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fMRI temporal lobe epilepsy

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https://www.readbyqxmd.com/read/30115603/brain-network-alterations-of-mesial-temporal-lobe-epilepsy-with-cognitive-dysfunction-following-anterior-temporal-lobectomy
#1
Chao Zhang, Hongyu Yang, Chang Liu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network connectivity alterations of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction before and after anterior temporal lobectomy (ATL) using resting-state functional magnetic resonance imaging (rs-fMRI) study and to further observe the correlation between the brain network connectivity with cognitive performance. Fourteen patients with unilateral left MTLE before and after ATL were compared with thirty healthy controls (HCs) on functional connectivity (FC) between resting-state networks (RSNs)...
August 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30001910/executive-dysfunction-is-associated-with-an-altered-executive-control-network-in-pediatric-temporal-lobe-epilepsy
#2
Temitayo Oyefunmike Oyegbile, John W VanMeter, Gholam Motamedi, Nassim Zecavati, Cesar Santos, Christabel Lee Earn Chun, William D Gaillard, Bruce Hermann
OBJECTIVES: Children with temporal lobe epilepsy (TLE) exhibit executive dysfunction on traditional neuropsychological tests. However, there is limited evidence of neural network alterations associated with this clinical executive dysfunction. The objective of this study was to characterize working memory deficits in children with TLE via activation of the executive control network on functional magnetic resonance imaging (fMRI) and determine the relationships to fMRI behavioral findings and traditional neuropsychological tests...
July 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29956405/language-network-measures-at-rest-indicate-individual-differences-in-naming-decline-after-anterior-temporal-lobe-resection
#3
Samantha Audrain, Alexander J Barnett, Mary P McAndrews
While anterior temporal lobe (ATL) resection is an effective treatment for temporal lobe epilepsy, surgery on the dominant hemisphere is associated with variable decline in confrontation naming. Accurate prediction of naming impairment is critical to inform clinical decision making, and while there has been some degree of success using task-based functional MRI (fMRI) paradigms, there remains a growing interest in the predictive utility of resting-state connectivity as it allows for relatively shorter scans with low task demands...
June 28, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29952080/the-impact-of-brain-derived-neurotrophic-factor-val66met-polymorphism-on-cognition-and-functional-brain-networks-in-patients-with-intractable-partial-epilepsy
#4
Meneka K Sidhu, Pamela J Thompson, Britta Wandschneider, Alexandra Foulkes, Jane de Tisi, Jason Stretton, Marina Perona, Maria Thom, Silvia B Bonelli, Jane Burdett, Elaine Williams, John S Duncan, Mar Matarin
INTRODUCTION: Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with cognition and variability in structural and functional hippocampal indices in healthy controls and some patient groups. AIMS: We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE...
June 27, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29934057/memory-loss-and-memory-reorganization-patterns-in-temporal-lobe-epilepsy-patients-undergoing-anterior-temporal-lobe-resection-as-demonstrated-by-pre-versus-post-operative-functional-mri
#5
Chusak Limotai, Richard S McLachlan, Susan Hayman-Abello, Brent Hayman-Abello, Suzan Brown, Frank Bihari, Seyed M Mirsattari
This study was aimed to longitudinally assess memory function and whole-brain memory circuit reorganization in patients with temporal lobe epilepsy (TLE) by comparing activation potentials before versus after anterior temporal lobe (ATL) resection. Nineteen patients with medically-intractable TLE (10 left TLE, 9 right TLE) and 15 healthy controls were enrolled. Group analyses were conducted pre- and post-ATL of a novelty complex scene-encoding paradigm comparing areas of blood oxygen-level-dependent (BOLD) signal activations on functional magnetic resonance imaging (fMRI)...
June 19, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29932365/changes-in-resting-state-connectivity-in-pediatric-temporal-lobe-epilepsy
#6
Fabio Grassia, Andrew V Poliakov, Sandra L Poliachik, Kaitlyn Casimo, Seth D Friedman, Hillary Shurtleff, Carlo Giussani, Edward J Novotny, Jeffrey G Ojemann, Jason S Hauptman
OBJECTIVE Functional connectivity magnetic resonance imaging (fcMRI) is a form of fMRI that allows for analysis of blood oxygen level-dependent signal changes within a task-free, resting paradigm. This technique has been shown to have efficacy in evaluating network connectivity changes with epilepsy. Presurgical data from patients with unilateral temporal lobe epilepsy were evaluated using the fcMRI technique to define connectivity changes within and between the diseased and healthy temporal lobes using a within-subjects design...
June 22, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29883917/functional-network-changes-in-the-hippocampus-contribute-to-depressive-symptoms-in-epilepsy
#7
Weifeng Peng, Lingyan Mao, Dazhi Yin, Wei Sun, He Wang, Qianqian Zhang, Jing Wang, Caizhong Chen, Mengsu Zeng, Jing Ding, Xin Wang
PURPOSE: Our study aimed to investigate the functional connectivity (FC) between the hippocampus and other brain regions in epilepsy patients with depressive symptoms. METHODS: Epilepsy patients with and without depressive symptoms, assessed using the 17-item Hamilton Depression Rating Scale scores, were enrolled. Healthy volunteers were recruited as the control group. Resting state functional magnetic resonance imaging was performed, and the data were processed using Resting-State fMRI (DPARSFA2...
June 1, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29878076/revealing-the-dynamic-modulations-that-underpin-a-resilient-neural-network-for-semantic-cognition-an-fmri-investigation-in-patients-with-anterior-temporal-lobe-resection
#8
Grace E Rice, Helen Caswell, Perry Moore, Matthew A Lambon Ralph, Paul Hoffman
One critical feature of any well-engineered system is its resilience to perturbation and minor damage. The purpose of the current study was to investigate how resilience is achieved in higher cognitive systems, which we explored through the domain of semantic cognition. Convergent evidence implicates the bilateral anterior temporal lobes (ATLs) as a conceptual knowledge hub. While bilateral damage to this region produces profound semantic impairment, unilateral atrophy/resection or transient perturbation has a limited effect...
August 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29859335/hippocampal-activations-in-mesial-temporal-lobe-epilepsy-due-to-hippocampal-sclerosis-an-observational-study-on-intramural-encoding-delayed-recall-paradigms-using-task-based-memory-fmri
#9
P G Rajesh, Bejoy Thomas, V S Chandrasekhar Pammi, C Kesavadas, Aley Alexander, Ashalatha Radhakrishnan, S V Thomas, R N Menon
OBJECTIVES: To validate concurrent utility of within-scanner encoding and delayed recognition-memory paradigms to ascertain hippocampal activations during task-based memory fMRI. METHODS: Memory paradigms were designed for faces, word-pairs and abstract designs. A deep-encoding task was designed comprising of a total of 9 cycles run within a 1.5T MRI scanner. A recall session was performed after 1 h within the scanner using an event-related design. Group analysis was done with 'correct-incorrect' responses applied as parametric modulators in Statistical Parametric Mapping version 8 using boot-strap method to enable estimation of laterality indices (LI) using custom anatomical masks involving the medio-basal temporal structures...
May 26, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29782369/neuroimaging-in-epilepsy
#10
Meneka Kaur Sidhu, John S Duncan, Josemir W Sander
PURPOSE OF REVIEW: Epilepsy neuroimaging is important for detecting the seizure onset zone, predicting and preventing deficits from surgery and illuminating mechanisms of epileptogenesis. An aspiration is to integrate imaging and genetic biomarkers to enable personalized epilepsy treatments. RECENT FINDINGS: The ability to detect lesions, particularly focal cortical dysplasia and hippocampal sclerosis, is increased using ultra high-field imaging and postprocessing techniques such as automated volumetry, T2 relaxometry, voxel-based morphometry and surface-based techniques...
August 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29740268/study-of-resting-state-functional-connectivity-networks-using-eeg-electrodes-position-as-seed
#11
Gonzalo M Rojas, Carolina Alvarez, Carlos E Montoya, María de la Iglesia-Vayá, Jaime E Cisternas, Marcelo Gálvez
Electroencephalography (EEG) is the standard diagnosis method for a wide variety of diseases such as epilepsy, sleep disorders, encephalopathies, and coma, among others. Resting-state functional magnetic resonance (rs-fMRI) is currently a technique used in research in both healthy individuals as well as patients. EEG and fMRI are procedures used to obtain direct and indirect measurements of brain neural activity: EEG measures the electrical activity of the brain using electrodes placed on the scalp, and fMRI detects the changes in blood oxygenation that occur in response to neural activity...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29681927/altered-structural-and-functional-connectivity-of-juvenile-myoclonic-epilepsy-an-fmri-study
#12
Chengqing Zhong, Rong Liu, Cheng Luo, Sisi Jiang, Li Dong, Rui Peng, Fuqiang Guo, Pu Wang
The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects. A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29501535/encoding-and-immediate-retrieval-tasks-in-patients-with-epilepsy-a-functional-mri-study-of-verbal-and-visual-memory
#13
REVIEW
Najat Saddiki, Sophie Hennion, Romain Viard, Nassima Ramdane, Renaud Lopes, Marc Baroncini, William Szurhaj, Nicolas Reyns, Jean Pierre Pruvo, Christine Delmaire
PURPOSE: Medial lobe temporal structures and more specifically the hippocampus play a decisive role in episodic memory. Most of the memory functional magnetic resonance imaging (fMRI) studies evaluate the encoding phase; the retrieval phase being performed outside the MRI. We aimed to determine the ability to reveal greater hippocampal fMRI activations during retrieval phase. MATERIALS AND METHODS: Thirty-five epileptic patients underwent a two-step memory fMRI...
May 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29499551/task-activation-and-functional-connectivity-show-concordant-memory-laterality-in-temporal-lobe-epilepsy
#14
Noah Sideman, Ganne Chaitanya, Xiaosong He, Gaelle Doucet, Na Young Kim, Michael R Sperling, Ashwini D Sharan, Joseph I Tracy
OBJECTIVE: In epilepsy, asymmetries in the organization of mesial temporal lobe (MTL) functions help determine the cognitive risk associated with procedures such as anterior temporal lobectomy. Past studies have investigated the change/shift in a visual episodic memory laterality index (LI) in mesial temporal lobe structures through functional magnetic resonance imaging (fMRI) task activations. Here, we examine whether underlying task-related functional connectivity (FC) is concordant with such standard fMRI laterality measures...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29477011/adapting-a-memory-fmri-research-protocol-in-clinical-routine-feasibility-and-results
#15
Ovidio Solano Cabrera, Stéphane Lehéricy, Véronique Masson, Séverine Samson, Sophie Dupont
OBJECTIVE: The objective of this study was to test the reliability of functional magnetic resonance imaging (fMRI) evaluation of memory function in clinical practice to predict postoperative memory decline in patients with refractory medial temporal lobe epilepsy (MTLE) candidate to surgery. METHODS: Twenty-six consecutive patients with MTLE who underwent a complete presurgical evaluation were included. All patients underwent fMRI memory study and complete neuropsychological assessment...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29475172/brain-network-alteration-in-patients-with-temporal-lobe-epilepsy-with-cognitive-impairment
#16
Hongyu Yang, Chao Zhang, Chang Liu, Tao Yu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n=21) and cognitive nonimpairment (CNI) groups (n=19) according to MoCA performance...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29406962/altered-spontaneous-brain-activity-in-mri-negative-refractory-temporal-lobe-epilepsy-patients-with-major-depressive-disorder-a-resting-state-fmri-study
#17
Xi Zhu, Zhongqiong He, Cheng Luo, Xiangmiao Qiu, Shixu He, Anjiao Peng, Lin Zhang, Lei Chen
OBJECTIVE: To investigate alterations in spontaneous brain activity in MRI-negative refractory temporal lobe epilepsy patients with major depressive disorder using resting-state functional magnetic resonance imaging (RS-fMRI). METHODS: Eighteen MRI-negative refractory temporal lobe epilepsy patients with major depressive disorder (PDD), 17 MRI-negative refractory temporal lobe epilepsy patients without major depressive disorder (nPDD), and 21 matched healthy controls (HC) were recruited from West China Hospital of SiChuan University from April 2016 to June 2017...
March 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29376090/cognitive-impairment-in-epilepsy-the-role-of-reduced-network-flexibility
#18
Chris Tailby, Magdalena A Kowalczyk, Graeme D Jackson
Objective: The dominant model of cognitive impairment in focal epilepsy has emphasised structural bases for cognitive deficits. Current theories of cognition in the healthy brain emphasise the importance of the reweighting of brain network interactions in support of task performance. Here, we explore the hypothesis that cognitive deficits in epilepsy arise through abnormalities of dynamic functional network interactions. Method: We studied 19 healthy controls and 37 temporal lobe epilepsy (TLE) patients, using a behavioural measure of verbal fluency (the Controlled Oral Word Association Test) and an fMRI verbal fluency paradigm (Orthographic Lexical Retrieval)...
January 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29351584/the-roles-of-left-versus-right-anterior-temporal-lobes-in-semantic-memory-a-neuropsychological-comparison-of-postsurgical-temporal-lobe-epilepsy-patients
#19
Grace E Rice, Helen Caswell, Perry Moore, Paul Hoffman, Matthew A Lambon Ralph
The presence and degree of specialization between the anterior temporal lobes (ATLs) is a key issue in debates about the neural architecture of semantic memory. Here, we comprehensively assessed multiple aspects of semantic cognition in a large group of postsurgical temporal lobe epilepsy (TLE) patients with left versus right anterior temporal lobectomy (n = 40). Both subgroups showed deficits in expressive and receptive verbal semantic tasks, word and object recognition, naming and recognition of famous faces and perception of faces and emotions...
April 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29113406/altered-dmn-functional-connectivity-and-regional-homogeneity-in-partial-epilepsy-patients-a-seventy-cases-study
#20
Chong-Yu Hu, Xiaoping Gao, Lili Long, Xiaoyan Long, Chaorong Liu, Yayu Chen, Yuanyuan Xie, Chujuan Liu, Bo Xiao, Zhe-Yu Hu
Purpose: Clinically diagnosed partial epilepsy is hard to be functionally diagnosed by regular electroencephalograph (EEG) and conventional magnetic resonance imaging (MRI). By collecting transient brain regional signals, blood oxygenation level-dependent (BOLD) function MRI (BOLD-fMRI) can provide brain function change information with high accuracy. By using resting state BOLD-fMRI technique, we aim to investigate the changes of brain function in partial epilepsy patients. Methods: BOLD-fMRI scanning was performed in 70 partial epilepsy and 70 healthy people...
October 6, 2017: Oncotarget
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