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Rat burn

Adeleh Gholipour-Kanani, Monireh Mohsenzadegan, Mohammadreza Fayyazi, Hajir Bahrami, Ali Samadikuchaksaraei
Poly (ɛ-caprolactone)-chitosan-poly (vinyl alcohol) (PCL: Cs: PVA) nanofibrous blend scaffolds were known as useful materials for skin wound healing and would help the healing process about 50% faster at the final time point. From the previous studies by the authors, PCL: Cs: PVA (in 2: 1: 1.5 mass ratio) nanofibres showed high efficacy in healing on rat models. In this study, the scaffolds were examined in burn and excision wounds healing on dogs as bigger models. The scaffolds were applied on dorsum skin wounds ( n  = 5) then macroscopic and microscopic investigations were carried out to measure the wounds areas and to track healing rate, respectively...
August 2018: IET Nanobiotechnology
Mustafa Onur Oztan, Fatma Demet Arslan, Sule Oztan, Gulden Diniz, Gokhan Koyluoglu
BACKGROUND: Caustic esophageal burn is still an important health problem in pediatric surgery. Although there are a number of experimental and clinical studies to increase the recovery of the esophagus and reduce the stenosis rate, there is no consensus on the treatment protocol. Platelet-rich plasma (PRP) is an autologous blood product, which has positive effects on wound healing, reepithelization and scar prevention. The aim of our study was to investigate the effects of PRP on stricture formation and oxidative status after caustic esophageal injury in rats...
August 1, 2018: Journal of Pediatric Surgery
Ahmad Oryan, Maryam Jalili, Amir Kamali, Behrooz Nikahval
Treatment of burn wounds is technically demanding and several attempts have been taken to improve wound healing. Silver sulfadiazine antibiotic has been shown to have some beneficial effects on wound healing via reduction in infection. This study was designed to investigate the impact of collagen hydrogel-scaffold dressing with or without topical use of Saccharomyces cerevisiae on cutaneous burn wound healing in rat. Four circular 1cm cutaneous wounds were created in the dorsum back of rats, 48h post-burning...
August 2, 2018: Burns: Journal of the International Society for Burn Injuries
Vetrichevvel Palanivelu, Siaavash Maghami, Hilary J Wallace, Dulharie Wijeratne, Fiona M Wood, Mark W Fear
Burn scars can be associated with significant loss of cutaneous sensation, paresthesia and chronic pain. Long-term systemic changes in cutaneous innervation may contribute to these symptoms and dorsal root ganglia have been implicated in the development of chronic neuropathic pain. Therefore we hypothesized that changes in cutaneous innervation after burn injury may be mediated at the level of the dorsal root ganglia. Burn group rats (n=20) were subjected to a unilateral burn injury while 12 control rats underwent sham procedure...
July 30, 2018: Burns: Journal of the International Society for Burn Injuries
Xu Luo, Jianmin Li, Lihui Yin, Jian Pan, Yang Zhang, Zipei Jiang
The aim of the present study was to investigate the effect of microRNA 146a (miR146a) on promoting the repair of corneal alkali burn with bone marrow mesenchymal stem cells (MSCs). A total of 24 Sprague‑Dawley female rats were divided into a normal group (Control), a normal MSC treatment group (Normal MSCs), an miR146a knockout MSC treatment group (miR146a‑low MSCs) and an miR146a high‑expression MSC treatment group (miR146a‑high MSCs) according to the random number table. Quantitative polymerase chain reaction was used to evaluate the expression levels of miR146a...
July 27, 2018: Molecular Medicine Reports
Qiyu Zhu, Ming Jiang, Qiang Liu, Shina Yan, Longbao Feng, Yong Lan, Guiqiu Shan, Wei Xue, Rui Guo
Burn wounds are associated with a series of risks, such as infection and pathologic scar tissue formation, which significantly delay wound healing and lead to complications. In this study, we successfully fabricated a dextran-hyaluronic acid (Dex-HA) hydrogel enriched with sanguinarine (SA) incorporated into gelatin microspheres (GMs), which had high porosity, good swelling ratio, enhanced NIH-3T3 fibroblast cell proliferation, and sustained SA release profile. The in vitro degradation results indicate that the SA/GMs/Dex-HA hydrogel can be degraded...
August 1, 2018: Biomaterials Science
Zong-Sheng Wu, Jing-Jou Lo, Sheng-Hua Wu, Chau-Zen Wang, Rong-Fu Chen, Su-Shin Lee, Chee-Yin Chai, Shu-Hung Huang
Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation in rats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effects of HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague-Dawley (SD) rats were randomly assigned to the following six groups ( n = 6 per group): (1) sham burn with sham HBO treatment; (2) sham burn with HBO treatment; (3) burn with one-week sham HBO treatment; (4) burn with two-week sham HBO treatment; (5) burn with one-week HBO treatment; and (6) burn with two-week HBO treatment...
July 27, 2018: International Journal of Molecular Sciences
P Cui, H M Xin, Q Zhan, Z P Tang, C J Deng, X H Li, Y H Lai, R S Li, A N Chen, Y L Tong
Objective: To explore mechanism of lung injury of rats induced by inhalation of white smoke from burning smoke pot. Methods: Forty-eight Sprague Dawley rats were divided into control group ( n =12) and injury group ( n =36) according to the random number table. Rats in injury group were placed in smoke-induced injury experimental equipment fulled with white smoke from burning smoke pot for 5 minutes to make lung injury, and rats in control group were placed in smoke-induced injury experimental equipment fulled with air for 5 minutes to make sham injury...
July 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Anju Yadav, Saurabh Verma, Gaurav K Keshri, Asheesh Gupta
Burn wound is a complex multi-factorial pathophysiology producing excruciating pain and psychological discomfort among patients, which imposes a major burden on the healthcare system. Multi-target therapy focuses on augmented healing by regulating different phases of tissue repair. Recently, photobiomodulation (PBM)-induced wound healing has achieved profound impetus as a non-invasive, drug-free biophysical therapeutic approach. On the other hand, medicinal honey known to possess antibacterial and immunomodulatory properties and is being used as an effective treatment option for infected wounds...
July 18, 2018: Journal of Photochemistry and Photobiology. B, Biology
Bing Wang, Pui-Kai Li, Jian-Xing Ma, Danyang Chen
Purpose: Neovascularization (NV) and retinal vascular leakage are major causes of impaired vision in ocular diseases. The purpose of this study was to identify novel phenylphthalimide analogs with therapeutic effects on NV and vascular leakage and to explore the mechanism of action. Methods: Antiangiogenic activities of novel phenylphthalimide analogs were assessed in vitro by using VEGF ELISA and endothelial cell proliferation assay. Their efficacies on retinal vascular leakage were evaluated using rat models of oxygen-induced retinopathy (OIR) and streptozotocin (STZ)-induced diabetes...
July 2, 2018: Investigative Ophthalmology & Visual Science
Bo Peng, Xinyi Lai, Lei Chen, Xuemei Lin, Chengxin Sun, Lixin Liu, Shaohai Qi, Yongming Chen, Kam W Leong
Burn, trauma, and various medical conditions including bacterial infection, diabetes complication, and surgery could lead to an acute cutaneous wound and scar formation. Application of tissue glues instead of sutures could minimize the additional trauma and scar formation. Despite the countless efforts devoted to the development of high-strength tissue glues, little attention has been paid to their influence on the scar formation. Here, we report the development of a new tissue glue with excellent biocompatibility and tunable degradability for scarless wound closure...
September 30, 2017: ACS Omega
Qiyi Zhai, Fei Zhou, Mohamed M Ibrahim, Jingling Zhao, Xusheng Liu, Jun Wu, Lei Chen, Shaohai Qi
Skin grafting is the routine standard of care to manage third degree burns and problematic skin defects. Several commercially available dermal substitutes and biologic skin equivalents are placed in the wound bed to facilitate the healing process of the skin grafts, as well as to provide mechanical support for the cells to grow and to delay the contracture. To study pathology and develop new therapies, an immune-competent rat model is required. We have created two different skin graft animal models to mimic the clinical skin grafting operation, the dorsum skin grafting (DG) and inguinal skin grafting (IG)...
2018: American Journal of Translational Research
J Brian McAlvin, Ryan G Wylie, Krithika Ramchander, Minh T Nguyen, Charles K Lok, Morgan Moroi, Andre Shomorony, Nikolay V Vasilyev, Patrick Armstrong, Jason Yang, Alexander M Lieber, Obiajulu S Okonkwo, Rohit Karnik, Daniel S Kohane
Cytokines play an important role in dysregulated immune responses to infection, pancreatitis, ischemia/reperfusion injury, burns, hemorrhage, cardiopulmonary bypass, trauma, and many other diseases. Moreover, the imbalance between inflammatory and antiinflammatory cytokines can have deleterious effects. Here, we demonstrated highly selective blood-filtering devices - antibody-modified conduits (AMCs) - that selectively eliminate multiple specific deleterious cytokines in vitro. AMCs functionalized with antibodies against human vascular endothelial growth factor A or tumor necrosis factor α (TNF-α) selectively eliminated the target cytokines from human blood in vitro and maintained them in reduced states even in the face of ongoing infusion at supraphysiologic rates...
July 12, 2018: JCI Insight
Yong Hu, Chun Yu, Maolin Yao, Lei Wang, Bing Liang, Bixia Zhang, Xiaoxin Huang, Aihua Zhang
Arsenic poisoning is a worldwide endemic disease that affects thousands of people. Growing evidence from animal, cell, and human studies indicates that arsenic has deleterious effects on the liver. Oxidative stress is considered the primary mechanism for arsenic toxicity in liver damage. However, the mechanisms remain unclear. In light of this fact, the main objective of this study was to investigate the effects of the protein kinase C delta-nuclear factor E2-related factor 2-antioxidant response element (PKCδ-Nrf2-ARE) signalling pathway on oxidative stress in liver damage...
May 22, 2018: Environmental Toxicology and Pharmacology
Yalong Han, Hui Yang, Wenjun Liu, Wuquan Li, Yulan Miao, Haibing Wang
Objective To investigate the expressions of high mobility group box 1 (HMGB1) and Toll-like receptor 4 (TLR4) in the intestinal tract of severely burned rats and their relationship with intestinal immune function. Methods Forty male SD rats were randomly divided into control group (n=10) and severe burn group (n=30). 60% of the rats' body (the back and ventral side) was burned in the severe burn group, and only anesthesia was performed in normal control group. Rats were sacrificed at 6, 12 and 18 hours after injury in the burn group, while sacrificed immediately after anesthesia in control group...
April 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Gehan Fathy Balata, Hanan Abd El-Moneom Shamardl, Hanan Mohamed Abd Elmoneim, Afnan Abdullah Hakami, Maeen Abdulaziz Almodhwahi
OBJECTIVES: To develop an alternative medicine, propolis, in emulgel formulation for burn and wound treatment. METHODS: The effect of two independent variables: emulsifying agent concentration and oil concentration on the cumulative amount of propolis release (dependent variable) from liquid paraffin and isopropyl palmitate emulgels was investigated. Eight formulations were prepared and evaluated for physical appearance, pH, propolis content, viscosity and in vitro propolis release...
July 5, 2018: Drug Development and Industrial Pharmacy
Y N Zhao, Z Y Li, K Kan, H T Su
Objective: To investigate the mechanism of cell autophagy for regulating skeletal muscle wasting of rats after severe burns. Methods: Seventy-two Sprague-Dawley rats were collected and divided into sham injury group, simple burn group, burn+ phosphate buffer solution (PBS) group, and burn+ 3-methyladenine (3-MA) group according to the random number table, with 18 rats in each group. Rats in simple burn group, burn+ PBS group, and burn+ 3-MA group were inflicted with 30% total body surface area full-thickness scald (hereinafter referred to as burns)...
February 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
H S Li, X K Yang, Z M Hao, J Lei
Objective: To investigate the interventional effects of BAY11-7082 on lung inflammatory response at the early stage and acute lung injury of rats with severe burns. Methods: (1) Experiment 1. Twelve Sprague-Dawley (SD) rats were divided into control (C) group and burn (B) group according to the random number table, with 3 rats in group C and 9 rats in group B. Rats in group C did not receive any special treatment. Rats in group B were inflicted with 30% total body surface area full-thickness burn on the back...
February 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Eric F Lucking, Kevin H Murphy, David P Burns, Anirudh V Jaisimha, Kevin J Barry-Murphy, Pardeep Dhaliwal, Barry Boland, Mark G Rae, Ken D O'Halloran
Alzheimer's disease (AD) is a progressive neurodegenerative condition disturbing major brain networks, including those pivotal to the motor control of breathing. The aim of this study was to examine respiratory control in the TgF344-AD transgenic rat model of AD. At 8-11 months of age, basal minute ventilation and ventilatory responsiveness to chemostimulation were equivalent in conscious wild-type (WT) and TgF344-AD rats. Under urethane anesthesia, basal diaphragm and genioglossus EMG activities were similar in WT and TgF344-AD rats...
June 30, 2018: Respiratory Physiology & Neurobiology
G Y Zheng, J H Zhan, J H Luo, X Cheng
Objective: To explore effect of alprostadil on wound healing of scalded rats and the mechanism. Methods: According to random number table method, forty-eight Sprague Dawley rats were divided into sham scald group, simple scald group, lithium chloride group, and alprostadil group, with 12 rats in each group. Rats in sham injury group were sham injured on the back, and rats in the other three groups were inflicted with 30% total body surface area deep partial thickness scald on the back.Immediately after scald, rats in sham scald group and simple scald group were injected with 1 mL saline through caudal vein, and rats in lithium chloride group and alprostadil group were injected respectively with 1 mL lithium chloride and alprostadil through caudal vein...
June 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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