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fracture osteoporosis

Arnaud Wiedemann, Emeline Renard, Magali Hernandez, Brigitte Dousset, François Brezin, Laetitia Lambert, Georges Weryha, François Feillet
Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. We observed the effects of annual zoledronic acid (ZA) infusion in a cohort of children with cerebral palsy and Rett's syndrome. 27 children under 18 years (19 with cerebral palsy and 8 girls with Rett syndrome confirmed by MCEP2 mutation) were treated with an annual injection of 0...
December 15, 2018: Calcified Tissue International
Shuta Yamada, Ko Chiba, Narihiro Okazaki, Makoto Era, Yuichiro Nishino, Kazuaki Yokota, Akihiko Yonekura, Masato Tomita, Toshiyuki Tsurumoto, Makoto Osaki
PURPOSE: A vertebral fracture is the most common complication of osteoporosis, and various factors are involved in its occurrence. The purpose of this study was to investigate the role of trabecular and cortical bone microstructure on vertebral strength using high-resolution peripheral quantitative computed tomography (HR-pQCT). METHODS: Three female cadaveric spines were investigated (average age: 80.3 years). The whole spine (T1-L4) was scanned by second-generation HR-pQCT at a voxel size of 60...
December 13, 2018: Bone
Saman Bahrambeigi, Bahman Yousefi, Mahdi Rahimi, Vahid Shafiei-Irannejad
The prevalence of diabetes mellitus especially type 2 diabetes mellitus is increasing all over the world. In addition to cardiomyopathy and nephropathy, diabetics are at higher risk of mortality and morbidity due to greater risk of bone fractures and skeletal abnormalities. Patients with diabetes mellitus have lower bone quality in comparison to their non-diabetic counterparts mainly because of hyperglycemia, toxic effects of advanced glycosylation end-products (AGEs) on bone tissue, and impaired bone microvascular system...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Raviv Allon, Yahav Levy, Idit Lavi, Aviv Kramer, Menashe Barzilai, Ronit Wollstein
Because fragility fractures have an enormous impact on the practice of medicine and global health systems, effective screening is imperative. Currently, dual-energy X-ray absorptiometry (DXA), which has limited ability to predict fractures, is being used. We evaluated the current literature for a method that may constitute a better screening method to predict fragility fractures. A systematic review of the literature was conducted on computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound to evaluate screening methods to predict fragility fractures...
December 2018: Israel Medical Association Journal: IMAJ
Dimitri Martel, Benjamin Leporq, Amit Saxena, H Michael Belmont, Gabrielle Turyan, Stephen Honig, Ravinder R Regatte, Gregory Chang
BACKGROUND: Osteoporosis (OP) results in weak bone and can ultimately lead to fracture. Drugs such as glucocorticoids can also induce OP (glucocorticoid-induced osteoporosis [GIO]). Bone marrow adipose tissue composition and quantity may play a role in OP pathophysiology, but has not been thoroughly studied in GIO compared to primary OP. PURPOSE/HYPOTHESIS: Chemical shift-encoded (CSE) MRI allows detection of subregional differences in bone marrow adipose tissue composition and quantity in the proximal femur of GIO compared to OP subjects and has high agreement with the reference standard of magnetic resonance spectroscopy (MRS)...
December 12, 2018: Journal of Magnetic Resonance Imaging: JMRI
Juan Marcelo Rosales Rocabado, Masaru Kaku, Kosuke Nozaki, Takako Ida, Megumi Kitami, Yujin Aoyagi, Katsumi Uoshima
BACKGROUND: Postmenopausal osteoporosis develops due to a deficiency of estrogen that causes a decrease in bone mass and changes in the macro- and micro-architectural structure of the bone, leading to the loss of mechanical strength and an increased risk of fracture. Although the assessment of bone mineral density (BMD) has been widely used as a gold standard for diagnostic screening of bone fracture risks, it accounts for only a part of the variation in bone fragility; thus, it is necessary to consider other determinants of bone strength...
December 13, 2018: Journal of Orthopaedic Surgery and Research
Maritza Vidal, Ross J Thibodaux, Luis Fernando Vidal Neira, Osvaldo Daniel Messina
Osteoporosis is characterized by the loss of bone mass, deterioration of the bone microarchitecture, and an increased risk of fractures; these later complications are associated with significant morbidity and mortality. The asymptomatic and progressive nature of osteoporosis underscores the importance of identifying this entity in early stages. Despite the various treatments available, the prevention of the disease represents the most important aspect of management. An adequate intake of calcium and vitamin D as well as a healthy lifestyle is the basis for maintaining bone health...
December 12, 2018: Clinical Rheumatology
Radwan G Metwaly, Zeiad M Zakaria
Introduction: Distal femoral fractures in elderly population had recorded an increase in incidence in the last 2 decades. Lateral distal femoral locking plating is considered one of the best options especially when dealing with comminuted fractures but varus collapse of the medial femoral condyle occurs frequently in patients with osteoporosis. Anatomical reduction of the fracture with stable rigid fixation using double-plating approach allows early mobilization of geriatric population and prevents varus collapse minimizing the comorbidities in such fractures...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
Mariana R Gazzotti, Carolina M Roco, Cristiane O Pradella, Oliver A Nascimento, Elias F Porto, Mariana Adas, Marise Lazaretti-Castro, José R Jardim
BACKGROUND: Osteoporosis is a systemic skeletal disease characterized by low bone mass and/or microarchitectural deterioration of bone. Osteoporosis is a risk factor for fractures specially in patients with advanced COPD. The aim of this cross-sectional study was to determine the frequency of osteoporosis and vertebral fracture in COPD patients. METHODS: We evaluated 91 COPD patients and compared to 82 healthy subjects (control group) matched for gender and age...
December 9, 2018: Archivos de Bronconeumología
Siobhan O'Donnell
INTRODUCTION: This study provides a benchmark for the nationwide use of osteoporosis screening, prevention and management strategies among Canadians aged 40 years and older (40+) using data collected one year prior to the release of Osteoporosis Canada's latest (2010) clinical practice guidelines. METHODS: Data are from the 2009 Canadian Community Health Survey-Osteoporosis Rapid Response Component. The study sample (n = 5704) was divided into four risk subgroups: (1) osteoporosis diagnosis and major fracture; (2) osteoporosis diagnosis only; (3) major fracture only; or (4) neither osteoporosis diagnosis nor major fracture...
December 2018: Health Promotion and Chronic Disease Prevention in Canada
S Lou, H Lv, P Yin, Z Li, P Tang, Y Wang
Combination therapy with parathyroid hormone (PTH) analogs and antiresorptive agents may be more effective than monotherapy for the treatment of osteoporosis. This study aimed to estimate the effectiveness and safety of this combination therapy for osteoporosis. MEDLINE, EMBASE, and Cochrane Library were searched from inception to May 1, 2018, including randomized controlled trials (RCTs) with a duration of at least 6 months on adults with osteoporosis treated with combination therapy versus monotherapy. Outcomes included fractures, bone mineral density (BMD) changes, and adverse events...
December 11, 2018: Osteoporosis International
Carolyn J Crandall, Joseph Larson, JoAnn E Manson, Jane A Cauley, Andrea LaCroix, Jean Wactawski-Wende, Mridul Datta, Maryam Sattari, John T Schousboe, William D Leslie, Kristine E Ensrud
The optimal approach to osteoporosis screening and treatment in postmenopausal women is unclear. We compared 1) the United States Preventive Services Task Force (USPSTF) and Osteoporosis Canada osteoporosis screening strategies; and 2) the National Osteoporosis Foundation (NOF) and Canadian treatment strategies. We used data from the prospective Women's Health Initiative Observational Study and Clinical Trials of women aged 50-79 years at baseline (n = 117,707 followed for self-reported fractures; n = 8,134 in bone mineral density [BMD] subset)...
December 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Zhenxi Li, Jinping Huang, Fanhua Wang, Wenjun Li, Xian Wu, Chenglong Zhao, Jian Zhao, Haifeng Wei, Zhipeng Wu, Ming Qian, Peng Sun, Liang He, Yunyun Jin, Jie Tang, Wenwei Qiu, Stefan Siwko, Mingyao Liu, Jian Luo, Jianru Xiao
Osteoporosis is a global bone disease characterized by reduced bone mineral density (BMD) and increased risk of fractures. The risk of developing osteoporosis increases with aging, especially after menopause in women. Discovering the signaling pathways which play a significant role in aging- and menopause-induced osteoporosis should accelerate osteoporosis drug discovery. In this study, we found that bile acid membrane receptor Tgr5 knockout C57BL/6J mice had similar bone mass as wild type mice during early and middle age (before 4 months old) bone remodeling; however, Tgr5-/- markedly decreased bone mass in aged (more than 7 months old) and ovariectomized (OVX) mice compared with wild type mice...
December 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Dong Ryul Lee, Jungun Lee
Using a nationwide database from the Korean National Health Insurance Service, this study showed that once-monthly oral ibandronate (150 mg) had better anti-fracture efficacy than once-monthly oral risedronate (150 mg), as seen on assessing overall and non-vertebral fractures among Korean elderly women with osteoporosis. INTRODUCTION: Once-monthly oral bisphosphonates have been used widely without appropriate comparison. Therefore, we aimed to compare the anti-fracture efficacy of once-monthly ibandronate (150 mg) and once-monthly risedronate (150 mg)...
December 8, 2018: Osteoporosis International
Georgios Orfanos, Justin Lim, Bishoy Youssef
BACKGROUND: The increasing demand for arthroplasty has resulted in an inevitable rise in the number of periprosthetic fractures around implants. Survival factors looking into patient's comorbidities and how they influence outcome are rare. This study aims to identify correlations between survival post-injury and pre-existing comorbidities. METHODS: A total of 144 patients underwent operative treatment for either a hip or a knee periprosthetic fracture from January 2008 to August 2017 at our Major Trauma Hospital...
December 7, 2018: Archives of Orthopaedic and Trauma Surgery
Houchen Lyu, Bakr Jundi, Chang Xu, Sara K Tedeschi, Kazuki Yoshida, Sizheng Zhao, Sagar U Nigwekar, Benjamin Z Leder, Daniel H Solomon
Background: Among the currently available osteoporosis therapeutics, bisphosphonates and denosumab are widely used. However, it remains uncertain which therapy is more effective. Objective: To determine whether the use of denosumab increases bone mineral density (BMD) and reduces the risk of fractures more than bisphosphonates in patients with low BMD or osteoporosis. Data Sources: We searched PubMed, Embase and the Cochrane Library through Nov 2018...
December 10, 2018: Journal of Clinical Endocrinology and Metabolism
Avinash Kumar Rai, Rajesh Goel, Chirag Bhatia, Sumer Singh, Srikiran Thalanki, Ashwin Gondane
Purpose: The purpose of this study is to describe a method of inserting cement in the femoral head before fixation with dynamic hip screw to prevent screw cut out due to osteoporosis and to evaluate its clinical outcome in these patients. Materials and Methods: In this prospective study, 30 patients aged 60 years and older with intertrochanteric fracture were included. Bone mineral density was measured. After reaming of the femoral head and neck with a triple reamer and polymethyl methacrylate, bone cement was introduced into the femoral head using a customized nozzle and a barrel fitted on a cement gun...
December 2018: Hip & Pelvis
Jae Han Ko, Suhan Lim, Young Han Lee, Ick Hwan Yang, Jin Hwa Kam, Kwan Kyu Park
Purpose: This study aimed to evaluate the efficacy of simultaneous computed tomography (CT) and quantitative CT (QCT) in patients with osteoporotic hip fracture (OHF) by analyzing the osteoporosis detection rate and physician prescription rate in comparison with those of conventional dual-energy X-ray absorptiometry (DXA). Materials and Methods: This study included consecutive patients older than 65 years who underwent internal fixation or hip arthroplasty for OHF between February and May 2015...
December 2018: Hip & Pelvis
Zubair Ahammad, Jason Milton, Kailash Narayan, Victor Awuor
Background: Ankylosing spondylitis (AS) is a seronegative spondyloarthropathy within the spectrum of rheumatologic diseases. The systemic inflammation that characterizes AS leads to bone resorption and reformation. Pathologic remodeling may include kyphosis, osteoporosis, and multi-segment auto-fusion. Cervical fractures account for 53-78% of spinal trauma seen with AS. Surgical planning is often challenging owing to spinal deformity, medical comorbidities, the cervicothoracic foci of injury, and gross instability of these fracture...
2018: Surgical Neurology International
Romina H Aspera-Werz, Sabrina Ehnert, Daniel Heid, Sheng Zhu, Tao Chen, Bianca Braun, Vrinda Sreekumar, Christian Arnscheidt, Andreas K Nussler
Cigarette smoking has been identified as a major risk factor for osteoporosis decades ago. Several studies have shown a direct relationship between cigarette smoking, decreased bone mineral density, and impaired fracture healing. However, the mechanisms behind impaired fracture healing and cigarette smoking are yet to be elucidated. Migration and osteogenesis of mesenchymal stem/stromal cells (MSCs) into the fracture site play a vital role in the process of fracture healing. In human nicotine, the most pharmacologically active and major addictive component present in tobacco gets rapidly metabolized to the more stable cotinine...
2018: Oxidative Medicine and Cellular Longevity
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