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https://www.readbyqxmd.com/read/30317631/altered-bone-microarchitecture-in-a-type-1-diabetes-mouse-model-ins2-akita
#1
Filipe R Carvalho, Sofia M Calado, Gabriela A Silva, Gabriela S Diogo, Joana Moreira da Silva, Rui L Reis, M Leonor Cancela, Paulo J Gavaia
Type 1 diabetes mellitus (T1DM) has been associated to several cartilage and bone alterations including growth retardation, increased fracture risk, and bone loss. To determine the effect of long term diabetes on bone we used adult and aging Ins2 Akita mice that developed T1DM around 3-4 weeks after birth. Both Ins2 Akita and wild-type (WT) mice were analyzed at 4, 6, and 12 months to assess bone parameters such as femur length, growth plate thickness and number of mature and preapoptotic chondrocytes. In addition, bone microarchitecture of the cortical and trabecular regions was measured by microcomputed tomography and gene expression of Adamst-5, Col2, Igf1, Runx2, Acp5, and Oc was quantified by quantitative real-time polymerase chain reaction...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317577/effects-of-microrna-370-on-mesangial-cell-proliferation-and-extracellular-matrix-accumulation-by-binding-to-canopy-1-in-a-rat-model-of-diabetic-nephropathy
#2
Feng-Na Yu, Ming-Lan Hu, Xin-Fang Wang, Xiang-Ping Li, Bei-Hao Zhang, Xiao-Qing Lu, Rui-Qiang Wang
As one major diabetic complication, diabetic nephropathy (DN) has been reported to be associated with various kinds of microRNA (miRNA). Thus, we conducted this study to explore the potential of miR-370 in a rat model of DN through investigation of mesangial cell proliferation and extracellular matrix (ECM). A total of 40 healthy adult male Sprague-Dawley rats were enrolled and assigned into normal (n = 10) and DN ( n = 30, DN rat model) groups. Dual-luciferase reporter assay was performed for the targeting relationship between miR-370 and canopy 1 (CNPY1)...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30316682/handgrip-strength-among-korean-adolescents-with-metabolic-syndrome-in-2014-2015
#3
Yunkoo Kang, Sowon Park, Seung Kim, Hong Koh
The prevalence of metabolic syndrome is increasing worldwide in adolescents. Metabolic syndrome is a systemic disease that is likely to be associated with other diseases. Studies have shown a relationship between muscle strength, muscle quality, and metabolic syndrome. Handgrip strength is known as a simple tool to measure muscle strength. Therefore, we aimed to investigate the relationship between handgrip strength and metabolic syndrome and each metabolic syndrome features in adolescents. Data were obtained from 1050 adolescents (574 boys, 476 girls; age 10-18 years) who participated in the Korea National Health and Nutrition Examination Survey...
September 8, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/30316653/-ageing-with-cystic-fibrosis-classical-and-emerging-comorbidities-in-adults-with-cystic-fibrosis
#4
L Regard, H Lafoeste, C Martin, G Chassagnon, P-R Burgel
Cystic fibrosis (CF) is a genetic disease with pulmonary involvement being predominant and often leading to respiratory failure and premature death. Non-pulmonary complications related to CF transmembrane conductance regulator (CFTR) defect are numerous and account for significant morbidity (exocrine pancreatic insufficiency, diabetes, CF-related liver disease, chronic sinusitis, osteoporosis). Improvement in patients' care led to a continuous increase in life expectancy, with a subsequent increase in the number of adult CF patients worldwide...
October 10, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/30316542/the-early-natural-history-of-albuminuria-in-young-adults-with-youth-onset-type-1-and-type-2-diabetes
#5
Anna R Kahkoska, Scott Isom, Jasmin Divers, Elizabeth J Mayer-Davis, Lawrence Dolan, Amy S Shah, Maryam Afkarian, David J Pettitt, Jean M Lawrence, Santica Marcovina, Sharon H Saydah, Dana Dabelea, David M Maahs, Amy K Mottl
AIMS: To determine among adolescents and young adults with youth-onset type 1 diabetes and type 2 diabetes the rates and risk factors for albuminuria regression and progression. METHODS: Data from SEARCH, a longitudinal observational study of youth-onset type 1 diabetes (N = 1316) and type 2 diabetes (N = 143) were analyzed. Urine albumin:creatinine ratio (UACR) was measured from random urine specimens at baseline and follow-up visits (mean 7 years later)...
October 4, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/30316370/higher-incidence-of-renal-allograft-glomerulonephritis-in-living-related-donor-kidney-transplantation
#6
R Deng, Y Dai, H Zhang, L Liu, J Li, Y Xiong, S Deng, Q Fu, C Wang
Glomerulonephritis recurrence has emerged as one of the leading causes of allograft loss. We aimed to investigate the effect of living-related and deceased donation on the incidence of renal allograft glomerulonephritis and its effect on renal allograft survival. METHODS: Adult renal allograft recipients with primary glomerulonephritis were enrolled. Transplantation date was from Feb 2004 to Dec 2015. Exclusion criteria included combined organ transplantation, structural abnormality, diabetic nephropathy, hypertension nephropathy, obstructive nephropathy, and primary uric acid nephropathy...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316209/studies-on-prevalence-of-infection-with-trichomonas-tenax-identified-by-molecular-techniques-%C3%A2-in-respect-to-oral-health-of-patients-with-various-systemic-disease-requiring-immunosuppressive-therapy
#7
Monika Dybicz, Konrad Perkowski, Aleksandra Sędzikowska, Wanda Baltaza, Lidia Chomicz
Trichomonas tenax, cosmopolitan flagellate inhabiting human oral cavity, is the etiological agent of oral trichomonosis associated with gingival and periodontium deterioration. Purpose of this studies was to investigate the prevalence of infection with Trichomonas tenax identified by molecular techniques amplifying the region of ITS1-5.8S rRNA-ITS2 specific for T. tenax. The study included 498 persons: diabetic, renal transplant, rheumatoid arthritis patients and the control group. Prevalence of T. tenax in oral cavity was 10...
2018: Annals of Parasitology
https://www.readbyqxmd.com/read/30316184/associations-of-cumulative-exposure-to-heavy-metal-mixtures-with-obesity-and-its-comorbidities-among-u-s-adults-in-nhanes-2003-2014
#8
Xin Wang, Bhramar Mukherjee, Sung Kyun Park
BACKGROUND: Some heavy metals (e.g., arsenic, cadmium, lead, mercury) have been associated with obesity and obesity comorbidities. The analytical approach for those associations has typically focused on individual metals. There is a growing interest in evaluating the health effects of cumulative exposure to metal mixtures. OBJECTIVES: We utilized our Environmental Risk Score (ERS), a summary measure to examine the risk of exposure to multi-pollutants in epidemiologic research, to evaluate the associations of cumulative exposure to a mixture of correlated heavy metals with obesity and its comorbidities including hypertension, and type-2 diabetes mellitus (T2DM) while accounting for high degree correlations and interactions among metal mixtures components...
October 10, 2018: Environment International
https://www.readbyqxmd.com/read/30315894/body-mass-index-and-the-risk-of-deep-surgical-site-infection-following-posterior-cervical-instrumented-fusion
#9
Christina W Cheng, Amy M Cizik, Armagan H C Dagal, Larissa Lewis, John Lynch, Carlo Bellabarba, Richard J Bransford, Haitao Zhou
BACKGROUND: Surgical site infection (SSI) following spine surgery is associated with increased morbidity, reoperation rates, hospital readmissions and cost. The incidence of SSI following posterior cervical spine surgery is higher than anterior cervical spine surgery, with rates from 4.5-18%. It is well documented that higher body mass index (BMI) is associated with increased risk of SSI after spine surgery. There are only a few studies that examine the correlation of BMI and SSI after posterior cervical instrumented fusion (PCIF) using national databases, however, none that compare trauma and non-traumatic patients...
October 10, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/30315560/clinical-characteristics-and-therapeutic-outcomes-of-postneurosurgical-bacterial-meningitis-in-elderly-patients-over-65-a-hospital-based-study
#10
Jun-Jun Lee, Chia-Yi Lien, Chi-Ren Huang, Nai-Wen Tsai, Chiung-Chih Chang, Cheng-Hsien Lu, Wen-Neng Chang
PURPOSE: To investigate the clinical characteristics, laboratory features and prognostic factors of elderly patients with postneurosurgical bacterial meningitis. METHODS: Five hundred and forty patients with adult bacterial meningitis (ABM) were collected from 1986-2015, of whom 167 were ≥ 65 years. Of these 167 elderly patients, 82 had postneurosurgical infections and 85 had spontaneous infections. Clinical, laboratory and therapeutic data of these two groups were compared...
December 15, 2017: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/30315315/the-mediterranean-diet-and-risk-of-type-2-diabetes-in-iranian-population
#11
Sajjad Khalili-Moghadam, Parvin Mirmiran, Zahra Bahadoran, Fereidoun Azizi
BACKGROUND/OBJECTIVES: Type 2 diabetes (T2D) is fast increasing in recent decades. Limited prospective studies are available on Mediterranean diet protective effect against T2D development. We assessed longitudinal association of the Mediterranean diet with T2D risk in Iranian men and women. SUBJECTS/METHODS: Diet was measured using a 168-item food frequency questionnaire in 2139 adults (free of T2D), aged 20-70 years. All individuals, based on the traditional Mediterranean diet score (MDS), received scores between 0 and 8 points...
October 12, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30313083/bone-mineral-loss-and-cognitive-impairment-the-present-project
#12
Hyun Goo Kang, Hyun Young Park, Han Uk Ryu, Seung-Han Suk
Low bone mineral density (BMD) is correlated with Alzheimer's disease and its severity, but the association remains unclear in adults (≥50 years) without a history of stroke or dementia.We assessed BMD and cognitive function using the Mini-Mental Status Examination (MMSE) in 650 stroke- and dementia-free subjects (≥50 years) who were recruited for an early health check-up program between January 2009 and December 2010.The mean age was 62.9 ± 8.0 years and mean MMSE score was 27.6 ± 3.6. A total of 361 subjects had reduced BMD: 197 (30...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312937/prevalence-of-ankle-equinus-and-correlation-with-foot-plantar-pressures-in-people-with-diabetes
#13
A Searle, M J Spink, V H Chuter
BACKGROUND: An association between equinus and plantar pressure may be important for people with diabetes, as elevated plantar pressure has been linked with foot ulcer development. To determine the prevalence of equinus in community dwelling people with diabetes and to examine any association between presence of equinus and forefoot plantar pressures. METHODS: Barefoot (Tekscan HR Mat™) and in-shoe (Novel Pedar-X®) plantar pressure variables, non-weight bearing ankle range of motion and neuropathy status were assessed in 136 adults with diabetes (52...
October 5, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/30312893/multicomorbidity-of-chronic-diseases-and-substance-use-disorders-and-their-association-with-hospitalization-results-from-electronic-health-records-data
#14
Li-Tzy Wu, He Zhu, Udi E Ghitza
BACKGROUND: Chronic diseases are prevalent and the leading causes of mortality. Comorbidity of substance use disorders (SUDs) and chronic diseases is understudied to inform behavioral healthcare integration. OBJECTIVES: This study leveraged electronic health record (EHR) data of 211,880 adults from a large health system to examine prevalence and correlates of comorbidity of SUDs and nine chronic disease groups and to determine their association with hospitalization...
October 2, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/30312714/effects-of-intensive-interventions-compared-to-standard-care-in-people-with-type-2-diabetes-and-microalbuminuria-on-risk-factors-control-and-cardiovascular-outcomes-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#15
Muhammad Usman, Clare L Gillies, Kamlesh Khunti, Melanie J Davies
AIMS: The effect of intensive glycaemic control, blood pressure control and lipid levels control alone or as part of a multifactorial intervention has not been fully evaluated. We aimed to estimate the effects of more intensive interventions, compared with standard care, on risk factor control and cardiovascular outcomes in people with type 2 diabetes and microalbuminuria. METHODS: We searched MEDLINE, Embase and the Cochrane library without language restrictions from inception to August 10, 2018...
October 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30312713/strategy-for-early-identification-of-prediabetes-in-lean-populations-new-insight-from-a-prospective-chinese-twin-cohort-of-children-and-young-adults
#16
Guoying Wang, Sally Radovick, Xiping Xu, Houxun Xing, Genfu Tang, Tami R Bartell, Binyan Wang, Xiaobin Wang
AIMS: To identify certain subgroups in young and lean populations, who may be at a high risk of developing prediabetes/diabetes, which is not captured by current BMI-based screening algorithms. METHODS: Incidence of prediabetes/diabetes was assessed using oral glucose tolerance tests among 1859 children and 1073 young adults from a prospective Chinese twin cohort. RESULTS: Over a 6-year follow-up, 507 (27.3%) children and 293 (27.3%) adults developed prediabetes/diabetes...
October 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30312674/outpatient-surgical-management-for-acquired-buried-penis
#17
Scott G Erpelding, Marilyn Hopkins, Adam Dugan, James Y Liau, Shubham Gupta
OBJECTIVE: To demonstrate the safety and feasibility of outpatient surgical management for patients with acquired buried penis. METHODS: We conducted an IRB approved review of patients who underwent surgical repair of acquired buried penis at a single institution from September 2014 to Aug 2017. Patient characteristics, operative details, and 30 and 90-day complications were assessed. RESULTS: Sixteen patients underwent surgical repair of acquired buried penis at the University of Kentucky during the study period...
October 9, 2018: Urology
https://www.readbyqxmd.com/read/30312628/dermal-microvessel-density-and-maturity-is-closely-associated-with-atherogenic-dyslipidemia-and-accumulation-of-advanced-glycation-end-products-in-adult-patients-with-type-1-diabetes
#18
Anna Adamska, Aleksandra Araszkiewicz, Stanislaw Pilacinski, Agnieszka Gandecka, Agata Grzelka, Katarzyna Kowalska, Agnieszka Malinska, Michal Nowicki, Dorota Zozulinska-Ziolkiewicz
In patients with diabetes, functional changes in microcirculation and subclinical vascular pathology precede clinical manifestation of microangiopathic complications. The objective of this study was to evaluate the association between established vascular risk factors and density, maturity, and reactivity of dermal blood vessels in adults with type 1 diabetes (DM1). We included 148 DM1 patients (87 men) with a median (IQR) age of 40.5 (30.5-49) years and a median diabetes duration of 21 (17-29.5) years. The control group consisted of 13 healthy volunteers (6 men) with a median (IQR) age of 36 (31-43)...
October 9, 2018: Microvascular Research
https://www.readbyqxmd.com/read/30312551/cystic-fibrosis-emerging-understanding-and-therapies
#19
Michael M Rey, Michael P Bonk, Denis Hadjiliadis
Cystic fibrosis (CF) is the most common life-limiting genetic disease in Caucasian patients. Continued advances have led to improved survival, and adults with CF now outnumber children. As our understanding of the disease improves, new therapies have emerged that improve the basic defect, enabling patient-specific treatment and improved outcomes. However, recurrent exacerbations continue to lead to morbidity and mortality, and new pathogens have been identified that may lead to worse outcomes. In addition, new complications, such as CF-related diabetes and increased risk of gastrointestinal cancers, are creating new challenges in management...
October 12, 2018: Annual Review of Medicine
https://www.readbyqxmd.com/read/30312474/cardiovascular-disease-profile-of-the-oldest-adults-in-rural-south-africa-data-from-the-haalsi-study-health-and-aging-in-africa-longitudinal-studies-of-indepth-communities
#20
Thiago Veiga Jardim, Miles D Witham, Shafika Abrahams-Gessel, F Xavier Gómez-Olivé, Stephen Tollman, Lisa Berkman, Thomas A Gaziano
OBJECTIVES: To characterize the cardiovascular disease (CVD) profile of individuals aged 80 and older in rural South Africa. DESIGN: First wave of population-based longitudinal cohort. SETTING: Agincourt subdistrict (Mpumalanga Province) in rural South Africa. PARTICIPANTS: Adults residents (N = 5,059). MEASUREMENTS: In-person interviews were conducted to obtain social, behavioral, economic, and clinical data...
October 12, 2018: Journal of the American Geriatrics Society
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