Esmaeel Sharifi, Seyede Athar Sadati, Satar Yousefiasl, Rossella Sartorius, Mahdi Zafari, Leila Rezakhani, Morteza Alizadeh, Ehsan Nazarzadeh Zare, Shadi Omidghaemi, Fatemeh Ghanavatinejad, Mohammad-Saeid Jami, Erfan Salahinejad, Hadi Samadian, Ana Cláudia Paiva-Santos, Piergiuseppe De Berardinis, Abbas Shafiee, Franklin R Tay, Samiramis Pourmotabed, Pooyan Makvandi
An ideal tissue-engineered dermal substitute should possess angiogenesis potential to promote wound healing, antibacterial activity to relieve the bacterial burden on skin, as well as sufficient porosity for air and moisture exchange. In light of this, a glass-ceramic (GC) has been incorporated into chitosan and gelatin electrospun nanofibers (240-360 nm), which MEFs were loaded on it for healing acceleration. The GC was doped with silver to improve the antibacterial activity. The bioactive nanofibrous scaffolds demonstrated antibacterial and superior antibiofilm activities against Gram-negative and Gram-positive bacteria...
September 2022: Bioengineering & Translational Medicine