keyword
https://read.qxmd.com/read/38536082/a-phase-i-trial-of-enzalutamide-plus-selective-glucocorticoid-receptor-modulator-relacorilant-in-patients-with-metastatic-castration-resistant-prostate-cancer
#21
JOURNAL ARTICLE
Kunal B Desai, Anthony V Serritella, Walter M Stadler, Peter H O'Donnell, Randy F Sweis, Russell Z Szmulewitz
PURPOSE: Majority of patients with metastatic prostate cancer who receive androgen deprivation therapy and androgen receptor (AR) signaling inhibitors progress. Activation of the glucocorticoid receptor (GR) is associated with ARSI-resistance. This single-arm phase I trial assessed safety and pharmacokinetic feasibility of combined AR antagonist (enzalutamide) and selective GR modulator (relacorilant) in metastatic castration-resistant prostate cancer (mCRPC) patients. PATIENTS AND METHODS: This was a phase I trial (NCT03674814) of relacorilant and enzalutamide in refractory mCRPC patients enrolled using 6+3 design...
March 27, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38535994/npepps-is-a-druggable-driver-of-platinum-resistance
#22
JOURNAL ARTICLE
Robert T Jones, Mathijs Scholtes, Andrew Goodspeed, Maryam Akbarzadeh, Saswat Mohapatra, Lily Elizabeth Feldman, Hedvig Vekony, Annie Jean, Charlene B Tilton, Michael V Orman, Shahla Romal, Cailin Deiter, Tsung Wai Kan, Nathaniel Xander, Stephanie P Araki, Molishree Joshi, Mahmood Javaid, Eric T Clambey, Ryan Layer, Teemu D Laajala, Sarah J Parker, Tokameh Mahmoudi, Tahlita C M Zuiverloon, Dan Theodorescu, James C Costello
UNLABELLED: There is an unmet need to improve the efficacy of platinum-based cancer chemotherapy, which is used in primary and metastatic settings in many cancer types. In bladder cancer, platinum-based chemotherapy leads to better outcomes in a subset of patients when used in the neoadjuvant setting or in combination with immunotherapy for advanced disease. Despite such promising results, extending the benefits of platinum drugs to a greater number of patients is highly desirable. Using the multiomic assessment of cisplatin-responsive and -resistant human bladder cancer cell lines and whole-genome CRISPR screens, we identified puromycin-sensitive aminopeptidase (NPEPPS) as a driver of cisplatin resistance...
March 27, 2024: Cancer Research
https://read.qxmd.com/read/38535790/a-comparison-of-the-efficacy-of-antivenoms-and-varespladib-against-the-in-vitro-pre-synaptic-neurotoxicity-of-thai-and-javanese-russell-s-viper-daboia-spp-venoms
#23
JOURNAL ARTICLE
Mimi Lay, Wayne C Hodgson
The heterogeneity in venom composition and potency in disparate Eastern Russell's viper ( Daboia siamensis ) populations has repercussions for the efficacy of antivenoms. This is particularly pronounced in geographical areas in which the venom of the local species has not been well studied and locally produced antivenoms are unavailable. In such cases, alternative therapies following envenoming, which are not limited by species specificity, may be employed to complement antivenoms. We studied the neuromuscular activity of D...
March 1, 2024: Toxins
https://read.qxmd.com/read/38535706/static-magnetic-field-enhances-the-bone-remodelling-capacity-of-human-demineralized-bone-matrix-in-a-rat-animal-model-of-cranial-bone-defects
#24
JOURNAL ARTICLE
SeyedJamal Hosseini, Houman Parsaei, MirJavad Moosavifar, Narjes Tavakoli, Reza Ahadi, Kaveh Roshanbinfar
The regeneration of bone defects that exceed 2 cm is a challenge for the human body, necessitating interventional therapies. Demineralized bone matrices (DBM) derived from biological tissues have been employed for bone regeneration and possess notable osteoinductive and osteoconductive characteristics. Nevertheless, their efficiency in regenerating critically sized injuries is limited, and therefore additional signaling cues are required. Thanks to the piezoelectric properties of the bone, external physical stimulation is shown to accelerate tissue healing...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38535646/fe-3-o-4-tio-2-microspheres-harnessing-o-2-release-and-ros-generation-for-combination-cdt-pdt-ptt-chemotherapy-in-tumours
#25
JOURNAL ARTICLE
Bo Zhao, Xiuli Hu, Lu Chen, Xin Wu, Donghui Wang, Hongshui Wang, Chunyong Liang
In the treatment of various cancers, photodynamic therapy (PDT) has been extensively studied as an effective therapeutic modality. As a potential alternative to conventional chemotherapy, PDT has been limited due to the low Reactive Oxygen Species (ROS) yield of photosensitisers. Herein, a nanoplatform containing mesoporous Fe3 O4 @TiO2 microspheres was developed for near-infrared (NIR)-light-enhanced chemodynamical therapy (CDT) and PDT. Titanium dioxide (TiO2 ) has been shown to be a very effective PDT agent; however, the hypoxic tumour microenvironment partly affects its in vivo PDT efficacy...
March 10, 2024: Nanomaterials
https://read.qxmd.com/read/38535626/nonnegligible-contribution-of-non-lymphoid-tissue-to-viral-reservoir-during-the-short-term-early-cart-in-sivmac239-infected-chinese-rhesus-macaques
#26
JOURNAL ARTICLE
Tian Renrong, Ting Li, Ming-Xu Zhang, Tian-Zhang Song, Hong-Yi Zheng, Yong-Tang Zheng
HIV/AIDS cannot be cured because of the persistence of the viral reservoir. Due to the complexity of the cellular composition and structure of the human organs, HIV reservoirs of anatomical site is also complex. Recently, although a variety of molecules have been reported to involved in the establishment and maintenance of the viral reservoirs, or as marker of latent cells, the research mainly focuses on blood and lymph nodes. Now, the characteristics of the viral reservoir in tissue are not yet fully understood...
March 27, 2024: AIDS Research and Human Retroviruses
https://read.qxmd.com/read/38535582/brucellar-endocarditis-of-the-tricuspid-valve-a-case-report-and-review-of-the-literature
#27
Evangelo Boumis, Pierangelo Chinello, Vincenzo Galati, Simone Topino, Francesca Gavaruzzi, Stefania Cicalini
Brucellar endocarditis is a rare entity commonly described as a severe disease associated with high mortality and generally requiring valve surgery for cure. Right-sided endocarditis, a very uncommon presentation of brucellosis, may be associated with a better prognosis. We describe the case of a 72-year-old woman admitted to our institution with a persistent fever and multiple pulmonary infiltrates. Transthoracic echocardiography and serologic tests led to the diagnosis of brucellar tricuspid endocarditis...
March 8, 2024: Pathogens
https://read.qxmd.com/read/38535536/supportive-treatment-of-a-dog-with-leishmaniosis-and-severe-glomerulopathy-with-immunoadsorption
#28
Florian Sänger, Michèle Bergmann, Katrin Hartmann, René Dörfelt
A three-year-old, intact female mix-breed dog, weighing 30 kg, was presented due to vomitus and diarrhea. At presentation, the patient had a slightly reduced general condition and moderately enlarged mandibular and popliteal lymph nodes. The initial blood work showed severe azotemia and hypoalbuminemia. In the urinalysis, marked proteinuria with a urine protein/creatinine ratio (UPC) of 4.69 was found. Further workup showed a high leishmania antibody titer. The dog was diagnosed with leishmaniosis and glomerulonephritis...
February 21, 2024: Pathogens
https://read.qxmd.com/read/38535504/combining-immunotherapy-and-targeted-therapies-with-cryotherapy-in-patients-with-cutaneous-metastatic-melanoma
#29
JOURNAL ARTICLE
Bengu Nisa Akay, Ahmet Taha Aydemir
No abstract text is available yet for this article.
March 27, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38535474/novel-1-3-4-thiadiazole-3-2-a-pyrimidin-5-ones-as-promising-biofilm-dispersal-agents-against-relevant-gram-positive-and-gram-negative-pathogens
#30
JOURNAL ARTICLE
Daniela Carbone, Camilla Pecoraro, Fabio Scianò, Valentina Catania, Domenico Schillaci, Barbara Manachini, Stella Cascioferro, Patrizia Diana, Barbara Parrino
Biofilm-associated infections pose significant challenges in healthcare settings due to their resistance to conventional antimicrobial therapies. In the last decade, the marine environment has been a precious source of bioactive molecules, including numerous derivatives with antibiofilm activity. In this study, we reported the synthesis and the biological evaluation of a new series of twenty-two thiadiazopyrimidinone derivatives obtained by using a hybridization approach combining relevant chemical features of two important classes of marine compounds: nortopsentin analogues and Essramycin derivatives...
March 15, 2024: Marine Drugs
https://read.qxmd.com/read/38535455/marine-derived-anticancer-agents-targeting-apoptotic-pathways-exploring-the-depths-for-novel-cancer-therapies
#31
REVIEW
Doralyn S Dalisay, Chuckcris P Tenebro, Edna M Sabido, Angelica Faith L Suarez, Melissa June V Paderog, Rikka Reyes-Salarda, Jonel P Saludes
Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages...
February 28, 2024: Marine Drugs
https://read.qxmd.com/read/38535420/functional-recovery-and-regenerative-effects-of-direct-transcutaneous-electrical-nerve-stimulation-in-treatment-of-post-covid-19-guillain-barr%C3%A3-and-acute-transverse-myelitis-overlap-syndrome-a-clinical-case
#32
Mustafa Al-Zamil, Natalia G Kulikova, Inessa A Minenko, Numman Mansur, Denis M Zalozhnev, Marat B Uzdenov, Alina A Dzhanibekova, Alikhan A Gochiyayev, Natalia A Shnayder
Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain-Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome...
February 26, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535305/unraveling-metabolic-changes-following-stroke-insights-from-a-urinary-metabolomics-analysis
#33
JOURNAL ARTICLE
Jamie N Petersson, Elani A Bykowski, Chelsea Ekstrand, Sean P Dukelow, Chester Ho, Chantel T Debert, Tony Montina, Gerlinde A S Metz
The neuropathological sequelae of stroke and subsequent recovery are incompletely understood. Here, we investigated the metabolic dynamics following stroke to advance the understanding of the pathophysiological mechanisms orchestrating stroke recovery. Using a nuclear magnetic resonance (NMR)-driven metabolomic profiling approach for urine samples obtained from a clinical group, the objective of this research was to (1) identify novel biomarkers indicative of severity and recovery following stroke, and (2) uncover the biochemical pathways underlying repair and functional recovery after stroke...
February 28, 2024: Metabolites
https://read.qxmd.com/read/38535229/the-oxidative-stress-response-highly-depends-on-glucose-and-iron-availability-in-aspergillus-fumigatus
#34
JOURNAL ARTICLE
Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi
Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron-carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose-peptone or peptone containing media supplemented or not with deferiprone as an iron chelator. Changes in the transcriptome in these cultures were recorded after H2 O2 treatment. Responses to oxidative stress were highly dependent on the availability of glucose and iron. Out of the 16 stress responsive antioxidative enzyme genes, only the cat2 catalase-peroxidase gene was upregulated in more than two culturing conditions...
March 18, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535221/copper-sulfate-combined-with-photodynamic-therapy-enhances-antifungal-effect-by-downregulating-aif1
#35
JOURNAL ARTICLE
Meimei Zhang, Qiyuan An, Yingzhe Wang, Shigan Ye, Xiaoliang Zhu
Candida albicans is a clinically significant opportunistic fungus that is generally treated with antifungal drugs such as itraconazole and fluconazole. However, the recent emergence of fungal resistance has made treatment increasingly difficult. Therefore, novel antifungal treatment methods are urgently required. Hexanol ethosome photodynamic therapy (HE-PDT) is a method that uses photosensitizers (PS), such as hexanol ethosome, to exert antifungal effects, and can be used to treat resistant fungal strains...
March 14, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535131/cardiometabolic-risk-profiles-of-adolescents-living-with-perinatally-acquired-hiv-in-south-africa
#36
JOURNAL ARTICLE
Leonore Greybe, Shaun Barnabas, Mark Cotton, Penelope Rose, Helena Rabie, Lisa Frigati
BACKGROUND: We assessed the Pathological Determinants of Atherosclerosis in Youth (PDAY) score and other potential cardiovascular disease risk factors in adolescents previously enrolled in the Children with HIV Early antiRetroviral (CHER) and International Maternal Pediatric Adolescent AIDS Clinical Trials Network P1060 clinical trials. METHODS: Coronary artery and abdominal aorta (AA) PDAY scores were calculated for 56 participants over 15 years of age using a weighted combination of dyslipidemia, cigarette smoking, hypertension, obesity, and hyperglycemia...
March 26, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38535074/combined-anti-pd-1-and-anti-ctla-4-treatment-in-stage-iv-melanoma-patients-a-bicentric-analysis-of-real-world-data-and-a-modern-treatment-scenario-proving-lactate-dehydrogenase-s-usefulness
#37
JOURNAL ARTICLE
Alexandru Dorin Adrian Silași, Anna Carolin Sievert, Paul Danciu, Andrei Vlad Lefter, Vlad Adrian Afrasanie, Daniel Sur
BACKGROUND: This retrospective study evaluates patients with stage IV melanoma treated with nivolumab and ipilimumab combination therapy from two regional oncology centers in Romania from the year 2019 to the end of 2022. METHODS: The data were analyzed in SAS for Windows, V9.4. LDH means were stratified by the number of metastatic sites before treatment and compared using an independent sample T-test. The survival curves were estimated using the Kaplan-Meier method, and the survival distributions were compared with the log-rank test...
March 20, 2024: Diagnostics
https://read.qxmd.com/read/38534977/pre-stroke-antihypertensive-therapy-affects-stroke-severity-and-3-month-outcome-of-ischemic-mca-territory-stroke
#38
JOURNAL ARTICLE
Lehel-Barna Lakatos, Manuel Bolognese, Mareike Österreich, Laura Weichsel, Martin Müller
OBJECTIVES: Whether different antihypertensive drug classes in high blood pressure (HBP) pre-stroke treatment affect dynamic cerebral autoregulation (dCA), stroke severity, and outcome. METHODS: Among 337 consecutive ischemic stroke patients (female 102; median age 71 years [interquartile range, [IQR 60; 78]; NIHSS median 3 [IQR 1; 6]) with assessment of dCA, 183 exhibited the diagnosis of HBP. dCA parameters' gain and phase were determined by transfer function analysis of spontaneous oscillations of blood pressure and cerebral blood flow velocity...
March 3, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534965/safety-and-efficacy-of-convalescent-plasma-combined-with-other-pharmaceutical-agents-for-treatment-of-covid-19-in-hospitalized-patients-a-systematic-review-and-meta-analysis
#39
REVIEW
Massimo Franchini, Daniele Focosi, Mario Cruciani, Michael J Joyner, Liise-Anne Pirofski, Jonathon W Senefeld, Shmuel Shoham, David J Sullivan, Arturo Casadevall
Plasma collected from people recovered from COVID-19 (COVID-19 convalescent plasma, CCP) was the first antibody-based therapy employed to fight the pandemic. CCP was, however, often employed in combination with other drugs, such as the antiviral remdesivir and glucocorticoids. The possible effect of such interaction has never been investigated systematically. To assess the safety and efficacy of CCP combined with other agents for treatment of patients hospitalized for COVID-19, a systematic literature search using appropriate Medical Subject Heading (MeSH) terms was performed through PubMed, EMBASE, Cochrane central, medRxiv and bioRxiv...
February 21, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534951/ductal-adenocarcinoma-of-the-prostate-with-novel-genetic-alterations-characterized-by-next-generation-sequencing
#40
Alexandra Zara Rozalen, Jose Manuel Martin, Rithika Rajendran, Maneesh Jain, Victor E Nava
Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic characteristics are still evolving, prompting the suggestion that all DAP would benefit from molecular analysis with the purpose of improving tumor recognition, genetic classification, and, ultimately, personalized therapy...
March 19, 2024: Current Oncology
keyword
keyword
159378
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.