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https://www.readbyqxmd.com/read/30552892/tear-inflammatory-cytokines-analysis-and-clinical-correlations-in-diabetes-and-non-diabetes-with-dry-eye
#1
Rongjun Liu, Baikai Ma, Yufei Gao, Boping Ma, Yiyun Liu, Hong Qi
PURPOSE: To enhance the understanding of dry eye (DE) in diabetes by evaluating the ocular surface characteristics and the levels of tear inflammatory cytokines. DESIGN: Cross-sectional study. METHODS: Subjects were divided into four groups: 32 patients in diabetes with DE group; 24 patients in diabetes without DE group; 28 patients in non-diabetes with DE group and 29 volunteers in normal group. Ocular surface disease index (OSDI) was self-answered and ocular surface characteristics including tear-film breakup time (BUT), Schirmer I test, cornea fluorescein staining (CFS) and corneal sensitivity were evaluated...
December 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30551808/benzoxazinone-thiosemicarbazones-as-antidiabetic-leads-via-aldose-reductase-inhibition-synthesis-biological-screening-and-molecular-docking-study
#2
Muhammad Tariq Shehzad, Aqeel Imran, Guy Sedar Singor Njateng, Abdul Hameed, Muhammad Islam, Mariya Al-Rashida, Maliha Uroos, Asnuzilawati Asari, Zahid Shafiq, Jamshed Iqbal
Aldose reductase is an important enzyme in the polyol pathway, where glucose is converted to fructose, and sorbitol is released. Aldose reductase activity increases in diabetes as the glucose levels increase, resulting in increased sorbitol production. Sorbitol, being less cell permeable tends to accumulate in tissues such as eye lenses, peripheral nerves and glomerulus that are not insulin sensitive. This excessive build-up of sorbitol is responsible for diabetes associated complications such as retinopathy and neuropathy...
December 11, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/30551201/dynamic-changes-of-retinal-microaneurysms-in-diabetes-imaged-with-in-vivo-adaptive-optics-optical-coherence-tomography
#3
Julia Hafner, Matthias Salas, Christoph Scholda, Wolf-Dieter Vogl, Wolfgang Drexler, Ursula Schmidt-Erfurth, Michael Pircher, Sonja Karst
Purpose: To prospectively monitor microaneurysms (MAs) in three dimensions using adaptive optics optical coherence tomography (AOOCT). Methods: Patients with diabetes mellitus and parafoveal MAs were included in this longitudinal study. At baseline, MAs were identified in standard fluorescein angiography (FA) and subsequently imaged with an AOOCT prototype, incorporated into an AO fundus camera (RTX1, Imagine Eyes) device. Imaging was repeated every 3 months in each patient to explore the potential structural change of MAs over time including size, shape, intraretinal position, (intra-) luminal reflectivity, and other qualitative morphologic characteristics...
December 3, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30550612/diabetic-nonperfused-areas-in-macular-and-extramacular-regions-on-wide-field-optical-coherence-tomography-angiography
#4
Shota Yasukura, Tomoaki Murakami, Kiyoshi Suzuma, Tatsuya Yoshitake, Hideo Nakanishi, Masahiro Fujimoto, Maho Oishi, Akitaka Tsujikawa
Purpose: To investigate the nonperfused areas (NPAs) in each subfield segmented by large arterioles on wide-field swept-source optical coherence tomography angiography (SS-OCTA) images in diabetic retinopathy. Methods: We retrospectively reviewed 101 consecutive eyes of 67 patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR), for whom 12 × 12-mm SS-OCTA images centered on the optic disc were acquired. Both eyes were included in 34 patients...
December 3, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30550375/the-impact-of-anti-vascular-endothelial-growth-factor-agents-on-visual-impairment-blindness-prevention-in-patients-with-diabetic-macular-edema-and-on-associated-patient-and-caregiver-burden-in-japan
#5
Shigehiko Kitano, Taiji Sakamoto, Rei Goto, Ayako Fukushima, Anne-Lise Vataire, Yusuke Hikichi
AIMS: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan. METHODS: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80.0%], as estimated by an expert panel) of DME patients...
December 14, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/30548307/curcumin-a-new-candidate-for-retinal-disease-therapy
#6
Hasan Farajipour, Susan Rahimian, Mohsen Taghizadeh
The retina is the neural portion and light-sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light-sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. It has been shown that many pathogenesis conditions, including inflammation, angiogenesis, oxidative stress, and imbalanced histone modifications in the retina are associated with initiation and progression of retinal diseases (ie, glaucoma, diabetic retinopathy, and age-related macular degeneration)...
December 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30541300/results-of-treatment-of-diabetic-retinopathy-by-the-laser-system-pascal
#7
J Němčanský, A Stepanov, S Němčanská, H Langrová, J Studnička
PURPOSE: To evaluate anatomical, functional and clinical efficacy of the pattern scanning laser (PASCAL®) photocoagulation in patients with diabetic retinopathy. METHODS: The cohort included 91 eyes in 50 patients (average age 63 years, 24 men and 26 women) treated at the Clinic of Ophthalmology, Faculty Hospital Ostrava, from 2008 to 2013. All eyes showed the signs of diabetic retinopathy (20.9% of eyes - very severe non-proliferative diabetic retinopathy (NPDR), 79...
2018: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/30541296/oct-findings-and-long-term-follow-up-results-of-vitrectomy-in-patients-with-optic-disc-pit-and-associated-maculopathy
#8
M Kováčová, M Meliška, B Kalvodová
PURPOSE: To evaluate OCT findings and long-term follow-up results in patient with optic disc pit (ODP) and associated maculopathy treated with pars plana vitrectomy (PPV). METHODS: Six eyes of 6 patients (3 females, 3 males) were included in a retrospective study. We excluded patients with ODP without maculopathy. Patients were followed in years 2008-2017. Mean age at the first examination was 40,3 years (15-70 years). Duration of worsening of the best corrected visual acuity (BCVA) ranged from 2 days to few years...
2018: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/30539668/sequence-effect-in-the-treatment-of-proliferative-diabetic-retinopathy-with-intravitreal-ranibizumab-and-panretinal-photocoagulation
#9
Guofan Cao, Xiangzhong Xu, Chenghu Wang, Shu Zhang
PURPOSE: To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy. METHODS: This retrospective study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes; 18 (22 eyes) received intravitreal ranibizumab before panretinal photocoagulation (intravitreal ranibizumab+ group), while the other 17 (21 eyes) received panretinal photocoagulation before intravitreal ranibizumab (panretinal photocoagulation+ group)...
December 12, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/30538421/safety-of-high-dose-intravitreal-triamcinolone-acetonide-as-low-cost-alternative-to-anti-vascular-endothelial-growth-factor-agents-in-lower-middle-income-countries
#10
Hammouda Hamdy Ghoraba, Mahmoud Leila, Sameh Mohamed Elgouhary, Emad Eldin Mohamed Elgemai, Haithem Mamon Abdelfattah, Hashem Hammouda Ghoraba, Mohamed Amin Heikal
Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries. Patients and methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/30537339/relationship-between-retinal-vessel-diameter-with-both-retinal-nerve-fibre-layer-thickness-and-optic-nerve-head-parameters-in-middle-aged-caucasians-the-northern-finland-birth-cohort-eye-study
#11
Mohamed Geneid, Joonas Kettunen, Iida Nuuttila, Timo Lintonen, Janne-Joonas Uusitalo, Ville Saarela, M Johanna Liinamaa
PURPOSE: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians. METHODS: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Retinal nerve fibre layer (RNFL) thickness and ONH parameters were assessed with Heidelberg retinal tomography (HRT)...
December 10, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30536185/use-of-commercially-available-sodium-hyaluronate-0-18-eye-drops-for-corneal-epithelial-healing-in-diabetic-patients
#12
KietPhang Ling, Mae-Lynn Catherine Bastion
PURPOSE: To evaluate the effect of topical sodium hyaluronate (SH) 0.18% treatment on corneal epithelial healing after epithelial debridement in pars plana vitrectomy in diabetic patients. METHOD: This is prospective and randomized clinical trial. Our study population included 30 eyes undergoing pars plana vitrectomy that required near total corneal debridement intra-operatively for surgical view. We compared the residual wound and wound healing rate in between 3 groups: 10 diabetic eyes (DMV) on topical SH 0...
December 7, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/30535492/a-comprehensive-competitive-endogenous-rna-network-pinpoints-key-molecules-in-diabetic-retinopathy
#13
Yingcheng Wu, Keren Jia, Huiqun Wu, Aimin Sang, Lei Wang, Lili Shi, Kui Jiang, Jiancheng Dong
Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and the primary cause of vision loss in diabetic patients. Previous research has revealed that long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) play pivotal roles in the pathogenesis of DR. However, the roles of lncRNA‑miRNA‑mRNA interactions in DR are poorly understood. In the present study, we aimed to compute a global triple network of competitive endogenous RNAs (ceRNAs) in order to pinpoint essential molecules. We found that there were 802 nodes (121 lncRNA nodes, 17 miRNA nodes, and 664 mRNA nodes) and 949 edges in the ceRNA network...
December 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30535121/genome-wide-association-analyses-identify-139-loci-associated-with-macular-thickness-in-the-uk-biobank-cohort
#14
X Raymond Gao, Hua Huang, Heejin Kim
The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Here, we describe the first GWAS of macular thickness, which was measured by spectral-domain optical coherence tomography using 68,423 participants from the UK Biobank cohort...
December 7, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30534771/a-novel-dual-response-ratiometric-fluorescent-probe-for-the-determination-of-h-2-o-2-and-glucose-via-etching-of-silver-nanoparticles
#15
Hongzhi Lu, Chunwei Yu, Shuai Quan, Shoufang Xu
Based on the inner filter effect and charge transfer dual response mechanism, a dual response ratiometric fluorescent probe (D-RFP) with two reversible signal changes for sensing H2O2 and glucose was developed. The D-RFP was proposed by embedding glycine-derived carbon dots (CDs) (λem = 400 nm) into silica nanoparticles and covalently linking CdTe quantum dots (QDs) (λem = 600 nm) onto the surface of silica nanoparticles. When silver nanoparticles (Ag NPs) were mixed with D-RFP, the fluorescence intensity of CDs can be quenched by Ag NPs via the inner filter effect...
December 11, 2018: Analyst
https://www.readbyqxmd.com/read/30533048/choroidal-structural-analysis-in-eyes-with-diabetic-retinopathy-and-diabetic-macular-edema-a-novel-oct-based-imaging-biomarker
#16
Chanda Gupta, Roy Tan, Chitaranjan Mishra, Neha Khandelwal, Rajiv Raman, Ramasamy Kim, Rupesh Agrawal, Parveen Sen
PURPOSE: To evaluate structural changes in the choroid among patients with diabetic macular edema (DME), with varying grades of diabetic retinopathy (DR), using enhance depth imaging spectral domain optical coherence tomography (EDI SD-OCT) scans. METHODS: A cross-sectional study was conducted on 82 eyes with DR and DME and 86 healthy control eyes. Eyes with DME were classified according to the severity of DR as per the international DR severity scale. Sub foveal choroidal thickness (SFCT)was obtained using EDI SD-OCT scans...
2018: PloS One
https://www.readbyqxmd.com/read/30532519/expanding-the-role-of-medical-retina-virtual-clinics-using-multimodal-ultra-widefield-and-optical-coherence-tomography-imaging
#17
Jing Xian Lee, Vina Manjunath, S James Talks
Background: An increasingly elderly population with a corresponding increase in ophthalmic conditions has led to increased pressure on hospital eye services (HES). In this study, we evaluated the use of a medical retina virtual clinic (MRVC), which has expanded into assessing all new medical retina referrals, where the need for urgent treatment was not clear. Methods: Retrospective analysis of all new patients who were seen in the MRVC between April 2016 and May 2018...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/30532517/risk-factors-for-neovascular-glaucoma-after-vitrectomy-in-eyes-with-proliferative-diabetic-retinopathy
#18
Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Makoto Ubuka, Takatoshi Maeno
Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy. Subjects and methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/30532093/-comparaci%C3%A3-n-de-la-densidad-capilar-parafoveal-entre-sujetos-sanos-y-diab%C3%A3-ticos-con-y-sin-retinopat%C3%A3-a
#19
Virgilio Lima-Gómez, Dulce Milagros Razo Blanco-Hernández, Selma Alin Somilleda-Ventura
Background: Parafoveal capillary density changes have not been characterized in type 2 diabetics without retinopathy. Objective: To compare parafoveal capillary density between healthy subjects, and diabetics with and without retinopathy. Method: Observational, prospective, transversal and comparative study; subjects without diabetes (group 1), diabetics without retinopathy (group 2), with retinopathy (group 3) and with diabetic macular edema (group 4), without macular ischemia, were included...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/30531420/comparative-evaluation-of-anterior-segment-optical-coherence-tomography-ultrasound-biomicroscopy-and-intraocular-pressure-changes-after-panretinal-photocoagulation-by-pascal-and-conventional-laser
#20
Suman Lata, Pradeep Venkatesh, Shreyas Temkar, Harathy Selvan, Viney Gupta, Tanuj Dada, Ashish D Upadhyay, Ramanjit Sihota
PURPOSE: To compare intraocular pressure, anterior segment optical coherence tomography, and ultrasound biomicroscopy parameters over 3 months after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy after 1 of 2 sittings by conventional laser (half PRP) and a single sitting of Pattern Scan Laser (PASCAL) PRP. METHODS: This was a prospective, randomized, interventional study. All tests were performed at baseline, and at 1, 6, and 24 hours, and 1, 4, 8, and 12 weeks after PRP...
November 28, 2018: Retina
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