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Rat burn

Amber L Harris Bozer, Ai-Ling Li, Perry N Fuchs, Yuan B Peng
BACKGROUND: Neuropathic pain patients have described experiencing unprovoked, intermittent pain attacks with shooting, stabbing, and burning qualities. Rodent models used in previous literature usually only involve acute exposure, and/or are unable to manipulate the stimulation intensity in vivo by the experimenter during an experiment. NEW METHOD: This paper describes a method to induce controllable pain behaviors in rodents using a wireless portable electronic device that can be manipulated within the course of an experiment...
October 10, 2018: Journal of Neuroscience Methods
Chunyu Yuan, Congsong Sun, Yexiang Sun, Qincheng Wang, Biao Wang, Chunhua Wang, Yizhong Tang, Delin Hu, Xingzhao Li, Junhui Song
OBJECTIVE: To explore the mechanism of hypertonic salt solution (HS) alleviates lung injury of rats at the early stage of severe scald. METHODS: Thirty-two female Sprague-Dawley (SD) rats were randomly assigned to sham group, lactated Ringer solution (LR) group, HS200 group (200 mmol/L HS group, 1 L 200 mmol/L HS contained 955 mL LR and 45 mL 10% NaCl) and HS400 group (400 mmol/L HS group, 1 L 400 mmol/L HS contained 846 mL LR and 154 mL 10% NaCl), with 8 rats in each group...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Min Liang, Zhongmin Chen, Fuping Wang, Lan Liu, Runan Wei, Mei Zhang
Few burn dressings can self-regulate the optimal humidity levels that are required for wound healing, while also providing good anti-adhesive properties to prevent damage that can occur when wound dressings are changed. Consequently, a water-soluble carboxymethylcellulose sodium/sodium alginate/chitosan (CMC-Na/SA/CS) composite hydrogel has been developed as a potential burn wound dressing, with orthogonal testing revealing an optimal ratio of CMC-Na, SA, and CS as 2, 3, and 1 wt % for hydrogel preparation, respectively...
October 8, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
L L Wang, S X Guo, P Wu, H W Shao, C M Han
Objective: To explore the influences of hydrogen-rich saline on acute kidney injury in severely burned rats and to analyze the related mechanism. Methods: Fifty-six Sprague Dawley rats were divided into sham injury group ( n =8), burn group ( n =24), and hydrogen-rich saline group ( n =24) according to the random number table. Rats in sham injury group were treated by 20 ℃ water bath on the back for 15 s to simulate injury, and rats in burn group and hydrogen-rich saline group were inflicted with 30% total body surface area (TBSA) full-thickness scald (hereinafter referred to as burns) by 100 ℃ water bath on the back for 15 s...
September 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Jinyong Ju, Du Yu, Feng Xue, Yong Zhao, Weizhe Shi, Mingmang Pan, Guo Tang, Haijun Xiao
PURPOSE: To investigate the pathogenesis and find a better prophylactic method of acquired heterotopic ossification (HO). MATERIALS AND METHODS: In the first part, we designed the brain-traumatic/burn/tenotomy rat model and testified its efficacy as HO model. 44 rats were randomly divided into experimental group and control group. After operation, the bilateral tendons of 2 rats were collected at the 2nd , 3rd , 4th , 6th , 8th , and 10th weeks to determine the expression levels of p65...
October 5, 2018: Connective Tissue Research
José de Alencar Fernandes Neto, Cassiano Francisco Weege Nonaka, Maria Helena Chaves de Vasconcelos Catão
The aim of this study was to evaluate the effects of blue light-emitting diode (LED) on the healing process of third-degree skin burns in rats through clinical and histological parameters. Forty male Wistar rats were divided into two groups: control (CTR) (n = 20) and blue LED (BLUE) (n = 20), with subgroups (n = 5) for each time of euthanasia (7, 14, 21, and 28 days). LED (470 nm, 1 W, 12.5 J/cm2 per point, 28 s) was applied at four points of the wound (total, 50 J/cm2 ). Feed intake was measured every other day...
October 1, 2018: Lasers in Medical Science
Solmaz Ghaffari, Faezeh Alihosseini, Seyed Mahdi Rezayat Sorkhabadi, Sepideh Arbabi Bidgoli, Seyyedeh Elaheh Mousavi, Setareh Haghighat, Ahoo Afshar Nasab, Nooshin Kianvash
Purpose: Wound healing is a natural biologic process, but the duration of it may take too long. Trying to shorten this process is one of the challenges for scientists. Many technologies were applied to achieve this goal as well as nanotechnology. In this study semi solid formulations containing curcumin and ampicillin solid lipid nanoparticles (SLNs) were prepared to evaluate as burn wound healing agent. Methods: Curcumin as an anti-inflammatory and anti-bacterial agent and ampicillin as an antibiotic were applied...
August 2018: Advanced Pharmaceutical Bulletin
I Saputro, B Riestiano, L T Hoekstra, L Zarasade
BACKGROUND: Electric burn patients usually suffer permanent injury and sequelae. Salvage of the zone of stasis is an important topic in the treatment of burn patients. N-Acetylcysteine (NAC), as an antioxidant, has effect on the saving zone of stasis and extensive rhabdomyolisis. The aim of this study was therefore to evaluate the effect of oral NAC on tissue destruction indicators in an electric burn rat model. MATERIAL AND METHODS: An experimental study was conducted with thirty six male Wistar albino rats divided into 2 groups...
September 28, 2018: Burns: Journal of the International Society for Burn Injuries
Chang-Xue Wu, Yi-Heng Wang, Yi Li, Zhi-Zhong Guan, Xiao-Lan Qi
To investigate the relationship between DNA repair gene methylation and chronic coal-burning fluorosis. The methylation rates of O6 -methylguanine-DNA- methyltransferase gene MGMT, a DNA repair gene and mismatch repair gene MutL homolog 1 (MLH1) were analysed by methylation of specific PCR (MSP), and the levels of mRNA in the blood of the chronic fluorosis rats and the patients in the region of endemic coal-burning fluorosis were determined by real-time PCR. The levels of mRNA and protein of MGMT and MLH1 in the liver tissue of the chronic fluorosis rats were determined by real-time PCR and Western blot respectively...
December 2018: Journal of Trace Elements in Medicine and Biology
Ozan Luay Abbas, Orhan Özatik, Zeynep Burçin Gönen, Serdal Öğüt, Emre Entok, Fikriye Yasemin Özatik, Dilek Bahar, Zehra Burcu Bakir, Ahmet Musmul
INTRODUCTION: Burns are dynamic wounds that may present a progressive expansion of necrosis into the initially viable zone of stasis. Therefore, salvage of this zone is a major subject of focus in burn research. The beneficial effects of mesenchymal stem cells (MSCs) on the survival of the zone of stasis have been previously documented. However, many gaps still exist in our knowledge regarding the underlying protective mechanisms. Hence, this study was designed to evaluate the pathophysiological basis of MSCs in the prevention of burn wound progression...
September 26, 2018: Annals of Plastic Surgery
Ifukibot L Usende, James O Olopade, Benjamin O Emikpe, Ademola A Oyagbemi, Adeolu A Adedapo
Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600-850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively...
June 2018: International Journal of Veterinary Science and Medicine
Ling Chen, Jing Zhong, Saiqun Li, Weihua Li, Bowen Wang, Yuqing Deng, Jin Yuan
Purpose: To investigate the effect of tacrolimus in alkali burn-induced corneal neovascularization (NV) and inflammation and to compare with anti-vascular endothelial growth factor (anti-VEGF). Methods: After corneal alkali-burn, 84 Wistar rats were randomly divided into three groups and received either saline solution or 0.05% tacrolimus (0.5 mg/mL) four times daily, or subconjunctival anti-VEGF injection (0.5 mg/0.05 mL). Corneal NV, opacity and epithelial defects, the status of inflammation, and the levels of proinflammatory and angiogenic cytokines were assessed on Days 3, 7, 14 and 28 post-injury...
2018: Drug Design, Development and Therapy
Ludivine Vitet, Christine Patte-Mensah, Naoual Boujedaini, Ayikoé-Guy Mensah-Nyagan, Laurence Meyer
Chemotherapeutic drugs induce various side effects including painful peripheral neuropathy that represents a major concern. The widely used anticancer drug paclitaxel causes neurological side effects such as burning pain, allodynia, and hyperalgesia. Neuroprotective substances that may effectively counteract paclitaxel-induced neuropathic symptoms are needed. Here, we investigated the potential of Gelsemium sempervirens (GS) to counteract paclitaxel-evoked painful neuropathy in rats. Using the von Frey hair and acetone behavioral tests, we investigated the potential of GS centesimal (C) dilutions 3, 5, and 9C to prevent or to correct paclitaxel-induced cold allodynia and mechanical allodynia/hyperalgesia involved in neuropathic pain...
September 24, 2018: Neurological Sciences
Bahman Mirzaei, Somayeh Etemadian, Hamid Reza Goli, Sara Bahonar, Sanaz Amir Gholami, Parisima Karami, Mojgan Farhadi, Rahmatollah Tavakoli
Developing a strategy for making the alginate base hydrogel components against burned wound infections could be promising for healing the mentioned wounds followed by elimination of the biofilm forming bacteria colonization. Construction of an alginate based hydrogel and evaluating healing activities of the mentioned component as local ointment were the main objectives of the current study. Following the collection of the honey from three different provinces of Iran, the components and structures of the collected materials were analyzed taking advantage of INSO-92 procedure subsequently, antibacterial effect of diluted three different kinds of honey against wild-type bacterial species got evaluated via agar well diffusion method...
2018: International Journal of Burns and Trauma
Caren Tatiane de David Antoniazzi, Samira Dal-Toé De Prá, Paula Ronsani Ferro, Mariane Arnoldi Silva, Gabriela Adamante, Amanda Spring de Almeida, Camila Camponogara, Cássia Regina da Silva, Gustavo de Bem Silveira, Paulo Cesar Lock Silveira, Sara Marchesan Oliveira, Flávia Karine Rigo, Francesco De Logu, Romina Nassini, Gabriela Trevisan
Thermal injury promotes tissue inflammation and pain, which is difficult to control. Different peripheral mechanisms seem to be involved in burn pain, such as free radical-induced damage, but further study is still needed to understand how oxidant substances induced nociceptor sensitization. The transient receptor potential ankyrin 1 (TRPA1) is an ion channel activated by oxidants substances, and it could be sensitized after tissue inflammation. This study evaluated the TRPA1 involvement in nociception and inflammation produced by a thermal injury model...
September 17, 2018: European Journal of Pharmaceutical Sciences
Caihong Li, Yuping Liu, Hongjuan Liu
This study aimed to investigate the expression features of Beclin-1 and c-Myc in the skin burn of rats. A total of 48 Sprague-Dawley (SD) rats were randomly divided into the normal group (n=12), the 3-day burn group (n=12), the 5-day burn group (n=12) and the 7-day burn group (n=12). Except for the normal group, the rat models of burn were established in the other three groups, burn wounds were given routine dressing change, and rats were sacrificed at 3, 5 and 7 days after modeling to collect materials. Then, immunohistochemistry was applied to detect the expression of c-Myc and Beclin-1...
October 2018: Experimental and Therapeutic Medicine
F He, Y Song, W-J Ying, X-Y Jin, Z-X Wang, J-D Su, G-Y Wang
OBJECTIVE: By constructing the severe burns model in rat, we explored the effects of different doses of Ulinastatin (UTI) on protecting myocardium from oxidative stress and inflammatory reaction. MATERIALS AND METHODS: The severe burns model in rat was first constructed. Burned rats were intervened with different doses of UTI. Contents of cardiac troponin I (cTnI), Interleukin-1 (IL-1), Interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in rat serum and heart homogenate were detected by enzyme-linked immunosorbent assay (ELISA)...
September 2018: European Review for Medical and Pharmacological Sciences
Huan Tang, Ikuo Yonemitsu, Yuhei Ikeda, Kenzo Watakabe, Shunichi Shibata, Jun Hosomichi, Ono Takashi
OBJECTIVES: Mouth breathing caused by nasal obstruction (owing to abnormal pressure of masticatory muscles) affects craniofacial growth and development. The influence of unilateral nasal obstruction on jaw-closing muscles was investigated in rats to reveal one of the etiologic mechanisms. MATERIALS AND METHODS: Forty 8-day-old male Wistar rats were used in this study. Experimental rats were subjected to left-sided nasal obstruction by burning the external nostril tissue at the age of 8 days...
September 17, 2018: Angle Orthodontist
Dawei Li, Yuru Shang, Chuanan Shen, Longzhu Li, Dongxu Zhao, Li Ma, Yongming Yu
BACKGROUND: It has been established that Glucagon-like peptide 1 (GLP 1) inhibits pancreatic β cell apoptosis, increases insulin secretion and improves glucose tolerance in scald injury. However, the effects of Exendin-4, a long-acting incretin similar to GLP 1, remained unclear in severe scald injury. Hence, this study attempted to investigate whether Exendin-4 had similar effects by protecting the histology of pancreas in severely scalded rats. METHODS: 162 adult Wistar rats were equally randomized to sham burn (SB) group, burn (B) group and burn with Exendin-4 treatment (BE) group...
September 11, 2018: Journal of Trauma and Acute Care Surgery
Ying Zhao, Qiang Wang, Yuan Jin, Yadan Li, Changjun Nie, Peipei Huang, Zhixin Li, Bihui Zhang, Zijian Su, An Hong, Xiaojia Chen
BACKGROUND/AIMS: How to aid recovery from severe skin injuries, such as burns, chronic or radiation ulcers, and trauma, is a critical clinical problem. Current treatment methods remain limited, and the discovery of ideal wound-healing therapeutics has been a focus of research. Functional recombinant proteins such as basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) have been developed for skin repair, however, some disadvantages in their use remain. This study reports the discovery of a novel small peptide targeting fibroblast growth factor receptor 2 IIIc (FGFR2IIIc) as a potential candidate for skin wound healing...
2018: Cellular Physiology and Biochemistry
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