Nabeel Merali, Tarak Chouari, Julien Terroire, Maria-Danae Jessel, Daniel S K Liu, James-Halle Smith, Tyler Wooldridge, Tony Dhillon, José I Jiménez, Jonathan Krell, Keith J Roberts, Timothy A Rockall, Eirini Velliou, Shivan Sivakumar, Elisa Giovannetti, Ayse Demirkan, Nicola E Annels, Adam E Frampton
Pancreatic ductal adenocarcinoma (PDAC) has a very poor survival. The intra-tumoural microbiome can influence pancreatic tumourigenesis and chemoresistance and, therefore, patient survival. The role played by bile microbiota in PDAC is unknown. We aimed to define bile microbiome signatures that can effectively distinguish malignant from benign tumours in patients presenting with obstructive jaundice caused by benign and malignant pancreaticobiliary disease. Prospective bile samples were obtained from 31 patients who underwent either Endoscopic Retrograde Cholangiopancreatography (ERCP) or Percutaneous Transhepatic Cholangiogram (PTC)...
November 28, 2023: International Journal of Molecular Sciences