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https://www.readbyqxmd.com/read/30316188/microrna-199a-may-be-involved-in-the-pathogenesis-of-lupus-nephritis-via-modulating-the-activation-of-nf-%C3%AE%C2%BAb-by-targeting-klotho
#1
Hong Ye, Bofeng Su, Haizhen Ni, Linlin Li, Xuduan Chen, Xiaohan You, Huidi Zhang
Klotho is considered to have renal protective effect by prohibiting the activation of the nuclear factor (NF)-κB pathway, while the role of microRNA-199a (miR-199a)/Klotho in lupus nephritis (LN) is still unknown. A single dose of pristane (0.5 ml) was intraperitoneally injected into 8 weeks-old female mice to establish the LN model. MiR-199a mimic or miR-199a inhibitor, Klotho plasmid or Klotho siRNA, and miR-199a inhibitor plus si-Klotho were transfected into lipopolysaccharides (LPS) stimulated human embryonic kidney 293 T (HEK293 T) cells...
October 10, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/30316074/ketotifen-fumarate-attenuates-feline-gingivitis-related-with-gingival-microenvironment-modulation
#2
Weifeng Yuan, Shaohua Hou, Hong Jia, Zhizhao Qiu, Tao Liu, Xinsheng Chen, Hongjun Li, Yanchen Sun, Lin Liang, Xiukun Sui, Xinghui Zhao, Zhanzhong Zhao
Gingivitis is evidenced by inflammation of the free gingiva, and still reversible. If left untreated, it may then progress to periodontitis. In the present study, the therapeutical effect of ketotifen fumarate on gingivitis was explored. Domestic cats with varying degrees of gingivitis naturally were enrolled in this study. Subgroups of animals were treated twice daily for one week with or without ketotifen fumarate (5 mg/kg). Effects of ketotifen fumarate were measured on gingival index, cells accumulation, mediators release, receptor-ligand interaction, oxidative stress, MAPK and NF-κB pathways, epithelial barrier and apoptosis...
October 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30312114/repurposing-simvastatin-as-a-therapy-for-preterm-labor-evidence-from-preclinical-models
#3
Ashley K Boyle, Sara F Rinaldi, Adriano G Rossi, Philippa T K Saunders, Jane E Norman
Preterm birth (PTB), the leading cause of neonatal morbidity and mortality, urgently requires novel therapeutic agents. Spontaneous PTB, resulting from preterm labor, is commonly caused by intrauterine infection/inflammation. Statins are well-established, cholesterol-lowering drugs that can reduce inflammation and inhibit vascular smooth muscle contraction. We show that simvastatin reduced the incidence of PTB in a validated intrauterine LPS-induced PTB mouse model, decreased uterine proinflammatory mRNA concentrations (IL-6, Cxcl1, and Ccl2), and reduced serum IL-6 concentration...
October 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30307604/il4-10-fusion-protein-a-novel-immunoregulatory-drug-combining-activities-of-il-4-il-10
#4
C Steen-Louws, S A Y Hartgring, J Popov-Celeketic, A P Lopes, M B M de Smet, N Eijkelkamp, F P J G Lafeber, C E Hack, J A G van Roon
OBJECTIVE: To test the capacity of a newly developed fusion protein of IL-4 and IL-10 (IL4-10 FP) to shift multiple pro-inflammatory pathways towards immune regulation, and to inhibit pro-inflammatory activity in arthritis models. METHODS: The effects of IL4-10 FP in comparison with IL-4, IL-10 and IL-4 plus IL-10 on pro- and anti-inflammatory mediators, T-cells, and Ig receptors in favour of immunoregulatory activity were studied. In addition, the capacity of IL4-10 FP to inhibit pro-inflammatory activity in ex-vivo and in-vivo arthritis models was investigated...
October 11, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30303516/nci-8628-a-randomized-phase-2-study-of-ziv-aflibercept-and-high-dose-interleukin-2-or-high-dose-interleukin-2-alone-for-inoperable-stage-iii-or-iv-melanoma
#5
Ahmad A Tarhini, Paul Frankel, Christopher Ruel, Marc S Ernstoff, Timothy M Kuzel, Theodore F Logan, Nikhil I Khushalani, Hussein A Tawbi, Kim A Margolin, Sanjay Awasthi, Lisa H Butterfield, David McDermott, Alice Chen, Primo N Lara, John M Kirkwood
BACKGROUND: Interleukin 2 (IL-2) is a growth factor for T and natural killer cells, promotes proinflammatory cytokines, and can lead to durable responses in patients with melanoma. Vascular endothelial growth factor (VEGF) promotes angiogenesis and modulates host innate and adaptive immunity. High VEGF levels were found to be associated with nonresponse to IL-2. Ziv-aflibercept may deplete VEGF and thereby enhance antitumor T-cell responses, thus supporting a combination immunotherapeutic strategy with IL-2...
October 10, 2018: Cancer
https://www.readbyqxmd.com/read/30301506/smar1-promotes-immune-escape-of-tri-negative-breast-cancer-through-a-mechanism-involving-t-bet-pd-1-axis
#6
Wang Xiaohua, Xu Hongxia, Deng Rong, Wu Pingping, Huang Xing, Zhu Yichao, Chen Cheng
This study was aimed at investigating the specific molecular mechanisms involved in the regulation of immune escape of triple-negative breast cancer (TNBC) by SMRI, so as to provide a new clinical treatment target for the disease. Mouse original 4T1 breast cancer cells were inoculated subcutaneously in BALB/C to establish TNBC mouse model. CD8+T cells with immunological effects were selected from mouse thymus glands for primary culture. The CD8+positive T cells were infected with lentivirus interference vectors, and the proliferation of CD8+ T cells were determined by trypan blue staining and flow cytometry...
September 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/30296620/design-and-development-of-ph-responsive-polyurethane-membranes-for-intravaginal-release-of-nanomedicines
#7
Seungil Kim, Yannick Leandre Traore, Emmanuel A Ho, Muhammad Shafiq, Soo-Hyun Kim, Song Liu
The objective of this study was to develop and characterize a novel intravaginal membrane platform for pH-triggered release of nanoparticles (NPs), which is essential for efficient intravaginal delivery of certain effective but acid-labile therapeutic agents for sexually transmitted infections, such as small interfering RNA (siRNA). pH-responsive polyurethane (PU) was electrospun into a porous nanofibrous membrane. The diameters of the fibers, as well as the thickness and pore sizes of the membrane under dry and wet conditions (pH 4...
October 5, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30295964/estradiol-regulated-innate-antiviral-responses-of-human-endometrial-stromal-fibroblasts
#8
Mickey V Patel, Zheng Shen, Richard M Rossoll, Charles R Wira
PROBLEM: The contribution of fibroblasts to innate immune protection of the human female reproductive tract (FRT) against viral pathogens is relatively unknown. METHOD OF STUDY: Endometrial (EM), endocervical (Cx) and ectocervical (ECx) fibroblasts were isolated from hysterectomy patients and grown in vitro. Fibroblasts were treated with the viral mimic poly (I:C) in the presence or absence of the sex hormone estradiol (E2 ), with gene expression measured by real-time RT-PCR and protein secretion by ELISA...
September 17, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/30295126/innate-inflammatory-bioregulation-and-clinical-effectiveness-of-whole-body-hyperthermia-balneotherapy-in-elderly-patients-with-osteoarthritis
#9
Isabel Gálvez, Silvia Torres-Piles, Eduardo Ortega
OBJECTIVES: Balneotherapy with mud application (mud therapy) is a common hydrothermal intervention for the treatment and rehabilitation of elderly patients with osteoarthritis, leading to anti-inflammatory effects. The main purpose of this investigation was to study a role for regulatory T cells in these anti-inflammatory effects. The second objective was to assess whether the neutrophil-mediated innate response is affected by these anti-inflammatory effects. METHODS: Thirty-six elderly patients with knee osteoarthritis underwent a 10-day cycle of balneotherapy at a spa center...
October 8, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/30294773/the-immune-influence-of-a-parabiosis-model-on-tumour-bearing-mice
#10
Nan Feng, Jian Min Luo, Ximin Guo
AIM: The aim of this study was to analyse the immune influence of a parabiosis model on tumour-bearing mice. METHODS: Parabiosis was established between C57BL/6 wild-type mice expressing green fluorescent protein (GFP+) and C57BL/6 wild-type mice without green fluorescent protein (GFP) to ensure blood cross-circulation between animals, and then the expression of CD4+ T cells, CD8+ T cells and interleukins 2, 4 and 10, and interferon-gamma (INF-γ) in spleen cells of parabiosis model mice were examined with flow cytometry...
September 24, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/30293597/acute-fish-oil-supplementation-modulates-the-inflammatory-response-after-strenuous-exercise-in-obese-men-a-cross-over-study
#11
Alessandra Peres, Gilson P Dorneles, Maria Carolina R Boeira, Lucas L Schipper, Ângela Beretta, Thais Vilela, Vanessa M Andrade, Pedro R T Romão
AIM: To evaluate the effects of acute fish oil supplementation (FOS) in DNA damage, lymphocyte phenotype and cytokines production after strenuous exercise in obese individuals. METHODS: Sixteen sedentary obese (BMI >30.0 to <35.0 kg/m²) men performed two sessions of exhaustive exercise and consumed 2000 mg of either placebo or fish oil one hour before the exercise session; trials were separated by 14 days. Peripheral blood mononuclear cells were collected pre, immediately after and 1 h after both exercise sessions and stimulated in vitro with 2% phytohemagglutinin for cytokines secretion (IL-6, IL-8, TNF-α)...
October 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/30293352/-effect-of-dexmedetomidine-on-perioperative-inflammatory-response-and-cellular-immune-in-patients-undergoing-radical-operation-of-thoracoscopic-lung-cancer
#12
L Kong, X H Lu
Objective: To evaluate the effect of dexemdetomidine on perioperative inflammatory response and cellular immune in patients undergoing radical operation of thoracoscopic lung cancer. Methods: One hundred and twenty patients undergone radical operation of thoracoscopic lung cancer were randomly divided into control group(group B) and dexemdetomidine group(group A), 60 patients in each group. They were all implemented one-lung ventilation. In group A, dexmedetomidine at a loading dose of 1.0 μg/kg was intravenously infused starting from 20 min before anesthesia induction, followed by continuous infusion of 0...
September 25, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/30291166/il-4-and-il-13-guide-early-thymic-progenitors-to-mature-toward-dendritic-cells
#13
Subhasis Barik, Alexis N Cattin-Roy, Mindy M Miller, Tobechukwu K Ukah, Habib Zaghouani
Recently we reported that IL-4 and IL-13 signaling in murine early thymic progenitors (ETPs) expressing the heteroreceptor (HR) comprising IL-4 receptor α (IL-4Rα) and IL-13 receptor α 1 (IL-13Rα1) activate STAT6 and inhibit ETP maturation potential toward T cells. In this study, we asked whether IL-4 and IL-13 signaling through the HR mobilizes other STAT molecules to shape ETP fate decision. The findings indicate that HR+ ETPs undergoing cytokine signaling display increased STAT1, but not STAT3, phosphorylation in addition to STAT6 activation...
October 5, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30288998/chemokine-and-adhesion-molecule-profiles-in-aqueous-humor-of-clinically-quiescent-uveitic-cataracts
#14
Minghang Pei, Xinshu Liu, Chan Zhao, Fei Gao, Yong Tao, Meifen Zhang
PURPOSE: To investigate the chemokine and adhesion molecule profiles in aqueous humor (AH) of eyes with inactive uveitis and their correlations with inflammation relapse after cataract surgery. METHODS: Patients with inactive uveitis who underwent cataract surgery between July 2014 and January 2016 at our center were included. Undiluted AH samples (100-120 µl) were obtained through lateral corneal incisions during surgery, and concentrations of monocyte chemoattractant protein 1 (MCP-1/CCL2), macrophage inflammatory protein 1 (MIP-1), interleukin 8 (IL-8), regulated on activation, normal T cell expressed and secreted (RANTES/CCL5), soluble vascular cell adhesion molecule (sVCAM) and soluble intercellular adhesion molecule (sICAM) were measured by cytometric bead array (BD Bioscience, San Jose, CA)...
October 5, 2018: Current Eye Research
https://www.readbyqxmd.com/read/30285512/the-effect-of-a-polysaccharide-based-multinutrient-dietary-supplementation-regimen-on-infections-and-immune-functioning-in-multiple-sclerosis
#15
H Reginald McDaniel, Christopher LaGanke, Laura Bloom, Sharon Goldberg, Lucas C Lages, Laura A Lantigua, Steven E Atlas, Judi M Woolger, John E Lewis
Multiple sclerosis (MS) is a progressive neurodegenerative disease associated with increased infection rates, chronic inflammation, and premature death. Optimization of nutritional status via dietary supplementation may improve immune function in people suffering from MS and lead to decreased rates of infection. Fifteen individuals with a diagnosis of relapsing-remitting MS for an average of 12.4 years (SD =7.4; R = 2, 25) were enrolled in a one-year open-label clinical trial. Participants consumed a broad-spectrum dietary supplement regimen containing polysaccharides, phytochemicals, antioxidants, vitamins, and minerals three times per day...
October 4, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/30284691/adaptation-to-occupational-exposure-to-moderate-endotoxin-concentrations-a-study-in-sewage-treatment-plants-in-germany
#16
M A Rieger, V Liebers, M Nübling, T Brüning, B Brendel, F Hoffmeyer, M Raulf
Acute or chronic inhalation of endotoxin may lead to changes of lung function and inflammatory markers in the airways. Adaptation to workplace exposure may be possible. In this study, we investigated the possible difference in inflammatory markers assessed in nasal lavage fluid (NALF) in chronical exposure compared to voluntary subjects exposed acutely to endotoxin. We sought to define the variability of inflammatory markers in NALF and the dose-related changes after moderate exposure in naïve subjects. Endotoxin exposure (4-1039 EU/m3 ) resulted from routine work during one shift in sewage treatment plants...
October 5, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30282826/the-dilfrequency-study-is-an-adaptive-trial-to-identify-optimal-il-2-dosing-in-patients-with-type-1-diabetes
#17
Eleonora Seelig, James Howlett, Linsey Porter, Lucy Truman, James Heywood, Jane Kennet, Emma L Arbon, Katerina Anselmiova, Neil M Walker, Ravinder Atkar, Marcin L Pekalski, Ed Rytina, Mark Evans, Linda S Wicker, John A Todd, Adrian P Mander, Simon Bond, Frank Waldron-Lynch
BACKGROUND: Type 1 diabetes (T1D) results from loss of immune regulation, leading to the development of autoimmunity to pancreatic β cells, involving autoreactive T effector cells (Teffs). Tregs, which prevent autoimmunity, require IL-2 for maintenance of immunosuppressive functions. Using a response-adaptive design, we aimed to determine the optimal regimen of aldesleukin (recombinant human IL-2) to physiologically enhance Tregs while limiting expansion of Teffs. METHODS: DILfrequency is a nonrandomized, open-label, response-adaptive study of participants, aged 18-70 years, with T1D...
October 4, 2018: JCI Insight
https://www.readbyqxmd.com/read/30278208/bacterial-respiratory-tract-inflammation-in-neonatal-rat-model-is-attenuated-by-benzofuran-through-inhibition-of-gata3
#18
Aibibai Aierken, Peiru Xu
The current study was aimed to investigate the effect of benzofuran on asthma neonatal rat model. Twenty-five neonatal rats were assigned into five groups; Normal control, untreated, 1 mg/kg, 8 mg/kg and 10 mg/kg treatment groups. Methacholine was administered orally to the rats of untreated and treatment groups. Animals in the normal control group were given PBS as a vehicle. FlexiVent system employing a computer-controlled mouse ventilator along with respiratory mechanics was used for the analysis of airway resistance in the rats...
September 29, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30277854/the-acute-effect-of-training-fire-exercises-on-fire-service-instructors
#19
Emily R Watkins, Mark Hayes, Peter Watt, Alan Richardson
Fire service instructors (FSI) regularly experience different types of fire exercises, however the strain experienced from these scenarios is not well understood. This study aims to identify the physiological and perceptual strain of Fire Service Instructors (FSI) to three training exercises: DEMO, ATTACK, COMPARTMENT, and the different roles performed: SETTER, INSTRUCTOR. The study also aims to assess the effect that different exercise patterns over a day (BOX, MULTI, COMBINATION) have on immunological responses...
October 2, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/30272133/matrix-solid-phase-dispersion-combined-with-hplc-dad-for-simultaneous-determination-of-nine-lignans-in-saururus-chinensis
#20
Hongjiang Chen, Tao Ji, Jianwei Chen, Xiang Li
A simple and rapid method, based on matrix solid-phase dispersion (MSPD) and high-performance liquid chromatography (HPLC) was developed for simultaneous determination of nine lignans, including (-)-(7R,8R)-machilin D (Wang, C., Wang, P., Chen, X., Wang, W., Jin, Y.; Saururus chinensis (Lour.) Baill blocks enterovirus 71 infection by hijacking MEK1-ERK signaling pathway; Antiviral Research, (2015); 119:47-56), dihydroguaiaretic acid (Quan, Z., Lee, Y.J., Yang, J.H., Lu,Y., Li,Y., Lee,Y.K., et al.; Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation; Journal of Ethnopharmacology, (2010); 132:143-149...
October 1, 2018: Journal of Chromatographic Science
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