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https://www.readbyqxmd.com/read/25106914/molecular-cloning-and-characterizations-of-porcine-samhd1-and-its-roles-in-replication-of-highly-pathogenic-porcine-reproductive-and-respiratory-syndrome-virus
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Shen Yang, Tongling Shan, Yanjun Zhou, Yifeng Jiang, Wu Tong, Fei Liu, Feng Wen, Qingzhan Zhang, Guangzhi Tong
The sterile alpha motif and HD domain 1 (SAMHD1) protein is a novel innate immunity restriction factor that inhibits HIV-1 infection in myeloid cells. Here, we cloned the full-length SAMHD1 complementary DNA (cDNA) from porcine peripheral blood lymphocytes. The porcine SAMHD1 cDNA was of 3951 bp with an open reading frame of 1884 bp, encoding a polypeptide of 627 amino acids. Porcine SAMHD1 mRNA was detected in all swine tissues examined, with the higher expression in the tonsil, lung, liver, and lymph node tissues...
December 2014: Developmental and Comparative Immunology
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