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Wheezing infant

Carole Egron, Laurence Roszyk, Emmanuelle Rochette, Matthieu Jabaudon, Vincent Sapin, Aurélien Mulliez, André Labbé, Karen Coste
INTRODUCTION: Acute bronchiolitis is a major cause of acute respiratory distress in infants. The soluble receptor for advanced glycation end-products (sRAGE) is a biomarker of pulmonary damage processes, with a diagnostic and a prognostic value in acute respiratory distress syndrome (ARDS). The RAGE pathway is also implicated in the pathogenesis of other respiratory diseases like asthma, but the value of sRAGE levels in acute bronchiolitis remains under-investigated. MATERIAL AND METHODS: A prospective, observational, and analytical study was conducted at Clermont-Ferrand University Hospital...
August 16, 2018: Pediatric Pulmonology
Cláudio D'Elia, Javier Mallol, Dirceu Solé
BACKGROUND: Recurrent wheezing during the first year of life is a major cause of respiratory morbidity worldwide, yet there are no studies on its prevalence in Portugal. OBJECTIVE: Determine the prevalence and severity of recurrent wheezing, treatments employed and other related aspects, in infants during their first year of life in Setúbal, Portugal. METHODS: This is a cross-sectional study of a random sample of infants aged 12-15 months living in Setúbal district...
August 2, 2018: Allergologia et Immunopathologia
Amy K Hutchinson, Raymond T Kraker, Stacy L Pineles, Deborah K VanderVeen, Lorri B Wilson, Jennifer A Galvin, Scott R Lambert
OBJECTIVE: To review the published literature assessing the efficacy of beta-blockers for the treatment of periocular hemangioma in infants. METHODS: Literature searches were conducted in May 2018 in PubMed with no date restrictions and limited to studies published in English and in the Cochrane Library database without any restrictions. The combined searches yielded 437 citations. Of these,16 articles were deemed appropriate for inclusion in this assessment and assigned a level of evidence rating by the panel methodologist...
July 31, 2018: Ophthalmology
Saad B Omer, Robert Bednarczyk, Momin Kazi, L Beryl Guterman, Fatima Aziz, Kristen E Allen, Inci Yildirim, S Asad Ali
Standardized case definitions are needed in decision-making regarding respiratory syncytial virus(RSV) control strategies, including vaccine evaluation. A syndromic case definition comprising of "wheeze or apnea or cyanosis" could be useful for community-based surveillance of moderate RSV infection among young infants particularly in resource-limited settings. However, this definition showed modest specificity (29.2-49.6%) indicating that community-based surveillance may need augmentation with other data...
August 2, 2018: Pediatric Infectious Disease Journal
Maria Cristina Ribeiro Dos Santos Simões, Yuri Inoue, Natasha Y Matsunaga, Maria R V Carvalho, Gisleine L T Ribeiro, Eliane O Morais, Maria A G O Ribeiro, André M Morcillo, José D Ribeiro, Adyléia A D C Toro
OBJECTIVE: To evaluate the prevalence and risk factors associated with progression to recurrent wheezing in preterm infants. METHODS: The cross-sectional study was carried out in 2014 and 2015 and analyzed preterm infants born between 2011 and 2012. The search for these children was performed in a university maternity hospital and a Special Immunobiological Reference Center. The evaluation was performed through a questionnaire applied during a telephone interview...
July 20, 2018: Jornal de Pediatria
Song-Ying Shen, Wan-Qing Xiao, Jin-Hua Lu, Ming-Yang Yuan, Jian-Rong He, Hui-Min Xia, Xiu Qiu, Kar Keung Cheng, Kin Bong Hubert Lam
BACKGROUND: Vitamin D deficiency has been linked to an increased risk of asthma. This study aimed to quantify the effect of early life vitamin D status on asthma and wheeze later in life. METHODS: PubMed, Embase, CINAHL, and CNKI databases, the Cochrane Central Register of Controlled Trials, and Google Scholar were searched up to July 2017. We included randomized controlled trials (RCTs) and cohort studies with vitamin D level in blood (maternal or cord or infant) or intake (maternal intake during pregnancy or infant intake) and asthma and/or wheeze...
July 20, 2018: BMC Pulmonary Medicine
Hooman Mirzakhani, Amal A Al-Garawi, Vincent J Carey, Weiliang Qiu, Augusto A Litonjua, Scott T Weiss
Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways...
July 18, 2018: Thorax
A R Ouedraogo, K Boncoungou, S Maïga, G Ouedraogo, G Badoum, O Diallo, G Bonkoungou, R Nacanabo, M Ouedraogo
INTRODUCTION: Abnomalies of the aortic arches are rare and account for 1% of congenital cardiovascular malformations. They constitute one of the causes of compression of the airways with attacks of dyspnea sometimes simulating an asthma. We report the case of an infant with an anomaly development of aortic arches with impact breathing. CASE REPORT: It was a 22-month-old infant who consulted for a dyspnea with a type of stridor associated with a fat cough. This clinical table started 45 days after its birth and led to many hospitalizations in the pediatric emergency...
July 14, 2018: Revue de Pneumologie Clinique
Ghada Abo-Zaid, Richard A Sharpe, Lora E Fleming, Michael Depledge, Nicholas J Osborne
The influence of early life exposures on later life disease has for some time provided clues to modifiable risk factors of disease. The “atopic march” is thought to play a role in the progression of allergic diseases and may offer an opportunity to lower asthma’s health and socioeconomic burden, although evidence remains controversial. We aimed to examine the relationship between early life eczema and asthma later in life. Using the National Child Development Study, we examined infant eczema and childhood and adult asthma...
July 5, 2018: International Journal of Environmental Research and Public Health
Nada Sindičić Dessardo, Elvira Mustać, Srdjan Banac, Sandro Dessardo
Introduction; Long-lasting respiratory symptoms have a huge impact on the quality of life in prematurely born children.The aim was to investigate paths of assumed causality leading from Foetal Inflammatory Response Syndrome to asthma symptoms in preterms. Methods; Demographic, antenatal, delivery and outcome data were collected from 262 infants with less than 32 completed weeks of gestational age over a 10-year period in a prospective cohort study. The presence of symptoms of asthma beyond the age of 5 years was the primary outcome measure...
July 4, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Marketa Vrbova, Petra Dorociakova, Roman Vyskovsky, Lubica Palkovicova Murinova, Peter Ciznar, Katarina Rausova, Scott J N McNabb, Eva Reichrtova, Eva Budinska, Vojtech Thon
Allergic diseases have increased in developed countries during the past decades. A cohort of Slovak children was followed from birth to track allergic symptoms dynamics in early childhood. Information on allergic symptoms (atopic dermatitis = AD, rhino conjunctivitis = RC, wheezing = Wh, urticaria = Ur) and food allergies among children was based on clinical evaluation of children by allergists at three developmental stages (infant, toddler, preschool). Out of 320 cases of allergies, 64 infants, 145 toddlers, and 195 preschool children suffered from AD, RC, Wh, Ur, or their combinations (i...
June 22, 2018: European Journal of Pediatrics
Megha Thakur, Paulien A W Nuyts, Esther A Boudewijns, Javier Flores Kim, Timor Faber, Giridhara R Babu, Onno C P van Schayck, Jasper V Been
OBJECTIVES: Improved biomass cookstoves may help reduce the substantial global burden of morbidity and mortality due to household air pollution (HAP) that disproportionately affects women and children in low and middle income countries (LMICs). DESIGN: Systematic review and meta-analysis of (quasi-)experimental studies identified from 13 electronic databases (last update: 6 April 2018), reference and citation searches and via expert consultation. SETTING: LMICs PARTICIPANTS: Women and children INTERVENTIONS: Improved biomass cookstoves MAIN OUTCOME MEASURES: Low birth weight (LBW), preterm birth, perinatal mortality, paediatric acute respiratory infections (ARIs) and COPD among women...
June 20, 2018: Thorax
Zihang Lu, Rachel E Foong, Krzysztof Kowalik, Theo J Moraes, Ayanna Boyce, Aimee Dubeau, Susan Balkovec, Per Magnus Gustafsson, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Wendy Lou, Felix Ratjen, Malcolm Sears, Padmaja Subbarao
BACKGROUND: The care of infants with recurrent wheezing relies largely on clinical assessment. The lung clearance index (LCI), a measure of ventilation inhomogeneity, is a sensitive marker of early airway disease in children with cystic fibrosis, but its utility has not been explored in infants with recurrent wheezing. OBJECTIVE: To assess ventilation inhomogeneity using LCI among infants with a history of recurrent wheezing compared with healthy controls. METHODS: This is a case-control study, including 37 infants with recurrent wheezing recruited from outpatient clinics, and 113 healthy infants from a longitudinal birth cohort, the Canadian Healthy Infant Longitudinal Development study...
June 15, 2018: Thorax
O Del Moral-Hernández, C Santiago-Olivares, E Rivera-Toledo, J Gaona, E Castillo-Villanueva, B Gómez
Respiratory syncytial virus (RSV) is a highly prevalent infectious agent that causes severe respiratory tract illnesses in infants and children worldwide. Children who have suffered severe RSV infections during infancy are prone to develop recurrent episodes of wheezing and asthma that may be associated with viral persistence. RSV infections in humans and animal models are characterized by extensive inflammatory responses. Epithelial cell lines acutely infected by RSV have shown activation of the NF-κB signaling through two independent pathways: the canonical pathway, mediated by RelA and p50 subunits, and the non-canonical pathway, mediated by the subunits RelB and p52...
2018: Acta Virologica
Brittney M Donovan, Kelli K Ryckman, Patrick J Breheny, Tebeb Gebretsadik, Kedir N Turi, Emma K Larkin, Yinmei Li, Mary C Dorley, Tina V Hartert
BACKGROUND: There are critical gaps in our understanding of the temporal relationships between metabolites and subsequent asthma development. This is the first study to examine metabolites from newborn screening in the etiology of early childhood wheezing. METHODS: One thousand nine hundred and fifty one infants enrolled between 2012 and 2014 from pediatric practices located in Middle Tennessee in the population-based birth cohort study, the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE), were linked with metabolite data from the Tennessee Newborn Screening Program...
June 1, 2018: Pediatric Research
Matteo Bonato, Erica Bazzan, Deborah Snijders, Mariaenrica Tinè, Davide Biondini, Graziella Turato, Elisabetta Balestro, Alberto Papi, Manuel G Cosio, Angelo Barbato, Simonetta Baraldo, Marina Saetta
RATIONALE: Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. AIM: To assess the clinical and pathological factors possibly predicting the future development of asthma in children. METHODS: 80 children (mean age 3.8±1 yrs) undergoing a clinically indicated bronchoscopy were followed prospectively for a median of 5 yrs...
May 29, 2018: American Journal of Respiratory Cell and Molecular Biology
Louisa Owens, Ingrid A Laing, Guicheng Zhang, Steve Turner, Peter N Le Souëf
INTRODUCTION: Increasing evidence suggests that poor lung function in adulthood is determined very early in life. Our study aims were: (1) identify factors associated with early infant lung function; (2) quantify the link between early infant lung function and early adult lung function; and (3) identify environmental and inherited factors which predict lung function throughout the post-natal growth period. METHODS: In this longitudinal study, 253 individuals were recruited antenatally...
May 27, 2018: Pediatric Pulmonology
Anna Maria Hibbs, Kristie Ross, Leigh Ann Kerns, Carol Wagner, Mamta Fuloria, Sharon Groh-Wargo, Teresa Zimmerman, Nori Minich, Curtis Tatsuoka
Importance: Black infants born preterm face high rates of recurrent wheezing throughout infancy. Vitamin D supplementation has the potential to positively or negatively affect wheezing through modulation of the pulmonary and immune systems. Objective: To assess the effectiveness of 2 vitamin D dosing strategies in preventing recurrent wheezing. Design, Setting, and Participants: A randomized clinical trial enrolled 300 black infants born at 28 to 36 weeks' gestation between January 2013 and January 2016 at 4 sites in the United States, and followed them up through March 2017...
May 22, 2018: JAMA: the Journal of the American Medical Association
Frank R Greer
No abstract text is available yet for this article.
May 22, 2018: JAMA: the Journal of the American Medical Association
Kimberly D Gerhart, Debra A Stern, Stefano Guerra, Wayne J Morgan, Fernando D Martinez, Anne L Wright
RATIONALE: Breastfeeding protects from respiratory infections in early life but its relationship to recurrent cough and other respiratory outcomes in adult life is not well established. METHODS: Infant feeding practices were assessed prospectively in the Tucson Children's Respiratory Study, a non-selected birth cohort and categorised into formula from birth or introduced <1 month, formula introduced ≥1 to <4 months and exclusive breastfeeding for ≥4 months...
May 21, 2018: Thorax
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