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Li Wang, Jun Xu, Xiaolong Tian, Tingting Lv, Guolin Yuan
BACKGROUND/AIMS: The aim of this work was to investigate the efficacy and predictive factors of CLAG treatment in refractory or relapsed (R/R) acute myeloid leukemia (AML) patients. METHODS: Sixty-seven R/R AML patients were enrolled in this prospective cohort study and treated by a CLAG regimen: 5 mg/m2/day cladribine (days 1-5), 2 g/m2/day cytarabine (days 1-5), and 300 μg/day filgrastim (days 0-5). The median follow-up duration was 10 months. RESULTS: A total of 57 out of 67 patients were evaluable for remission after CLAG therapy, of whom 57...
December 5, 2018: Acta Haematologica
Maria A Lilli, Nikolaos P Nikolaidis, George P Karatzas, Nicolas Kalogerakis
A laboratory study was conducted to assess the mobility and mechanisms of chromium release from soils obtained from an area of wide spread geogenic contamination. The agricultural soil sample used in this study was taken from the Schimatari area in Asopos River basin in Greece. In order to refine the isolation of minerals contained in the soil, two types of separation analysis were conducted. First, a size fractionation with hydrocyclone and second, a weight fractionation with heavy liquids. The separated fractions were characterized using chemical, mineralogical and surface analysis...
November 27, 2018: Journal of Hazardous Materials
Girish Choppala, Edward D Burton
Schwertmannite is an Fe(III)-oxyhydroxysulfate which is common in acid mine drainage (AMD) and acid sulfate soil (ASS) environments. Natural schwertmannite is often enriched in Cr(III), yet the effects of Cr(III) substitution on schwertmannite transformation to more stable Fe(III) minerals has not been addressed. Here we examine, for the first time, the effects of Cr(III) substitution on the Fe(II)-accelerated transformation of schwertmannite. X-ray diffraction (XRD) and Fe K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy shows that Cr(III) substitution inhibits schwertmannite transformation...
2018: PloS One
Shouryadipta Ghosh, Kenneth Tran, Lea M D Delbridge, Anthony J R Hickey, Eric Hanssen, Edmund J Crampin, Vijay Rajagopal
Recent electron microscopy data have revealed that cardiac mitochondria are not arranged in crystalline columns but are organised with several mitochondria aggregated into columns of varying sizes often spanning the cell cross-section. This raises the question-how does the mitochondrial arrangement affect the metabolite distributions within cardiomyocytes and their impact on force dynamics? Here we employed finite element modelling of cardiac bioenergetics, using computational meshes derived from electron microscope images, to address this question...
December 5, 2018: PLoS Computational Biology
Un Jeong Kim, Jun Suk Kim, Noejung Park, Sanghyub Lee, Ukjae Lee, Yeonsang Park, Jinbong Seok, Sungwoo Hwang, Hyungbin Son, Young Hee Lee
Metal/graphene interface has been one of the most important research topics with regard to charge screening, charge transfer, contact resistance, and solar cells. Chemical bond formation of metal/graphene can be deduced from the defect induced D-band and its second-order mode, 2D band, measured by Raman spectroscopy, as a simple and non-destructive method. However, a phonon mode located at ~ 1350 cm-1 , which is normally known as the defect-induced D-band, is intriguing for graphene deposited with noble metals (Ag, Au, and Cu)...
December 5, 2018: ACS Nano
Shan Ben, Wang Jun Yan, Wang Xia, Fu Juan Juan, Li Li, Pan Xiu Cheng, Li Jian Jun, Tang Xian Tuan
AIM: To evaluate the predictive value of vitamin D and its metabolic pathway gene polymorphisms in response to pegylated interferon (Peg-IFN) in HBeAg-positive CHB patients. METHODS: 119 HBeAg-positive CHB patients who received Peg-IFN monotherapy for 48 weeks and then were followed-up for another 48 weeks were prospectively enrolled; baseline 25-(OH)D and HBV serologic marker levels were detected, 9 critical single nucleotide polymorphisms within vitamin D metabolism were genotyped...
December 5, 2018: Journal of Medical Virology
Dipali Srivastava, Giti Verma, Abhishek Singh Chauhan, Veena Pande, Debasis Chakrabarty
Glutathione S-transferases (GSTs) are well-known enzymes due to their role in detoxification of xenobiotic compounds. However, their biochemical action is still not so clear in imparting tolerance to several abiotic stresses in crop plants. In our previous study, we observed that rice tau class OsGSTU30 plays a significant role in the detoxification of Cr(vi). Interestingly, q-RT PCR analysis also revealed higher expression of OsGSTU30 under drought conditions. In this study, we characterize OsGSTU30 in response to drought as well as heavy metal [Cr(vi)] stresses through overexpression in Arabidopsis thaliana...
December 5, 2018: Metallomics: Integrated Biometal Science
Yu-Chen Chen, Pei-Heng Jiang, Hsuan-Ming Chen, Chang-Han Chen, Yi-Ting Wang, Yu-Ju Chen, Chia-Jung Yu, Shu-Chun Teng
Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link aging pathways are still elusive. Here, we conducted a quantitative mass spectrometry screen and identified all phosphorylation/dephosphorylation sites on yeast proteins that significantly responded to calorie restriction, a well-established approach to extend lifespan...
December 5, 2018: ELife
Nathanael A Hirscher, Jay A Labinger, Theodor Agapie
The selectivity-determining mechanistic steps of ethylene tetramerization and trimerization are evaluated in light of isotopic labeling experiments. A mechanism based upon a shared chromacycloheptane intermediate rather than the C-C coupling of chromacyclopentanes or Cr speciation into independent trimerization and tetramerization catalysts is consistent with the data, including observed upper limits on 1-octene selectivity.
December 5, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Chen-Xue Wang, Yu-Pei Xia, Zhao-Quan Yao, Jialiang Xu, Ze Chang, Xian-He Bu
Two luminescent coordination polymers (CPs), {[Cd2L2(H2O)4]·H2O}n (1) and {[Zn2L2(H2O)4]·H2O}n (2) (H2L = 5-(1H-1,2,4-triazol-1-yl)isophthalic acid) are reported herein. The CPs reveal readily dispersible two-dimensional (2D) layer structures with considerable stability in aqueous media within a wide pH range (pH = 2-12). Sensing experiments indicate that they can serve as highly selective and sensitive fluorescent probes toward CrVI-anions (CrO42- and Cr2O72-).
December 5, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Baohua Su, Xu Zhu, Yina Jiang, Lida Wang, Ningning Zhao, Xuehong Ran, Xiaobin Zheng, Hui Guo
To evaluate the role of high-dose melphalan plus autologous stem-cell transplantation (ASCT) as consolidation therapy for patients with newly diagnosed multiple myeloma (NDMM) in the era of novel agents, we undertook this meta-analysis. Medline, Embase, the Cochrane controlled trials register, the SCI, ASH, EHA, and ASCO were searched for clinical trials including high-dose chemotherapy plus ASCT for patients with NDMM. Finally, we identified four RCTs of ASCT versus novel agents based consolidations, and 10 single-arm prospective trials of ASCT alone...
December 5, 2018: Leukemia & Lymphoma
Karin Hohloch, Christiane Windemuth-Kieselbach, Julia Kolz, Pier Luigi Zinzani, Roberto Cacchione, Woijciech Jurczak, Angelika Bischof Delaloye, Lorenz Trümper, Christian W Scholz
To assess efficacy of radioimmunotherapy (RIT) in follicular lymphoma, data from 281 patients collected in the RIT Network, with a median follow-up of 8·2 years after RIT were analysed. RIT was given at first line in 18·5% and at relapse in 81·5%. Following first line therapy, 76·9% achieved complete remission (CR), 9·6% partial remission (PR), 1·9% stable disease (SD) and 1·9% had progressive disease (PD); response was not documented in 9·7%. At relapse, the rate of CR was 48·5% and that of PR was 16·6%, SD 2·6% and PD 10·5%; response was not documented in 21·8%...
December 4, 2018: British Journal of Haematology
Sanaz Tavasoli, Maryam Taheri, Fatemeh Taheri, Abbas Basiri, Fahimeh Bagheri Amiri
PURPOSE: Magnesium plays numerous vital roles in human's body. It is known as a protective factor in stone formation by binding to oxalate in the intestinal and urinary system, and decreasing its absorption and crystallization, respectively. Due to controversies about the association between the 24-h urine magnesium and other urine metabolites in different studies, this study was designed to find a clear answer to this question. METHODS: In this retrospective cross-sectional study, data from 24-h urinalysis of the calcium stone-forming (CSF) patients were assessed...
December 4, 2018: International Urology and Nephrology
Ruohua Chen, Yining Wang, Xiang Zhou, Gang Huang, Jianjun Liu
Purpose: We evaluated the prognostic value of preoperative 18 F-FDG uptake by suspected lymph nodes (LNs) using 18 F-FDG PET/CT in colorectal cancer patients. Methods: Patients with CRC underwent 18 F-FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the 18 F-FDG maximum standardized uptake value (SUVmax) in the suspected LNs (SUVLN ) on 18 F-FDG PET/CT. Results: Clinical data, treatment modalities, and results from 90 CR C patients were reviewed...
2018: Contrast Media & Molecular Imaging
Guoliang Qiao, Xiao-Li Wang, Lei Zhou, Xin-Na Zhou, Yuguang Song, Shuo Wang, Lei Zhao, Michael A Morse, Amy Hobeika, Jin Song, Xin Yi, Xuefeng Xia, Jun Ren, Herbert Kim Lyerly
PURPOSE: We have assessed the combination of DC-CIK with S-1 plus cisplatin chemotherapy in advanced gastric cancer(AGC) and the role of mutational analysis of circulating tumor DNA(ctDNA) and T cell receptor (TCR) repertoire in predicting clinical outcomes. EXPERIMENTAL DESIGN: Consecutive patients (n=63) with advanced gastric cancer were allocated to treatment with S-1 alone, S-1 plus cisplatin, DC-CIK combined with S-1 or DC-CIK combined with S-1 plus cisplatin...
December 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Marzougui Salem, Radhia Souissi, Fouad Souissi, Noureddine Abbes, Jacques Moutte
The present study was carried out to show the potential in heavy metals (HM) and the rare earth elements (REE) which presents the residues of phosphoric-acid(PA) purification. Three different cadmiferous solid residues (according to the nature of the purification process of the PA: BG, BC and BS) were collected from an industrial site located in the south of Tunisia. The mineralogical study showed the predominance of anhydrite, accompanied by quartz, malladrite; calcium sulfate hemihydrate and fluorapophyllite...
January 2019: Waste Management
Eleftherios Zacharis, Claire Utton, Panos Tsakiropoulos
The paper presents the results of an experimental study of large (≈0.6 kg) arc melted buttons of four Ti free Nb-silicide based alloys with Sn addition with nominal compositions (at.%) Nb-18Si-5Hf-5Sn (EZ1), Nb-18Si-5Al-5Sn (EZ7), Nb-18Si-5Cr-5Hf-5Sn (EZ3) and Nb-18Si-5Al-5Hf-5Sn (EZ4). The alloys were studied in the as-cast and heat treated conditions. In all the alloys there was macrosegregation of Si (MACSi). Among the single element additions Hf had the weakest and Sn the strongest effect on MACSi. The simultaneous presence of Cr and Hf in the alloy EZ3 had the strongest effect on MACSi...
December 3, 2018: Materials
Yuka Sudo, Hiroki Otsuka, Ryota Miyakawa, Akifumi Goto, Yohei Kashiwase, Kiyoshi Terawaki, Kanako Miyano, Yuto Hirao, Kanari Taki, Ryoma Tagawa, Masaki Kobayashi, Naoyuki Okita, Yasuhito Uezono, Yoshikazu Higami
Despite the similar phenotypes, including weight loss, reduction of food intake, and lower adiposity, associated with caloric restriction (CR) and cancer cachexia (CC), CC is a progressive wasting syndrome, while mild CR improves whole body metabolism. In the present study, we compared adipose metabolic changes in a novel rat model of CC, mild CR (70% of the food intake of control rats, which is similar to the food consumption of CC rats), and severe CR (30% of the food intake of controls). We show that CC and severe CR are associated with much smaller adipocytes with significantly lower mitochondrial DNA content; but, that mild CR is not...
December 3, 2018: International Journal of Molecular Sciences
Monika Kamianowska, Marek Szczepański, Elżbieta Ewa Kulikowska, Barbara Bebko, Anna Wasilewska
BACKGROUND: Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease. OBJECTIVES: The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1)...
December 4, 2018: Neonatology
Ying Li, Gaoling Wei, Caihua Zhang, Xiaoliang Liang, Wei Chu, Hongping He, Joseph W Stucki, Lingya Ma, Xiaoju Lin, Jianxi Zhu
The interaction between magnetite and aqueous Fe(II) profoundly impacts the mineral recrystallization, trace-metal sequestration, and contaminant reduction. The iron ions in natural magnetite are extensively substituted by other cations. It is still unclear whether the substitution with thermodynamically favorable redox repairs (e.g., Co2+ /Co3+ ) plays a vital role in the reducing capability of the coupled system. Herein, a series of Co-substituted magnetite samples (Fe3-x Cox O4 , 0.00 ≤ x ≤ 1...
November 24, 2018: Science of the Total Environment
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