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Combination Therapy

Yangzhou Liu, Shankun Zhao, Jiamin Wang, Zhiguo Zhu, Lianmin Luo, Ermao Li, Fucai Tang, Zhigang Zhao
PURPOSE: To evaluate whether serum neuroendocrine markers could effectively predict treatment outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: The PubMed, Cochrane Library and Embase databases were sought to identify eligible studies concerning serum neuroendocrine markers and the prognosis of post-treatment mCRPC from inception to April 2018. The association between serum neuroendocrine markers, that is, chromogranin A (CgA) and neurone-specific enolase (NSE), levels and the prognosis of post-treatment mCRPC were summarized using a random-effects model and hazard ratio (HR) with 95% CI Sensitivity analyses were conducted to assess potential bias...
December 5, 2018: Urologia Internationalis
Salomón Durand, Arnaldo Lachira-Alban, César Cabezas Sánchez
At the end of the 90s in Peru, after determining the resistance to antimalarial drugs, a change in antimalarial treatment schemes was decided; this change included the combined therapy for P. falciparum, mefloquine/artesunate in the Amazon region, and sulfadoxine pyrimethamine/artesunate in the North coast. After two decades, and aimed at assessing the impact of these schemes on the malaria endemic, a review was conducted of malaria reports in three departments accounting for more than 70% of cases reported in the country...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Fabiani Palagi Machado, Alessandra Rosa Vicari, Fábio Spuldaro, João Batista Saldanha de Castro Filho, Roberto Ceratti Manfro
OBJECTIVE: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. METHODS: A single-center, retrospective study involving 226 patients submitted to kidney transplant between 2008 and 2013, and treated with anti-thymocyte globulin for induction or treatment of cellular rejection. Doses were adjusted according to CD3+ T cell or total lymphocyte counts in peripheral blood...
November 29, 2018: Einstein
Paulo Roberto Barbosa Évora, Agnes Afrodite Sumarelli Albuquerque, Tales Rubens de Nadai, Enio David Mente, Ajith Kumar Sankarankuty, Orlando Castro-E-Silva
Early cancer diagnosis, new therapies that increased survival of patients, besides the increasingly elderly population are some factors would be associated with possible cancer dissemination in patients under cardiopulmonary bypass (CPB) cardiac surgery. Also, the benefits, and risks, regarding long-term survival, have not yet been established. Therefore, cardiac surgery morbimortality may be superior in patients with cancer disease. Also, immunologic and inflammatory changes secondary to CPB can also increase tumor recurrence...
November 2018: Acta Cirúrgica Brasileira
Ingridt Hildegard Vogler, Daniela Frizon Alfieri, Heloisa Damazio Bruna Gianjacomo, Elaine Regina Delicato de Almeida, Edna Maria Vissoci Reiche
The cascade of care for people living with HIV infection (PLHIV) describes steps in diagnosis, linkage and retention in care, as well as the provision and success of combination antiretroviral therapy (cART). The aim of this study was to evaluate the rates regarding the retention in care, on cART, and suppressed viral load for PLHIV attended at a Brazilian public health network. Data on PLHIV from 116 cities of Paraná, Southern Brazil, attended from 2012 to 2015, were retrospectively collected through the Laboratory Tests Control System (SISCEL)...
November 29, 2018: Cadernos de Saúde Pública
Frans Everson, Amanda Genis, Temitope Ogundipe, Patrick De Boever, Nandu Goswami, Amanda Lochner, Dee Blackhurst, Hans Strijdom
HIV-infection, certain antiretroviral drug classes, especially protease inhibitors (PI), and obesity are associated with increased ischaemic heart disease (IHD) risk. However, the effect of PI-free fixed dose combination (FDC) antiretroviral therapy (ART) on hearts exposed to ischaemia-reperfusion injury (I/R) is unknown, particularly in obesity. This is becoming relevant as World Health Organisation guidelines recommend a FDC ART containing (non-) nucleoside reverse transcriptase inhibitors (tenofovir (TDF), emtricitabine (FTC) and efavirenz (EFV)) as first-line HIV treatment...
2018: PloS One
Kari Remes, Pekka Anttila, Raija Silvennoinen, Mervi Putkonen, Hanna Ollikainen, Venla Terävä, Marjatta Sinisalo, Kristiina Kananen, Frida Schain, Päivi Castren-Kortegangas, Tiina M Järvinen, Marta Pisini, Felix Wahl, Tricia Dixon, Amy Leval
Outcomes for patients with multiple myeloma (MM) have improved with the advent of novel therapies, however, real-world evidence of outcomes in clinical practice is scarce. We conducted a multi-center registry study to build a reliable picture of treatment and patient outcomes in Finland. The aim of this study was also to understand any methodological challenges in assessing treatment outcomes using disease registry data. METHODS: We carried out a retrospective, observational study using data from the national Finnish Hematology Registry (FHR) to provide real-world evidence of outcomes for all adult patients diagnosed with and treated for MM between 2009-2013 at one of the six regional hospitals, with at least six months of recorded follow-up...
2018: PloS One
Vigneshwaran Namasivayam, Murugesan Vanangamudi, Victor G Kramer, Sonali Kurup, Peng Zhan, Xinyong Liu, Jacob Kongsted, Siddappa N Byrareddy
Human immunodeficiency virus (HIV) infection is now pandemic. Targeting HIV-1 reverse transcriptase (HIV-1 RT) has been considered one of the most successful targets for the development of anti-HIV treatment. Among the HIV-1 RT inhibitors, non-nucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive place due to their unique antiviral potency, high specificity and low toxicity in antiretroviral combination therapies used to treat HIV. Till now, >50 structurally diverse classes of compounds have been reported as NNRTIs...
December 5, 2018: Journal of Medicinal Chemistry
Jean Terrier, Jean-Luc Reny, Pierre Fontana
Antithrombotic drugs are regularly prescribed for the treatment and prevention of venous or arterial thromboembolic events. The co-prescription of an anticoagulant and antiplatelet drug is frequent in daily practice even if evidence of benefit associated with such an association is limited, while the increased bleeding risk is well established. The aim of this article is to review the situations where antiplatelet drugs are indicated in patients already treated with long-term anticoagulants. The perspective of adapting and personalizing antithrombotic therapy according to each patient's characteristics is also discussed...
December 5, 2018: Revue Médicale Suisse
Suzanne C van Bronswijk, Lotte H J M Lemmens, John R Keefe, Marcus J H Huibers, Robert J DeRubeis, Frenk P M L Peeters
BACKGROUND: Major depressive disorder (MDD) has a highly recurrent nature. After successful treatment, it is important to identify individuals who are at risk of an unfavorable long-term course. Despite extensive research, there is no consensus yet on the clinically relevant predictors of long-term outcome in MDD, and no prediction models are implemented in clinical practice. The aim of this study was to create a prognostic index (PI) to estimate long-term depression severity after successful and high quality acute treatment for MDD...
December 5, 2018: Depression and Anxiety
Alessia Castellino, Jose S Pulido, Patrick B Johnston, Kay M Ristow, N Nora Bennani, David J Inwards, William R Macon, Ivana N M Micallef, Rebecca L King, Diva R Salomao, Thomas E Witzig, Thomas M Habermann, Grzegorz S Nowakowski
Vitreoretinal lymphoma (VRL) management remains a challenge. We present 72 patients with VRL, diagnosed at Mayo Clinic between 1990-2018. Three nondiffuse large B-cell lymphoma (DLBCL) histology cases were excluded. Among 69 DLBCL, 33 patients had primary VRL (PVRL), 18 concurrent intraocular and central nervous system (CNS) or systemic disease and 18 secondary VRL. Patients received intraocular chemotherapy (intraocular injections of rituximab or metothrexate or steroids or in combination), radiotherapy, systemic or combined systemic plus intraocular treatment in 9, 10, 35, and 15 cases, respectively...
December 5, 2018: American Journal of Hematology
Kerstin Rauwolf, Heidi Herbrüggen, Stefan Zöllner, Heike Thorer, Olga Makarova, Thomas Kaiser, Aleksandra Pettke, Claudia Rossig, Birgit Burkhardt, Andreas H Groll
Chronic hepatitis C virus (HCV) infection carries increased risks for morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) but has become curable through the advent of directly acting antiviral compounds. Current guidelines of the American Society for Blood and Marrow Transplantation (ASBMT) recommend that HCV-infected HSCT candidates preferably start and complete therapy prior to transplant. However, this is often not feasible due to time constraints or treatment limiting comorbidities, conditions and treatments...
December 5, 2018: Journal of Viral Hepatitis
Tianqun Lang, Yiran Liu, Zhong Zheng, Wei Ran, Yihui Zhai, Qi Yin, Pengcheng Zhang, Yaping Li
Metastatic breast cancer may be resistant to chemo-immunotherapy due to the existence of cancer stem cells (CSC). And the control of particle size and drug release of a drug carrier for multidrug combination is a key issue influencing therapy effect. Here, a cocktail strategy is reported, in which chemotherapy against both bulk tumor cells and CSC and immune checkpoint blockade therapy are intergraded into one drug delivery system. The chemotherapeutic agent paclitaxel (PTX), the anti-CSC agent thioridazine (THZ), and the PD-1/PD-L1 inhibitor HY19991 (HY) are all incorporated into an enzyme/pH dual-sensitive nanoparticle with a micelle-liposome double-layer structure...
December 5, 2018: Advanced Materials
Sheila A M Rauch, H Myra Kim, Corey Powell, Peter W Tuerk, Naomi M Simon, Ron Acierno, Carolyn B Allard, Sonya B Norman, Margaret R Venners, Barbara O Rothbaum, Murray B Stein, Katherine Porter, Brian Martis, Anthony P King, Israel Liberzon, K Luan Phan, Charles W Hoge
Importance: Meta-analyses of treatments for posttraumatic stress disorder (PTSD) suggest that trauma-focused psychotherapies produce greater benefits than antidepressant medications alone. Objective: To determine the relative efficacy of prolonged exposure therapy plus placebo, prolonged exposure therapy plus sertraline hydrochloride, and sertraline plus enhanced medication management in the treatment of PTSD. Design, Setting, and Participants: The Prolonged Exposure and Sertraline Trial was a randomized, multisite, 24-week clinical trial conducted at the Veterans Affairs Ann Arbor Healthcare System, Veterans Affairs San Diego Healthcare System, Ralph H...
December 5, 2018: JAMA Psychiatry
Małgorzata Konieczyńska, Piotr Bijak, Lien Desteghe, Hein Heidbuchel, Anetta Undas
INTRODUCTION Little is known about the current awareness of venous thromboembolism (VTE) and knowledge of thromboprophylaxis among patients receiving oral anticoagulation therapy (OAC). OBJECTIVES We sought to develop and evaluate the usefulness of the Jessa AF Knowledge Questionnaire (JAKQ) modified for VTE patients. PATIENTS AND METHODS Consecutive patients at least one month since the VTE event (n=273, mean [SD] age 51 [17] years; 52.7% women; 55.9% unprovoked event) were enrolled at the study. RESULTS The median percentage of correct responses was 64...
December 5, 2018: Polish Archives of Internal Medicine
Yu Parfenov, M Vasilevskaya, S Parfenov, K Sapozhnikov, A Kovalenko, V Zaplutanov
The aim of the study was to assess the impact of cytoflavin and bioflavin therapy on the dynamics of clinical and psychophysiological status of patients with Osteochondrosis. 150 patients with osteochondrosis of a backbone were investigated. The patients were divided into two groups using method of randomization: the main group - 75 patients - and control group -75 patients. All patients received a standard treatment (non-steroidal anti-inflammatory drugs, myorelaxants, chondroprotectors, as well as physiotherapy)...
October 2018: Georgian Medical News
V Gavrysyuk, E Merenkova, G Gumeniuk, M Gumeniuk, Y Dziublyk
Immunosuppressants are traditionally administered in sarcoidosis patients with contraindications for the use of glucocorticosteroids (GCS), or in those with serious adverse reactions on GCS, as well as in the cases of GCS-therapy resistance. Aim - to study the effectiveness and safety of methotrexate monotherapy in pulmonary sarcoidosis patients with either GCS contraindication or adverse reactions. We examined 33 patients with st. II pulmonary sarcoidosis, 20 men and 13 women, 23-67 years of age. In all cases a general physical examination; chest computed tomography and spirometry were performed...
October 2018: Georgian Medical News
Benjamin Mesure, Patrick Menu, Jagadeesh Kumar Venkatesan, Magali Cucchiarini, Émilie Velot
Musculoskeletal pathologies, especially those affecting bones and joints, remain a challenge for regenerative medicine. The main difficulties affecting bone tissue engineering are the size of the defects, the need for blood vessels and the synthesis of appropriate matrix elements in the engineered tissue. Indeed, the cartilage is an avascular tissue and consequently has limited regenerative abilities. Thanks to their self-renewal, plasticity and immunomodulatory properties, mesenchymal stem cells (MSCs) became a central player in tissue engineering, and have already been shown to be able to differentiate towards chondrogenic or osteogenic phenotypes...
December 5, 2018: Current Stem Cell Research & Therapy
Gaia Chiara Mannino, Francesco Andreozzi, Giorgio Sesti
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control it is often necessary to rely on combination therapy of multiple drugs or insulin, because uncontrolled glucose levels result in T2DM progression and enhanced risk of complications and mortality. Several anti-hyperglycemic agents have been developed over time, and T2DM pharmacotherapy should be prescribed based on suitability for the individual patient's characteristics...
December 4, 2018: Diabetes/metabolism Research and Reviews
E Rosi, L Pescitelli, F Ricceri, A Di Cesare, A Novelli, N Pimpinelli, F Prignano
BACKGROUND AND OBJECTIVE: The Rifampicin (RF) - Clindamycin (CL) combination is recommended as first line therapy in moderate to severe Hidradenitis Suppurativa (HS) by European S1 guidelines. Although prolonged use of RF should be discouraged, there are currently few alternatives to this combination therapy. The aim of this study was to assess retrospectively the efficacy of oral CL monotherapy in patients diagnosed with HS. METHODS: In the period January 2017 - May 2018 31 HS patients who received a 300 mg b...
December 5, 2018: Dermatologic Therapy
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