremor-effects-of-deep-brain-stimulation-of-caudal-zona-incerta
#11
Patricia Hägglund, Linda Sandström, Patric Blomstedt, Fredrik Karlsson
OBJECTIVES: The present study aimed at evaluating the effect of deep brain stimulation (DBS) of the caudal zona incerta (cZi) on voice tremor in patients with essential tremor (ET). STUDY DESIGN: This is a prospective nonrandomized design with consecutive patients. METHODS: Twenty-six patients operated with cZi DBS were evaluated under two conditions: without stimulation (Stim OFF) and with stimulation (Stim ON). Voice tremor was assessed on the basis of recordings of sustained vowel productions using a four-point rating scale in a blinded and randomized procedure...
March 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/25983689/disruption-in-proprioception-from-long-term-thalamic-deep-brain-stimulation-a-pilot-study
#12
Jennifer A Semrau, Troy M Herter, Zelma H Kiss, Sean P Dukelow
Deep brain stimulation (DBS) is an excellent treatment for tremor and is generally thought to be reversible by turning off stimulation. For tremor, DBS is implanted in the ventrointermedius (Vim) nucleus of the thalamus, a region that relays proprioceptive information for movement sensation (kinaesthesia). Gait disturbances have been observed with bilateral Vim DBS, but the long-term effects on proprioceptive processing are unknown. We aimed to determine whether Vim DBS surgical implantation or stimulation leads to proprioceptive deficits in the upper limb...
2015: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/24455344/syncope-associated-with-subthalamic-nucleus-deep-brain-stimulation-in-a-patient-with-parkinson-s-disease
#13
Dursun Aygun, Ersoy Kocabicak, Onur Yildiz, Musa Kazim Onar, Hatice Guz, Omer Boke, Murat Kurt, Yasin Temel
In advanced Parkinson's disease (PD), deep brain stimulation (DBS) may be an alternative option for the treatment of motor symptoms. Side effects associated with subthalamic nucleus (STN) DBS in patients with PD are emerging as the most frequent sensory and motor symptoms. DBS-related syncope is reported as extremely rare. We wanted to discuss the mechanisms of syncope associated with STN DBS in a patient with Parkinson's disease. Case report. Sixty-three-year-old female patient is followed up with diagnosis of idiopathic Parkinson's disease for 6 years in our clinic...
2013: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/24353336/effect-of-subthalamic-nucleus-deep-brain-stimulation-on-driving-in-parkinson-disease
#14
Carsten Buhmann, Lea Maintz, Jonas Hierling, Eik Vettorazzi, Christian K E Moll, Andreas K Engel, Christian Gerloff, Wolfgang Hamel, Wolfgang H Zangemeister
OBJECTIVE: To examine the influence of subthalamic nucleus (STN) deep brain stimulation (DBS) on driving in patients with Parkinson disease (PD). METHODS: Using a driving simulator setup proven to reflect on-road driving, 2 main analyses were performed: 1) comparison of driving performance among 23 patients with deep brain surgery (DBS patients), 21 patients without surgery (no-DBS patients), and 21 controls; and 2) analysis of the effect of stimulation vs levodopa on driving performance...
January 7, 2014: Neurology
https://www.readbyqxmd.com/read/24249783/controlled-general-anaesthesia-for-subthalamic-nucleus-stimulation-in-parkinson-s-disease
#15
F Fluchere, T Witjas, A Eusebio, N Bruder, R Giorgi, M Leveque, J-C Peragut, J-P Azulay, J Regis
OBJECTIVE: To report the short-term (1 year) and long-term (5 years) outcome of patients with Parkinson's disease (PD) with subthalamic nucleus (STN) stimulation operated upon under controlled general anaesthesia (GA). METHODS: 213 consecutive patients with PD were included between January 2000 and March 2009 and operated upon under a particular type of GA with close control of the level of sedation allowing intraoperative recordings. 188 patients were assessed 1 year postoperatively...
October 2014: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/24126022/the-impact-of-age-and-disease-duration-on-the-long-term-outcome-of-neurostimulation-of-the-subthalamic-nucleus
#16
Ali Shalash, Athanasia Alexoudi, Karina Knudsen, Jens Volkmann, Maximilian Mehdorn, Günther Deuschl
BACKGROUND: Selection of patients with Parkinson's disease for neurostimulation of subthalamic nucleus (STN-DBS) is still poorly studied. AIM: To identify the impact of age and disease duration on the outcome of bilateral STN-DBS. METHODS: 110 operated patients in a single center covering a large range of age and disease duration were retrospectively included and followed for up-to 5 years. Standardized UPDRS assessments were obtained at 0...
January 2014: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/23670034/chronic-30-hz-deep-cerebellar-stimulation-coupled-with-training-enhances-post-ischemia-motor-recovery-and-peri-infarct-synaptophysin-expression-in-rodents
#17
Andre G Machado, Jessica Cooperrider, Havan T Furmaga, Kenneth B Baker, Hyun-Joo Park, Zhihong Chen, John T Gale
BACKGROUND: Over 500,000 Americans have strokes every year, making stroke the leading cause for disability in the United States and in the industrialized world. New treatments to improve poststroke motor recovery are needed. OBJECTIVE: To investigate a novel approach for enhancing motor recovery that involves chronic, electrical stimulation of ascending cerebellar output combined with motor training. METHODS: Adult Sprague-Dawley rats underwent unilateral endothelin-1 injections in the dominant cerebral cortex and placement of a chronic stimulating electrode in the contralateral lateral cerebellar nucleus...
August 2013: Neurosurgery
https://www.readbyqxmd.com/read/23633215/deep-brain-stimulation-of-the-subthalamic-nucleus-regulates-postabsorptive-glucose-metabolism-in-patients-with-parkinson-s-disease
#18
Marie Batisse-Lignier, Isabelle Rieu, Christelle Guillet, Estelle Pujos, Béatrice Morio, Jean-Jacques Lemaire, Franck Durif, Yves Boirie
OBJECTIVE: Subthalamic nucleus-deep brain stimulation (STN-DBS) is an alternative treatment for patients with uncontrolled symptoms of Parkinson's disease (PD), but it has other nonmotor impact. Because STN-DBS alters the energy expenditure in humans, we hypothesized that STN-DBS may affect postabsorptive glucose metabolism in patients with PD. RESEARCH DESIGN AND METHODS: Endogenous glucose production (EGP) and whole-body glucose disposal rates (GDRs) were assessed in the postabsorptive state during a primed continuous iv infusion of D-[6,6-(2)H2]glucose for 5 hours in 8 STN-DBS-treated patients with PD, without (Stim-OFF) and during STN-DBS (Stim-ON) treatment...
June 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/22522070/control-of-phonatory-onset-and-offset-in-parkinson-patients-following-deep-brain-stimulation-of-the-subthalamic-nucleus-and-caudal-zona-incerta
#19
Fredrik Karlsson, Patric Blomstedt, Katarina Olofsson, Jan Linder, Erik Nordh, Jan van Doorn
Laryngeal hypokinesia is a common symptom in Parkinson's disease (PD) that affects quality of life. Deep brain stimulation (DBS) is well recognized as a complementary method for treatment of motor symptoms in PD but the outcomes on patients' control over phonatory alternation have yet not been clearly elucidated. The present study examined the effect of subthalamic nucleus STN-DBS (n = 8, aged 51-72 yrs; median = 63 yrs) and caudal Zona incerta cZi-DBS (n = 8, aged 49-71 yrs; median = 61 yrs) on control of onset and offset of phonation in connected speech...
August 2012: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/22437494/successful-subthalamic-stimulation-but-levodopa-induced-dystonia-in-a-genetic-parkinson-s-disease
#20
Alessandro Stefani, Francesco Marzetti, Mariangela Pierantozzi, Simona Petrucci, Enrica Olivola, Salvatore Galati, Mario Stampanoni Bassi, Paola Imbriani, Enza Maria Valente, Francesco Saverio Pastore
Recently, it is under scrutiny the possibility to anticipate the stereotactic implantation of the subthalamic nucleus (STN) even in relatively mild Parkinson's disease (PD) patients with an unsatisfying response to drugs. In addition, it is debated whether levodopa (LD) and deep brain stimulation (DBS) are congruent or, instead, mutually exclusive. A 56-year-old LRRK2-positive PD patient, with 7 years of disease history, dominated by severe left resting tremor, was submitted to bilateral implantation of the subthalamic nucleus (STN)...
March 2013: Neurological Sciences
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