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Hormone Adult

Aliya Aziz Khan, Christian Koch, Stanislaus Hendrikus Maria Van Uum, Jean Patrice Baillargeon, Jens Bollerslev, Maria Luisa Brandi, Claudio Marcocci, Lars Rejnmark, Rene Rizzoli, M Zakarea Shrayyef, Rajesh V Thakker, Bulent O Yildiz, Bart Clarke
PURPOSE: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included...
December 1, 2018: European Journal of Endocrinology
Ai Hironaka-Mitsuhashi, Hitoshi Tsuda, Masayuki Yoshida, Chikako Shimizu, Sota Asaga, Takashi Hojo, Kenji Tamura, Takayuki Kinoshita, Toshikazu Ushijima, Nobuyoshi Hiraoka, Yasuhiro Fujiwara
BACKGROUND: Limited knowledge exists concerning the clinicopathological features of breast cancers (BCs) occurring in adolescent and young adult (AYA) women. We evaluated tumor characteristics in AYA women in comparison with those in middle-aged premenopausal women. METHODS: From consecutive AYA patients (< 35-year-old) with invasive BC in a single institute, 82 patients first treated with surgery were examined. As the control group, 82 tumors from middle-aged premenopausal patients (40-44 years) were selected by matching pathological T and N factors...
December 11, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
S Lou, H Lv, P Yin, Z Li, P Tang, Y Wang
Combination therapy with parathyroid hormone (PTH) analogs and antiresorptive agents may be more effective than monotherapy for the treatment of osteoporosis. This study aimed to estimate the effectiveness and safety of this combination therapy for osteoporosis. MEDLINE, EMBASE, and Cochrane Library were searched from inception to May 1, 2018, including randomized controlled trials (RCTs) with a duration of at least 6 months on adults with osteoporosis treated with combination therapy versus monotherapy. Outcomes included fractures, bone mineral density (BMD) changes, and adverse events...
December 11, 2018: Osteoporosis International
Yonghong Sheng, Dongping Huang, Shun Liu, Xuefeng Guo, Jiehua Chen, Yantao Shao, Guoqiang Zhang, Liangjia Wei, Xiaoyun Zeng, Xiaoqiang Qiu
Ethnic differences in the level of thyroid hormones exist among individuals. The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy. To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill. This study was performed to establish trimester-specific reference ranges of thyroid hormones in Zhuang ethnic pregnant women and explore the role of body mass index (BMI) on thyroid function...
2018: BioMed Research International
M Ahmid, S F Ahmed, M G Shaikh
Childhood-onset growth hormone deficiency (CO-GHD) is an endocrine condition associated with a broad range of health issues from childhood through to adulthood, which requires particular attention during the transition period from adolescence to young adulthood. There is uncertainty in the clinical practice of the management of CO-GHD during transition regarding the clinical assessment and management of individual patients during and after transition to obtain optimal follow-up and improved health outcomes...
2018: Therapeutics and Clinical Risk Management
Xiaowei Nie, Youjin Dai, Yuan Zheng, Dan Bao, Qin Chen, Yuan Yin, Heling Fu, Daorong Hou
BACKGROUND/AIMS: This study investigated the effect of consecutive superovulation on the ovaries and established a premature ovarian failure (POF) model in mice. METHODS: The mouse POF model was induced by 5-15 consecutive superovulation treatments with pregnant mare serum gonadotropin (PMSG), human chorionic gonadotropin (HCG) and prostaglandin F2α (PGF2α). Normal adult mice were compared with mice displaying natural ovarian aging. The following serum biochemical parameters were measured: including follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P), estradiol (E2), inhibin B (INH B), malondialdehyde (MDA), total superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels...
2018: Cellular Physiology and Biochemistry
Benedict Herhaus, Katja Petrowski
OBJECTIVE: Approximately 600 million adults worldwide suffer from obesity. In addition to individual's eating behavior and lack of physical activity in the development of obesity and overweight, psychosocial stress as well as hormonal stress reactivity must also be considered as important contributing factors. In the current study we compared the cortisol stress response pathway in a psychosocial stress induction (Trier Social Stress Test; TSST) with obese individuals and normal-weight controls...
December 11, 2018: Obesity Facts
Qing-Ya Zeng, Zhi-Yin Xia, Yan-Shan Tong, Liang Sun, Hong-Bin Mou, Rui Chen, Guang-Yu Bi, Chang-Hua Liu
BACKGROUND: Klotho G-395-A gene polymorphism is associated with several diseases; however, its association with calcium-phosphate metabolism disorders in end-stage renal disease (ESRD) is unknown. METHODS: 137 patients with ESRD and 80 healthy adults (control) were enrolled in the study. Patients with ESRD were divided into three subgroups: hemodialysis (A1, n=52), peritoneal dialysis (A2, n=30), and non-dialysis (A3, n=55). The Klotho G-395-A genotype was detected by TaqMan PCR assay, and ELISA was used to detect the soluble Klotho protein (sKL) and fibroblast growth factor (FGF23)...
December 8, 2018: Nephrology
Chantal M Wiepjes, Renate T de Jongh, Christel Jm de Blok, Mariska C Vlot, Paul Lips, Jos Wr Twisk, Martin den Heijer
Concerns about the effects of gender-affirming hormonal treatment (HT) on bone mineral density (BMD) in transgender people exist, particularly regarding the decrease in estrogen concentrations in transmen. Although it is known that HT is safe for BMD in the short term, long-term follow-up studies are lacking. Therefore this study aimed to investigate the change in BMD during the first 10 years of HT, to determine whether HT is safe and if assessing BMD during HT is necessary. A follow-up study was performed in adult transgender people receiving HT at the VU University Medical Center Amsterdam between 1998 and 2016...
December 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Chang Kyun Choi, Sun-Seog Kweon, Young-Hoon Lee, Hae-Sung Nam, Kyeong-Soo Park, So-Yeon Ryu, Seong-Woo Choi, Sun A Kim, Min-Ho Shin
Levels of vitamin D and parathyroid hormone (PTH) are closely associated with renal function. We evaluated the associations among 25-hydroxyvitamin D (25OHD) levels, PTH levels, and mortality, and whether these associations varied by renal function. We used data from the Dong-gu Study, a population-based cohort in Korean adults. We analyzed the associations among intact PTH, 25OHD levels and mortality in 8580 participants. Hazard ratios (HRs) for mortality were calculated using Cox proportional hazards regression after adjusting for age, sex, month of sampling, lifestyle, and comorbidities...
December 7, 2018: Journal of Bone and Mineral Metabolism
Rashin Mohseni, Mahmood Reza Ashrafi, Jafar Ai, Mahin Nikougoftar, Mahmoud Mohammadi, Masood Ghahvechi-Akbari, Alireza Shoae-Hassani, Amir Ali Hamidieh
Cell therapy and stem cell transplantation strategies have provided potential therapeutic approaches for the treatment of neurological disorders. Adipose-derived mesenchymal stem cells (ADMSCs) are abundant adult stem cells with low immunogenicity, which can be used for allogeneic cell replacement therapies. Differentiation of ADMSCs into acetylcholine-secreting motoneurons (MNs) is a promising treatment for MN diseases, such as spinal muscular atrophy (SMA), which is associated with the level of SMN1 gene expression...
December 7, 2018: Journal of Molecular Neuroscience: MN
Patricia Álvarez-Campos, Nathan J Kenny, Aida Verdes, Rosa Fernández, Marta Novo, Gonzalo Giribet, Ana Riesgo
Stolonization in syllid annelids is a unique mode of reproduction among animals. During the breeding season, a structure resembling the adult but containing only gametes, called stolon, is formed generally at the posterior end of the animal. When stolons mature, they detach from the adult and gametes are released into the water column. The process is synchronized within each species, and it has been reported to be under environmental and endogenous control, probably via endocrine regulation. To further understand reproduction in syllids and to elucidate the molecular toolkit underlying stolonization, we generated Illumina RNA-seq data from different tissues of reproductive and non-reproductive individuals of Syllis magdalena, and characterized gene expression during the stolonization process...
December 11, 2018: Genome Biology and Evolution
Kylie L Mills, Angelica M Gomes, Courtney R Standlee, Michelle D Rojo, Peter Carmeliet, Zhen Lin, Heather L Machado
Mammary gland development is a complex and dynamic process that occurs mainly postnatally. Ductal elongation and branching morphogenesis are regulated by a plethora of factors, including cytokines, hormones, growth factors and the extracellular matrix. Gas6 is a secreted gamma-carboxylated protein that binds to a family of receptors tyrosine kinase receptors known as the TAMR family (Tyro3, Axl, Mer). Gas6 function in developmental processes has been shown in nervous, reproductive and immune systems. In this study, we found that Gas6 is highly expressed in virgin adult mammary glands but declines during pregnancy and lactation...
2018: PloS One
Elaine L Bearer, Brianna S Mulligan
Background: Adverse Childhood Experiences (ACEs), which include traumatic injury, are associated with poor health outcomes in later life, yet the biological mechanisms mediating this association are unknown. Neurocircuitry, immune system and hormone regulation differ from normal in adults reporting ACEs. These systems could be affected by epigenetic changes, including methylation of cytosine (5mC) in genomic DNA, activated by ACEs. Since 5mC levels influence gene expression and can be long-lasting, altered 5mC status at specific sites or throughout the genome is hypothesized to influence mental and physical outcomes after ACE(s)...
December 2018: Current Genomics
Xinrui Tan, Xiaochuan Wu, Jie Chen, Yan Wu, Shijun Li, Xianmei Chen, Xingxing Zhang
Background Aromatase excess syndrome (AEXS) is a rare autosomal dominant disorder caused by CYP19A1 overexpression. Clinical manifestations of AEXS include pre- or peri-pubertal gynecomastia, advanced bone age and compromised adult height. Case presentation Here we report an 8-year-old boy diagnosed with AEXS by chromosomal array that revealed a 1.1 Mb novel de novo duplication at 15q21.2, with a predicted final height of 157.4 cm. We prescribed letrozole and growth hormone (GH) to maximize his linear growth...
December 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Jonathan Tea, Sarah L Alderman, Kathleen M Gilmour
Many animals, including zebrafish ( Danio rerio ), form social hierarchies through competition for limited resources. Socially subordinate fish may experience chronic stress, leading to prolonged elevation of the glucocorticoid stress hormone cortisol. Since elevated cortisol levels can impair neurogenesis, the present study tested the hypothesis that social stress suppresses cell proliferation in the telencephalon of subordinate zebrafish via a cortisol-mediated mechanism. Cell proliferation was assessed using incorporation of the thymidine analogue, 5-bromo-2'-deoxyuridine (BrdU)...
December 10, 2018: Journal of Experimental Biology
Marilyn N Vera-Chang, Antony D St-Jacques, Rémi Gagné, Chris J Martyniuk, Carole L Yauk, Thomas W Moon, Vance L Trudeau
The global prevalence of depression is high during childbearing. Due to the associated risks to the mother and baby, the selective serotonin reuptake inhibitor fluoxetine (FLX) is often the first line of treatment. Given that FLX readily crosses the placenta, a fetus may be susceptible to the disruptive effects of FLX during this highly plastic stage of development. Here, we demonstrate that a 6-day FLX exposure to a fetus-relevant concentration at a critical developmental stage suppresses cortisol levels in the adult zebrafish (F0 )...
December 10, 2018: Proceedings of the National Academy of Sciences of the United States of America
Marit Navis, Tânia Martins Garcia, Ingrid B Renes, Jacqueline Lm Vermeulen, Sander Meisner, Manon E Wildenberg, Gijs R van den Brink, Ruurd M van Elburg, Vanesa Muncan
During the suckling-to-weaning transition, the intestinal epithelium matures, allowing digestion of solid food. Transplantation experiments with rodent fetal epithelium into subcutaneous tissue of adult animals suggest that this transition is intrinsically programmed and occurs in the absence of dietary or hormonal signals. Here, we show that organoids derived from mouse primary fetal intestinal epithelial cells express markers of late fetal and neonatal development. In a stable culture medium, these fetal epithelium-derived organoids lose all markers of neonatal epithelium and start expressing hallmarks of adult epithelium in a time frame that mirrors epithelial maturation in vivo In vitro postnatal development of the fetal-derived organoids accelerates by dexamethasone, a drug used to accelerate intestinal maturation in vivo Together, our data show that organoids derived from fetal epithelium undergo suckling-to-weaning transition, that the speed of maturation can be modulated, and that fetal organoids can be used to model the molecular mechanisms of postnatal epithelial maturation...
December 10, 2018: EMBO Reports
Marek Kociuba, Raja Chakraborty, Zofia Ignasiak, Sławomir Kozieł
BACKGROUND: The ratio of the lengths of second finger (2D) to the fourth (4D) is a putative indicator of foetal hormonal exposure. The link between 2D:4D and physical strength or sports performance in not consistent. It was suggested that the association of 2D:4D with the sporting and physical ability is better demonstrated in the context of challenge and competition, either real or simulated. However the evidence is limited to a few studies till date. AIM: The objective of this study was to assess whether an aggressive video show could increase muscular strength and if 2D:4D moderated such increase...
December 6, 2018: Early Human Development
Aida I El Makawy, Faten M Ibrahim, Dalia M Mabrouk, Kawkab A Ahmed, Mohamed Fawzy Ramadan
Sexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. The target of this work was to appraise the sexual dysfunction of antiepileptic Topiramate (TPM) and cold pressed ginger oil (CPGO) as antiepileptic alternative medicine in male mice. Fifty-four adult male albino mice were divided into nine groups (n = 6 mice)...
December 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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