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fracture osteoporosis

Soeun Jeon, Kyungho Cho, Gina Ok, Sukho Lee, Hyon Park
PURPOSE: The purpose of this study was to investigate the impact of weight loss practices on nutritional status, bone health, and injury history among Korean professional jockeys. METHODS: Forty-three male jockeys completed a questionnaire to assess their weight loss practices. Of these, 10 jockeys were selected for in-depth assessment of their nutritional status, bone health, and injury history. RESULTS: The questionnaires revealed that 81...
September 30, 2018: Journal of Exercise Nutrition & Biochemistry
Stuart Silverman, Bente L Langdahl, Saeko Fujiwara, Ken Saag, Nicola Napoli, Satoshi Soen, Hiroyuki Enomoto, Thomas E Melby, Damon P Disch, Fernando Marin, John H Krege
The phase 3 teriparatide Fracture Prevention Trial showed significant reductions in vertebral (VF) and nonvertebral (NVF) fractures; however, patient exposure was insufficient for full analysis of low-incidence fractures, including hip. We assessed fracture results in pooled data from four prospective, observational teriparatide studies. Ambulatory women and men with osteoporosis received subcutaneous teriparatide 20 µg/day for up to 24 months per routine clinical practice. Fracture rates were compared between 6-month periods, using 0 to 6 months of treatment as the reference period...
October 20, 2018: Calcified Tissue International
Heidi Chandler, Beate Lanske, Aurore Varela, Martin Guillot, Marilyne Boyer, Jeffrey Brown, Allen Pierce, Michael Ominsky, Bruce Mitlak, Roland Baron, Paul Kostenuik, Gary Hattersley
Male osteoporosis can occur with advanced age and with hypogonadism, with increased bone resorption and/or inadequate bone formation contributing to reduced bone mass and increased fracture risk. Abaloparatide is a selective PTH receptor agonist that increases bone formation and bone mass in postmenopausal women with osteoporosis and in estrogen-deficient animals. The current study evaluated the effects of abaloparatide in orchiectomized (ORX) rats, a model of male osteoporosis. Four-month-old Sprague-Dawley rats underwent ORX or sham surgery; 8 weeks later the ORX groups exhibited relative osteopenia vs sham controls, based on dual X-ray absorptiometry (DXA) and/or peripheral quantitative computed tomography (pQCT) assessments at the total body, lumbar spine, femur, and tibia...
October 18, 2018: Bone
Antoine Morvan, Jacques Boddaert, Judith Cohen-Bittan, Hervé Picard, Hugues Pascal-Mousselard, Frédéric Khiami
INTRODUCTION: Proximal femoral fracture is associated with severe morbidity and mortality and high socioeconomic costs. The main mechanical complication of internal fixation in trochanteric fracture is lag-screw cut-out through the femoral head. Several factors are involved, but remain controversial. The aim of the present study was to determine risk factors for cut-out in internal fixation of extracapsular proximal femoral fracture. METHODS: A single-center retrospective study was conducted on a continuous series of 228 patients aged over 75 years, operated on for trochanteric fracture by gamma3 nail or DHS screw plate between July 2009 and December 2014...
October 17, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Parminder Singh
Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Bone diseases such as rickets in children, osteomalacia and osteoporosis in adults are related with vitamin D insufficiency...
January 2018: Journal of the Association of Physicians of India
Manon Belhassen, Bernard Cortet, Cyrille B Confavreux, Liliane Lamezec, Marine Ginoux, Eric Van Ganse
Limited information is available on the impact of bisphosphonate compliance levels on fracture risk in osteoporosis patients in France. The results of this nested case-control, retrospective study suggest that fracture risk did not significantly change with bisphosphonate compliance levels, except for highly compliant patients. PURPOSE/INTRODUCTION: This was the first study conducted in France to evaluate the impact of compliance levels for bisphosphonates, the most frequently prescribed first-line anti-osteoporotic treatment, on fracture risk...
October 19, 2018: Archives of Osteoporosis
Claire I A van Houdt, Paulo R Gabbai-Armelin, Paula M Lopez-Perez, Dietmar J O Ulrich, John A Jansen, Ana Claudia M Renno, Jeroen J J P van den Beucken
Osteoporosis represents a major health problem in terms of compromising bone strength and increasing the risk of bone fractures. It can be medically treated with bisphosphonates, which act systemically upon oral or venous administration. Further, bone regenerative treatments in osteoporotic conditions present a challenge. Here, we focused on the development of a synthetic bone substitute material with local diminishing effects on osteoporosis. Composites were created using calcium phosphate cement (CPC; 60 wt%) and polylactic-co-glycolic acid (PLGA; 40 wt%), which were loaded with alendronate (ALN)...
October 18, 2018: Scientific Reports
Patricia C S Parreira, Christopher G Maher, Adrian C Traeger, Mark J Hancock, Aron Downie, Bart W Koes, Manuela L Ferreira
OBJECTIVES: (1) Describe the evolution of guideline-endorsed red flags for fracture in patients presenting with low back pain; (2) evaluate agreement between guidelines; and (3) evaluate the extent to which recommendations are accompanied by information on diagnostic accuracy of endorsed red flags. DESIGN: Systematic review. DATA SOURCES: MEDLINE and PubMed, PEDro, CINAHL and EMBASE electronic databases. We also searched in guideline databases, including the National Guideline Clearinghouse and Canadian Medical Association Infobase ...
October 18, 2018: British Journal of Sports Medicine
Kun-Hung Lai, Chih-Yung Chiang, Rong-Sen Yang, Kai-Chiang Yang, Chang-Chin Wu
BACKGROUND: Patients with chronic obstructive pulmonary disease have a high prevalence of osteoporosis, and different osteoporosis drugs are used to prevent fractures in these patients. Although the overall incidence of complete or incomplete, atypical femoral fracture (AFF) is low, long-term use of antiresorptive agents is associated with an increased risk of developing AFF. METHODS: We present a patient with chronic obstructive pulmonary disease with recurrent symptoms of an incomplete AFF who had been treated with glucocorticoids, and sequentially with alendronate, zoledronic acid, strontium ranelate, raloxifene, denosumab and finally with teriparatide...
October 19, 2018: Acta Clinica Belgica
Ya-Kang Wang, Yu-Min Zhang, Si-Qing Qin, Xu Wang, Tao Ma, Jian-Bin Guo, Chao Zhu, Zhuo-Jing Luo
BACKGROUND: Alendronate has been used to prevent or treat glucocorticoid-induced osteoporosis (GIO), data regarding its efficacy are inconsistent. We conducted the current systematic review and meta-analysis to evaluate both efficacy and safety of alendronate in the treatment of GIO. METHODS: PubMed, Embase, the Cochrane Controlled Trials Registry, and the China Academic Journal Network Publishing Databases were searched up through March 1, 2018. Randomized controlled trials (RCTs) involving patients which received alendronate treatment were included...
October 2018: Medicine (Baltimore)
Magnus Bernhardsson, Per Aspenberg
Background and purpose - Teriparatide accelerates fracture healing in animals and probably in man. Abaloparatide is a new drug with similar although not identical effects on the teriparatide receptor. Given at 4 times the teriparatide dose in a human osteoporosis trial, abaloparatide increased bone density more than teriparatide, and both reduced fracture risk. We investigated in mice whether abaloparatide stimulates fracture healing, and if it does so with the suggested dose effect relation (4:1). Patients and methods - In a validated mouse model for metaphyseal healing (burr hole with screw pull-out), 96 mice were randomly allocated to 11 groups: control (saline), teriparatide or abaloparatide, where teriparatide and abaloparatide were given at 5 different doses each...
October 18, 2018: Acta Orthopaedica
Wenhou Duan, Xin Meng, Yanxin Sun, Chongqi Jia
The association between osteoporosis and polycyclic aromatic hydrocarbons was not clear. However, recent studies showed that both osteoporosis and polycyclic aromatic hydrocarbons were associated with reactive oxygen species. So we presumed that polycyclic aromatic hydrocarbons were associated with increased odds of osteoporosis. We found 3-hydroxyfluorene was associated with decreased odds of osteoporosis, while 2-hydroxyfluorene was associated with increased odds of osteoporosis. PURPOSE: Previous studies showed that polycyclic aromatic hydrocarbons were involved in the production of reactive oxygen species that played an important role in illness...
October 17, 2018: Archives of Osteoporosis
Feng Wang, Chen Meng, Xing-Bing Cao, Qi Chen, Xiao-Feng Xu, Qian Chen
OBJECTIVE: To discuss the hemiarthroplasty for the threatment of femoral intertrochanteric fracture in elderly patients. METHODS: From August 2013 to January 2017, 66 elderly patients with complicated femoral intertrochanteric fracture were treated including 20 males and 46 females with an average age of 85 years old ranging from 80 to 95. According to improve Evans classification, 33 cases were type III, 24 cases were type IV, 9 cases were type V. History included 31 cases of hypertension, 10 cases of diabetes, 12 cases of severe osteoporosis, 5 cases of atrial fibrillation, 3 cases of pulmonary heart disease, and 1 case of multiple myeloma...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Alina T Midro, Beata Stasiewicz-Jarocka, Jan Borys, Kazimierz Kozłowski, Bożena Skotnicka, Eugeniusz Tarasów, Ewa Hubert, Jerzy Konstantynowicz, Barbara Panasiuk, Małgorzata Rydzanicz, Agnieszka Pollak, Piotr Stawiński, Rafał Skowroński, Rafał Płoski
We present a natural history of a 32-year-old man with Hajdu-Cheney syndrome (HJCYS), because of the de novo truncating mutation in the exon 34 of NOTCH2 (c.6424-6427delTCTG, p.Ser2142ArgfsX4), who has been followed up for a period of 23 years (between 9 and 32 years). During follow-up, we observed abnormalities of vision, hearing, voice, and progression of craniofacial features in the form of skeletal dysplasia with affected skull, dentition, spine, limbs, fingers, and toes. Low bone mineral density and history of fragility fractures also suggested primary osteoporosis being a clinical manifestation...
October 17, 2018: American Journal of Medical Genetics. Part A
Camilla Bergh, Ann-Charlott Söderpalm, Helena Brisby
BACKGROUND: Osteoporosis implies an increased risk of complications after orthopedic surgery. For the mostly elderly group of patients undergoing lumbar spinal stenosis surgery (LSS), it is important to include skeletal health evaluation in the preoperative planning. The aim of this study was to assess spine and femoral neck (FN) bone mineral density (BMD) in LSS patients and to evaluate whether the World Health Organization (WHO) fracture risk assessment tool (FRAX) can identify patients with reduced BMD levels in the spine...
October 16, 2018: Journal of Orthopaedic Surgery and Research
Nathan Kirzner, Eldho Paul, Ash Moaveni
BACKGROUND: Bony increased-offset reverse shoulder arthroplasty (BIO-RSA) may address issues such as inferior scapular notching, prosthetic instability and limited postoperative shoulder rotation; all of which have been reported with the standard RSA and attributed to the medialized design. We hypothesised that this lateralization may increase the rate of scapular stress fractures. METHODS: A retrospective review of prospectively collected data was performed on patients who had undergone a RSA between January 2013 and October 2016...
October 16, 2018: Journal of Orthopaedic Surgery and Research
Hayfa Romdhane, Shema Ayadi, Nour Elleuch, Kawther Abdelghani
BACKGROUND: Proton pump inhibitors (PPIs) are widespread nowadays. Recent concerns haveemerged about possible bone complications of their long-term use, as lowbone mineral density (BMD) and an increased risk of fractures. AIM: To evaluate the effect of long-term use of PPIs on boneby estimating the frequency of osteopenia andosteoporosis, and determining the risk factors associated to these complications. METHODS: A prospective study including consecutive patients taking PPI for at least one year...
March 2018: La Tunisie Médicale
Qudong Yin, Jian Wang, Qiang Fu, Sanjun Gu, Yongjuan Rui
OBJECTIVE: We aimed to discover the molecular mechanism of hsa_circ_0076694 (circRUNX2) on osteogenic differentiation. We also explored the interaction between circRUNX2, miR-203 and RUNX2. METHODS: Clinical samples obtained from femoral neck fracture patients' bone tissues were used to collect circRUNX2, miR-203, and RUNX2 expression data, while their expression changes were observed in human bone mesenchymal stem cells (hBMSCs) during osteogenic differentiation...
October 16, 2018: Journal of Cellular and Molecular Medicine
M Wallander, K F Axelsson, D Lundh, M Lorentzon
Osteoporosis is a common complication of androgen deprivation therapy (ADT). In this large Swedish cohort study consisting of a total of nearly 180,000 older men, we found that those with prostate cancer and ADT have a significantly increased risk of future osteoporotic fractures. INTRODUCTION: Androgen deprivation therapy (ADT) in patients with prostate cancer is associated to increased risk of fractures. In this study, we investigated the relationship between ADT in patients with prostate cancer and the risk of incident fractures and non-skeletal fall injuries both compared to those without ADT and compared to patients without prostate cancer...
October 15, 2018: Osteoporosis International
J A Kanis, C Cooper, R Rizzoli, J-Y Reginster
Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis. INTRODUCTION: The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2013. This manuscript updates these in a European setting. METHODS: Systematic reviews were updated. RESULTS: The following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fracture risk; general and pharmacological management of osteoporosis; monitoring of treatment; assessment of fracture risk; case-finding strategies; investigation of patients; health economics of treatment...
October 15, 2018: Osteoporosis International
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