Dharshan Sivaraj, Chikage Noishiki, Nina Kosaric, Harriet Kiwanuka, Hudson C Kussie, Dominic Henn, Katharina S Fischer, Artem A Trotsyuk, Autumn H Greco, Britta A Kuehlmann, Filiberto Quintero, Melissa C Leeolou, Maia B Granoski, Andrew C Hostler, William W Hahn, Michael Januszyk, Ferid Murad, Kellen Chen, Geoffrey C Gurtner
INTRODUCTION: According to the American Diabetes Association (ADA), 9-12 million patients suffer from chronic ulceration each year, costing the healthcare system over USD $25 billion annually. There is a significant unmet need for new and efficacious therapies to accelerate closure of non-healing wounds. Nitric Oxide (NO) levels typically increase rapidly after skin injury in the inflammatory phase and gradually diminish as wound healing progresses. The effect of increased NO concentration on promoting re-epithelization and wound closure has yet to be described in the context of diabetic wound healing...
2023: Frontiers in Medicine