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t cell IL-8

Surina Bo, Mu Dan, Wenxi Li, Ping Zhang
A polysaccharide from Arnebia euchroma (Royle) Johnst. named ARP, was obtained and purified by the hot water extraction, ethanol precipitation and deproteinization of TCA. The molecular weight of the polysaccharide fraction of ARP was calculated to be 1.23 × 104  Da from a calibration curve obtained with dextran standards. Monosaccharide composition analysis revealed that ARP was composed of Gal, Ara, Glu, Man, Rha and Fuc at a molar ratio of 53.8:21.3:11.7:6.8:4.3:2.2. Methylation analysis suggested that ARP was likely an arabinogalactan and that its backbone mainly consisted of Galp residues of 1,6‑linkages and Ara residues of 1,5‑ or 1,3‑linkages...
December 13, 2018: International Journal of Biological Macromolecules
Cinzia Maria Chinnici, Giada Pietrosi, Gioacchin Iannolo, Giandomenico Amico, Nicola Cuscino, Valeria Pagano, Pier Giulio Conaldi
We isolated a population of proliferating cells from cultured human fetal hepatocytes of 16-22 weeks gestational age. The cells shared a similar phenotype to that of mesenchymal stromal cells (MSCs) according to the International Society for Cellular Therapy (ISCT), including plastic adherence, antigen expression profile, and in vitro multilineage differentiation potential. Fetal liver (FL)-MSCs expressed the albumin gene, and harbored a subpopulation of CK18+ cells (20-40%), which defined their hepatic origin...
December 5, 2018: Differentiation; Research in Biological Diversity
Z Shen, B Y Li, H Dai, S Q Zhang, Y X Bai, Y Shao
Objective: To investigate the immunologic functional changes of peripheral dendritic cells (DC) in patients with allergic rhinitis (AR) during the treatment by budesonide aerosol inhalation. Method: 25 patients with moderate to severe persistent AR were concluded in current study, and they were given budesonide aerosol inhalation for 8 weeks. AR related nasal symptom scores and indices, peripheral DC counts and percentages as well as their activation before and 4 weeks, 8 weeks after treatment were determined...
September 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Ali Gürkan, Gözde Peker Tekdal, Nagihan Bostancı, Georgios N Belibasakis
AIM: To evaluate the cytokine, chemokine and growth factor levels in peri-implant sulcular fluid (PISF) during healing and osseointegration at osteotomy sites prepared either with piezosurgery (PS) or drills. MATERIALS AND METHODS: Fourteen patients having contralateral partial edentulism in the posterior maxilla were enrolled and 38 osteotomies were prepared. Implants were placed with one-stage surgery. Insertion torque, early healing index, probing depth and modified gingival and plaque indices and crestal bone loss (CBL) were measured...
December 14, 2018: Journal of Periodontology
Takao Shigenobu, Takashi Ohtsuka, Masayuki Shimoda
Bronchiolitis obliterans (BO), which begins with lymphocytic bronchiolitis (LB), is the most serious manifestations of chronic rejection following lung transplantation. We have evaluated the effects of intraperitoneal administration of pioglitazone, a peroxisome proliferator-activated receptor (PPAR) gamma agonist, on LB in mice tracheal transplant model. Tracheal grafts from BALB/c or C57BL/6 were transplanted to C57BL/6 recipients. Animals were divided into three groups (n = 8), isograft (IG) and allograft with (AGP) or without (AGN) pioglitazone...
December 10, 2018: Transplant Immunology
Irina Tcymbarevich, Shola M Richards, Giancarlo Russo, Jelena Kühn-Georgijevic, Jesus Cosin-Roger, Katharina Baebler, Silvia Lang, Susan Bengs, Kirstin Atrott, Carla Bettoni, Sven Gruber, Isabelle Frey-Wagner, Michael Scharl, Benjamin Misselwitz, Carsten A Wagner, Klaus Seuwen, Gerhard Rogler, Pedro A Ruiz, Marianne Spalinger, Cheryl de Vallière
Background: Tissue inflammation in inflammatory bowel diseases [IBD] is associated with local acidification. Genetic variants in the pH-sensing G protein-coupled receptor 65, also known as T cell death-associated gene 8 [TDAG8], have been implicated in IBD and other autoimmune diseases. Since the role of TDAG8 in intestinal inflammation remains unclear, we investigated the function of TDAG8 using murine colitis models. Methods: The effects of TDAG8 deficiency were assessed in dextran sodium sulphate [DSS], IL-10-/-, and T cell transfer colitis murine models...
October 9, 2018: Journal of Crohn's & Colitis
Helge Hasselmann, Stefanie Gamradt, Aline Taenzer, Jan Nowacki, Rami Zain, Kostas Patas, Caren Ramien, Friedemann Paul, Katja Wingenfeld, Dominique Piber, Stefan M Gold, Christian Otte
Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of major depressive disorder (MDD). However, the cellular origin of inflammatory signals and their specificity remain unclear. We examined the phenotype and glucocorticoid signaling in key cell populations of the innate immune system (monocytes) vs. adaptive immunity (T cells) in a sample of 35 well-characterized, antidepressant-free patients with MDD and 35 healthy controls individually matched for age, sex, smoking status and body mass index...
2018: Frontiers in Immunology
Fan Wang, Ruiling Wang, Haifang Liu
Inhalation of pathogenic bacteria transported by particulate matter (PM) presents an important potential threat to human health. Therefore, the pulmonary toxicity in mice caused by Staphylococcus aureus (S. aureus) and PM as individual matter and mixtures was studied. PM and S. aureus were instilled intratracheally into Kunming mice at doses of 0.2 mg/mouse and 5.08 × 106 CFU /mouse, respectively, as individual matter and in combination two times at 5-day intervals. After the exposure period, oxidative stress markers and nitric oxide (NO) in the lung, cellular infiltration, neurotrophins, chemokines, andcytokines in bronchoalveolar lavage fluid (BALF), and immunoglobulin (Ig) in sera were examined...
December 10, 2018: Experimental Animals
Li Xiaoli, Zou Wujun, Liu Jing
Acute lung injury (ALI) and its more serious form, respiratory distress syndrome (ARDS), are considered as an acute and severe inflammatory process existing in lungs, and still remain high mortality rates. Tripartite motif 8 (TRIM8) contains an N-terminal RING finger, which is followed by two B-boxes and a coiled-coil domain, belonging to the TRIM/RBCC family and playing significant role in meditating inflammation, oxidative stress and apoptosis. In the study, we investigated the role of TRIM8 in ALI induced by lipopolysaccharide (LPS) and the underlying molecular mechanisms...
December 4, 2018: Biochemical and Biophysical Research Communications
Archana Thakur, Ritesh Rathore, Sri Vidya Kondadasula, Joseph P Uberti, Voravit Ratanatharathorn, Lawrence G Lum
This proof-of-concept study investigates the immune effects in metastatic breast cancer (MBC) patients after "vaccination" with activated T cells (ATC) armed with anti-CD3 x anti-HER2 bispecific antibody (HER2 BATs) followed by immune consolidation with immune ATC "boost" after high dose chemotherapy (HDC) and autologous stem cell transplant (SCT). Approximately 2 weeks after completion of vaccination portion of the study, immune T cells were obtained by leukopheresis, activated and expanded ex vivo and re-infused after HDC and SCT to test the hypothesis that transfer of immune unarmed ATC would accelerate reconstitution of anti-tumor activity after SCT...
2018: Oncoimmunology
W J Zhuang, Y Xie, J L Gu, S Y Wei
Objective: To study the role and mechanism of CD(4)(+) CD(25)(+) FoxP3(+) regulatory T cells (Tregs) in the pathophysiological process of indirect acute lung injury (iALI) in mice. Methods: The iALI model was successfully induced by shock/cecal ligation and puncture method. Sham ( n= 8), cecal ligation and puncture (CLP, n= 10), and hemorrhage (Hem, n= 12) groups were established as controls. Two experimental groups were established: CLP+Hem ( n= 15) without Tregs adoptive transfer (AT), and CLP+Hem with Tregs adoptive transfer (CLP+Hem+AT, n= 14)...
December 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
Kuo-Hao Ho, Chih-Ju Chang, Tzu-Wen Huang, Chwen-Ming Shih, Ann-Jeng Liu, Peng-Hsu Chen, Kur-Ta Cheng, Ku-Chung Chen
Tumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune responses. PD-L1 upregulation can impede infiltrating T-cell functions in lung adenocarcinoma (LUAD), a lung cancer subtype. However, associations between the expression of PD-L1 and infiltration of B cells (a major immunoregulatory cell) remain unknown. Therefore, we investigated the role of infiltrating B cells in LUAD progression and its correlation with PD-L1 expression...
2018: PloS One
Marta Calatayud, Olivier Dezutter, Emma Hernandez-Sanabria, Silvia Hidalgo-Martinez, Filip J R Meysman, Tom Van de Wiele
The intestinal epithelium plays an essential role in the balance between tolerant and protective immune responses to infectious agents. In vitro models do not typically consider the innate immune response and gut microbiome in detail, so these models do not fully mimic the physiologic aspects of the small intestine. We developed and characterized a long-term in vitro model containing enterocyte, goblet, and immune-like cells exposed to a synthetic microbial community representative of commensal inhabitants of the small intestine...
December 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Y Luo, Y Y Huang, Y Jin, C R Li, J Yang
Objective: To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). Methods: From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). The age-matched 34 healthy children were included as the control group for prospective cohort study...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Kaitlin N Calhoun, Lerin R Luckett-Chastain, Benjamin Frempah, Randle M Gallucci
Irritant contact dermatitis (ICD), the most common occupational cutaneous illness, is an acute inflammatory response caused by topical irritant exposure. Multiple factors are associated with the manifestation and severity of ICD and contribute to the lack of effective prophylactic and treatment strategies. To determine the pathomechanism of ICD caused by the irritants, benzalkonium chloride (BKC) and JP-8 jet fuel, two mouse strains, C57BL/6 and Balb/c, were assessed due to their differential immune predispositions...
December 4, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Fernanda Cristina Winckler, Aline Marcia Marques Braz, Vanessa Nogueira da Silva, Marjorie de Assis Golim, Vanessa Gutierrez de Andrade, Paulo Eduardo de Abreu Machado, Liciana Vaz de Arruda Silveira, Giovanni Faria Silva
INTRODUCTION: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytokine imbalance and ultimately affecting treatment. Studies using interferon (IFN) and ribavirin (RBV) showed that TCD8+ cells and cytokine levels are associated with sustainable virological response (SVR)...
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
María A Natale, Gonzalo A César, María G Alvarez, Melisa D Castro Eiro, Bruno Lococo, Graciela Bertocchi, María C Albareda, Susana A Laucella
BACKGROUND: The severity of cardiac disease in chronic Chagas disease patients is associated with different features of T-cell exhaustion. Here, we assessed whether the ability of T cells to secrete IFN-γ in response to T. cruzi was linked to disruption in immune homeostasis and inflammation in patients with chronic Chagas disease. METHODOLOGY/PRINCIPAL FINDINGS: PBMCs from chronic Chagas disease patients and uninfected controls were examined for frequencies of T...
December 2018: PLoS Neglected Tropical Diseases
W J Chang, B H Chen, B S Inbaraj, J T Chien
BACKGROUND: Allyl isothiocyanate (AITC), a volatile and water-insoluble compound present in several cruciferous vegetables, has been shown to possess several biological activities such as anti-bacteria, anti-fungi and anti-cancer. In this study, water-soluble allyl isothiocyanate nanoparticles (AITC-NPs) were prepared by O/W microemulsion and complex coacervation techniques and evaluated for their anti-inflammatory and anti-cancer effects on human bladder cancer cell HT1376. RESULTS: The AITC-NPs with a particle size of 9...
December 5, 2018: Journal of the Science of Food and Agriculture
Massimo Maddaloni, Irina Kochetkova, Carol Hoffman, David W Pascual
IL-35, a relatively newly discovered cytokine belonging to the larger IL-12 family, shows unique anti-inflammatory properties, believed to be associated with dedicated receptors and signaling pathways. IL-35 plays a pivotal role in the development and the function of both regulatory B (Bregs) and T cells (Tregs). In order to further its therapeutic potential, a dairy Lactococcus lactis strain was engineered to express murine IL-35 (LL-IL35), and this recombinant strain was applied to suppress collagen-induced arthritis (CIA)...
2018: Frontiers in Immunology
Yanhua Liu, Ruo Wang, Jing Jiang, Zhihong Cao, Fei Zhai, Weiguo Sun, Xiaoxing Cheng
The role of primary subsets of DCs in Mycobacterium tuberculosis infection in humans is incompletely understood. In this study, we identified a CD1c DC subset with phenotype of CD1c+ CD11c+ CD19- CD11b+ that was significantly increased in tuberculous pleural effusions and in peripheral blood from patients with TB compared with that from healthy controls (p < 0.0001). Sputum smear/culture-positive patients with tuberculosis had significantly higher frequency of CD1c+ CD11b+ DC subset than sputum smear/culture-negative patients (p < 0...
December 2018: Tuberculosis
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