Yuan He, Tingting Yang, Jiao Li, Kaiying Li, Chunlin Zhuang, Meng Zhang, Ran Li, Yaxing Zhao, Qianqian Song, Mengyuan Jiang, Shuichun Mao, Xin-Gang Song, Yufeng Guo, Xuran Li, Fei Tan, Siriporn Jitkaew, Wen Zhang, Zhenyu Cai
BACKGROUND AND PURPOSE: Tumour necrosis factor (TNF) is a pleiotropic inflammatory cytokine that not only directly induces inflammatory gene expression but also triggers apoptotic and necroptotic cell death, which leads to tissue damage and indirectly exacerbates inflammation. Thus, identification of inhibitors for TNF-induced cell death has broad therapeutic relevance for TNF-related inflammatory diseases. In the present study, we isolated and identified a marine fungus-derived sesquiterpenoid, 9α,14-dihydroxy-6β-p-nitrobenzoylcinnamolide (named as Cpd-8), that inhibits TNF receptor superfamily-induced cell death by preventing the formation of cytosolic death complex II...
March 31, 2024: British Journal of Pharmacology