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Diabetes AND Eyes

Ya Xing Wang, Wen Bin Wei, Liang Xu, Jost B Jonas
PURPOSE: To assess associations between the amount of physical activity and the prevalence of ocular diseases. METHODS: The participants of the population-based Beijing Eye Study underwent a detailed ophthalmological examination and an interview. Physical activity was assessed in a standardized questionnaire. RESULTS: Out of 3468 study participants, information on their physical activity was available for 3031 (87.4%) individuals (age: 64...
October 18, 2018: Acta Ophthalmologica
April Meier, Ralph Nelson, Victoria P Connaughton
Zebrafish ( Danio rerio ) is a model organism for vertebrate developmental processes and, through a variety of mutant and transgenic lines, various diseases and their complications. Some of these diseases relate to proper function of the visual system. In the US, the National Eye Institute indicates >140 million people over the age of 40 have some form of visual impairment. The causes of the impairments range from refractive error to cataract, diabetic retinopathy and glaucoma, plus heritable diseases such as retinitis pigmentosa and color vision deficits...
2018: Frontiers in Cellular Neuroscience
Anirban Mitra, Priya Shankar Banerjee, Sudipta Roy, Somasis Roy, Sanjit Kumar Setua
BACKGROUND AND OBJECTIVES: Retinal fundus image analysis without manual intervention has been rising as an imperative analytical approach for early detection of eye-related diseases such as glaucoma and diabetic retinopathy. For analysis and detection of Glaucoma and some other disease from retinal image, there is a significant role of predicting the bounding box coordinates of Optic Disc (OD) that acts as a Region of Interest (ROI). METHODS: We reframe ROI detection as a solitary regression predicament, from image pixel values to ROI coordinates including class probabilities...
October 2018: Computer Methods and Programs in Biomedicine
Alessandro Rabiolo, Francesco Gelormini, Riccardo Sacconi, Maria Vittoria Cicinelli, Giacinto Triolo, Paolo Bettin, Kouros Nouri-Mahdavi, Francesco Bandello, Giuseppe Querques
PURPOSE: To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. METHODS: Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms...
2018: PloS One
Juan Wu, Haixia Zeng, Rui Xuan, Shuihong Lei, Jing Li, Xiaoyang Lai, Jianping Liu
RATIONALE: Cataracts can occur in children and adolescents with Type 1 Diabetes Mellitus who have poorly controlled glycemia. Here, we report a case of a 16-year-old female, who was diagnosed with bilateral cataracts, and genetic screening identified a mutation in the PRRC2A gene which is rarely reported. After surgery, retinopathy was found in this patient, combined with the published literature, we encourage that postoperative monitoring for retinal lesions during the follow-up visits should be conducted...
October 2018: Medicine (Baltimore)
Hisanori Imai, Keiko Otsuka, Akira Tetsumoto, Akiko Miki, Makoto Nakamura
PURPOSE: To introduce the methodology and outcomes of en bloc removal of the component of cystoid lesion during pars plana vitrectomy as a novel approach for the treatment of cystoid macular edema and show evidence that the component is an aggregation of fibrinogen by mass spectrometry analysis. METHODS: The surgical en bloc extraction of the component of cystoid lesion was performed for cystoid macular edemas secondary to diabetic retinopathy and retinal vein occlusion...
October 16, 2018: Retina
Renato M Passos, José Belucio-Neto, Camilla O Xavier, Eduardo A Novais, Mauricio Maia, Michel Eid Farah
OBJECTIVE: To compare two different laser strategies of panretinal photocoagulation for diabetic retinopathy. METHODS: Single-center, randomized study including 41 eyes treated with 577-nm multispot laser with a 20-ms pulse duration (group 1) or a 532-nm single-spot laser with a 100-ms pulse duration (group 2). The outcomes included best-corrected visual acuity (BCVA) and imaging changes at baseline, 6 and 12 months, laser parameters, and results of subjective pain analysis...
October 17, 2018: Ophthalmologica. Journal International D'ophtalmologie
Yutaka Yamada, Yoshihiro Takamura, Takehiro Matsumura, Masakazu Morioka, Makoto Gozawa, Masaru Inatani
PURPOSE: To estimate the effect of sub-Tenon's capsule triamcinolone acetonide injection (STTA) combined with panretinal photocoagulation (PRP) using pattern scan laser (PSL) for high risk non-proliferative diabetic retinopathy (NPDR), in terms of the inflammation and the progression of diabetic macular edema (DME). STUDY DESIGN: Retrospective comparative analysis. METHODS: NPDR patients who underwent PRP using PSL with (STTA+PSL group, n=24) or without (PSL group, n=19) pretreatment of STTA were enrolled...
October 17, 2018: Japanese Journal of Ophthalmology
Alfred Maroyi
The bark, leaves, and roots of Albizia adianthifolia are highly sought after in tropical Africa as herbal medicines. Therefore, the aim of this study was to review the botany, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia so as to provide baseline data required for evaluating the therapeutic potential of the species. Information on the botanical profile, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia was undertaken using databases such as ScienceDirect, SciFinder, Pubmed, Google Scholar, Medline, SCOPUS, EThOS, ProQuest, OATD, and Open-thesis...
2018: TheScientificWorldJournal
Minhaj Alam, Devrim Toslak, Jennifer I Lim, Xincheng Yao
Purpose: This study aimed to develop a method for automated artery-vein classification in optical coherence tomography angiography (OCTA), and to verify that differential artery-vein analysis can improve the sensitivity of OCTA detection and staging of diabetic retinopathy (DR). Methods: For each patient, the color fundus image was used to guide the artery-vein differentiation in the OCTA image. Traditional mean blood vessel caliber (m-BVC) and mean blood vessel tortuosity (m-BVT) in OCTA images were quantified for control and DR groups...
October 1, 2018: Investigative Ophthalmology & Visual Science
Virginie Naël, Gwendoline Moreau, Solène Monfermé, Audrey Cougnard-Grégoire, Anne-Catherine Scherlen, Angelo Arleo, Jean-François Korobelnik, Cécile Delcourt, Catherine Helmer
Importance: Uncorrected refractive error (URE) is a common cause of visual impairment, but its prevalence in groups of older adults who could be pragmatic targets for improving optical correction remains unknown. Objectives: To estimate the prevalence of URE in older adults, particularly in those with age-related eye disease and those who are unable to attend an outpatient clinic, and to identify the factors associated with URE. Design, Setting, and Participants: This population-based cross-sectional analysis included 707 adults 78 years or older from the Alienor Study in Bordeaux, France...
September 20, 2018: JAMA Ophthalmology
Walid Zbiba, Emna Bouayed, Nadia Ben Abdesslem, Issam Elleuch, Malek Kharrat
PURPOSE: To report a case of complete ophthalmoplegia and blindness in sino-orbital mucormycosis. CASE REPORT: A 68-year-old woman with history of diabetes and breast cancer presented with sudden onset of fever, orbital pain and blindness in the right eye. The patient was found to have no light perception, complete ophthalmoplegia, chemosis, corneal ulcer and optic nerve atrophy. In rhinologic examination, necrosis was noticed. Brain and orbit magnetic resonance imaging showed diffuse sinusitis with orbital involvement...
March 2018: La Tunisie Médicale
Gianni Virgili, Mariacristina Parravano, Jennifer R Evans, Iris Gordon, Ersilia Lucenteforte
BACKGROUND: Diabetic macular oedema (DMO) is a common complication of diabetic retinopathy. Antiangiogenic therapy with anti-vascular endothelial growth factor (anti-VEGF) can reduce oedema, improve vision and prevent further visual loss. These drugs have replaced laser photocoagulation as the standard of care for people with DMO. OBJECTIVES: The 2014 update of this review found high-quality evidence of benefit with anti-VEGF modalities, compared to laser photocoagulation, for the treatment of DMO...
October 16, 2018: Cochrane Database of Systematic Reviews
Koji Kanda, Kei Takayama, Toshio Enoki, Masaru Takeuchi
Objective: Penicillium species are abundant, generally saprophytic, and widely distributed in the environment. On rare occasions, they cause endophthalmitis in immunocompromised patients or in immunocompetent patients with uncontrolled diabetic mellitus or immunosuppressive agents. We report a case of endophthalmitis caused by Penicillium species in an immunocompetent patient without any disorders. Case presentation: A 67-year-old woman presented with ocular pain, hyperemia, and blurred vision in her right eye...
2018: International Medical Case Reports Journal
Eliane C Jorge, Edson N Jorge, Mayra Botelho, Joyce G Farat, Gianni Virgili, Regina El Dib
BACKGROUND: Diabetic macular oedema (DMO) is a complication of diabetic retinopathy and one of the most common causes of visual impairment in people with diabetes. Clinically significant macular oedema (CSMO) is the most severe form of DMO. Intravitreal antiangiogenic therapy is now the standard treatment for DMO involving the centre of the macula, but laser photocoagulation is still used in milder or non-central DMO. OBJECTIVES: To access the efficacy and safety of laser photocoagulation as monotherapy in the treatment of diabetic macular oedema...
October 15, 2018: Cochrane Database of Systematic Reviews
Rui Zheng, Lei Liu, Shulin Zhang, Chun Zheng, Filiz Bunyak, Ronald Xu, Bin Li, Mingzhai Sun
Diabetic retinopathy (DR) is a leading cause of blindness worldwide. However, 90% of DR caused blindness can be prevented if diagnosed and intervened early. Retinal exudates can be observed at the early stage of DR and can be used as signs for early DR diagnosis. Deep convolutional neural networks (DCNNs) have been applied for exudate detection with promising results. However, there exist two main challenges when applying the DCNN based methods for exudate detection. One is the very limited number of labeled data available from medical experts, and another is the severely imbalanced distribution of data of different classes...
October 1, 2018: Biomedical Optics Express
Lun Liu, Jian Gao, Weili Bao, Chengyang Hu, Yajing Xu, Bingying Zhao, Jie Zheng, Lingling Fan, Yehuan Sun
Purpose: To analyze foveal microvascular abnormalities in different stages of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) with projection artifact removal (PAR). Methods: We analyzed 93 eyes of 59 patients with diabetes-31 with no DR (no DR), 34 with mild to moderate nonproliferative DR (mild DR), and 28 with severe nonproliferative DR to proliferative DR (severe DR)-and 31 age-matched healthy controls. Sections measuring 3 × 3 mm2 centered on the fovea were obtained using OCTA...
2018: Journal of Ophthalmology
Vincenza Bonfiglio, Michele Reibaldi, Alessandra Pizzo, Andrea Russo, Iacopo Macchi, Giuseppe Faro, Teresio Avitabile, Antonio Longo
PURPOSE: To analyse the effects of intravitreal dexamethasone implant (DEX) in patients with diabetic macular oedema (DME) unresponsive to ranibizumab treatment, in relation to the inflammatory optical coherence tomography (OCT) retinal features, subfoveal neuroretinal detachment (SND) and hyperreflective retinal spots (HRS). METHODS: Patients with DME poorly responsive to three injections of ranibizumab were treated with DEX. Best-corrected visual acuity (BCVA) and central macula thickness (CMT, measured by Spectralis SD-OCT) were assessed at baseline and at 1, 3, and 6 months...
October 14, 2018: Acta Ophthalmologica
Panagiotis D Velentzas, Lejie Zhang, Gautam Das, Tsun-Kai Chang, Charles Nelson, William R Kobertz, Eric H Baehrecke
Nutrient availability influences the production and degradation of materials that are required for cell growth and survival. Autophagy is a nutrient-regulated process that is used to degrade cytoplasmic materials and has been associated with human diseases. Solute transporters influence nutrient availability and sensing, yet we know little about how transporters influence autophagy. Here, we screen for solute transporters that are required for autophagy-dependent cell death and identify CG11665/hermes. We show that hermes is required for both autophagy during steroid-triggered salivary gland cell death and TNF-induced non-apoptotic eye cell death...
October 9, 2018: Developmental Cell
Muhammad Kutubi, Alaric Smith
A 60-year-old woman, with no significant medical or ophthalmic history, presented with a unilateral large corneal ulcer and hypopyon. Despite a severely injected conjunctiva and large corneal epithelial defect, the patient denied any discomfort in the eye. The ulcer was extremely slow to heal requiring prolonged treatment with topical and systemic broad-spectrum antibiotics. Due to the corneal opacification, fundal examination was not possible. Subsequent examination of the fellow eye revealed an appearance consistent with proliferative diabetic retinopathy...
October 12, 2018: BMJ Case Reports
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