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Diabetes AND Eyes

Giovanni Cennamo, Maria Angelica Breve, Nunzio Velotti, Federica Sparnelli, Claudio Iovino, Antonio Farella, Raffaele Liuzzi, Giuseppe de Crecchio, Gilda Cennamo
AIM: The purpose of this paper was to evaluate whether optical coherence tomography angiography (OCT-A) can be used to quantify the vascular changes in radiation maculopathy, and changes in the tumor vasculature in eyes treated with plaque radiotherapy for choroidal melanoma. METHODS: In this prospective study, we evaluated 39 Caucasian patients with choroidal melanoma (39 eyes) treated with ruthenium-106 plaque radiotherapy. The patients underwent complete ophthalmic examination, bulbar echography, and OCT-A before and 1 year after treatment...
August 17, 2018: Ophthalmic Research
George E Sanborn, John J Wroblewski
AIMS: Pilot study to determine whether an instrument combining a non-mydriatic retinal camera and spectral domain optical coherence tomography (SD-OCT) is effective for screening patients with diabetic retinopathy (DR). METHODS: Case series conducted between 2012 and 2013. DR imaged with a retinal camera/SD-OCT instrument viewed remotely was compared to a dilated examination by a retina specialist. RESULTS: The combination instrument was better than the retina specialist in detecting more severe retinopathy, primarily because of the SD-OCT...
August 11, 2018: Journal of Diabetes and its Complications
Marisa Taechajongjintana, Ngamjit Kasetsuwan, Usanee Reinprayoon, Sirinuch Sawanwattanakul, Phattrawan Pisuchpen
BACKGROUND: We report a rare case of Phialophora verrucosa fungal keratitis, which required various types of treatment according to the intractable natural history of the disease. CASE PRESENTATION: A 51-year-old Thai man with poorly controlled diabetes received a bamboo branch injury and developed a perforated corneal lesion on his left eye. A pathological study from therapeutic penetrating keratoplasty showed fungal hyphae. This was later identified as Phialophora verrucosa by polymerase chain reaction...
August 19, 2018: Journal of Medical Case Reports
Wei S Lim, Tejal Magan, Omar A Mahroo, Pirro G Hysi, Juliana Helou, Moin D Mohamed
OBJECTIVE: Temporal macula thinning has been reported in sickle cell patients, but it remains unclear if there is a difference between HbSS and HbSC genotypes. We aimed to quantitatively compare macular thickness between eyes with HbSS and HbSC genotype. DESIGN: Retrospective descriptive study. METHODS: Consecutive patients seen over a 5.5-year period in the Ophthalmology Department at St Thomas' Hospital, London, were identified. Macular optical coherence tomography images were retrospectively analyzed...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Zaid Shalchi, Mali Okada, Alice Bruynseels, David Palethorpe, Ammar Yusuf, Rohan Hussain, Christina Herrspiegel, Antonio Scazzarriello, Abubakar Habib, Razia Amin, Ranjan Rajendram
OBJECTIVE: To investigate the effect of serum glycosylated hemoglobin (HbA1c) on the outcomes of ranibizumab therapy for diabetic macular edema (DME). DESIGN: Retrospective cohort study. PARTICIPANTS: Patients receiving ranibizumab injections for centre-involving DME in a National Health Service setting. METHODS: The Moorfields OpenEyes database was used to study eyes with DME treated with ranibizumab from October 2013 to November 2015 at the Moorfields City Road, Ealing, Northwick Park, and St George's Hospital sites...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Zofia Michalewska, Michael W Stewart, Maurice B Landers, Maciej Bednarski, Ron A Adelman, Jerzy Nawrocki
OBJECTIVE: To determine the efficacy of vitrectomy in eyes with treatment-naïve diabetic macular edema (DME). METHODS: Consecutive patients with treatment-naïve DME who underwent pars plana vitrectomy with internal limiting membrane peeling at a single institution were identified from the electronic medical records. Morphologic and visual acuity changes from baseline were analyzed at both the primary temporal endpoint (6 months) and the final examination with the investigators...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Elizabeth Y Lee, Kangping Cui, Graham E Trope, Yvonne M Buys, Christina H Chan, Kednapa Thavorn, Ya-Ping Jin
OBJECTIVE: Our prior study revealed significantly lower use of eye care providers in Newfoundland and Labrador (NFLD). This study reports factors associated with this low use and related vision health outcomes. DESIGN: Cross-sectional survey. PARTICIPANTS: A total of 14 925 Caucasian respondents to the Canadian Community Health Survey - Healthy Aging 2008/2009 aged ≥65 years. METHODS: Univariate and multivariate analyses were performed using self-reported survey data...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Amina Rezkallah, Ariane Malclès, Corinne Dot, Nicolas Voirin, Émilie Agard, Anne-Laure Vié, Philippe Denis, Thibaud Mathis, Laurent Kodjikian
PURPOSE: To compare the efficacy and safety of the dexamethasone intravitreal implant of vitrectomized and nonvitrectomized eyes in real-world conditions. METHODS: This was a retrospective, multicenter, observational study. All consecutive patients presenting with at least one 0.7-mg intravitreal injection (IVI) of DEX implant from October 2010 to February 2015 were included in this study. Three hundred sixty-eight eyes in 330 patients were studied. Sixty-seven eyes were vitrectomized at baseline, 301 had not undergone vitrectomy at the last visit...
August 17, 2018: Journal of Ocular Pharmacology and Therapeutics
Jiajun Lu, Minjie Sheng, Panpan Yao, Chaochao Ran, Hao Liu, Li Chen, Rui Liu, Bing Li
Objective: To investigate the effect of high concentration of glucose on reactive oxygen species (ROS) production in rabbit corneal epithelial cells (RECEs) and explore whether the increased ROS initiates the apoptosis process of RECEs through oxidative stress and endoplasmic reticulum (ER) stress pathway. Methods: RECEs were treated by different concentrations of glucose for a while, and then the production of ROS was detected by flow cytometry. The expressions of PERK, p-PERK, Akt, p-Akt, and CHOP were determined by western blot, and the cell viability was measured by Cell Counting Kit-8 (CCK-8)...
2018: Journal of Ophthalmology
Fanglin He, Zhanlin Zhao, Yan Liu, Linna Lu, Yao Fu
Purpose: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5-10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore)...
2018: Journal of Ophthalmology
Eugene Yu-Chuan Kang, Fu-Sung Lo, Jung-Pan Wang, Lung-Kun Yeh, An-Lun Wu, Yun-Ju Tseng, Chun-Ting Yeh, Laura Liu, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Nan-Kai Wang
The need for screening for retinopathy in patients with type 1 diabetes mellitus (T1DM) has been emphasised, but diagnostic delays were reported when screening was done at fixed intervals. To establish an individualised risk-prediction model to assist screening non-proliferative diabetic retinopathy (NPDR) in T1DM, we performed a retrospective cohort study enrolling participants in the Chang Gung Juvenile Diabetes Eye Study. There were 413 patients with 12 381 records analysed from 2005 to 2015. A time-dependent Cox proportional hazard analysis was used to evaluate the risks of NPDR development and a nomogram with risk-stratification indicators was established based on the results...
August 15, 2018: Scientific Reports
Shwu-Jiuan Sheu, Wen-Liang Lin, Yea-Huei Kao Yang, Chi-Min Hwu, Ching-Lan Cheng
BACKGROUND: Pay-for-Performance programs have shown improvement in indicators monitoring adequacy and target achievement in diabetic care. However, less is known regarding the impact of this program on the occurrence and long-term effects of diabetic retinopathy. The objective of this study was to determine the effect of pay-for-performance program on the development of treatment needed for diabetic retinopathy in type 2 diabetes patients. METHODS: We conducted a nationwide retrospective cohort study with a matching design using the Taiwan National Health Insurance Research Database from 2000 to 2012...
August 15, 2018: BMC Health Services Research
Ivana Šušaníková, Jana Balleková, Milan Štefek, Jan Hošek, Pavel Mučaji
In the previous study, the artichoke leaf extract showed effective inhibition of AKR1B1, the first enzyme of polyol pathway, which reduces high level of glucose to osmotically active sorbitol, important for development of chronic diabetic complications. In the present study, the effect of artichoke leaf extract and of several participating phenols (caffeic acid, chlorogenic acid, quinic acid, and luteolin) was tested on sorbitol level in rat lenses exposed to high glucose ex vivo, on cytotoxicity as well as on oxidative stress in C2C12 muscle cell line induced by high glucose in vitro...
August 15, 2018: Phytotherapy Research: PTR
S N Sangeethaa, P Uma Maheswari
Diabetic retinopathy (DR) is an eye disease, which affects the people who are all having the diabetes for more than 10 years. The ophthalmologist identifies when the dilated eye exam causes severe in any one of the following deviations in the retina: changes in blood vessels, leaking blood vessels, newly grown blood vessels, swelling of the macula, changes in the lens, and damages to the nerve tissue. It can eventually lead to vision loss. The early detection of DR prevents the cause of blindness. In this paper, we propose the retinal image segmentation and extraction of blood vessels by morphological processing, thresholding, edge detection, and adaptive histogram equalization...
August 15, 2018: Journal of Medical Systems
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage...
August 14, 2018: Scientific Reports
L Wen, X Sun, F H Wang, W Luo, K M Feng, Y Xue, G Y Mao, Y Wang, Y B Liang, G Zhai, C Xie, N L Wang
Objective: To investigate the attainment of therapeutic targets for glycosylated hemoglobin and blood pressure, ophthalmologic examination, diagnosis and treatment of diabetic retinopathy (DR) with type 2 diabetes mellitus. Methods: A cross-sectional study in type 2 diabetic patients was conducted in a community of Fushun between July 2012 and May 2013. Questionnaire, detailed ophthalmic examination and laboratory tests were completed to collect the information about sociodemographic and healthcare characteristics...
August 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Y Wan, N L Wang, J Hao, Z Dong, Y Zhang, K Cao
Objective: To assess the utilization of eye care services in the rural area of Handan, China under the New Rural Cooperative Medical Scheme, and to analyze the factors associated with the uptake of these services. Methods: In a cohort population-based study, subjects who joined both the baseline (2006-2007) and follow-up (2012-2013) were included. Information of demographic characteristics, participation in the New Rural Cooperative Medical Insurance and use of eye care services, comprehensive ophthalmic examinations, blood pressure and fasting was collected...
August 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
V T S Kaluarachchi, Uditha Bulugahapitiya, Maulee Arambewela, Sonali Gunathilake
A 34-year-old mother with diabetes mellitus for 6 years presented in the late second trimester of her third pregnancy with new onset hypertension and characteristic hyperadrenergic spells. Clinical examination was unremarkable except a blood pressure of 170/110 mmhg. She had an elevated 24 hour urinary normetanephrine level with ultrasonic evidence of a hyperechoic hypervascular well-defined right supra renal mass of 6 x 5 cm in size which was very suggestive of a pheochromocytoma. Her management decisions were made by a multidisciplinary team which decided to deliver the baby by lower segment cesarean section (LSCS) as the pregnancy was advanced and to proceed with interval adrenalectomy after contrast enhanced computer tomography (CECT) of the abdomen with adrenal protocol...
2018: Case Reports in Endocrinology
Neda Laiteerapong, Sandra A Ham, Yue Gao, Howard H Moffet, Jennifer Y Liu, Elbert S Huang, Andrew J Karter
OBJECTIVE: To examine for a legacy effect of early glycemic control on diabetic complications and death. RESEARCH DESIGN AND METHODS: This cohort study of managed care patients with newly diagnosed type 2 diabetes and 10 years of survival (1997-2013, average follow-up 13.0 years, N = 34,737) examined associations between HbA1c <6.5% (<48 mmol/mol), 6.5% to <7.0% (48 to <53 mmol/mol), 7.0% to <8.0% (53 to <64 mmol/mol), 8.0% to <9.0% (64 to <75 mmol/mol), or ≥9...
August 13, 2018: Diabetes Care
Mark A Terry, Anthony J Aldave, Loretta B Szczotka-Flynn, Wendi Liang, Allison R Ayala, Maureen G Maguire, Christopher Croasdale, Yassine J Daoud, Steven P Dunn, Caroline K Hoover, Marian S Macsai, Thomas F Mauger, Sudeep Pramanik, George Od Rosenwasser, Jennifer Rose-Nussbaumer, R Doyle Stulting, Alan Sugar, Elmer Y Tu, David D Verdier, Sonia H Yoo, Jonathan H Lass
PURPOSE: To associate donor, recipient, and operative factors with graft success 3 years after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS). DESIGN: Cohort study within a multi-center, double-masked, randomized clinical trial. PARTICIPANTS: 1,090 individuals (1,330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic/aphakic corneal edema (PACE, 6% of eyes)...
August 8, 2018: Ophthalmology
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