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diabetic foot ulceration

Felipe Tavares Rodrigues, Valéria Magalhães Aguiar, Claudia Soares Lessa
No abstract text is available yet for this article.
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
Maria do Livramento Saraiva Lucoveis, Mônica Antar Gamba, Maria Angela Boccara de Paula, Ana Beatriz Pinto da Silva Morita
OBJECTIVE: To classify the level of risk for foot ulcers in people with diabetes mellitus and identify their main predictive risk factors. METHOD: Exploratory, descriptive study, in which patients were assessed in a municipal ambulatory of São Paulo through nursing consultation, following the guidelines of the International Consensus on the Diabetic Foot. Data were descriptively analyzed. RESULTS: The analyzed population was composed of 50 longevous and retired people, with household income of up to two minimum wages, with dermato-neurofunctional risk factors and unfavorable clinical indicators, and 66% had Risk 1; 16% Risk 2; 6% Risk 3 and 12% Risk 4...
November 2018: Revista Brasileira de Enfermagem
M A B Melo, W Caetano, E L Oliveira, P M Barbosa, A L B Rando, M M D Pedrosa, V A F Godoi
Photodynamic therapy, by reducing pain and inflammation and promoting the proliferation of healthy cells, can be used to treat recurrent lesions, such as diabetic foot ulcers. Studies using the photosensitizer phthalocyanine, together with the nanostructured copolymeric matrix of Pluronic® and Carbopol® for the treatment of diabetic foot ulcers and leishmaniosis lesions, are showing promising outcomes. Despite their topical or subcutaneous administration, these molecules are absorbed and their systemic effects are unknown...
December 3, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Jodi Binning, Jim Woodburn, Sicco Bus, Ruth Barn
Diabetic foot ulceration is a major complication associated with high morbidity. Little evidence exists on which interventions are effective at preventing ulceration. Participants who are adherent to self-care behaviours have significantly better outcomes. Motivational interviewing is an intervention that has been used successfully for conditions where adherence is important, such as reduction of obesity and HbA1c levels. A systematic review was conducted to determine whether motivational interviewing is effective at improving adherence for the prevention of Diabetic Foot Ulceration...
December 4, 2018: Diabetes/metabolism Research and Reviews
Laura Bolton
Diabetic foot ulcers (DFUs) remain a challenge for clinicians despite decades of study. Clinicians now realize that healing strategies should focus on the patient as well as the ulcer. The search continues for interventions that affected individuals and their care providers can count on to heal and manage these challenging wounds, stopping the dreaded progression to amputation and death. The path to healing a patient's DFU often requires multidisciplinary care, including consistent offloading of insensate areas, endocrinologic and metabolic control, and improved circulation...
December 2018: Wounds: a Compendium of Clinical Research and Practice
Xiaoxiao Hu, Weishuai Lian, Xiaojun Zhang, Xue Yang, Jinxia Jiang, Maoquan Li
Background: Diabetes mellitus, one of the most prevalent chronic metabolic diseases, causes many complications. Among the complications, one of the most common chronic complications is diabetic foot ulcers (DFUs). Objective: This study was conducted to investigate the efficacy of negative pressure wound therapy using vacuum-assisted closure (VAC) combined with photon therapy for the management of DFUs. Patients and methods: The study included a total of 69 patients with DFUs during the period from January 2014 to December 2015...
2018: Therapeutics and Clinical Risk Management
L H Hitchman, J P Totty, A Raza, P Cai, G E Smith, D Carradice, T Wallace, A E Harwood, I C Chetter
OBJECTIVES: To assess the current available evidence examining the efficacy of extracorporeal shockwave therapy (ESWT) on healing of diabetic foot ulcers (DFU). DATA SOURCES: PubMed, Ovid MEDLINE, Web of Science, Embase, CINAHL Plus, Cochrane Central Registry of Controlled Trials and Clinical Trials Registry electronic databases were searched up to November 2017 for terms related to ESWT in DFU. REVIEW METHODS: Articles were identified and data extracted by two independent reviewers onto Review Manager 5...
November 26, 2018: Annals of Vascular Surgery
Sanne M Schreuder, M Nieuwdorp, Marc J W Koelemay, Shandra Bipat, Jim A Reekers
Objective: There is evidence from the literature that dysfunctionality of the sympathetic nervous system of the foot with subsequent loss of local autoregulation could be a predictor of early amputation in patients with diabetes with a neuroischemic ulcer. To confirm this we tested the functionality of the sympathetic nervous system in the foot in a consecutive group of 31 patients with diabetes with critical limb ischemia and non-healing neuroischemic ulcer. Research design and methods: Prospective cohort with retrospective analysis after 12 months of routinely acquired clinical data...
2018: BMJ Open Diabetes Research & Care
Faaiz Ul Hassan, Muhammad Suhaib Qudus, Sheikh Arslan Sehgal, Jawad Ahmed, Momin Khan, Khayam Ul Haq, Shahina Mumtaz, Muhammad Arshad, Sami Siraj
BACKGROUND: Pseudomonas aeruginosa is one of the major pathogen associated with acute tissue damage in patients with diabetic foot ulcer (DFU). Antibiotic resistance in P. aeruginosa often bodes unpredictable and unfavourable clinical outcomes, owing to a variety of intrinsic and acquired molecular mechanisms. The study aimed to determine the frequency of ESBLs in Multi-drug resistant P. aeruginosa from diabetic foot patients. METHOD: Present study's duration was one year and 100 patients with DFU were enrolled...
November 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
A Searle MOsteo, M J Spink, V H Chuter
Background: Accurate measurement of ankle joint dorsiflexion is clinically important as a restriction has been linked to many foot and ankle pathologies, as well as increased ulcer risk and delayed ulcer healing in people with diabetes. Use of the reliable weight bearing (WB) Lunge test is limited as normal and restricted ranges for WB ankle joint dorsiflexion are not identified. Additionally the extent of WB dorsiflexion restriction that results in clinically adverse outcomes is unclear...
2018: Journal of Foot and Ankle Research
Ilaria Teobaldi, Vincenzo Stoico, Fabrizia Perrone, Massimiliano Bruti, Enzo Bonora, Alessandro Mantovani
Honey has been used as a wound dressing for hundreds of years by ancient civilizations, but only recently it has acquired scientific interest because of its relevant biological properties. In the last decade, indeed, several trials and observational studies have reported that, compared to conventional treatment (e.g. antiseptics, polyurethane film, paraffin gauze, soframycin-impregnated gauze), honey dressings seem to be better in healing time of different types of wounds, including diabetic foot ulcers. However, to date, information about a potential favorable biological effect of honey dressings on diabetic ulcers with exposed tendon are still scarce...
November 16, 2018: Endocrinology, Diabetes & Metabolism Case Reports
Nathan A Johnson, Alex L Barwick, Angela Searle, Martin J Spink, Stephen M Twigg, Vivienne H Chuter
AIMS: To describe the physical activity levels of an Australian community-based adult population with diabetes, and investigate the interaction between diabetes complications and physical activity. METHODS: Anthropometric, demographic, biochemical and self-reported physical activity measures (IPAQ) were performed. Associations and multiple regression analyses were undertaken between physical activity, known risk factors for diabetes complications, and history of cardiovascular disease (CVD), neuropathy and foot ulceration obtained from medical records...
November 4, 2018: Journal of Diabetes and its Complications
Talha Butt, Erika Lilja, Hedvig Örneholm, Jan Apelqvist, Anders Gottsäter, Magnus Eneroth, Stefan Acosta
BACKGROUND: Heel ulcers in patients with diabetes mellitus (DM) and peripheral arterial disease (PAD) are hard to heal. The aim of the present study was to evaluate the difference in amputation-free survival (AFS) between open and endovascular revascularization in patients with DM, PAD, and heel ulcers. METHODS: Retrospective comparative study of results of open versus endovascular surgery in patients with DM, PAD, and heel ulcer presented at the multidisciplinary diabetes foot clinic between 1983 and 2013...
November 22, 2018: Vascular and Endovascular Surgery
Minseok Jeon, So Young Kim
BACKGROUND: Chronic wounds occur due to failure of the normal healing process, associated with a lack of deposition of cellular components and a suitable microenvironment such as the extracellular matrix (ECM). Acellular dermal matrix (ADM) is viewed as an ECM substitute, and a paste-type ADM has recently been introduced. We hypothesized that CGPaste, an injectable paste-type ADM, could serve as a scaffold and promote wound healing. METHODS: We retrospectively studied seven patients in whom CGPaste was applied between 2017 and 2018, who had pressure ulcers, necrotizing fasciitis, diabetic foot ulcers, traumatic defects, and osteomyelitis...
November 2018: Archives of Plastic Surgery
R Davern, M Hatunic
No abstract text is available yet for this article.
April 19, 2018: Irish Medical Journal
Jiali Xiang, Shumin Wang, Yang He, Lei Xu, Shanshan Zhang, Zhengyi Tang
INTRODUCTION: The effect of glycemic control on wound healing in patients with diabetic foot ulcers (DFUs) is inconsistent among different studies. This study was performed to investigate the association between level of hemoglobin A1c (HbA1c) at baseline as well as during treatment and wound healing and mortality in patients with DFU. METHODS: Hospitalized DFU patients were recruited consecutively with their basic clinical data collected and treated according to clinical practice guidelines...
November 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Connie Harris, Dorace Ramage, Azi Boloorchi, Lisa Vaughan, Gabriella Kuilder
Chronic non-healing wounds are a burden in the Long-Term Care (LTC) sector, increasing costs, morbidity, and mortality and causing pain and suffering. The objective of this LTC Innovation pilot was to test the value of a promising new neuromuscular stimulation device in elevating the experience and satisfaction of the residents, engaging and empowering the nursing staff, and improving healing and/or reducing costs. Small, wireless, and worn at the knee, this muscle pump activator is self-contained, wearable, and battery-powered to increase lower-leg blood circulation (up to 60% of that achieved by walking)...
November 20, 2018: International Wound Journal
Hui-Chun Ku, Yao-Jen Liang
Diabetic foot ulcers are a serious complication of diabetes and are associated with pain, disability, and poor quality of life. Incretin-based therapy is available for type-2 diabetes. Aside from glucose control, such treatment can impart numerous beneficial effects. Areas covered: This review summarizes the preclinical and clinical evidence supporting incretin-based treatment approaches for diabetic ulcers. Expert opinion: Incretin-based therapy may have a role in the treatment of diabetic foot ulcers; the benefits of such treatment arise from attenuation of inflammatory response, improvement of keratinocyte migration, induction of angiogenesis, and the enhancement of tissue remodeling...
December 2018: Expert Opinion on Investigational Drugs
Masoud Edalati, Mary K Hastings, David Muccigrosso, Christopher J Sorensen, Charles Hildebolt, Mohamed A Zayed, Michael J Mueller, Jie Zheng
BACKGROUND: Impaired foot perfusion is a primary contributor to foot ulcer formation. There is no existing device nor method that can be used to measure local foot perfusion during standardized foot muscle exercise in an MRI environment. PURPOSE: To develop a new MRI-compatible foot dynamometer and MRI methods to characterize local perfusion in diabetic feet with ulcers. STUDY TYPE: Prospective. POPULATION/SUBJECTS: Seven participants without diabetes and 10 participants with diabetic foot ulcers...
November 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Ioanna Eleftheriadou, Anastasios Tentolouris, Pinelopi Grigoropoulou, Dimitrios Tsilingiris, Ioanna Anastasiou, Alexandros Kokkinos, Despoina Perrea, Nikolaos Katsilambros, Nikolaos Tentolouris
AIMS: To study the impact of diabetic neuropathy, both peripheral sensorimotor (DPN) and cardiac autonomic neuropathy (CAN), on transcutaneous oxygen tension (TcPO2 ) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 163 participants were recruited; 100 with T2DM and 63 healthy individuals. Peripheral arterial disease (PAD) was defined as ankle-brachial index (ABI) values ≤0.90. Diagnosis of DPN was based on neuropathy symptom score and neuropathy disability score (NDS), while diagnosis of CAN on the battery of the cardiovascular autonomic function tests...
October 12, 2018: Journal of Diabetes and its Complications
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