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DTI temporal lobe epilepsy

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https://www.readbyqxmd.com/read/30113469/cognitive-decline-and-white-matter-changes-in-mesial-temporal-lobe-epilepsy
#1
Shang-Wen Xu, Ji-Hui Xi, Chen Lin, Xiao-Yang Wang, Li-Yuan Fu, Stephen Francis Kralik, Zi-Qian Chen
Noninvasive imaging plays a pivotal role in assessing the brain structural and functional changes in presurgical mesial temporal lobe epilepsy (MTLE) patients. Our goal was to study the relationship between the changes of cerebral white matter (WM) and cognitive functions in MTLE patients.Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) MRI were performed on 24 right-handed MTLE patients (12 with left MTLE and 12 with right MTLE) and 12 matching healthy controls. Gray matter (GM), WM, and whole brain (WB) volumes were measured with VBM while fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured with TBSS...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29881803/widespread-abnormalities-in-white-matter-integrity-and-their-relationship-with-duration-of-illness-in-temporal-lobe-epilepsy
#2
Kumi Tsuda, Tomikimi Tsuji, Takuya Ishida, Shun Takahashi, Shinichi Yamada, Yuji Ohoshi, Masaki Terada, Kazuhiro Shinosaki, Satoshi Ukai
Objective: Elucidation of abnormal connections throughout the whole brain is necessary to understand temporal lobe epilepsy (TLE). We examined abnormalities in whole-brain white matter integrity and their relationship with duration of illness in patients with TLE. Methods: The subjects were 15 patients with TLE and 17 healthy controls. Mean duration of illness in the TLE group was 21.6 years. Tract-based spatial statistics (TBSS) were used for diffusion tensor imaging (DTI) analysis...
June 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29880477/thalamocortical-connections-and-executive-function-in-pediatric-temporal-and-frontal-lobe-epilepsy
#3
N Law, M L Smith, E Widjaja
BACKGROUND AND PURPOSE: Largely accepted in the literature is the role the interconnections between the thalamus and cortex play in generalized epilepsy. However, thalamocortical involvement is less understood in focal epilepsy in terms of the effect of seizures on thalamocortical circuitry in the developing brain and subsequent cognitive outcome. We investigated thalamocortical pathway microstructure in pediatric frontal lobe epilepsy and temporal lobe epilepsy and examined the associations between pathway microstructure and measures of executive function...
June 7, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29745545/-tract-based-spatial-statistics-analysis-on-the-white-matter-of-patients-with-temporal-lobe-epilepsy-and-automatic-recognition
#4
Di Zhao, Shengwen Guo, Congling Wu, Chunren Lai, Lina Cheng, Wensheng Wang
This study aims to determine the salient brain regions with abnormal changes in white matter structures from diffusion tensor imaging (DTI) images of the patients with temporal lobe epilepsy (TLE), and to discriminate the patients with TLE from normal controls (NCs). Firstly, the DTI images from 50 subjects (28 NCs and 22 TLE) were acquired. Secondly, the four measures including the fractional anisotropy (FA), the mean diffusivity (MD), the axial diffusivity (AD) and the radial diffusivity (RD) were calculated...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29653337/investigation-of-microstructural-abnormalities-in-white-and-gray-matter-around-hippocampus-with-diffusion-tensor-imaging-dti-in-temporal-lobe-epilepsy-tle
#5
Yixin Bao, Ruqian He, Qingyi Zeng, Pan Zhu, Rongyuan Zheng, Huiqin Xu
OBJECTIVE: The objective of this study was to apply diffusion tensor imaging (DTI) to investigate microstructural abnormalities in temporal lobe epilepsy (TLE) with and without hippocampal sclerosis (HS). MATERIALS: Totally, 19 patients with TLE with HS and 23 patients with TLE without HS were included. Fiber tracking fibers focused on the parahippocampal cingulum (PHC), cingulate gyrus (CG), and fornix (FORX). Fractional anisotropy (FA) and mean diffusivity (MD) values were obtained, and hippocampal volumes were measured...
June 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29620625/decreased-functional-connectivity-and-structural-deficit-in-alertness-network-with-right-sided-temporal-lobe-epilepsy
#6
Yujun Gao, Jinou Zheng, Yaping Li, Danni Guo, Mingli Wang, Xiangxiang Cui, Wei Ye
Patients with temporal lobe epilepsy (TLE) often suffer from alertness alterations. However, specific regions connected with alertness remain controversial, and whether these regions have structural impairment is also elusive. This study aimed to investigate the characteristics and neural mechanisms underlying the functions and structures of alertness network in patients with right-sided temporal lobe epilepsy (rTLE) by performing the attentional network test (ANT), resting-state functional magnetic resonance imaging (R-SfMRI), and diffusion tensor imaging (DTI)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29570898/novel-connectivity-map-normalization-procedure-for-improved-quantitative-investigation-of-structural-thalamic-connectivity-in-temporal-lobe-epilepsy-patients
#7
Brendan G Santyr, Jonathan C Lau, Seyed M Mirsattari, Jorge G Burneo, Sandrine de Ribaupierre, David A Steven, Andrew G Parrent, Keith MacDougall, Ali R Khan
BACKGROUND: Connectivity studies targeting the thalamus have revealed patterns of atrophy and deafferentiation in temporal lobe epilepsy (TLE). The thalamus can be parcellated using probabilistic tractography to demonstrate regions of cortical connectivity; however, sensitivity to smaller or less connected regions is low. PURPOSE/HYPOTHESIS: To investigate thalamic structural connectivity in a wider range of cortical and limbic structures in TLE patients using a novel connectivity map normalization procedure...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29331847/longitudinal-hippocampal-and-extra-hippocampal-microstructural-and-macrostructural-changes-following-temporal-lobe-epilepsy-surgery
#8
Cameron A Elliott, Donald W Gross, B Matt Wheatley, Christian Beaulieu, Tejas Sankar
OBJECTIVES: 1) Characterize the evolution of microstructural changes in the contralateral, non-operated hippocampus-using longitudinal diffusion tensor imaging (DTI)-following surgery for temporal lobe epilepsy (TLE). 2) Characterize the downstream extra-hippocampal volumetric changes of the fornix and mammillary bodies after TLE surgery. 3) Examine the relationship between these measures and seizure/cognitive outcome. METHODS: Serial structural and DTI brain MRI scans were collected in 25 TLE patients pre- and post-surgery (anterior temporal lobectomy, ATL - 13; selective amygdalohippocampectomy, SelAH - 12) and in 12 healthy controls...
February 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29227798/histological-and-mri-markers-of-white-matter-damage-in-focal-epilepsy
#9
REVIEW
Francesco Deleo, Maria Thom, Luis Concha, Andrea Bernasconi, Boris C Bernhardt, Neda Bernasconi
Growing evidence highlights the importance of white matter in the pathogenesis of focal epilepsy. Ex vivo and post-mortem studies show pathological changes in epileptic patients in white matter myelination, axonal integrity, and cellular composition. Diffusion-weighted MRI and its analytical extensions, particularly diffusion tensor imaging (DTI), have been the most widely used technique to image the white matter in vivo for the last two decades, and have shown microstructural alterations in multiple tracts both in the vicinity and at distance from the epileptogenic focus...
February 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29075561/using-machine-learning-to-classify-temporal-lobe-epilepsy-based-on-diffusion-mri
#10
John Del Gaizo, Neda Mofrad, Jens H Jensen, David Clark, Russell Glenn, Joseph Helpern, Leonardo Bonilha
BACKGROUND: It is common for patients diagnosed with medial temporal lobe epilepsy (TLE) to have extrahippocampal damage. However, it is unclear whether microstructural extrahippocampal abnormalities are consistent enough to enable classification using diffusion MRI imaging. Therefore, we implemented a support vector machine (SVM)-based method to predict TLE from three different imaging modalities: mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA). While MD and FA can be calculated from traditional diffusion tensor imaging (DTI), MK requires diffusion kurtosis imaging (DKI)...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29046235/white-matter-integrity-correlates-with-depressive-symptomatology-in-temporal-lobe-epilepsy
#11
Brian Kavanaugh, Stephen Correia, Jacob Jones, Andrew Blum, W C LaFrance, Jennifer Duncan Davis
RATIONALE: White matter abnormalities occur in both temporal lobe epilepsy (TLE) and depression, but there is limited research examining the depression-white matter association in depressed individuals with TLE. This study examined the relationship between white matter integrity (WMI) and depression including the influence of age at seizure onset, in adults with TLE, TLE and depression, and depression only. METHODS: Thirty-one adults were in one of three groups: TLE without depression (TLE; n=11), TLE with depression (TLE+DEP; n=9), and depression without TLE (DEP; n=11)...
December 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28988018/corpus-callosum-diffusion-abnormalities-in-refractory-epilepsy-associated-with-hippocampal-sclerosis
#12
Katarina P Lyra, Khallil T Chaim, Claudia C Leite, Eun J Park, Celi S Andrade, Valmir Passarelli, Rosa M F Valério, Carmen L Jorge, Luiz H M Castro, Maria C G Otaduy
OBJECTIVES: To detect by diffusion tensor imaging (DTI) the extent of microstructural integrity changes of the corpus callosum (CC) in patients with hippocampal sclerosis (HS) and to evaluate possible association with clinical characteristics. METHODS: Fourty-two patients with temporal lobe epilepsy (TLE) and HS and 30 control subjects were studied with DTI. We grouped patients according to lesion side (left or right) HS. Mean diffusivity (MD), fractional anisotropy (FA), radial (RD) and axial diffusivity (AD) were extracted from five segments in CC midsagittal section obtained by automatic segmentation...
November 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28941760/bilateral-cingulum-fiber-reductions-in-temporal-lobe-epilepsy-with-unilateral-hippocampal-sclerosis
#13
H Urbach, K Egger, K Rutkowski, J M Nakagawa, B Schmeiser, M Reisert, A Brandt, B J Steinhoff, A Schulze-Bonhage, T Hammen
PURPOSE: To evaluate whether white matter tracts within the Papez circuit are altered in patients with unilateral hippocampal sclerosis (HS). METHODS: Twenty patients with histologically proven unilateral HS and 20 age-matched controls were studied with a 3T Epilepsy-dedicated MRI protocol including a MPRAGE sequence for hippocampus volumetry and a diffusion tensor imaging (DTI) sequence (61 diffusion-encoding directions, 2×2×2mm3 voxels) for diffusion tensor tractography (DTT)...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28875534/postmortem-dti-reveals-altered-hippocampal-connectivity-in-wild-sea-lions-diagnosed-with-chronic-toxicosis-from-algal-exposure
#14
Peter F Cook, Gregory S Berns, Kathleen Colegrove, Shawn Johnson, Frances Gulland
Hundreds of wild California sea lions (Zalophus californianus) exposed to the algal neurotoxin domoic acid are treated in veterinary rehabilitation centers each year. Common chronic effects of toxic exposure in these animals are seizures and hippocampal damage, and they have been proposed as a natural animal model for human epilepsy. Humans with medial temporal lobe epilepsy present with white matter pathology in a number of tracts including the fornix and increased structural connectivity between the hippocampus and thalamus...
February 1, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28378878/network-evolution-in-mesial-temporal-lobe-epilepsy-revealed-by-diffusion-tensor-imaging
#15
Helen Wang, Yuegao Huang, Daniel Coman, Reshma Munbodh, Roni Dhaher, Hitten P Zaveri, Fahmeed Hyder, Tore Eid
OBJECTIVE: The objective of the present study is to identify novel, time-indexed imaging biomarkers of epileptogenesis in mesial temporal lobe epilepsy (MTLE). METHODS: We used high-resolution brain diffusion tensor imaging (DTI) of the translationally relevant methionine sulfoximine (MSO) brain infusion model of MTLE. MSO inhibits astroglial glutamine synthetase, which is deficient in the epileptogenic hippocampal formation of patients with MTLE. MSO-infused (epileptogenic) rats were compared with phosphate-buffered saline (PBS)-infused (nonepileptogenic) rats at early (3-4 days) and late (6-9 weeks) time points during epileptogenesis...
May 2017: Epilepsia
https://www.readbyqxmd.com/read/28325026/application-of-dti-connectivity-in-lateralization-of-mtle
#16
Mohammad R Nazem-Zadeh, Susan M Bowyer, John E Moran, Esmaeil Davoodi-Bojd, Andrew Zillgitt, Hassan Bagher-Ebadian, Fariborz Mahmoudi, Kost V Elisevich, Hamid Soltanian-Zadeh
Diffusion tensor imaging (DTI) is a noninvasive imaging method for measuring the diffusion properties of the underlying white matter tracts through which epileptiform activity is propagated. This study investigates the structural abnormalities quantified by DTI in mesial temporal lobe epilepsy (mTLE). Fiber tracts passing through 54 anatomical sites in 12 adult mTLE patients and 12 age- and gender-matched controls were identified using DTI tractography. DTI nodal degree (ND) and laterality index were then calculated...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324881/optic-radiation-tractography-and-visual-field-deficits-in-laser-interstitial-thermal-therapy-for-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy
#17
Dali Yin, John A Thompson, Cornelia Drees, Steven G Ojemann, Lidia Nagae, Victoria S Pelak, Aviva Abosch
BACKGROUND/AIMS: Laser interstitial thermal therapy (LITT) has become an alternative to open-resective surgery for refractory mesial temporal lobe epilepsy (MTLE). Occurrence of visual field defects (VFDs) following open surgery for MTLE is reported at 52-100%. We examined the rate of VFDs following LITT for amygdalohippocampectomy (AHE) and correlated the occurrence of VFDs with damage to the optic radiations, assessed by diffusion tensor tractography (DTI). METHODS: We performed a retrospective analysis of 5 patients who underwent LITT-AHE for medically refractory MTLE...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28227761/application-of-dti-connectivity-in-lateralization-of-mtle
#18
Mohammad R Nazem-Zadeh, Susan M Bowyer, John E Moran, Esmaeil Davoodi-Bojd, Andrew Zillgitt, Hassan Bagher-Ebadian, Fariborz Mahmoudi, Kost V Elisevich, Hamid Soltanian-Zadeh, Mohammad R Nazem-Zadeh, Susan M Bowyer, John E Moran, Esmaeil Davoodi-Bojd, Andrew Zillgitt, Hassan Bagher-Ebadian, Fariborz Mahmoudi, Kost V Elisevich, Hamid Soltanian-Zadeh, Susan M Bowyer, Hassan Bagher-Ebadian, Esmaeil Davoodi-Bojd, Andrew Zillgitt, Fariborz Mahmoudi, John E Moran, Hamid Soltanian-Zadeh, Kost V Elisevich, Mohammad R Nazem-Zadeh
Diffusion tensor imaging (DTI) is a noninvasive imaging method for measuring the diffusion properties of the underlying white matter tracts through which epileptiform activity is propagated. This study investigates the structural abnormalities quantified by DTI in mesial temporal lobe epilepsy (mTLE). Fiber tracts passing through 54 anatomical sites in 12 adult mTLE patients and 12 age- and gender-matched controls were identified using DTI tractography. DTI nodal degree (ND) and laterality index were then calculated...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28209314/connection-between-bilateral-temporal-regions-tractography-using-human-connectome-data-and-diffusion-spectrum-imaging
#19
Peng-Hu Wei, Zhi-Qi Mao, Fei Cong, Bo Wang, Zhi-Pei Ling, Shu-Li Liang, Xin-Guang Yu
Temporal lobe epilepsy often propagates inter-hemispherically. Although the pathway of the propagation was verified by electrophysiology, the trajectory remains poorly defined. DTI can depict fiber trajectory but it has limited angular resolution and cannot adequately assess cortical regions. We visualized potential pathways of bitemporal epilepsy propagation using diffusion spectrum imaging (DSI) with data consisting of 8 groups of 514 directions and diffusion templates of 842 subjects from the human connectome project (HCP)...
May 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28138428/automated-tractography-in-patients-with-temporal-lobe-epilepsy-using-tracts-constrained-by-underlying-anatomy-tracula
#20
Barbara A K Kreilkamp, Bernd Weber, Mark P Richardson, Simon S Keller
PURPOSE: A detailed understanding of white matter tract alterations in patients with temporal lobe epilepsy (TLE) is important as it may provide useful information for likely side of seizure onset, cognitive impairment and postoperative prognosis. However, most diffusion-tensor imaging (DTI) studies have relied on manual reconstruction of tract bundles, despite the recent development of automated techniques. In the present study, we used an automated white matter tractography analysis approach to quantify temporal lobe white matter tract alterations in TLE and determine the relationships between tract alterations, the extent of hippocampal atrophy and the chronicity and severity of the disorder...
2017: NeuroImage: Clinical
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