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Wheezing infant

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https://www.readbyqxmd.com/read/30550172/-analysis-of-infants-with-moderate-to-severe-laryngomalacia
#1
B H Zhang, X Y Luo, A M Chen, Y Q Jiang
Objective: To investigate the clinical features and the treatment of moderate-severe laryngeallacia, and the application of CO₂laser supraglotation in laryngeallacia. Method: Collecting the clinical data of 18 infants with moderate-to-severe laryngeallacia diagnosed in our hospital,10 cases were moderate. Eight cases were severe children; according to the classification of laryngeallacia, most of them were mixed type, including 2 cases of type Ⅱ, 3 cases of type Ⅲ, 5 cases of typeⅠ + type Ⅱ, 7 cases of typeⅡ+ type Ⅲ, and 1 case of typeⅠ+ typeⅡ + type Ⅲ...
September 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/30541831/verdinexor-kpt-335-a-selective-inhibitor-of-nuclear-export-reduces-rsv-replication-in-vitro
#2
Patricia A Jorquera, Cynthia Mathew, Jennifer Pickens, Colin Williams, Jasmina M Luczo, Sharon Tamir, Reena Ghildyal, Ralph A Tripp
Respiratory syncytial virus (RSV) is a leading cause of hospitalization of infants and young children causing considerable respiratory disease and repeat infections that may lead to chronic respiratory conditions such as asthma, wheezing, and bronchitis. RSV causes ∼34 million new episodes of lower respiratory tract illness (LTRI) in children younger than 5 years of age with >3 million hospitalizations due to severe RSV-associated LRTI. The standard of care is limited to symptomatic relief as there are no approved vaccines and few effective antiviral drugs, thus a safe and efficacious RSV therapeutic is needed...
December 12, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30540109/temporal-comparison-of-wheezing-prevalence-in-the-first-year-of-life-in-s%C3%A3-o-paulo-international-study-of-wheezing-in-infants
#3
Carolina Sanchez Aranda, Gustavo Falbo Wandalsen, Ana Caroline Cavalcanti Dela Bianca, Ellen de Oliveira Dantas, Javier Mallol, Dirceu Solé
OBJECTIVE: To assess the prevalence and severity of wheezing in the first year of life of infants, using the standardized protocol of the Estudio Internacional de Sibilancias en Lactantes- phase 3, and compare the values obtained with those found in phase 1, conducted at the same center. METHODS: Between 2009 and 2010, parents and guardians of infants answered the written questionnaire of the Estudio Internacional de Sibilancias en Lactantes - phase 3, and its results were compared to those of phase 1, performed between 2005 and 2006...
October 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/30527752/delineation-of-the-individual-effects-of-vitamin-e-isoforms-on-early-life-incident-wheezing
#4
Cosby A Stone, Joan Cook-Mills, Tebeb Gebretsadik, Christian Rosas-Salazar, Kedir Turi, Steven M Brunwasser, Alexandra Connolly, Patty Russell, Zhouwen Liu, Kaitlin Costello, Tina V Hartert
OBJECTIVES: To test the hypothesis that maternal plasma alpha-tocopherol levels are associated with protection from childhood wheeze and that this protection is modified by gamma-tocopherol. STUDY DESIGN: We conducted a prospective nested study in the Infant Susceptibility to Pulmonary Infections and Asthma Following Respiratory Syncytial Virus Exposure birth cohort of 652 children with postpartum maternal plasma vitamin E isoforms used as a surrogate for pregnancy concentrations...
December 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30475936/wheeze-and-food-allergies-in-children-born-via-cesarean-section-the-upstate-kids-study
#5
Temilayo E Adeyeye, Edwina H Yeung, Alexander C McLain, Shao Lin, David A Lawrence, Erin M Bell
We examined whether cesarean delivery (CD) increased the risk of wheeze or food allergy in early childhood compared to vaginal delivery and whether these associations were mediated by breastfeeding. The study population was the Upstate KIDS cohort (2008-2010) of mothers and infants from New York State (excluding New York City). Infant's wheeze was reported by questionnaire every 4-6 months until 3 years as was food allergies beginning at 8 months. Modified Poisson regression was used to compare risks of the outcomes by mode of delivery (MOD)...
November 26, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/30474038/dynamics-of-respiratory-symptoms-during-infancy-and-associations-with-wheezing-at-school-age
#6
Jakob Usemann, Binbin Xu, Edgar Delgado-Eckert, Insa Korten, Pinelopi Anagnostopoulou, Olga Gorlanova, Claudia Kuehni, Martin Röösli, Philipp Latzin, Urs Frey
Children with frequent respiratory symptoms in infancy have an increased risk for later wheezing, but the association with symptom dynamics is unknown. We developed an observer-independent method to characterise symptom dynamics and tested their association with subsequent respiratory morbidity. In this birth-cohort of healthy neonates, we prospectively assessed weekly respiratory symptoms during infancy, resulting in a time series of 52 symptom scores. For each infant, we calculated the transition probability between two consecutive symptom scores...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30473186/informing-randomized-clinical-trials-of-respiratory-syncytial-virus-vaccination-during-pregnancy-to-prevent-recurrent-childhood-wheezing-a-sample-size-analysis
#7
Corinne A Riddell, Niranjan Bhat, Louis J Bont, William D Dupont, Daniel R Feikin, Deshayne B Fell, Tebeb Gebretsadik, Tina V Hartert, Jennifer A Hutcheon, Ruth A Karron, Harish Nair, Robert C Reiner, Ting Shi, Peter D Sly, Renato T Stein, Pingsheng Wu, Heather J Zar, Justin R Ortiz
BACKGROUND: Early RSV illness is associated with wheeze-associated disorders in childhood. Candidate respiratory syncytial virus (RSV) vaccines may prevent acute RSV illness in infants. We investigated the feasibility of maternal RSV vaccine trials to demonstrate reductions in recurrent childhood wheezing in general paediatric populations. METHODS: We calculated vaccine trial effect sizes that depended on vaccine efficacy, allocation ratio, rate of early severe RSV illness, risk of recurrent wheezing at age 3, and increased risk of RSV infection on recurrent wheezing...
November 22, 2018: Vaccine
https://www.readbyqxmd.com/read/30472801/perinatal-probiotic-intervention-prevented-allergic-disease-in-a-caesarean-delivered-subgroup-at-13-year-follow-up
#8
S Kallio, A K Kukkonen, E Savilahti, M Kuitunen
BACKGROUND: The long-term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial. OBJECTIVE: To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age. METHODS: Pregnant women (n=1223) carrying a child at a high risk of allergy (at least one parent with allergic disease) were randomised to receive a mixture of probiotics (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii) or placebo in a double-blind manner from 36 weeks of gestation until birth...
November 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30464010/intra-breath-measures-of-respiratory-mechanics-in-healthy-african-infants-detect-risk-of-respiratory-illness-in-early-life
#9
Diane M Gray, Dorottya Czovek, Lauren McMillan, Lidija Turkovic, Jacob A M Stadler, Anessa Vanker, Bence L Radics, Zoltan Gingl, Graham L Hall, Peter D Sly, Heather J Zar, Zoltán Hantos
RATIONALE: Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and non-invasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. OBJECTIVE: To investigate whether lung function derived from the intra-breath forced oscillation technique (FOT), was able to identify healthy infants at risk of LRTI in the first year. METHODS AND MEASUREMENTS: Lung function was measured with the novel intra-breath FOT, in six-week infants in a South African birth cohort (Drakenstein Child Health Study)...
November 21, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30461089/impact-of-parental-asthma-prenatal-maternal-asthma-control-and-vitamin-d-status-on-risk-of-asthma-and-recurrent-wheeze-in-3-year-old-children
#10
Hooman Mirzakhani, Vincent J Carey, Robert Zeiger, Leonard B Bacharier, George T O'Connor, Michael X Schatz, Nancy Laranjo, Scott T Weiss, Augusto A Litonjua
BACKGROUND: While familial clustering of asthma is known, few studies have reported on the relative roles of paternal and maternal asthma, and the role of maternal asthma control in pregnancy on the risk for asthma in the child. OBJECTIVE: We aimed to investigate the relative roles of paternal asthma, maternal asthma, and maternal asthma control during pregnancy on the risk of asthma or recurrent wheeze in 3-year old children how prenatal and cord blood vitamin D status might affect this risk...
November 21, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30445537/metabolomic-profiling-of-infants-with-recurrent-wheezing-after-bronchiolitis
#11
Alessia Barlotta, Paola Pirillo, Matteo Stocchero, Filippo Donato, Giuseppe Giordano, Louis Bont, Stefania Zanconato, Silvia Carraro, Eugenio Baraldi
Background and Objective: Bronchiolitis is associated with a greater risk of developing recurrent wheezing, but with currently-available tools, it is impossible to know which infants with bronchiolitis will develop this condition. This preliminary prospective study aimed to assess whether urine metabolome analysis can be used to identify bronchiolitis children at risk of developing recurrent wheezing. Methods: 52 infants less than one year old treated at our department's ER for acute bronchiolitis were enrolled (77% RSV positive)...
November 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30430649/effects-of-lactobacillus-rhamnosus-hn001-in-early-life-on-the-cumulative-prevalence-of-allergic-disease-to-11-years
#12
Kristin Wickens, Christine Barthow, Edwin A Mitchell, Janice Kang, Noleen van Zyl, Gordon Purdie, Thorsten Stanley, Penny Fitzharris, Rinki Murphy, Julian Crane
BACKGROUND: In a two-centre randomized placebo-controlled trial of Lactobacillus rhamnosus HN001 (HN001) (6 × 109 colony-forming units [cfu]) or Bifidobacterium lactis HN019 (HN019) (9 × 109 cfu) taken daily from 35-week gestation to 6 months' post-partum in mothers while breastfeeding and from birth to age 2 years in infants, we showed that HN001 significantly protected against eczema development at 2, 4 and 6 years and atopic sensitization at 6 years. There was no effect of HN019...
November 14, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/30426955/clinical-characteristics-and-associated-congenital-lesions-with-tracheomalacia-in-infants
#13
D Vijayasekaran, S Balasubramanian, Somu Sivabalan, K Vindhiya
OBJECTIVE: To describe clinical presentation, bronchoscopy findings and associated anomalies in cases of congenital tracheomalacia in infants (age <1y). METHODS: Hospital record review of 88 infants (mean age 8 mo, 57 males) diagnosed as having tracheomalacia by flexible bronchoscopy between 2012 and 2015. RESULTS: The predominant features were wheeze (57.9%), stridor (42.1%), cough (38.6%), pneumonia (29.5%) and collapse (12.5%). On bronchoscopy, malacia was observed in lower half of trachea in 51 (57...
October 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/30423150/primary-and-repeated-respiratory-viral-infections-among-infants-in-rural-nepal
#14
Jim Boonyaratanakornkit, Janet A Englund, Amalia S Magaret, Yunqi Bu, James M Tielsch, Subarna K Khatry, Joanne Katz, Jane Kuypers, Laxman Shrestha, Steven C LeClerq, Mark C Steinhoff, Helen Y Chu
Background: Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described. Methods: From 2011 to 2014, a birth cohort of infants in rural Nepal was enrolled and followed with weekly household-based active surveillance for respiratory symptoms until 6 months of age...
November 12, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/30418579/fish-oil-supplementation-in-pregnancy-increases-gestational-age-size-for-gestational-age-and-birth-weight-in-infants-a-randomized-controlled-trial
#15
Rebecca Kofod Vinding, Jakob Stokholm, Astrid Sevelsted, Bo L Chawes, Klaus Bønnelykke, Malin Barman, Bo Jacobsson, Hans Bisgaard
Background: Randomized trials have reported that supplementation with n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in pregnancy can prolong pregnancy and thereby increase birth weight. Objective: We aimed to examine the relations of n-3 LCPUFA supplementation in pregnancy with duration of pregnancy, birth weight, and size for gestational age (GA). Methods: This was a double-blind randomized controlled trial conducted in 736 pregnant women and their offspring, from the Copenhagen Prospective Studies on Asthma in Childhood2010cohort...
November 9, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/30416016/variability-of-tidal-breathing-parameters-in-preterm-infants-and-associations-with-respiratory-morbidity-during-infancy-a-cohort-study
#16
Jakob Usemann, Andrea Suter, Emanuela Zannin, Elena Proietti, Sotirios Fouzas, Sven Schulzke, Philipp Latzin, Urs Frey
OBJECTIVE: To test whether low variability of tidal volume (VT ) and capnographic indices are predictive of subsequent respiratory morbidity in preterm infants. STUDY DESIGN: In a birth cohort of 133 preterm infants, lung function was performed at 44 weeks postmenstrual age. Associations between the coefficient of variation (CV) of VT (CVVT ) and of expired CO2 volume per breath (CVVE,CO2 ) with rehospitalization, wheeze, and inhalation therapy during infancy were assessed using logistic regression...
November 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30370798/postviral-atopic-airway-disease-pathogenesis-and-potential-avenues-for-intervention
#17
Syed-Rehan A Hussain, Asuncion Mejias, Octavio Ramilo, Mark E Peeples, Mitchell H Grayson
In early childhood, wheezing due to lower respiratory tract illness is often associated with infection by commonly known respiratory viruses such as respiratory syncytial virus (RSV) and human rhinovirus (RV). How respiratory viral infections lead to wheeze and/or asthma is an area of active research. Areas covered: This review provides an updated summary of the published information on the development of post-viral induced atopy and asthma and the mechanisms involved. We focus on the contribution of animal models in identifying pathways that may contribute to atopy and asthma following respiratory virus infection, different polymorphisms that have been associated with asthma development, and current options for disease management and potential future interventions...
October 27, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/30367103/early-inspired-oxygen-and-intermittent-hypoxemic-events-in-extremely-premature-infants-are-associated-with-asthma-medication-use-at-2-years-of-age
#18
Juliann M Di Fiore, Andrew M Dylag, Ryan D Honomichl, Anna Maria Hibbs, Richard J Martin, Curtis Tatsuoka, Thomas M Raffay
OBJECTIVE: Extremely premature infants are at risk for childhood wheezing. Early respiratory support and intermittent hypoxemia (IH) events may be associated with adverse breathing outcomes. STUDY DESIGN: A single-center retrospective cohort study of 137 premature infants <28 weeks gestational age characterized the associations of cumulative oxygen, cumulative mean airway pressure, IH, and oxygen saturation (SpO2 ) on the primary outcome of prescription asthma medication use at 2-year follow-up...
October 26, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30366577/direct-infant-uv-light-exposure-is-associated-with-eczema-and-immune-development
#19
Kristina Rueter, Anderson P Jones, Aris Siafarikas, Ee-Mun Lim, Natasha Bear, Paul S Noakes, Susan L Prescott, Debra J Palmer
BACKGROUND: Suboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes. OBJECTIVE: We sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development. METHODS: By using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age...
October 15, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30360875/vitamin-d-reduces-risk-of-recurrent-wheezing-in-premature-black-infants
#20
Augusto A Litonjua
No abstract text is available yet for this article.
November 2018: Journal of Pediatrics
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