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https://www.readbyqxmd.com/read/30093956/vincamine-prevents-lipopolysaccharide-induced-inflammation-and-oxidative-stress-via-thioredoxin-reductase-activation-in-human-corneal-epithelial-cells
#1
Li Wu, Meihong Ye, Jie Zhang
Lipopolysaccharide (LPS) induced keratitis is a progressive infectious ocular disease in which innate inflammatory responses often cause clinical tissue damage and vision loss. In this study, the potential protective effects of vincamine, a plant alkaloid used clinically as a peripheral vasodilator, against LPS induced inflammation and oxidative stress were investigated on human corneal epithelial cells (HCECs). HCECs were treated with LPS and vincamine at various concentrations. Cell viability, reactive oxygen species (ROS) levels, and the gene expression levels of interleukin-6 (IL-6), IL-8, IL-1β, TNF-α, transforming growth factor-β (TGF-β) in HCECs, were assessed...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30088437/interactions-between-the-aggregatibacter-actinomycetemcomitans-secretin-hofq-and-host-cytokines-indicate-a-link-between-natural-competence-and-interleukin-8-uptake
#2
Tuuli Ahlstrand, Annamari Torittu, Heli Elovaara, Hannamari Välimaa, Marja T Pöllänen, Sergo Kasvandik, Martin Högbom, Riikka Ihalin
Naturally competent bacteria acquire DNA from their surroundings to survive in nutrient-poor environments and incorporate DNA into their genomes as new genes for improved survival. The secretin HofQ from the oral pathogen Aggregatibacter actinomycetemcomitans has been associated with DNA uptake. Cytokine sequestering is a potential virulence mechanism in various bacteria and may modulate both host defense and bacterial physiology. The objective of this study was to elucidate a possible connection between natural competence and cytokine uptake in A...
2018: Virulence
https://www.readbyqxmd.com/read/30087730/immunotherapy-in-allergic-rhinitis-it-s-effect-on-the-immune-system-and-clinical-symptoms
#3
Samaneh Kouzegaran, Mohammad Ali Zamani, Reza Faridhosseini, Houshang Rafatpanah, Abdolrahim Rezaee, Hadis Yousefzadeh, Rahman Movahed, Farahzad Jabbari Azad, Hooman Tehrani
BACKGROUND: Allergic rhinitis is one of the most common allergic diseases and characterised by sneezing, rhinorrhea, nasal congestion and nasopharyngeal itching. Subcutaneous immunotherapy (SCIT) for specific allergens is an effective treatment and induces the inhibitory effect of T regulatory lymphocytes and decreases clinical symptoms in allergic rhinitis. AIM: In this study effect of subcutaneous immunotherapy with specific allergens on clinical symptoms and T regulatory and T Helper cells cytokines, in patients with allergic rhinitis are evaluated...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/30087107/cxcr5-and-icos-expression-identifies-a-cd8-t-cell-subset-with-t-fh-features-in-hodgkin-lymphomas
#4
Kieu-Suong Le, Patricia Amé-Thomas, Karin Tarte, Françoise Gondois-Rey, Samuel Granjeaud, Florence Orlanducci, Etienne D Foucher, Florence Broussais, Reda Bouabdallah, Thierry Fest, Dominique Leroux, Sapna Yadavilli, Patrick A Mayes, Luc Xerri, Daniel Olive
A better characterization of T-cell subsets in the microenvironment of classical Hodgkin lymphoma (cHL) would help to develop immunotherapies. Using multicolor flow cytometry, we identified in 6 of 43 cHL tissue samples a previously unrecognized subset of CD8 T cells coexpressing CXCR5 and inducible T-cell costimulator (ICOS) molecules (CD8CXCR5+ICOS+ ). These cells shared phenotypic features with follicular helper T (TFH ) cells including low CCR7 expression together with high expression of B-cell lymphoma-6, programmed cell death 1, B and T lymphocyte attenuator, CD200, and OX40...
August 14, 2018: Blood Advances
https://www.readbyqxmd.com/read/30083140/-staphylococcus-aureus-bacteriophage-suppresses-lps-induced-inflammation-in-mac-t-bovine-mammary-epithelial-cells
#5
Lili Zhang, Xiang Hou, Lichang Sun, Tao He, Ruicheng Wei, Maoda Pang, Ran Wang
Several previous studies have shown that bacteriophages can significantly affect the production of various cytokines. The aim of this present study was to investigate the inflammatory effects and mechanisms of bacteriophage vB_SauM_JS25 in stimulated MAC-T bovine mammary epithelial cells by real-time polymerase chain reaction (PCR) and Western blotting. Experiments show that vB_SauM_JS25 reduces Staphylococcus aureus - or lipopolysaccharide (LPS)-induced levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-10, and regulated on activation, normal T cell expressed and secreted (RANTES) mRNA in MAC-T cells, in a manner expected to be unrelated to its antibacterial action...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30081688/il-17a-and-il-23-plausible-risk-factors-to-induce-age-associated-inflammation-in-alzheimer-s-disease
#6
Vahid Mohammadi Shahrokhi, Ali Ravari, Tayebeh Mirzaei, Mohammad Zare-Bidaki, Gholamreza Asadikaram, Mohammad Kazemi Arababadi
BACKGROUND: Aging and its complications such as Alzheimer's disease (AD) are associated with chronic low-grade inflammation entitled age-associated inflammation. However, the main mechanisms whichinduce age-associated inflammation in aging and AD are yet to beclarified. L-23/IL-17A axis plays important roles in the induction of inflammation and consequently autoimmune disease. This review evaluates the main roles played by IL-17A, IL-23, and IL-17A/IL-23 axis in the pathogenesis of age-associated inflammation in AD patients...
August 6, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/30078983/anti-inflammatory-activity-of-ckc-containing-cationic-emulsion-eye-drop-vehicles
#7
Philippe Daull, Samuel Guenin, Valérie Hamon de Almeida, Jean-Sébastien Garrigue
Purpose: Preservative-free cationic emulsion-based artificial tears (ATs) or drug vehicles are innovative eye drop formulations with tear film stabilization and drug delivery properties, and valuable in vivo anti-inflammatory and wound healing properties. These ATs have recently reached the market as ATs for the management of dry eye disease (DED) symptoms (i.e., Cationorm) or as a drug vehicle for cyclosporine (Ikervis). The aim of the present study was to explore the mechanism of action underlying the intrinsic anti-inflammatory and wound-healing efficacies harbored by the cationic emulsions of cetalkonium chloride (CE-CKC)...
2018: Molecular Vision
https://www.readbyqxmd.com/read/30077612/blocking-macrophage-migration-inhibitory-factor-protects-against-cisplatin-induced-acute-kidney-injury-in-mice
#8
Jinhong Li, Ying Tang, Patrick M K Tang, Jun Lv, Xiao-Ru Huang, Christine Carlsson-Skwirut, Lydie Da Costa, Anna Aspesi, Suada Fröhlich, Pawel Szczęśniak, Philipp Lacher, Jörg Klug, Andreas Meinhardt, Günter Fingerle-Rowson, Rujun Gong, Zhihua Zheng, Anping Xu, Hui-Yao Lan
Macrophage migration inhibitory factor (MIF) is elevated in patients with acute kidney injury (AKI) and is suggested as a potential predictor for renal replacement therapy in AKI. In this study, we found that MIF also plays a pathogenic role and is a therapeutic target for AKI. In a cisplatin-induced AKI mouse model, elevated plasma MIF correlated with increased serum creatinine and the severity of renal inflammation and tubular necrosis, whereas deletion of MIF protected the kidney from cisplatin-induced AKI by largely improving renal functional and histological injury, and suppressing renal inflammation including upregulation of cytokines such as interleukin (IL)-1β, tumor necrosis factor-alpha (TNF-α), IL-6, inducible nitric oxide synthase (iNOS), MCP-1, IL-8, and infiltration of macrophages, neutrophils, and T cells...
July 17, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/30077008/lps-induces-il-6-and-il-8-gene-expression-in-bovine-endometrial-cells-through-dna-methylation
#9
Jun Wang, Xiaoxiao Yan, Lucky T Nesengani, He Ding, Lianyu Yang, Wenfa Lu
Uterine infection in dairy cows causes great economic loss. In bovine endometrial cells, lipopolysaccharide (LPS)-stimulated increase in interleukin 6 (IL-6) and interleukin 8 (IL-8) mRNA is crucial for the inflammatory response; however, the regulatory mechanisms remain unclear. Here, we investigated the role of DNA methylation in IL-6 and IL-8 mRNA expression following LPS-induction in bovine endometrial cells. IL-6 and IL-8 mRNA expression was evaluated under DNA methylation inhibition using 5-Aza-2'-deoxycytodine (5Aza) following LPS stimulation...
August 1, 2018: Gene
https://www.readbyqxmd.com/read/30076070/rapid-ex-vivo-expansion-of-highly-enriched-human-invariant-natural-killer-t-cells-via-single-antigenic-stimulation-for-cell-therapy-to-prevent-graft-versus-host-disease
#10
Abel Trujillo-Ocampo, Hyun-Woo Cho, Amanda C Herrmann, Wilfredo Ruiz-Vazquez, Andrew B Thornton, Hong He, Dan Li, Mariam A Qazilbash, Qing Ma, Steven A Porcelli, Elizabeth J Shpall, Jeffrey Molldrem, Jin S Im
BACKGROUND AIMS: CD1d-restricted invariant natural killer (iNK) T cells are rare regulatory T cells that may contribute to the immune-regulation in allogeneic stem cell transplantation (ASCT). Here, we sought to develop an effective strategy to expand human iNK T cells for use in cell therapy to prevent graft-versus-host disease (GVHD) in ASCT. METHODS: Human iNK T cells were first enriched from peripheral blood mononuclear cells (PBMCs) using magnetic-activated cell sorting separation, then co-cultured with dendritic cells in the presence of agonist glycolipids, alpha-galactosylceramide, for 2 weeks...
July 31, 2018: Cytotherapy
https://www.readbyqxmd.com/read/30074152/down-regulation-of-helios-expression-in-tregs-from-patients-with-hypertension
#11
Zhu-Yue Chen, Feng Chen, Yan-Ge Wang, Ding-Hang Wang, Li-Li Jang, Long-Xian Cheng
Regulatory T cells (Tregs) play a pivotal role in the pathological development of hypertension. Helios, a transcription factor from the Ikaros family, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with suppression function, however, little has been known about its role in hypertension. This study was aimed to find whether Helios+ Tregs really play a vital role in hypertension. A total of 60 hypertension patients, and 46 normotension subjects were enrolled in this study...
February 2018: Current medical science
https://www.readbyqxmd.com/read/30073458/insight-into-inflammatory-cell-and-cytokine-profiles-in-adult-iga-vasculitis
#12
T Kuret, K Lakota, P Žigon, M Ogrič, Snezna Sodin-Šemrl, S Čučnik, M Tomšič, A Hočevar
Immunoglobulin A vasculitis (IgAV) is an immune complex, small vessel vasculitis with dominant IgA deposits in vessel walls, predominantly affecting the pediatric population. However, adults frequently have more severe gastrointestinal tract (GIT) and renal involvements as compared to children. Our aim was to study serological and cellular biomarkers to support clinicians in their diagnosis and the course of IgAV in adult patients. This cross-sectional study included 62 adult IgAV patients and 53 healthy blood donors (HBDs)...
August 2, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30072685/circulating-angiogenic-t-cells-are-increased-in-lupus-nephritis-patients
#13
Peng Zhao, Jinlin Miao, Kui Zhang, Minghua Lv, Qing Han, Ping Zhu
BACKGROUND Patients with systemic lupus erythematosus (SLE), especially with lupus nephritis (LN), undergo vascular damage and repair during the course of the disease. Since the recently identified angiogenic T cells (Tang) are involved in endothelial repair coupled with endothelial progenitor cells (EPCs), this study investigated the circulating Tang cells in LN patients and their potential correlations with disease features. MATERIAL AND METHODS Circulating Tang cells and EPCs were assessed by flow cytometry in peripheral blood samples from 67 SLE patients; of these, 32 had LN and 30 were matched healthy controls (HCs)...
August 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30061826/fasudil-in-combination-with-bone-marrow-stromal-cells-bmscs-attenuates-alzheimer-s-disease-related-changes-through-the-regulation-of-the-peripheral-immune-system
#14
Jiezhong Yu, Yuqing Yan, Qingfang Gu, Gajendra Kumar, Hongqiang Yu, Yijin Zhao, Chunyun Liu, Ye Gao, Zhi Chai, Jasleen Chumber, Bao-Guo Xiao, Guang-Xian Zhang, Han-Ting Zhang, Yuqiang Jiang, Cun-Gen Ma
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease. Its mechanism is still not clear. Majority of research focused on the central nervous system (CNS) changes, while few studies emphasize on peripheral immune system modulation. Our study aimed to investigate the regulation of the peripheral immune system and its relationship to the severity of the disease after treatment in an AD model of APPswe/PSEN1dE9 transgenic (APP/PS1 Tg) mice. APP/PS1 Tg mice (8 months old) were treated with the ROCK-II inhibitor 1-(5-isoquinolinesulfonyl)-homo-piperazine (Fasudil) (intraperitoneal (i...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/30060350/-mechanism-of-lung-injury-of-rats-induced-by-inhalation-of-white-smoke-from-burning-smoke-pot
#15
P Cui, H M Xin, Q Zhan, Z P Tang, C J Deng, X H Li, Y H Lai, R S Li, A N Chen, Y L Tong
Objective: To explore mechanism of lung injury of rats induced by inhalation of white smoke from burning smoke pot. Methods: Forty-eight Sprague Dawley rats were divided into control group ( n =12) and injury group ( n =36) according to the random number table. Rats in injury group were placed in smoke-induced injury experimental equipment fulled with white smoke from burning smoke pot for 5 minutes to make lung injury, and rats in control group were placed in smoke-induced injury experimental equipment fulled with air for 5 minutes to make sham injury...
July 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/30059361/novel-molecules-mediate-specialized-functions-of-human-regulatory-macrophages
#16
Paloma Riquelme, James A Hutchinson
PURPOSE OF REVIEW: Now that adoptive transfer of regulatory macrophages (Mregs) is clinically practicable, we ask whether this approach could be used to achieve self-sustaining peripheral regulation and what mechanisms may be involved. RECENT FINDINGS: Dehydrogenase/reductase 9 (DHRS9)-expressing Mregs are a specialized subset of monocyte-derived macrophages that are currently being investigated as a tolerogenic cell-based therapy. Human Mregs are defined by their capacity to convert naïve CD4 T cells to IL-10-secreting FoxP3 regulatory T cells (Tregs) through an activation-dependent process involving signals mediated by TGF-β, retinoic acid, indoleamine 2,3-dioxygenase activity, notch and progestagen associated endometrial protein (PAEP)...
July 27, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/30058806/nobiletin-and-5-hydroxy-6-7-8-3-4-pentamethoxyflavone-ameliorate-12-o-tetradecanoylphorbol-13-acetate-induced-psoriasis-like-mouse-skin-lesions-by-regulating-the-expression-of-ki-67-and-proliferating-cell-nuclear-antigen-and-the-differentiation-of-cd4-t-cells
#17
Guliang Yang, Shiming Li, Yiwen Yang, Li Yuan, Peilei Wang, Hui Zhao, Chi-Tang Ho, Chi-Chen Lin
Psoriasis is a chronic and benign proliferative skin disease. Flavonoids in chenpi (aged tangerine peel) from tangerine ( Citrus reticulate Blanco), such as nobiletin (Nob), tangeretin, and 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (5-HPMF), possess anti-inflammation and regulation of immune activity among others. In this study, psoriasis-like skin lesions were induced by 12- O-tetradecanoylphorbol-13-acetate (TPA), and the preventive effect of Nob and 5-HPMF on psoriasis-like skin lesions was evaluated. Results showed that skin lesions were dramatically reduced by Nob and 5-HPMF...
July 30, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30057554/eplerenone-reverses-cardiac-fibrosis-via-the-suppression-of-tregs-by-inhibition-of-kv1-3-channel
#18
Pei-Pei Shao, Chang-Jiang Liu, Qi Xu, Bo Zhang, Shao-Hua Li, Yang Wu, Zhan Sun, Lu-Feng Cheng
Background: Fibroblast proliferation is a critical feature during heart failure development. Previous studies reported regulatory T-lymphocytes (Tregs)' protective role against myocardial fibrosis. However, notably, Tregs also secrete fibrogenic cytokine TGF-β when activated. This study aimed to clarify the intriguing link between Tregs and fibrosis, the role of Tregs Kv1.3 potassium channel (regulating T-lymphocytes activation) in the fibrosis process, and how selective aldosterone receptor antagonist Eplerenone affects Tregs and fibrosis through its action on Kv1...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30050532/plasmatic-levels-of-il-18-ip-10-and-activated-cd8-t-cells-are-potential-biomarkers-to-identify-hiv-1-elite-controllers-with-a-true-functional-cure-profile
#19
Fernanda H Côrtes, Hury H S de Paula, Gonzalo Bello, Marcelo Ribeiro-Alves, Suwellen S D de Azevedo, Diogo G Caetano, Sylvia L M Teixeira, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G Veloso, Monick L Guimarães, Mariza G Morgado
Elite controllers (ECs) are rare individuals able to naturally control HIV-1 replication below the detection limit of viral load (VL) commercial assays. It is unclear, however, whether ECs might be considered a natural model of a functional cure because some studies have noted CD4+ T cell depletion and disease progression associated with abnormally high levels of immune activation and/or inflammation in this group. Here, we propose the use of immunological parameters to identify HIV-1 ECs that could represent the best model of a functional cure...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30044599/impact-of-intravesical-hyaluronic-acid-treatment-on-bladder-inflammation-in-interstitial-cystitis-rat-model
#20
Ilker Fatih Sahiner, Hakan Soylu, Erhan Ates, Nuray Acar, Ismail Ustunel, Ahmet Danisman
OBJECTIVE: To evaluate the effect of intravesical hyaluronic acid (HA) treatment on inflammatory cells and the severity of inflammation in an interstitial cystitis rat model created with hydrogen chloride (HCL) via immunohistochemical studies and myeloperoxidase activity for the first time in the literature. MATERIALS AND METHODS: A total of 30 adult female white Rattus Norvegicus rats were divided into 3 groups as the HCL group, hyaluronic acid treatment (HCL-HA) group and control group...
April 15, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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