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Vitamin d signaling

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https://www.readbyqxmd.com/read/30334169/hedgehog-signaling-pathway-and-vitamin-d-receptor-gene-variants-as-potential-risk-factors-in-odontogenic-cystic-lesions
#1
Marko Magic, Katarina Zeljic, Stevo Jovandic, Jelena Stepic, Marko Pejovic, Snjezana Colic, Zvonko Magic, Gordana Supic
OBJECTIVES: Genetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts. MATERIAL AND METHODS: Current study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232)...
October 17, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/30329020/cardioprotective-effects-of-paricalcitol-alone-and-in-combination-with-fgf23-receptor-inhibition-in-chronic-renal-failure-an-experimental-and-clinical-studies
#2
Brian Czaya, Wacharee Seeherunvong, Saurav Singh, Christopher Yanucil, Phillip Ruiz, Yasmir Quiroz, Alexander Grabner, Chryso Katsoufis, Sethuraman Swaminathan, Carolyn Abitbol, Bernardo Rodriguez-Iturbe, Christian Faul, Michael Freundlich
Background: In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc) attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans with chronic kidney disease. Elevated fibroblast growth factor 23 (FGF23) levels cause cardiac hypertrophy with activation of the myocardial calcineurin/nuclear factor of activated T cell (NFAT) axis and may antagonize the cardioprotective effects of VDR agonist therapy. We hypothesized that the effectiveness of Pc may depend on the prevailing circulating levels of FGF23 and could be potentiated by the combined administration of a pan-FGF23 receptor (FGFR) blocker agent (PD173074)...
October 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/30326825/hepatitis-b-virus-downregulates-vitamin-d-receptor-levels-in-hepatoma-cell-lines-thereby-preventing-vitamin-d-dependent-inhibition-of-viral-transcription-and-production
#3
Neta Gotlieb, Irena Tachlytski, Yelena Lapidot, Maya Sultan, Michal Safran, Ziv Ben-Ari
BACKGROUND: Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum levels of vitamin D are associated with increased hepatitis B virus (HBV) replication. Our study aimed to assess the in-vitro relationship between HBV production and Vitamin D signaling pathway and to explore the associated mechanism(s). METHODS: HBV transcription and replication was evaluated by qRT-PCR of the HBV-RNA and covalently closed circular DNA (cccDNA)...
October 16, 2018: Molecular Medicine
https://www.readbyqxmd.com/read/30322337/autophagy-a-new-strategy-for-host-directed-therapy-of-tuberculosis
#4
Seungwha Paik, Jin Kyung Kim, Chaeuk Chung, Eun-Kyeong Jo
Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort has been made to develop novel/improved therapies by modulating host responses to TB (i.e., host-directed therapy). Autophagy is an intracellular catabolic process that helps maintain homeostasis or the removal of invading pathogens via a lysosomal degradation process. The activation of autophagy by diverse drugs or agents may represent a promising treatment strategy against Mtb infection, even to drug-resistant strains...
October 15, 2018: Virulence
https://www.readbyqxmd.com/read/30321335/skeletal-and-extra-skeletal-actions-of-vitamin-d-current-evidence-and-outstanding-questions
#5
Roger Bouillon, Claudio Marcocci, Geert Carmeliet, Daniel Bikle, John H White, Bess Dawson-Hughes, Paul Lips, Craig F Munns, Marise Lazaretti-Castro, Andrea Giustina, John Bilezikian
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR). The effects of the vitamin D endocrine system on bone and its growth plate is primarily indirect and mediated by its effect on intestinal calcium transport and serum calcium and phosphate homeostasis. Rickets and osteomalacia can be prevented by daily supplements of 400 IU of vitamin D. Vitamin D deficiency (serum 25OHD < 50 nmol/l) accelerates bone turnover, bone loss and osteoporotic fractures...
October 12, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/30314996/vitamin-d-induced-vitamin-d-receptor-expression-induces-tamoxifen-sensitivity-in-mcf-7-stem-cells-via-the-suppression-of-wnt-%C3%AE-catenin-signaling
#6
Wei Zheng, Bofeng Duan, Qian Zhang, Linna Ouyang, Wei Peng, Fuyong Qian, Yibin Wang, Shiting Huang
OBJECTIVE: Cancer stem cells (CSCs) are responsible for the drug resistance of breast cancers. Vitamin D deficiency promotes tumor resistance. This study examined the effect of vitamin D and vitamin D receptor (VDR) expression on the tamoxifen resistance of CSCs. METHODS: MCF-7 cells were treated with 1,25(OH)2 D3 and their levels of VDR expression, viability, and apoptosis were detected. CD133+ MCF-7 stem cells were identified and transfected with a VDR-overexpression plasmid...
October 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30312636/genome-wide-analysis-of-gene-expression-after-one-year-of-venom-immunotherapy
#7
Pawel Karpinski, Pawel Skiba, Magdalena Kosinska, Marta Rosiek-Biegus, Emilia Królewicz, Nikolaus Blin, Eckart Meese, Bernard Panaszek, Marita Nittner-Marszalska, Maria Malgorzata Sasiadek
BACKGROUND: Insect venom immunotherapy (VIT) is used to protect patients against Hymenoptera insects' venom allergy (HVA), which can result in severe systemic or even life-threatening conditions. Molecular mechanisms triggered by VIT remain largely unknown. OBJECTIVE: To compare genome-wide gene expression of patients with severe HVA prior to VIT and 12 months after. METHODS: Whole blood RNA samples were analyzed on an expression array. Results from differential expression obtained on a microarray platform were confirmed by quantitative real -time PCR (qRT-PCR)...
October 9, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30309792/association-of-snp-snp-interactions-between-rankl-opg-chi3l1-and-vdr-genes-with-breast-cancer-risk-in-egyptian-women
#8
Olfat G Shaker, Mahmoud A Senousy
BACKGROUND: Genetic susceptibility for breast cancer (BC) is still poorly understood. A combination of multiple low-penetrant alleles of cancer-related genes and gene-gene interactions (epistasis) contributes to BC risk. Genetic variants in receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), chitinase-3-like protein 1 (CHI3L1), and vitamin D receptor (VDR) genes are implicated in breast carcinogenesis; however, the influence of their epistatic effects on BC susceptibility has not yet been studied...
September 19, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/30297679/differential-and-overlapping-effects-of-20-23-oh-%C3%A2-d3-and-1-25-oh-%C3%A2-d3-on-gene-expression-in-human-epidermal-keratinocytes-identification-of-ahr-as-an-alternative-receptor-for-20-23-oh-%C3%A2-d3
#9
Andrzej T Slominski, Tae-Kang Kim, Zorica Janjetovic, Anna A Brożyna, Michal A Żmijewski, Hui Xu, Thomas R Sutter, Robert C Tuckey, Anton M Jetten, David K Crossman
A novel pathway of vitamin D activation by CYP11A has previously been elucidated. To define the mechanism of action of its major dihydroxy-products, we tested the divergence and overlap between the gene expression profiles of human epidermal keratinocytes treated with either CYP11A1-derived 20,23(OH)₂D3 or classical 1,25(OH)₂D3. Both secosteroids have significant chemical similarity with the only differences being the positions of the hydroxyl groups. mRNA was isolated and examined by microarray analysis using Illumina's HumanWG-6 chip/arrays and subsequent bioinformatics analyses...
October 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30296271/vitamin-d-and-macrophage-polarization-in-epicardial-adipose-tissue-of-atherosclerotic-swine
#10
Palanikumar Gunasekar, Vicki J Swier, Jonathan P Fleegel, Chandra S Boosani, Mohamed M Radwan, Devendra K Agrawal
Vitamin D functions as a potent immunomodulator by interacting with many immune cells however, its role in regulating inflammation in the epicardial adipose tissue (EAT) is unclear. In the EAT of atherosclerotic microswine that were fed with deficient, sufficient or supplemented levels of vitamin D, we evaluated the phenotype of the macrophages. Vitamin D treatment was continued for 12 months and serum 25(OH)D levels were measured regularly. Infiltration of M1/M2 macrophage was investigated by immunostaining for CCR7 and CD206, respectively in conjunction with a pan macrophage marker CD14...
2018: PloS One
https://www.readbyqxmd.com/read/30295181/cubilin-the-intrinsic-factor-vitamin-b12-receptor-in-development-and-disease
#11
Renata Kozyraki, Olivier Cases
Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic substances including albumin, vitamin D-binding protein or cadmium.Cubilin is a peripheral membrane protein consisting of 8 epidermal growth factor (EGF)-like repeats and 27 CUB (defined as Complement C1r/C1s, Uegf, BMP1) domains. This structurally unique protein interacts with at least two molecular partners, amnionless (AMN) and Lrp2/Megalin...
October 8, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/30292449/implications-of-the-transcription-factor-wt1-linked-to-the-pathologic-cardiac-remodeling-post-myocardial-infarction
#12
Raúl Lelio Sanz, Luciana Mazzei, Walter Manucha
New advances in the treatment of acute myocardial infarction involve novel signaling pathways and cellular progeny. In this sense, regeneration is a novel tool that would contribute to post-infarction physiological ventricular remodeling. More specifically, re-expression of the WT1 transcription factor in the myocardial wall by ischemia and infarction would be related to the invasion of cells with the capacity for regeneration. This mechanism seems not to be sufficient to restore muscle cells and lost vessels entirely...
October 3, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/30290853/innovative-method-for-the-analysis-of-dexpanthenol-in-hair-care-products
#13
Caryn L Weiss, Mark R Fairchild, Brian W Stanton, Bertil S Nshime, Paul D Parkanzky
Background: Dexpanthenol is a widely used humectant in hair care products, especially anti-hairfall products. The hair care industry is highly regulated in East Asia and treats products containing the combination of dexpanthenol, zinc pyrithione, and nicotinamide (vitamin B₃) as quasi-drugs. Objective: Because dexpanthenol lacks a UV chromophore, existing methodologies for analysis in finished products include pretreatments and/or HPLC-UV analysis at low wavelengths at which poor signal-to-noise is observed...
October 5, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/30290758/a-draft-genome-of-the-striped-catfish-pangasianodon-hypophthalmus-for-comparative-analysis-of-genes-relevant-to-development-and-a-resource-for-aquaculture-improvement
#14
Oanh T P Kim, Phuong T Nguyen, Eiichi Shoguchi, Kanako Hisata, Thuy T B Vo, Jun Inoue, Chuya Shinzato, Binh T N Le, Koki Nishitsuji, Miyuki Kanda, Vu H Nguyen, Hai V Nong, Noriyuki Satoh
BACKGROUND: The striped catfish, Pangasianodon hypophthalmus, is a freshwater and benthopelagic fish common in the Mekong River delta. Catfish constitute a valuable source of dietary protein. Therefore, they are cultured worldwide, and P. hypophthalmus is a food staple in the Mekong area. However, genetic information about the culture stock, is unavailable for breeding improvement, although genetics of the channel catfish, Ictalurus punctatus, has been reported. To acquire genome sequence data as a useful resource for marker-assisted breeding, we decoded a draft genome of P...
October 5, 2018: BMC Genomics
https://www.readbyqxmd.com/read/30273386/lack-of-vitamin-d-signalling-per-se-does-not-aggravate-cardiac-functional-impairment-induced-by-myocardial-infarction-in-mice
#15
Kristopher Ford, Nejla Latic, Svetlana Slavic, Ute Zeitz, Marlies Dolezal, Oleh Andrukhov, Reinhold G Erben, Olena Andrukhova
Epidemiological studies have linked vitamin D deficiency to an increased incidence of myocardial infarction and support a role for vitamin D signalling in the pathophysiology of myocardial infarction. Vitamin D deficiency results in the development of secondary hyperparathyroidism, however, the role of secondary hyperparathyroidism in the pathophysiology of myocardial infarction is not known. Here, we aimed to explore further the secondary hyperparathyroidism independent role of vitamin D signalling in the pathophysiology of myocardial infarction by inducing experimental myocardial infarction in 3-month-old, male, wild-type mice and in mice lacking a functioning vitamin D receptor...
2018: PloS One
https://www.readbyqxmd.com/read/30271082/mechanism-of-combined-use-of-vitamin-d-and-puerarin-in-anti-hepatic-fibrosis-by-regulating-the-wnt-%C3%AE-catenin-signalling-pathway
#16
Gan-Rong Huang, Si-Jun Wei, Yan-Qiang Huang, Wei Xing, Lu-Yao Wang, Ling-Ling Liang
AIM: To reveal the protective mechanism of the combined use of vitamin D and puerarin in the progression of hepatic fibrosis induced by carbon tetrachloride (CCl4 ). METHODS: Eight-week-old male Wistar rats were randomly divided into a normal control group (C group), a CCl4 group (CCl4 group), a vitamin D group (V group), a puerarin group (P group), and a combined group of vitamin D and puerarin (V + P group), each of which contained ten rats. In this way, we built a rat model of CCl4 -induced hepatic fibrosis with intervention by vitamin D, puerarin, or a combination of the two...
September 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30257386/astemizole-promotes-the-anti-tumor-effect-of-vitamin-d-through-inhibiting-mir-125a-5p-meidated-regulation-of-vdr-in-hcc
#17
Junli Xu, Yan Wang, Ya Zhang, Shan Dang, Shuixiang He
Hepatocellular carcinoma (HCC) accounts for the fifth most common cancer worldwide. Vitamin D and antihistamines have been shown to play an anti-tumor role in various tumors. In the present study, we ought to investigate the synergistic effect of astemizole and Vitamin D in HCC cells. We showed that astemizole enhanced the anti-tumor effect of Vitamin D in HCC both in vitro and in vivo. Astemizole enhanced Vitamin D-induced decrease of cell viability and proliferation, increase of apoptosis, decrease of cell migration and invasion in HCC cells in vitro and decrease of tumor number, mass and incidence in HCC in vivo...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30254488/assessment-of-functional-variants-and-expression-of-long-noncoding-rnas-in-vitamin-d-receptor-signaling-in-breast-cancer
#18
Vahid Kholghi Oskooei, Lobat Geranpayeh, Mir Davood Omrani, Soudeh Ghafouri-Fard
Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer. Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients. Results: VDR , MALAT1 , and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30253183/vitamin-d-attenuates-the-effect-of-advanced-glycation-end-products-on-anti-mullerian-hormone-signaling
#19
Zaher Merhi
Vitamin D3 (1,25-dihydroxyvitamin D3, VD3) in vitro attenuates the effect of the pro-inflammatory advanced glycation end products (AGEs) on steroidogenesis in human granulosa cells (GCs) by downregulating the receptor for AGEs (RAGE). It has been shown that VD3 alone downregulates anti-Mullerian hormone (AMH) type 2 receptor (AMHR-2) gene expression and suppresses AMH-induced SMAD 1/5/8 phosphorylation in granulosa cells. However, the effect of AGEs, in the absence or presence of VD3, on AMH action in GCs has not been studied...
September 22, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/30239288/impact-of-vitamin-d-depletion-during-development-on-mouse-sperm-dna-methylation
#20
Jing Xue, Raad Z Gharaibeh, Edward W Pietryk, Cory Brouwer, Lisa M Tarantino, William Valdar, Folami Y Ideraabdullah
Suboptimal environmental conditions during development can substantially alter the epigenome. Stable environmentally-induced changes to the germline epigenome, in particular, have important implications for the health of the next generation. We showed previously that developmental vitamin D depletion (DVD) resulted in loss of DNA methylation at several imprinted loci over two generations. Here, we assessed the impact of DVD on genome-wide methylation in mouse sperm in order to characterize the number, extent and distribution of methylation changes in response to DVD and to find genes that may be susceptible to this prevalent environmental perturbation...
September 21, 2018: Epigenetics: Official Journal of the DNA Methylation Society
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