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Wheezing infant

Antonio Del Vecchio, Caterina Franco, Karin Del Vecchio, Angela Umbaldo, Letizia Capasso, Francesco Raimondi
Infants born prematurely before 37 weeks of gestational age (GA), have particular anatomical, immunological and metabolic characteristics that predispose them, even in the absence of diseases at birth, to severe morbidity. Respiratory syncytial virus (RSV) is the leading cause of hospitalization for lower respiratory tract infections (LRTI) in the first year of life, as well as an important cause of respiratory outcomes as recurrent wheezing in industrialized countries or mortality in developing countries. Prematurity is an important risk factor for hospitalization for severe RSV disease, but epidemiological , environmental and demographic risk factors also play a role in RSV infection...
October 18, 2018: Minerva Pediatrica
Stefan Pilz, Armin Zittermann, Rima Obeid, Andreas Hahn, Pawel Pludowski, Christian Trummer, Elisabeth Lerchbaum, Faustino R Pérez-López, Spyridon N Karras, Winfried März
Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the "active vitamin D hormone" calcitriol support the important role of vitamin D in this setting...
October 12, 2018: International Journal of Environmental Research and Public Health
Shuwen Feng, Dongxin Zeng, Junwen Zheng, Dongchi Zhao
Respiratory syncytial virus (RSV) is the most important pathogen correlated to the first-time infant wheezing and later recurrence after its primary infection. RSV infection promotes the bronchial smooth muscle sensitivity to leukotrienes (LTs) in acute stage, causes the extensive inflammatory reaction and the aggregation of Th2-like cells during respiratory tract obstruction. Infants and young children infected with RSV exhibit an increased susceptibility to the exposure of exogenous allergens, easy to suffer from the recurrent wheezing, which prompts that the body is still in a state of inflammation or immunological bias...
2018: Frontiers in Microbiology
Carlos Kofman, Alejandro Teper
Background: In vitro and scintigraphic studies have suggested that effectiveness of metered-dose inhalers (MDI) with nonvalved spacers (NVS) is similar to that of MDI with valved holding chambers (VHC). Nevertheless, there are no clinical studies that compare these techniques in long-term treatment with inhaled steroids in young children with recurrent wheezing and risk factors for asthma. Objective: To compare the efficacy of a long-term treatment with Fluticasone Propionate administered by an MDI through both type of spacers, with and without valves, in young children with recurrent wheezing and risk factors for asthma...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Orianne Dumas, Kohei Hasegawa, Jonathan M Mansbach, Ashley F Sullivan, Pedro A Piedra, Carlos A Camargo
BACKGROUND: A better understanding of bronchiolitis heterogeneity may help clarify its relationship with the development of recurrent wheezing and asthma. OBJECTIVES: To identify severe bronchiolitis profiles by a clustering approach, and to investigate for the first time their association with allergy/inflammatory biomarkers; nasopharyngeal microbiota; and development of recurrent wheezing by age 3 years. METHODS: We analyzed data from a prospective, 17-center U...
September 18, 2018: Journal of Allergy and Clinical Immunology
Patrick G Holt, Danny Mok, Debasis Panda, Lynnsey Renn, Giulia Fabozzi, Nick H deKlerk, Merci Mh Kusel, Michael Serralha, Elysia M Hollams, Barbara J Holt, Peter D Sly, Ronald L Rabin
BACKGROUND: Virus-associated febrile lower respiratory tract infections (fLRI) during infancy have been identified as risk factors for persistent wheeze development. We hypothesized that variations in innate immune defence capacity during this period, exemplified by production of types 1 and 3 interferons (T1/3IFNs), may be an underlying determinant of risk. OBJECTIVE: To investigate relationships between postnatal development of innate interferon response capacity and susceptibility to early infections and persistent wheeze...
September 11, 2018: Journal of Allergy and Clinical Immunology
Shu Mei Teo, Howard H F Tang, Danny Mok, Louise M Judd, Stephen C Watts, Kym Pham, Barbara J Holt, Merci Kusel, Michael Serralha, Niamh Troy, Yury A Bochkov, Kristine Grindle, Robert F Lemanske, Sebastian L Johnston, James E Gern, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the nasopharyngeal microbiome (NPM) were characterized in 244 infants through their first five years of life. Through this analysis, we demonstrate that >80% of infectious events involve viral pathogens, but are accompanied by a shift in the NPM toward dominance by a small range of pathogenic bacterial genera...
September 12, 2018: Cell Host & Microbe
Paul Walsh, Stephen J Rothenberg
BACKGROUND: Bronchiolitis sometimes triggers the development of subsequent recurrent wheezing. Treatment with either acetaminophen or ibuprofen during the initial episode may affect the occurrence of subsequent wheezing. MATERIALS AND METHODS: We did a retrospective study comparing the effect of prescribing acetaminophen, ibuprofen, or neither for a first episode of bronchiolitis on medical attendances for subsequent wheezing in infants younger than 12 months. We created our cohorts using California Medicaid data from 2003 to 2010...
2018: PloS One
Nada Townsi, Ingrid A Laing, Graham L Hall, Shannon J Simpson
Children born preterm, less than 37 weeks' gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth...
2018: European Clinical Respiratory Journal
Yıldız Perk, Mine Özdil
Respiratory syncytial virus is one of the major causes of respiratory tract infections during infancy with high rates of hospitalization and mortality during the first years of life. It is the most common cause of acute bronchiolitis and viral pneumonia in children below two years of age and second the most common cause of postneonatal infant mortality all around the world following malaria. In addition, the virus has been causally linked to recurrent wheezing and associated with pediatric asthma. The respiratory syncytial virus infections tend to be severe in high risk patients such as patients below six months of age, with prematurity, congenital heart diseases, neuromuscular diseases and immune deficiencies...
June 2018: Türk Pediatri Arşivi
Carole Egron, Laurence Roszyk, Emmanuelle Rochette, Matthieu Jabaudon, Vincent Sapin, Aurélien Mulliez, André Labbé, Karen Coste
INTRODUCTION: Acute bronchiolitis is a major cause of acute respiratory distress in infants. The soluble receptor for advanced glycation end-products (sRAGE) is a biomarker of pulmonary damage processes, with a diagnostic and a prognostic value in acute respiratory distress syndrome (ARDS). The RAGE pathway is also implicated in the pathogenesis of other respiratory diseases like asthma, but the value of sRAGE levels in acute bronchiolitis remains under-investigated. MATERIAL AND METHODS: A prospective, observational, and analytical study was conducted at Clermont-Ferrand University Hospital...
October 2018: Pediatric Pulmonology
Cláudio D'Elia, Javier Mallol, Dirceu Solé
BACKGROUND: Recurrent wheezing during the first year of life is a major cause of respiratory morbidity worldwide, yet there are no studies on its prevalence in Portugal. OBJECTIVE: Determine the prevalence and severity of recurrent wheezing, treatments employed and other related aspects, in infants during their first year of life in Setúbal, Portugal. METHODS: This is a cross-sectional study of a random sample of infants aged 12-15 months living in Setúbal district...
August 2, 2018: Allergologia et Immunopathologia
Amy K Hutchinson, Raymond T Kraker, Stacy L Pineles, Deborah K VanderVeen, Lorri B Wilson, Jennifer A Galvin, Scott R Lambert
OBJECTIVE: To review the published literature assessing the efficacy of beta-blockers for the treatment of periocular hemangioma in infants. METHODS: Literature searches were conducted in May 2018 in PubMed with no date restrictions and limited to studies published in English and in the Cochrane Library database without any restrictions. The combined searches yielded 437 citations. Of these,16 articles were deemed appropriate for inclusion in this assessment and assigned a level of evidence rating by the panel methodologist...
July 31, 2018: Ophthalmology
Saad B Omer, Robert Bednarczyk, Momin Kazi, L Beryl Guterman, Fatima Aziz, Kristen E Allen, Inci Yildirim, S Asad Ali
Standardized case definitions are needed in decision-making regarding respiratory syncytial virus(RSV) control strategies, including vaccine evaluation. A syndromic case definition comprising of "wheeze or apnea or cyanosis" could be useful for community-based surveillance of moderate RSV infection among young infants particularly in resource-limited settings. However, this definition showed modest specificity (29.2-49.6%) indicating that community-based surveillance may need augmentation with other data...
August 2, 2018: Pediatric Infectious Disease Journal
Maria Cristina Ribeiro Dos Santos Simões, Yuri Inoue, Natasha Y Matsunaga, Maria R V Carvalho, Gisleine L T Ribeiro, Eliane O Morais, Maria A G O Ribeiro, André M Morcillo, José D Ribeiro, Adyléia A D C Toro
OBJECTIVE: To evaluate the prevalence and risk factors associated with progression to recurrent wheezing in preterm infants. METHODS: The cross-sectional study was carried out in 2014 and 2015 and analyzed preterm infants born between 2011 and 2012. The search for these children was performed in a university maternity hospital and a Special Immunobiological Reference Center. The evaluation was performed through a questionnaire applied during a telephone interview...
July 20, 2018: Jornal de Pediatria
Song-Ying Shen, Wan-Qing Xiao, Jin-Hua Lu, Ming-Yang Yuan, Jian-Rong He, Hui-Min Xia, Xiu Qiu, Kar Keung Cheng, Kin Bong Hubert Lam
BACKGROUND: Vitamin D deficiency has been linked to an increased risk of asthma. This study aimed to quantify the effect of early life vitamin D status on asthma and wheeze later in life. METHODS: PubMed, Embase, CINAHL, and CNKI databases, the Cochrane Central Register of Controlled Trials, and Google Scholar were searched up to July 2017. We included randomized controlled trials (RCTs) and cohort studies with vitamin D level in blood (maternal or cord or infant) or intake (maternal intake during pregnancy or infant intake) and asthma and/or wheeze...
July 20, 2018: BMC Pulmonary Medicine
Hooman Mirzakhani, Amal A Al-Garawi, Vincent J Carey, Weiliang Qiu, Augusto A Litonjua, Scott T Weiss
Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways...
July 18, 2018: Thorax
A R Ouedraogo, K Boncoungou, S Maïga, G Ouedraogo, G Badoum, O Diallo, G Bonkoungou, R Nacanabo, M Ouedraogo
INTRODUCTION: Abnomalies of the aortic arches are rare and account for 1% of congenital cardiovascular malformations. They constitute one of the causes of compression of the airways with attacks of dyspnea sometimes simulating an asthma. We report the case of an infant with an anomaly development of aortic arches with impact breathing. CASE REPORT: It was a 22-month-old infant who consulted for a dyspnea with a type of stridor associated with a fat cough. This clinical table started 45 days after its birth and led to many hospitalizations in the pediatric emergency...
September 2018: Revue de Pneumologie Clinique
Ghada Abo-Zaid, Richard A Sharpe, Lora E Fleming, Michael Depledge, Nicholas J Osborne
The influence of early life exposures on later life disease has for some time provided clues to modifiable risk factors of disease. The “atopic march” is thought to play a role in the progression of allergic diseases and may offer an opportunity to lower asthma’s health and socioeconomic burden, although evidence remains controversial. We aimed to examine the relationship between early life eczema and asthma later in life. Using the National Child Development Study, we examined infant eczema and childhood and adult asthma...
July 5, 2018: International Journal of Environmental Research and Public Health
Nada Sindičić Dessardo, Elvira Mustać, Srdjan Banac, Sandro Dessardo
INTRODUCTION: Long-lasting respiratory symptoms have a huge impact on the quality of life in prematurely born children. The aim was to investigate paths of assumed causality leading from foetal inflammatory response syndrome (FIRS) to asthma symptoms in preterms. METHODS: Demographic, antenatal, delivery and outcome data were collected from 262 infants with less than 32 completed weeks of gestational age over a 10-year period in a prospective cohort study. The presence of symptoms of asthma beyond the age of 5 years was the primary outcome measure...
August 24, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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