Luis Vázquez-Flores, Jessica Castañeda-Casimiro, Luis Vallejo-Castillo, Violeta D Álvarez-Jiménez, Eliud S Peregrino, Mariano García-Martínez, Dante Barreda, Víctor Hugo Rosales-García, C David Segovia-García, Teresa Santos-Mendoza, Carlos Wong-Baeza, Jeanet Serafín-López, Rommel Chacón-Salinas, Sergio Estrada-Parra, Iris Estrada-García, Isabel Wong-Baeza
Tuberculosis remains one of the leading public health problems in the world. The mechanisms that lead to the activation of the immune response against Mycobacterium tuberculosis (Mtb) have been extensively studied, with a focus on the role of cytokines as the main signals for immune cell communication. However, less is known about the role of other signals, such as extracellular vesicles (EVs), in the communication between immune cells, particularly during the activation of the adaptive immune response. In this study, we determined that EVs released by human neutrophils infected with Mtb (EV-Mtb) contained several host proteins that are ectosome markers...
March 29, 2023: Journal of Leukocyte Biology