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Vaginal progesterone preterm birth

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https://www.readbyqxmd.com/read/30112757/cervical-cerclage-versus-vaginal-progesterone-for-management-of-short-cervix-in-low-risk-women
#1
Amber M Wood, Sarah K Dotters-Katz, Brenna L Hughes
OBJECTIVE:  To evaluate the risk of preterm birth in low-risk women with cervical length (CL) ≤25 mm on transvaginal ultrasound (TVUS) managed with vaginal progesterone (VagP) therapy versus cerclage. STUDY DESIGN:  This is a retrospective cohort of women with no prior history of preterm birth or cervical insufficiency and CL ≤ 25 mm on TVUS, managed with either VagP therapy alone or cerclage (with or without VagP). The primary outcome was rate of preterm delivery < 37 weeks gestational age (GA)...
August 15, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30081430/progestogen-for-treating-threatened-miscarriage
#2
REVIEW
Hayfaa A Wahabi, Amel A Fayed, Samia A Esmaeil, Khawater Hassan Bahkali
BACKGROUND: Miscarriage is a common complication encountered during pregnancy. It is defined as spontaneous pregnancy loss before 20 weeks' gestation. Progesterone's physiological role is to prepare the uterus for the implantation of the embryo, enhance uterine quiescence and suppress uterine contractions, hence, it may play a role in preventing rejection of the embryo. Inadequate secretion of progesterone in early pregnancy has been linked to the aetiology of miscarriage and progesterone supplementation has been used as a treatment for threatened miscarriage to prevent spontaneous pregnancy loss...
August 7, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29962517/controversies-about-the-secondary-prevention-of-spontaneous-preterm-birth
#3
Ioannis Kyvernitakis, Holger Maul, Franz Bahlmann
Preterm birth is one of the major global health problems and part of the Millennium Development goals because of the associated high number of perinatal or neonatal mortality and long-term risks of neurodevelopmental and metabolic diseases. Transvaginal sonography has meanwhile been established as a screening tool for spontaneous preterm birth despite its relatively low sensitivity when considering only the cervical length. Vaginal progesterone has been shown to reduce prematurity rates below 34 weeks in a screening population of singleton pregnancies...
June 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29945711/does-progesterone-prophylaxis-to-prevent-preterm-labour-improve-outcome-a-randomised-double-blind-placebo-controlled-trial-opptimum
#4
Jane E Norman, Neil Marlow, Claudia-Martina Messow, Andrew Shennan, Philip R Bennett, Steven Thornton, Stephen C Robson, Alex McConnachie, Stavros Petrou, Neil J Sebire, Tina Lavender, Sonia Whyte, John Norrie
BACKGROUND: Progesterone prophylaxis is widely used to prevent preterm birth but is not licensed and there is little information on long-term outcome. OBJECTIVE: To determine the effect of progesterone prophylaxis in women at high risk of preterm birth on obstetric, neonatal and childhood outcomes. DESIGN: Double-blind, randomised placebo-controlled trial. SETTING: Obstetric units in the UK and Europe between February 2009 and April 2013...
June 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29941278/vaginal-progesterone-is-an-alternative-to-cervical-cerclage-in-women-with-a-short-cervix-and-a-history-of-preterm-birth
#5
EDITORIAL
Luis Sanchez-Ramos
No abstract text is available yet for this article.
July 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29920812/can-previous-preterm-birth-classification-influence-treatment-of-short-cervix-in-a-subsequent-pregnancy-comparison-of-vaginal-progesterone-and-arabin-pessary
#6
Angharad Care, Bertram Muller-Myhsok, Elena Olearo, Tullia Todros, Javier Caradeux, Maria Goya, Montse Palacio, Elena Carreras, Zarko Alfirevic
OBJECTIVE: The aim of this study was to investigate whether the classification of a previous spontaneous preterm birth (sPTB) into; i) sPTB or ii) PPROM, impacts the efficacy of cervical pessary or vaginal progesterone in pregnant women with short cervix on transvaginal ultrasound. METHODS: Four European hospitals using pessary or vaginal progesterone as a primary PTB prevention treatment for asymptomatic high-risk singletons with a short cervix, provided retrospective cohort data...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29806794/the-history-of-natural-progesterone-the-never-ending-story
#7
P Piette
The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium...
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29738749/the-vaginal-eukaryotic-dna-virome-and-preterm-birth
#8
Kristine M Wylie, Todd N Wylie, Alison G Cahill, George A Macones, Methodius G Tuuli, Molly J Stout
BACKGROUND: Despite decades of attempts to link infectious agents to preterm birth, an exact causative microbe or community of microbes remains elusive. Culture-independent sequencing of vaginal bacterial communities demonstrates community characteristics are associated with preterm birth, although none are specific enough to apply clinically. Viruses are important components of the vaginal microbiome and have dynamic relationships with vaginal bacterial communities. We hypothesized that vaginal eukaryotic DNA viral communities (the "vaginal virome") either alone or in the context of bacterial communities are associated with preterm birth...
August 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29724668/rationale-for-current-and-future-progestin-based-therapies-to-prevent-preterm-birth
#9
REVIEW
Megan Weatherborn, Sam Mesiano
Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. The only medicinal therapy currently recommended to prevent PTB is prophylactic progestin therapy in the form of micronized progesterone (P4) administered daily via vaginal suppository from the 24th to the 34th week of gestation or 17α-hydroxyprogesterone caproate in oil administered weekly from the 16th to the 36th week of gestation via an intramuscular injection. These therapies decrease the risk of PTB in women with an elevated risk of PTB indicated by a history of PTB or by a short cervix measured by sonography at mid-gestation...
April 11, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29708071/research-progress-of-progesterone-preparations-a-mini-review
#10
Mingzhu Ye, Weisan Pan, Xinggang Yang, Xiaoyu Zhang
BACKGROUND: Progesterone is a sex steroid hormone. Since it was discovered, it had been widely used in the prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions. METHOD: We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditionally preparations up through the very recent literatures. RESULTS: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29699436/the-association-of-different-progesterone-preparations-with-preterm-birth-prevention
#11
Eyal Krispin, Eran Hadar, Rony Chen, Arnon Wiznitzer, Boris Kaplan
OBJECTIVE: We aimed to compare the efficacy of commonly available progesterone preparations for preterm birth prevention. METHODS: A retrospective cohort study of all women treated with progesterone to prevent preterm birth and delivered in a single university-affiliated tertiary medical-center. Four progesterone preparations were compared: vaginal Endometrin 100 mg twice daily, vaginal Crinone 8% gel 90 mg daily, vaginal Utrogestan 200 mg daily, and intramuscular 17α-hydroxyprogesterone caproate (17-OHPC) 250 mg weekly...
April 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29557230/a-randomised-trial-to-compare-200-mg-micronised-progesterone-effervescent-vaginal-tablet-daily-with-250-mg-intramuscular-17-alpha-hydroxy-progesterone-caproate-weekly-for-prevention-of-recurrent-preterm-birth
#12
Shruti Shambhavi, Rashmi Bagga, Pallavi Bansal, Jasvinder Kalra, Praveen Kumar
For prevention of a recurrent preterm birth (PTB), intramuscular 17-α-hydroxy progesterone caproate (IM 17 OHPC) weekly is recommended. Vaginal progesterone is preferred for women at risk for PTB due to a short cervical length, but may be useful in women with a prior PTB. However, there is no consensus about the optimal vaginal formulation or its efficacy as compared to 17 OHPC to prevent recurrent PTB. We randomised 100 women with a singleton pregnancy between 16 and 24 weeks of gestation and ≥ one prior spontaneous PTB, of a singleton (>16 to <37 weeks of gestation) to receive the 200 mg vaginal progesterone effervescent tablet daily (Group A) or IM 17-OHPC, 250 mg weekly (Group B) till 37 weeks of gestation or delivery...
August 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29537316/routine-second-trimester-cervical-length-screening-in-low-risk-women-identified-women-at-risk-of-a-very-preterm-birth-but-did-not-reduce-the-preterm-birth-rate-a-randomised-study-from-india
#13
Siddhidatri Mishra, Rashmi Bagga, Jasvinder Kalra, Vanita Jain, Sourabh Dutta
Women (n = 300) at 'low risk' for a preterm birth (PTB), a singleton pregnancy and for a 16-24 week period of gestation (POG) were randomised to undergo cervical length (CL) measurement by transvaginal sonography (TVS) or not. The aim was to see if routine CL measurement and treatment of a short CL reduced the PTB rate. 'Low risk' was defined by an absence of a prior abortion or PTB of a singleton infant (>16 to <37 weeks) due to a spontaneous preterm labour (PTL) or a preterm pre-labour rupture of membranes (pPROM)...
August 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29536576/implementation-of-universal-screening-for-preterm-delivery-by-mid-trimester-cervical-length-measurement
#14
Athena P Souka, Ioannis Papastefanou, Athanasios Pilalis, Dimitrios Kassanos, George Papadopoulos
OBJECTIVES: To assess the feasibility and the results of introducing a policy of universal screening for preterm delivery. METHODS: Transvaginal sonography for cervical length (CL) measurement was performed at 20-24 weeks of gestation. Vaginal progesterone therapy was offered to women with CL ≤ 15mm. RESULTS: 10,969 singleton pregnancies were assessed. The decline rate was 1.32%. Spontaneous preterm delivery at less than 32 weeks (SPD32), less than 34 weeks (SPD34) and less than 37 weeks (SPD37) occurred in 0...
March 14, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29431359/risk-of-preterm-birth-with-vaginal-progesterone-in-twin-pregnancies
#15
M Christine Livergood, Amanda Trudell
No abstract text is available yet for this article.
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29422255/prevention-of-spontaneous-preterm-birth-universal-cervical-length-assessment-and-vaginal-progesterone-in-women-with-a-short-cervix-time-for-action
#16
EDITORIAL
Stuart Campbell
No abstract text is available yet for this article.
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29408268/the-development-of-progesterone-loaded-nanofibers-using-pressurized-gyration-a-novel-approach-to-vaginal-delivery-for-the-prevention-of-pre-term-birth
#17
Francis Brako, Bahijja Tolulope Raimi-Abraham, Suntharavathanan Mahalingam, Duncan Q M Craig, Mohan Edirisinghe
Recent evidence has continued to support the applicability of progesterone in preventing preterm birth, hence the development of an appropriate vaginal delivery system for this drug would be of considerable interest. Here, we describe the development of progesterone-loaded bioadhesive nanofibers using pressurized gyration for potential incorporation into a vaginal insert, with a particular view to addressing the challenges of incorporating a poorly water-soluble drug into a hydrophilic nanofiber carrier. Polyethylene oxide and carboxymethyl cellulose were chosen as polymers to develop the carrier systems, based on previous evidence of their yielding mucoadhesive nanofibers using the pressurized gyration technique...
April 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29260226/effect-of-cervical-pessary-on-spontaneous-preterm-birth-in-women-with-singleton-pregnancies-and-short-cervical-length-a-randomized-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Gabriele Saccone, Giuseppe Maria Maruotti, Antonia Giudicepietro, Pasquale Martinelli
Importance: Spontaneous preterm birth is a major cause of perinatal morbidity and mortality. It is unclear if a cervical pessary can reduce the risk of spontaneous preterm delivery. Objective: To test whether in asymptomatic women with singleton pregnancies and no prior spontaneous preterm birth but with short cervical length on transvaginal ultrasound, use of a cervical pessary would reduce the rate of spontaneous preterm birth at less than 34 weeks of gestation...
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29190738/cervical-hsv-2-infection-causes-cervical-remodeling-and-increases-risk-for-ascending-infection-and-preterm-birth
#19
Devin McGee, Arianna Smith, Sharra Poncil, Amanda Patterson, Alison I Bernstein, Karen Racicot
Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection. HSV2 infection resulted in histological changes in the cervix mimicking cervical ripening, including significant collagen remodeling and increased hyaluronic acid synthesis...
2017: PloS One
https://www.readbyqxmd.com/read/29180906/perceived-acceptability-of-progesterone-to-prevent-preterm-births-and-low-birth-weight-among-hiv-infected-and-hiv-uninfected-zambian-pregnant-women
#20
Jeffrey Man Hay Wong, Neha Kanga, Nupur Dogra, Mary Shilalukey Ngoma, Lena Serghides, Michael Silverman
Introduction: Intramuscular and vaginal progesterone are recommended for prevention of preterm labor (PTL) in women with risk factors. Studies are emerging to indicate that HIV-infected women on combination antiretroviral therapy (cART) are at risk of PTL and low birth weight (LBW), and may benefit from supplemental progesterone. This study aims to determine the perceived acceptability of various modes of progesterone supplementation to prevent PTL and LBW in HIV-infected and HIV-uninfected women...
2017: International Journal of Women's Health
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