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Reverse remodeling after myocardial infarction

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https://www.readbyqxmd.com/read/30101604/inhibition-of-microrna-9-5p-protects-against-cardiac-remodeling-following-myocardial-infarction-in-mice
#1
Yimin Xiao, Yanxia Zhang, Yueqiu Chen, Jingjing Li, Zihan Zhang, Yimin Sun, Han Shen, Zhenao Zhao, Zan Huang, Wencheng Zhang, Weiqian Chen, Zhenya Shen
Follistatin-like 1 (Fstl1) protects cardiomyocytes from a broad spectrum of pathologic injuries including myocardial infarction (MI). It is worthy of note that although cardiac Fstl1 is elevated in post-MI microenvironment, its cardioprotective role is still restricted to a limited extent considering the frequency and severity of adverse cardiac remodeling following MI. We therefore propose that intrinsic Fstl1-suppressing microRNA (miRNA) may exist in the heart and its neutralization may further facilitate post-MI recovery...
August 13, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/30090932/associations-of-circulating-extracellular-rnas-with-myocardial-remodeling-and-heart-failure
#2
Ravi V Shah, Jian Rong, Martin G Larson, Ashish Yeri, Olivia Ziegler, Kahraman Tanriverdi, Venkatesh Murthy, Xiaojun Liu, Chunyang Xiao, Alexander R Pico, Tianxiao Huan, Daniel Levy, Gregory D Lewis, Anthony Rosenzweig, Ramachandran S Vasan, Saumya Das, Jane E Freedman
Importance: Mortality is high among patients heart failure (HF) who are receiving treatment, and therefore identifying new pathways rooted in preclinical cardiac remodeling phenotypes may afford novel biomarkers and therapeutic avenues. Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects relevant to myocardial biology, although large human investigations remain limited. Objective: To measure the association of highly expressed circulating ex-RNAs with left ventricular remodeling and incident HF in a community-based cohort...
August 8, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/30058704/liraglutide-improves-myocardial-fibrosis-after-myocardial-infarction-through-inhibition-of-ctgf-by-activating-camp-in-mice
#3
D-D Huang, H-F Huang, Q Yang, X-Q Chen
OBJECTIVE: To study the role and mechanism of liraglutide in myocardial fibrosis after myocardial infarction (MI). MATERIALS AND METHODS: A total of 72 C57/BL male mice were randomly divided into sham operation group (Sham group), myocardial infarction group (MI group), and liraglutide intervention group (Lira group). The left anterior descending coronary artery (LAD) of the mice in MI group and Lira group was ligated to establish the MI model. One week after the operation, the mice in Lira group were intraperitoneally injected with 100 μg/kg of liraglutide once a day for 4 weeks...
July 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29952845/the-matter-of-reverse-ventricular-remodeling-after-acute-myocardial-infarction-between-fiction-and-reality
#4
Serenella Castelvecchio, Francesco Moroni, Lorenzo Menicanti
No abstract text is available yet for this article.
August 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29875658/integration-of-metabonomics-and-transcriptomics-reveals-the-therapeutic-effects-and-mechanisms-of-baoyuan-decoction-for-myocardial-ischemia
#5
Zhiyong Du, Zeliu Shu, Wei Lei, Chun Li, Kewu Zeng, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang
Myocardial ischemia (MI) is an escalating public health care burden worldwide. Baoyuan decoction (BYD) is a traditional Chinese medicine formula with cardioprotective activity; however, its pharmacological characteristics and mechanisms are obscured. Herein, a multi-omics strategy via incorporating the metabonomics, transcriptomics, and pharmacodynamics was adopted to investigate the effects and molecular mechanisms of BYD for treating MI in a rat model of left anterior descending coronary artery (LADCA) ligation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29851019/sulfur-dioxide-ameliorates-rat-myocardial-fibrosis-by-inhibiting-endoplasmic-reticulum-stress
#6
Xin-Bao Wang, Hong Cui, Jun-Bao Du
Myocardial remodeling occurs after myocardial infarction (MI), the leading cause of mortality worldwide. Although myocardial fibrosis plays an important role in the process of myocardial remodeling, there is not yet an effective method of reducing it. The aim of the present study was to determine the effects of sulfur dioxide (SO₂) on myocardial fibrosis and the possible mechanisms of these effects. SO₂ treatment reduced the extent of myocardial fibrosis and post-MI levels of collagens I and III in the left-ventricular myocardium...
May 31, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29761875/mir-130-aggravates-acute-myocardial-infarction-induced-myocardial-injury-by-targeting-ppar-%C3%AE
#7
Xianglin Chu, Yiqing Wang, Liewen Pang, Jiechun Huang, Xiaotian Sun, Xiaofeng Chen
Cardiac remodeling is a common pathophysiological change associated with acute myocardial infarction (AMI). Recent evidence indicates that microRNAs are strong posttranscriptional regulators which play an important role in regulating the microenvironment of myocardial tissue after AMI. In this study, we sought to explore the potential role and underlying mechanism of miR-130 in AMI. H9c2 cells were cultured under hypoxic conditions to simulate myocardial infarction. The influence of aberrantly expressed miR-130 on H9c2 cells under hypoxia was also estimated with RT-PCR, western blot and enzyme-linked immunosorbent assay...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29716898/load-dependent-changes-in-left-ventricular-structure-and-function-in-a-pathophysiologically-relevant-murine-model-of-reversible-heart-failure
#8
Carla J Weinheimer, Attila Kovacs, Sarah Evans, Scot J Matkovich, Philip M Barger, Douglas L Mann
BACKGROUND: To better understand reverse left ventricular (LV) remodeling, we developed a murine model wherein mice develop LV remodeling after transverse aortic constriction (TAC) and a small apical myocardial infarct (MI) and undergo reverse LV remodeling after removal of the aortic band. METHODS AND RESULTS: Mice studied were subjected to sham (n=6) surgery or TAC+MI (n=12). Two weeks post-TAC+MI, 1 group underwent debanding (referred to as heart failure debanding [HF-DB] mice; n=6), whereas the aortic band remained in a second group (heart failure [HF] group; n=6)...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29678512/galectin-3-is-associated-with-left-ventricular-reverse-remodeling-and-outcome-after-percutaneous-mitral-valve-repair
#9
Christine S Zuern, Niklas Floss, Iris I Mueller, Christian Eick, Martin Duckheim, Johannes Patzelt, Meinrad Gawaz, Andreas E May, Karin A L Mueller
BACKGROUND: Plasma Galectin-3 is a marker of myocardial inflammation and fibrosis, was associated with left ventricular (LV) reverse remodeling after conventional surgical mitral valve repair (MVR) and predicted clinical events in patients undergoing transcatheter aortic valve replacement (TAVR). We aimed to evaluate the association between pre-interventional Galectin-3 levels and (1) reverse LV remodeling and (2) major adverse cardiovascular events (MACE) in patients undergoing percutaneous MVR...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29524303/tanshinone-iia-prevents-left-ventricular-remodelling-via-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signalling-pathway-in-rats-with-myocardial-infarction
#10
Dong-Mei Wu, Yong-Jian Wang, Xin-Rui Han, Xin Wen, Lei Li, Lan Xu, Jun Lu, Yuan-Lin Zheng
In this study, we aim to investigate the role of tanshinone IIA in myocardial infarction (MI), especially in left ventricular remodelling (VR) and the underlying mechanism involving the TLR4/MyD88/NF-κB signalling pathway. Sprague-Dawley (SD) rats (n = 96) were selected, and 12 of them underwent sham surgery. The remaining 84 rats were subjected to MI modelling. HE and MT staining were carried out to estimate infract size, histopathological changes and fibrosis degree. Macrophage infiltration and cardiomyocyte apoptosis were evaluated by immunohistochemistry and TUNEL staining...
June 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29523183/association-of-serum-adamts-7-levels-with-left-ventricular-reverse-remodeling-after-st-elevation-myocardial-infarction
#11
Wenjing Wu, Jiahui Li, Changan Yu, Yanxiang Gao, Shuying Fan, Xiaojun Ye, Yong Wang, Jingang Zheng
BACKGROUND: Left ventricular reverse remodeling (LVRR) in patients with ST-elevation myocardial infarction (STEMI) is associated with a good prognosis. Serum levels of ADAMTS-7 might be used for the prognosis of STEMI. This study aimed to investigate the relationship between serum ADAMTS-7 levels and LVRR. METHODS: This was a prospective study of 104 patients with STEMI who underwent revascularization and 63 controls. ADAMTS-7 serum levels were measured on days 1, 3, and 7 and in months 1 and 6 after STEMI...
March 10, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29460403/effects-of-ivabradine-on-endothelial-function-aortic-properties-and-ventricular-arterial-coupling-in-chronic-systolic-heart-failure-patients
#12
Ivano Bonadei, Edoardo Sciatti, Enrico Vizzardi, Davide Fabbricatore, Mattia Pagnoni, Laura Rossi, Valentina Carubelli, Carlo M Lombardi, Marco Metra
AIM: Heart rate (HR) is an important prognostic factor in patients affected by chronic heart failure (CHF); ivabradine has been demonstrated to significantly reduce nonfatal myocardial infarction and hospitalization rate for acute heart failure and to improve left ventricular (LV) reverse remodeling, quality of life, exercise capacity, and arterial elastance (Ea) in these patients. We aimed at evaluating the short-term effects of ivabradine on ventricular-arterial coupling (VAC), aortic stiffness, and endothelial function in stable patients with CHF...
February 20, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29425550/efficacy-of-intramyocardial-injection-of-algisyl-lvr-for-the-treatment-of-ischemic-heart-failure-in-swine
#13
Jenny S Choy, Shuang Leng, Gabriel Acevedo-Bolton, Semion Shaul, Lijuan Fu, Xiaomei Guo, Liang Zhong, Julius M Guccione, Ghassan S Kassab
BACKGROUND: Progressive thinning and dilation of the LV due to ischemic heart failure (IHF) increases wall stress and myocardial oxygen consumption. Injectable biopolymers implanted in the myocardial wall have been used to increase wall thickness to reduce chamber volume, decrease wall stress, and improve cardiac function. We sought to evaluate the efficacy of a biopolymer (Algisyl-LVR) to prevent left ventricular (LV) remodeling in a swine model of IHF. METHODS: IHF was induced in 11 swine by occluding the marginal obtuse branches of the left circumflex artery...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29408714/effect-of-exercise-training-on-left-ventricular-mechanics-after-acute-myocardial-infarction-an-exploratory-study
#14
Gordon McGregor, Eric J Stöhr, David Oxborough, Peter Kimani, Rob Shave
BACKGROUND: Cardiac rehabilitation (CR) exercise training is beneficial after myocardial infarction (MI). Whilst the peripheral adaptations to training are well defined, little is known regarding the effect on left ventricular (LV) remodelling, particularly LV function. Efficient LV ejection and filling is achieved through deformation and rotation of the myocardium in systole and diastole - LV mechanics. The response of LV mechanics to CR exercise training in MI patients is unknown. METHODS: In this observational exploratory study, 36 (of 40 enrolled) male, MI patients completed either 10-weeks of twice-weekly gym based cardiovascular exercise at 60-80% VO2peak (n=18), or a non-exercise control period (n=18)...
May 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29366748/exercise-training-versus-t3-and-t4-hormones-treatment-the-differential-benefits-of-thyroid-hormones-on-the-parasympathetic-drive-of-infarcted-rats
#15
Rayane Brinck Teixeira, Alexsandra Zimmer, Alexandre Luz de Castro, Cristina Campos Carraro, Karina Rabello Casali, Ingrid Gonçalves Machuca Dias, Alessandra Eifler Guerra Godoy, Isnard Elman Litvin, Adriane Belló-Klein, Alex Sander da Rosa Araujo
AIMS: This study aimed to investigate whether beneficial effects of thyroid hormones are comparable to those provided by the aerobic exercise training, to verify its applicability as a therapeutic alternative to reverse the pathological cardiac remodeling post-infarction. MATERIALS AND METHODS: Male rats were divided into SHAM-operated (SHAM), myocardial infarction (MI), MI subjected to exercise training (MIE), and MI who received T3 and T4 treatment (MIH) (n = 8/group)...
March 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29358197/impact-of-renal-denervation-on-atrial-arrhythmogenic-substrate-in-ischemic-model-of-heart-failure
#16
Shinya Yamada, Man-Cai Fong, Ya-Wen Hsiao, Shih-Lin Chang, Yung-Nan Tsai, Li-Wei Lo, Tze-Fan Chao, Yenn-Jiang Lin, Yu-Feng Hu, Fa-Po Chung, Jo-Nan Liao, Yao-Ting Chang, Hsing-Yuan Li, Satoshi Higa, Shih-Ann Chen
BACKGROUND: Myocardial infarction increases the risk of heart failure (HF) and atrial fibrillation. Renal denervation (RDN) might suppress the development of atrial remodeling. This study aimed to elucidate the molecular mechanism of RDN in the suppression of atrial fibrillation in a HF model after myocardial infarction. METHODS AND RESULTS: HF rabbits were created 4 weeks after coronary ligation. Rabbits were classified into 3 groups: normal control (n=10), HF (n=10), and HF-RDN (n=6)...
January 22, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29276930/-perfusion-metabolic-myocardial-scintigraphy-in-prognosis-of-left-ventricular-remodeling-after-complex-surgical-treatment-of-ischemic-cardiomyopathy
#17
Y B Lishmanov, M O Gulya, K V Zavadovsky, S L Andreev, E A Alexandrova
PURPOSE: To study capabilities of perfusion-metabolic myocardial scintigraphy for prediction of the left ventricular (LV) reverse remodeling after comprehensive surgical treatment of ischemic cardiomyopathy (ICMP). METHODS: The study included ICMP patients aged 56±7 years (n=32) who underwent surgical correction of LV dysfunction (myocardial revascularization, LV reconstruction, and mitral valve restoration). Inclusion criteria were significant coronary artery disease; myocardial infarction; New York Heart Association (NYHA) class III-IV heart failure; LV ejection fraction (EF) ≤45%; LV end-systolic index (ESI) >60 mL/m2; and LV akinesia or dyskinesia according to echocardiography...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29249485/application-of-polymer-mesh-device-to-remodel-left-ventricular-mitral-valve-apparatus-in-ischemic-mitral-regurgitation
#18
Akihisa Kataoka, Xin Zeng, J Luis Guerrero, Adam Kozak, Gavin Braithwaite, Robert A Levine, Gus J Vlahakes, Judy Hung
OBJECTIVES: Ischemic mitral regurgitation (IMR) results from ischemic left ventricular (LV) distortion and remodeling, which displaces the papillary muscles and tethers the mitral valve leaflets apically. The aim of this experimental study was to examine efficacy of an adjustable novel polymer filled mesh (poly-mesh) device to reverse LV remodeling and reduce IMR. METHODS: Acute (N = 8) and chronic (8 weeks; N = 5) sheep models of IMR were studied. IMR was produced by ligation of circumflex branches to create myocardial infarction...
April 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29216197/shift-toward-greater-pathologic-post-myocardial-infarction-remodeling-with-loss-of-the-adaptive-hypertrophic-signaling-of-alpha1-adrenergic-receptors-in-mice
#19
Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang, Paul C Simpson, Michael J Mann
RATIONALE: We have hypothesized that post-infarction cardiac remodeling can be influenced by shifts in the balance between intracellular mediators of "pathologic" and "physiologic" hypertrophy. Although alpha1 adrenergic receptors (alpha1-ARs) mediate pro-adaptive hypertrophy during pressure overload, little is known about their role or downstream mediators after myocardial infarction. METHODS: We performed loss-of-function experiments via coronary ligation in alpha1A-AR knockout (AKO) mice...
2017: PloS One
https://www.readbyqxmd.com/read/28980299/extracellular-vesicles-in-post-infarct-ventricular-remodelling
#20
Aleksandra Gąsecka, Edwin van der Pol, Rienk Nieuwland, Ewa Stępień
No abstract text is available yet for this article.
2018: Kardiologia Polska
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