Lisa Chedik, Shamkhal Baybekov, Gilles Marcou, Frédéric Cosnier, Mélanie Mourot-Bousquenaud, Sandrine Jacquenet, Alexandre Varnek, Fabrice Battais
The Bone-Marrow derived Dendritic Cell (BMDC) test is a promising assay for identifying sensitizing chemicals based on the 3Rs (Replace, Reduce, Refine) principle. This study expanded the BMDC benchmarking to various in vitro, in chemico, and in silico assays targeting different key events (KE) in the skin sensitization pathway, using common substances datasets. Additionally, a Quantitative Structure-Activity Relationship (QSAR) model was developed to predict the BMDC test outcomes for sensitizing or non-sensitizing chemicals...
April 15, 2024: Regulatory Toxicology and Pharmacology: RTP