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fracture osteoporosis

Namki Hong, Chang Oh Kim, Yoosik Youm, Jin-Young Choi, Hyeon Chang Kim, Yumie Rhee
In a community-dwelling elderly cohort, dysmobility syndrome was associated with elevated odds of morphometric vertebral fracture or any prevalent fracture, independent of age and covariates. Dysmobility syndrome improved discrimination for fracture when added to the FRAX score. INTRODUCTION: Dysmobility syndrome was coined to indicate patients with impaired musculoskeletal health. Data on the association of dysmobility syndrome with prevalent morphometric vertebral fracture (VF) in elderly persons are limited...
August 14, 2018: Archives of Osteoporosis
Chandan Vangala, Jenny Pan, Ronald T Cotton, Venkat Ramanathan
The risk of mineral and bone disorders among patients with chronic kidney disease is substantially elevated, owing largely to alterations in calcium, phosphorus, vitamin D, parathyroid hormone, and fibroblast growth factor 23. The interwoven relationship among these minerals and hormones results in maladaptive responses that are differentially affected by the process of kidney transplantation. Interpretation of conventional labs, imaging, and other fracture risk assessment tools are not standardized in the post-transplant setting...
2018: Frontiers in Medicine
Qi Liu, Yunfeng Zhou, Zubing Li
Platelet‑derived growth factor‑BB (PDGF‑BB) serves a critical function in human osteoblast differentiation and proliferation. Src and Janus kinase 2 (JAK2) are involved in these processes. In our previous study, it was identified that Src could promote the phosphorylation of JAK2. However, it has yet to be determined whether the Src/JAK2 signaling pathway affects PDGF‑BB‑mediated osteoblast differentiation and proliferation. In the present study, western blotting, polymerase chain reaction, alizarin red staining, alkaline phosphatase and Cell Counting kit‑8 were employed to explore these questions...
August 3, 2018: Molecular Medicine Reports
H Tsuchie, N Miyakoshi, K Iba, Y Kasukawa, K Nozaka, T Dohke, I Kosukegawa, T Aizawa, S Maekawa, H Abe, M Takeshima, T Tomite, T Segawa, K Ouchi, H Kinoshita, M Suzuki, T Yamashita, Y Shimada
We compared the effectiveness of promoting bone healing between two teriparatide preparations for atypical femoral fracture (AFF). A total of 45 AFFs were included in this study, and we compared the duration of bone union. Teriparatide administered by daily injection enhanced bone union more than weekly administration in complete AFFs. INTRODUCTION: The efficacy of teriparatide for atypical femoral fracture (AFF) has been recently reported. Although two different teriparatide preparations can be used to treat osteoporosis in Japan, daily or weekly injection, all previous reports on the effectiveness of teriparatide for AFF only examined daily injection formulations...
August 13, 2018: Osteoporosis International
Nathan R Hendrickson, Perry J Pickhardt, Alejandro Munoz Del Rio, Humberto G Rosas, Paul A Anderson
Background: Clinical computed tomography (CT) studies performed for other indications can be used to opportunistically assess vertebral bone without additional radiation or cost. Reference values for young women are needed to evaluate diagnostic accuracy and track changes in CT bone mineral density values across the lifespan. The purpose of this study was to determine reference values for lumbar trabecular CT attenuation (Hounsfield units [HU]) and determine the diagnostic accuracy of HU T-scores (T-scoreHU ) for identifying individuals with osteoporosis...
2018: Iowa Orthopaedic Journal
Martin Frank, Dorothee Marx, Vedran Nedelkovski, Julia-Theresa Fischer, Dieter H Pahr, Philipp J Thurner
Trabecular bone is located inside flat bones as well as in the epi- and metaphysis of long bones and plays a key role with respect to load transfer. Disorders, such as osteoporosis, weaken the structural integrity and may also cause changes in the mechanical properties of individual trabeculae, such as Young's modulus. Knowledge of mechanical tissue properties are necessary to assess risk of bone fracture with finite element analysis (FEA). However, such parameters are most often obtained from experiments on air-dried specimens which do not reflect the physiological conditions...
August 1, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Chang-Hee Lee, Seung Hyun Son, Chae Moon Hong, Ju Hye Jeong, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Tae-Geon Kwon, Byeong-Cheol Ahn
Purpose: Bisphosphonate (BP) is the first-line therapy for the management of osteoporosis. BP-related osteonecrosis of the jaw (BRONJ) and atypical femoral fracture (AFF) are increasingly common comorbidities in patients with osteoporosis under long-term BP treatment. The aim of this study was to evaluate the incidence and risk factors for AFF features on bone scintigraphy in patients with BRONJ. Methods: Among total of 373 BRONJ patients treated between September 2005 and July 2014, 237 (220 women, 17 men; median age 73 years) who underwent three-phase bone scintigraphy were enrolled for this retrospective study...
August 2018: Nuclear Medicine and Molecular Imaging
Muhammad Haroon, Kamil Khan, Lorraine Thong, Kabir Ali, Fayyaz Janjua
AIMS: (1) To calculate the absolute fracture risk by using the fracture risk assessment (FRAX) model among elderly medical inpatients; (2) to assess the risk of falls, especially among patients with increased risk of fractures; and (3) to design and implement a bone health protocol to improve the assessment of fracture risk. METHODS: The study participants were all inpatients admitted to the medical wards at University Hospital Kerry, Ireland. All consecutive eligible patients aged ≥ 65 years were prospectively evaluated to populate clinical risk factor variables used in the FRAX model and the fall assessment was made by using Fracture Risk Questionnaire...
August 11, 2018: Irish Journal of Medical Science
Matthew C Reed, Yehudit Bauernfreund, Niamh Cunningham, Brendan Beaton, Atul B Mehta, Derralynn A Hughes
Gaucher disease (GD) is a rare autosomal recessive disorder caused by deficient activity of β-glucocerebrosidase resulting in the accumulation of glucosylceramide. Bone disease is a common feature with radiological evidence in up to 93% of patients. Severity of bone involvement ranges from osteoporosis to pathological fractures. The progressive course of type 1 GD is largely mitigated by treatment with enzyme replacement therapy (ERT) or substrate reduction. A number of studies have shown some patients suffer bone events while receiving ERT...
August 9, 2018: Gene
M Tiefenbach, M Scheel, A Maier, M Gehlen, M Schwarz-Eywill, M Werner, U Siebers-Renelt, M Hammer
Osteomalacia is a bone disease caused by impaired skeletal mineralization. Vitamin D dependent types have to be distinguished from hypophosphatemic forms. Typical signs and symptoms include diffuse bone pain, muscle weakness and fragility fractures. The fracture pattern in osteomalacia is typically different from that of osteoporosis. Fragility fractures of the pelvis, sacrum, distal parts of the foot, proximal tibia and ribs are indicators for osteomalacia, whereas femoral neck and vertebral fractures (wedged vertebra, fish vertebra, vertebra plana and cover plate impression fractures) are typical for osteoporosis...
August 10, 2018: Zeitschrift Für Rheumatologie
Mark Graves, Kim Snyder, Joni McFelea, Jan Szczepanski, Mark Philip Smith, Thomas Strobel, Nona Mehrnia, Jacob Schneider, Madison J Snyder, Andrew Kilian Graves, Judith Canlas
INTRODUCTION/BACKGROUND: Osteoporosis is a common disorder and is associated with an increased risk of bone fracture. Falls are a proximate cause of a high proportion of medical costs and mortality. Improving balance can reduce the risk of falls and improve health outcomes, especially for the at-risk population of people with osteoporosis and osteopenia. The FrameWorksTM exercise program is a formal, standardized, informational and interventional 10-month exercise program. The purpose of this study was to quantitatively assess the improvement in standing balance, functional reach, and overall confidence in balance after participating in the 10-month program...
June 23, 2018: Journal of Clinical Densitometry
Peihong Su, Ye Tian, Chaofei Yang, Xiaoli Ma, Xue Wang, Jiawei Pei, Airong Qian
During bone modeling, remodeling, and bone fracture repair, mesenchymal stem cells (MSCs) differentiate into chondrocyte or osteoblast to comply bone formation and regeneration. As multipotent stem cells, MSCs were used to treat bone diseases during the past several decades. However, most of these implications just focused on promoting MSC differentiation. Furthermore, cell migration is also a key issue for bone formation and bone diseases treatment. Abnormal MSC migration could cause different kinds of bone diseases, including osteoporosis...
August 9, 2018: International Journal of Molecular Sciences
Joshua A Hirsch, Douglas P Beall, M Renée Chambers, Thomas G Andreshak, Allan L Brook, Brian M Bruel, H Gordon Deen, Peter C Gerszten, D Scott Kreiner, Charles A Sansur, Sean M Tutton, Peter van der Meer, Herman J Stoevelaar
BACKGROUND CONTEXT: Vertebral fragility fractures (VFF), mostly due to osteoporosis, are very common and are associated with significant morbidity and mortality. There is a lack of consensus on the appropriate management of patients with or suspected of having a VFF. PURPOSE: This work aimed at developing a comprehensive clinical care pathway (CCP) for VFF. STUDY DESIGN/SETTING: The RAND/UCLA Appropriateness Method (RUAM) was used to develop patient-specific recommendations for the various components of the CCP...
August 7, 2018: Spine Journal: Official Journal of the North American Spine Society
A V Hauger, A Bergland, K Holvik, A Ståhle, N Emaus, B H Strand
Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality? BMD consistent with osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population in Tromsø, Norway. INTRODUCTION: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteoporosis, can predict mortality and if grip strength is an effect modifier...
August 9, 2018: Osteoporosis International
Stephen J Warner, Matthew R Garner, Peter D Fabricant, Dean G Lorich
INTRODUCTION: Osteoporosis and decreased bone density are known to increase fracture incidence and severity. Although much is known regarding the effects of bone density on fracture risk and the treatment options for prevention of fragility fractures, whether bone quality alters clinical outcomes after fracture fixation is unknown. The purpose of this study was to determine whether bone quality correlates with clinical outcomes after fracture fixation. MATERIALS AND METHODS: A prospective database of all operatively treated ankle fractures by a single surgeon from 2003 to 2013 was used to identify patients...
August 9, 2018: Archives of Orthopaedic and Trauma Surgery
Manuel Muñoz-Torres, Rossana Manzanares Córdova, Antonia García-Martín, María Dolores Avilés-Pérez, Rafael Nieto Serrano, Francisco Andújar-Vera, Beatriz García-Fontana
BACKGROUND: Patients with primary hyperparathyroidism usually show decreased bone strength that are often not well diagnosed by conventional Dual-energy X-ray absorptiometry (DXA). Trabecular Bone Score (TBS) is a new technique for assessing bone microarchitecture indirectly. This cross-sectional study evaluates the usefulness of TBS in patients with primary hyperparathyroidism in clinical practice. METHODOLOGY: Bone mineral density (BMD) by DXA and TBS values by TBS InSight® software were determined in 72 patients with primary hyperparathyroidism to analyze its relationship with fragility fractures...
June 27, 2018: Journal of Clinical Densitometry
Joon-Yong Jung, Seung Hee Han, Yeon Sik Hong, Sung-Hwan Park, Ji Hyeon Ju, Kwi Young Kang
OBJECTIVE: To determine the association between inflammatory lesions on spinal magnetic resonance imaging (MRI) and trabecular bone score (TBS) in patients with ankylosing spondylitis (AS). METHODS: Ninety-seven patients with AS underwent spine MRI and dual energy x-ray absorptiometry of the lumbar spine to measure TBS and bone mineral density. Bone marrow edema (BME) on MRI was considered an inflammatory lesion. The presence, depth (>1 cm), and intensity of BME on MRI were scored for the 1st-4th lumbar spine segments...
August 10, 2018: Modern Rheumatology
Y Xu, Q Wu
Studies examining recent bone mineral density (BMD) trends in the US population are limited. In our study, we found that age-adjusted mean BMD among US men and women was stable from 2005 to 2010, but then declined in 2013-2014. We also explored factors associated with decreasing BMD in recent years. INTRODUCTION: Osteoporosis prevalence in the USA declined between 1988 and 2006, while the declining trend in hip fracture may have plateaued in 2013-2014. We aimed to examine whether there has been a corresponding change in BMD trajectory for the US population...
August 8, 2018: Osteoporosis International
L M Giangregorio, J C Gibbs, J A Templeton, J D Adachi, M C Ashe, R R Bleakney, A M Cheung, K D Hill, D L Kendler, A A Khan, S Kim, C McArthur, N Mittmann, A Papaioannou, S Prasad, S C Scherer, L Thabane, J D Wark
We pilot-tested a trial of home exercise on individuals with osteoporosis and spine fracture. Our target enrollment was met, though it took longer than expected. Participants stayed in the study and completed the exercise program with no safety concerns. Future trials should expand the inclusion criteria and consider other changes. PURPOSE: Osteoporotic fragility fractures create a substantial human and economic burden. There have been calls for a large randomized controlled trial examining the effect of exercise on fracture incidence...
August 8, 2018: Osteoporosis International
Stuart L Silverman, E Siris, D Belazi, C Recknor, A Papaioannou, J P Brown, D T Gold, E M Lewiecki, G Quinn, A Balasubramanian, S Yue, B Stolshek, D L Kendler
Persistence with prescribed medications for chronic diseases is important; however, persistence with osteoporosis treatments is historically poor. In this prospective cohort study of postmenopausal women treated for osteoporosis in real-world clinical practice settings in the USA and Canada, 24-month persistence with denosumab was 58%. PURPOSE: Patients who persist with their prescribed osteoporosis treatment have increased bone mineral density (BMD) and reduced risk of fracture. Twelve-month persistence with denosumab in routine clinical practice is as high as 95%, but there are limited data on longer-term persistence with denosumab in this setting...
August 7, 2018: Archives of Osteoporosis
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