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Vaginal progesterone preterm birth

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https://www.readbyqxmd.com/read/30318880/effects-of-progestogens-in-women-with-preterm-premature-rupture-of-membranes
#1
Rossana Di Sarno, Antonio Raffone, Gabriele Saccone
Different strategies have been adopted for prevention of spontaneous preterm birth, including use of progestogens. So far, five randomized trials have been published evaluating the efficacy of progestogens in women with PPROM, including a total of 425 partipants. All the five trials enrolled pregnant women with singleton pregnancies randomized between 20 and 34 weeks of gestation. In four trials women were randomized to either weekly intramuscular 250 mg 17α-hydroxyprogesterone-caproate or placebo, while Mirzaei et al...
October 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/30237138/vaginal-progesterone-for-the-prevention-of-preterm-birth-and-the-risk-of-gestational-diabetes
#2
Yaniv Zipori, Roy Lauterbach, Emad Matanes, Ron Beloosesky, Zeev Weiner, Amir Weissman
INTRODUCTION: We aimed to determine whether daily vaginal progesterone use for the prevention of preterm birth has an effect on the incidence of abnormal glucose challenge test or gestational diabetes. STUDY DESIGN: A retrospective study in a large referral center. Women with cervical length ≤ 25 mm were given 200 mg vaginal micronized progesterone capsules daily at bed time until 36 weeks` gestation or delivery. Each progesterone-treated woman was matched randomly with three untreated controls...
September 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30225687/is-vaginal-progesterone-treatment-associated-with-the-development-of-gestational-diabetes-a-retrospective-case-control-study
#3
Klara Rosta, Johannes Ott, Fanni Kelemen, Wilhelm Temsch, Tobias Lahner, Theresa Reischer, Hanns Helmer, Aniko Somogyi
PURPOSE: To determine the incidence of gestational diabetes mellitus (GDM) in pregnant women who received vaginal progesterone due to short cervical length or to prevent recurrent preterm birth. METHODS: In this retrospective study, we included 190 women with singleton pregnancies at risk for preterm birth who received vaginal natural progesterone (200 mg daily between gestational weeks 16 + 0 and 36 + 0) for a minimum of 4 weeks and delivered > 28 weeks...
September 17, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/30140107/rescue-adjuvant-vaginal-progesterone-may-improve-outcomes-in-cervical-cerclage-failure
#4
Alina R Roman, Fabricio Da Silva Costa, Edward Araujo Júnior, Penelope M Sheehan
Introduction Aim of the study was to evaluate the effect of rescue adjuvant vaginal progesterone in women with ongoing, transvaginal ultrasound (TVUS)-confirmed cervical shortening despite cervical cerclage. Materials and Methods A retrospective case control study was performed of women undergoing cervical surveillance following either history- or ultrasound-indicated cervical cerclage. We compared women managed with cervical cerclage and vaginal progesterone to women managed with cervical cerclage alone. Women with a singleton pregnancy who underwent cervical cerclage were identified from a database...
August 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/30112757/cervical-cerclage-versus-vaginal-progesterone-for-management-of-short-cervix-in-low-risk-women
#5
Amber M Wood, Sarah K Dotters-Katz, Brenna L Hughes
OBJECTIVE:  To evaluate the risk of preterm birth in low-risk women with cervical length (CL) ≤25 mm on transvaginal ultrasound (TVUS) managed with vaginal progesterone (VagP) therapy versus cerclage. STUDY DESIGN:  This is a retrospective cohort of women with no prior history of preterm birth or cervical insufficiency and CL ≤ 25 mm on TVUS, managed with either VagP therapy alone or cerclage (with or without VagP). The primary outcome was rate of preterm delivery < 37 weeks gestational age (GA)...
August 15, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30081430/progestogen-for-treating-threatened-miscarriage
#6
REVIEW
Hayfaa A Wahabi, Amel A Fayed, Samia A Esmaeil, Khawater Hassan Bahkali
BACKGROUND: Miscarriage is a common complication encountered during pregnancy. It is defined as spontaneous pregnancy loss before 20 weeks' gestation. Progesterone's physiological role is to prepare the uterus for the implantation of the embryo, enhance uterine quiescence and suppress uterine contractions, hence, it may play a role in preventing rejection of the embryo. Inadequate secretion of progesterone in early pregnancy has been linked to the aetiology of miscarriage and progesterone supplementation has been used as a treatment for threatened miscarriage to prevent spontaneous pregnancy loss...
August 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29962517/controversies-about-the-secondary-prevention-of-spontaneous-preterm-birth
#7
Ioannis Kyvernitakis, Holger Maul, Franz Bahlmann
Preterm birth is one of the major global health problems and part of the Millennium Development goals because of the associated high number of perinatal or neonatal mortality and long-term risks of neurodevelopmental and metabolic diseases. Transvaginal sonography has meanwhile been established as a screening tool for spontaneous preterm birth despite its relatively low sensitivity when considering only the cervical length. Vaginal progesterone has been shown to reduce prematurity rates below 34 weeks in a screening population of singleton pregnancies...
June 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29945711/does-progesterone-prophylaxis-to-prevent-preterm-labour-improve-outcome-a-randomised-double-blind-placebo-controlled-trial-opptimum
#8
Jane E Norman, Neil Marlow, Claudia-Martina Messow, Andrew Shennan, Philip R Bennett, Steven Thornton, Stephen C Robson, Alex McConnachie, Stavros Petrou, Neil J Sebire, Tina Lavender, Sonia Whyte, John Norrie
BACKGROUND: Progesterone prophylaxis is widely used to prevent preterm birth but is not licensed and there is little information on long-term outcome. OBJECTIVE: To determine the effect of progesterone prophylaxis in women at high risk of preterm birth on obstetric, neonatal and childhood outcomes. DESIGN: Double-blind, randomised placebo-controlled trial. SETTING: Obstetric units in the UK and Europe between February 2009 and April 2013...
June 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29941278/vaginal-progesterone-is-an-alternative-to-cervical-cerclage-in-women-with-a-short-cervix-and-a-history-of-preterm-birth
#9
EDITORIAL
Luis Sanchez-Ramos
No abstract text is available yet for this article.
July 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29920812/can-previous-preterm-birth-classification-influence-treatment-of-short-cervix-in-a-subsequent-pregnancy-comparison-of-vaginal-progesterone-and-arabin-pessary
#10
Angharad Care, Bertram Muller-Myhsok, Elena Olearo, Tullia Todros, Javier Caradeux, Maria Goya, Montse Palacio, Elena Carreras, Zarko Alfirevic
OBJECTIVE: The aim of this study was to investigate whether the classification of a previous spontaneous preterm birth (sPTB) into; i) sPTB or ii) PPROM, impacts the efficacy of cervical pessary or vaginal progesterone in pregnant women with short cervix on transvaginal ultrasound. METHODS: Four European hospitals using pessary or vaginal progesterone as a primary PTB prevention treatment for asymptomatic high-risk singletons with a short cervix, provided retrospective cohort data...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29806794/the-history-of-natural-progesterone-the-never-ending-story
#11
P Piette
The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium...
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29738749/the-vaginal-eukaryotic-dna-virome-and-preterm-birth
#12
Kristine M Wylie, Todd N Wylie, Alison G Cahill, George A Macones, Methodius G Tuuli, Molly J Stout
BACKGROUND: Despite decades of attempts to link infectious agents to preterm birth, an exact causative microbe or community of microbes remains elusive. Culture-independent sequencing of vaginal bacterial communities demonstrates community characteristics are associated with preterm birth, although none are specific enough to apply clinically. Viruses are important components of the vaginal microbiome and have dynamic relationships with vaginal bacterial communities. We hypothesized that vaginal eukaryotic DNA viral communities (the "vaginal virome") either alone or in the context of bacterial communities are associated with preterm birth...
August 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29724668/rationale-for-current-and-future-progestin-based-therapies-to-prevent-preterm-birth
#13
REVIEW
Megan Weatherborn, Sam Mesiano
Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. The only medicinal therapy currently recommended to prevent PTB is prophylactic progestin therapy in the form of micronized progesterone (P4) administered daily via vaginal suppository from the 24th to the 34th week of gestation or 17α-hydroxyprogesterone caproate in oil administered weekly from the 16th to the 36th week of gestation via an intramuscular injection. These therapies decrease the risk of PTB in women with an elevated risk of PTB indicated by a history of PTB or by a short cervix measured by sonography at mid-gestation...
April 11, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29708071/research-progress-of-progesterone-preparations-a-mini-review
#14
REVIEW
Mingzhu Ye, Weisan Pan, Xinggang Yang, Xiaoyu Zhang
BACKGROUND: Progesterone is a sex steroid hormone. Since it has been discovered, it is widely used in the prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions. METHODS: We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditional preparations up through the very recent literatures. RESULTS: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations...
2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29699436/the-association-of-different-progesterone-preparations-with-preterm-birth-prevention
#15
Eyal Krispin, Eran Hadar, Rony Chen, Arnon Wiznitzer, Boris Kaplan
OBJECTIVE: We aimed to compare the efficacy of commonly available progesterone preparations for preterm birth prevention. METHODS: A retrospective cohort study of all women treated with progesterone to prevent preterm birth and delivered in a single university-affiliated tertiary medical-center. Four progesterone preparations were compared: vaginal Endometrin 100 mg twice daily, vaginal Crinone 8% gel 90 mg daily, vaginal Utrogestan 200 mg daily, and intramuscular 17α-hydroxyprogesterone caproate (17-OHPC) 250 mg weekly...
April 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29557230/a-randomised-trial-to-compare-200-mg-micronised-progesterone-effervescent-vaginal-tablet-daily-with-250-mg-intramuscular-17-alpha-hydroxy-progesterone-caproate-weekly-for-prevention-of-recurrent-preterm-birth
#16
Shruti Shambhavi, Rashmi Bagga, Pallavi Bansal, Jasvinder Kalra, Praveen Kumar
For prevention of a recurrent preterm birth (PTB), intramuscular 17-α-hydroxy progesterone caproate (IM 17 OHPC) weekly is recommended. Vaginal progesterone is preferred for women at risk for PTB due to a short cervical length, but may be useful in women with a prior PTB. However, there is no consensus about the optimal vaginal formulation or its efficacy as compared to 17 OHPC to prevent recurrent PTB. We randomised 100 women with a singleton pregnancy between 16 and 24 weeks of gestation and ≥ one prior spontaneous PTB, of a singleton (>16 to <37 weeks of gestation) to receive the 200 mg vaginal progesterone effervescent tablet daily (Group A) or IM 17-OHPC, 250 mg weekly (Group B) till 37 weeks of gestation or delivery...
August 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29537316/routine-second-trimester-cervical-length-screening-in-low-risk-women-identified-women-at-risk-of-a-very-preterm-birth-but-did-not-reduce-the-preterm-birth-rate-a-randomised-study-from-india
#17
Siddhidatri Mishra, Rashmi Bagga, Jasvinder Kalra, Vanita Jain, Sourabh Dutta
Women (n = 300) at 'low risk' for a preterm birth (PTB), a singleton pregnancy and for a 16-24 week period of gestation (POG) were randomised to undergo cervical length (CL) measurement by transvaginal sonography (TVS) or not. The aim was to see if routine CL measurement and treatment of a short CL reduced the PTB rate. 'Low risk' was defined by an absence of a prior abortion or PTB of a singleton infant (>16 to <37 weeks) due to a spontaneous preterm labour (PTL) or a preterm pre-labour rupture of membranes (pPROM)...
August 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29536576/implementation-of-universal-screening-for-preterm-delivery-by-mid-trimester-cervical-length-measurement
#18
Athena P Souka, Ioannis Papastefanou, Athanasios Pilalis, Dimitrios Kassanos, George Papadopoulos
OBJECTIVES: To assess the feasibility and the results of introducing a policy of universal screening for preterm delivery. METHODS: Transvaginal sonography for cervical length (CL) measurement was performed at 20-24 weeks of gestation. Vaginal progesterone therapy was offered to women with CL ≤ 15mm. RESULTS: 10,969 singleton pregnancies were assessed. The decline rate was 1.32%. Spontaneous preterm delivery at less than 32 weeks (SPD32), less than 34 weeks (SPD34) and less than 37 weeks (SPD37) occurred in 0...
March 14, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29431359/risk-of-preterm-birth-with-vaginal-progesterone-in-twin-pregnancies
#19
M Christine Livergood, Amanda Trudell
No abstract text is available yet for this article.
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29422255/prevention-of-spontaneous-preterm-birth-universal-cervical-length-assessment-and-vaginal-progesterone-in-women-with-a-short-cervix-time-for-action
#20
EDITORIAL
Stuart Campbell
No abstract text is available yet for this article.
February 2018: American Journal of Obstetrics and Gynecology
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