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Chunyan Zhu, Qionghong Xu, Zhiyun Mao, Na Lin
The comorbidity between the nociceptive and mental syndromes adds to the refractoriness of neuropathic pain (NP). Wu-Tou decoction (WTD) has been prescribed for chronic pain for thousands of years in China. Recently, we reported that WTD was helpful for hippocampus and co-curative for the nociceptive, depressive and anxiety behaviors in the spinal cord ligation (SNL) mice. However, the mechanism underlying the rescue of hippocampus, as well as the roles hippocampus assumed in co-curation remain unexplored. In this study, we validated that in SNL mice, the long-lasting damages to limbic system were mainly limited to hippocampus...
August 16, 2018: Scientific Reports
Hamayun Zafar, Ali Albarrati, Ahmad H Alghadir, Zaheen A Iqbal
Normal respiration is a very intricate function that comprises mechanical as well as nonmechanical components. It is shown to be affected by various factors including age, lifestyle, disease, and change in posture. With the increased use of hand held devices, everyone is prone to poor sitting postures like forward head posture. The purpose of this study was to evaluate the effect of assumed forward head posture and torticollis on the diaphragm muscle strength. A sample of 15 healthy males, aged 18-35 years, was recruited for this study...
2018: BioMed Research International
Sri Harsha Akella, Ebenezer D, Sai Siddhardha R S, Alkesh Ahire, Nawal Kishor Mal
Electrode fabrication and membrane electrode assembly (MEA) processes are critical steps in polymer electrolyte membrane fuel cell (PEMFC) technology. The properties of decal substrate material are important in decal coating technique for efficient transfer of catalyst layer. In the present study, MEAs are fabricated in decal method using 6 different decal substrates among which polypropylene (PP) is found ideal. Morphological, thermal, spectroscopic and sessile drop measurements are conducted for 6 decal substrates to evaluate the thermal and physicochemical properties...
August 14, 2018: Scientific Reports
Pedro Lavrador, Vítor M Gaspar, João F Mano
Naringin is a naturally occurring flavanone with recognized neuroprotective, cardioprotective, anti-inflammatory, and antiosteoporotic properties. Herein, the delivery of Naringin-loaded methoxy-poly(ethylene glycol)-maleimide-thiol-poly(l-lactide) (mPEGMSPLA) diblock polymeric micelles to human adipose-derived stem cells (hASCs) with the aim to augment its pro-osteogenic effect in these cells is reported for the first time. The synthesis of the diblock copolymer is performed via Michael-type addition reaction between hydrophilic methoxy-poly(ethylene glycol)-maleimide (mPEGMAL) and hydrophobic thiol-poly(l-lactide) (PLASH) and confirmed by 1 H NMR and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy...
August 14, 2018: Advanced Healthcare Materials
Yupeng Zhang, Chao Ma, Shikai Liang, Peng Yan, Fei Liang, Feng Guo, Chuhan Jiang
OBJECTIVE: To explore whether computed morphological features can be used as independent predictors of incomplete occlusion of aneurysms treated with pipeline embolization device. METHODS: From January 2016 to September 2017, 58 patients with 58 aneurysms were treated with pipeline embolization device in our center. Aneurysms were manually segmented from the DICOM file and we calculated 16 shape features voxel by voxel on the segmented aneurysm image. Along with other 13 clinical and radiographic variables, we performed univariate and multivariate analysis to explore predictors of incomplete occlusion...
August 10, 2018: World Neurosurgery
L Bunge, D Baruch, L Plantier, T Mazars, N Roche, A Izadifar
No abstract text is available yet for this article.
August 9, 2018: Revue des Maladies Respiratoires
Yoon-Hee Cha, Guofa Shou, Diamond Gleghorn, Benjamin C Doudican, Han Yuan, Lei Ding
To determine intrinsic functional connectivity (IFC) related to symptom changes induced by rTMS in mal de debarquement syndrome (MdDS), a motion perceptual disorder induced by entrainment to oscillating motion. Twenty right-handed women (mean age: 52.9 ± 12.6 years; mean duration illness: 35.2 ± 24.2 months) with MdDS received five sessions of rTMS (1 Hz right DLPFC, 10 Hz left DLPFC) over consecutive days. High-density (128-channel) resting-state EEG were recorded prior to and following treatment sessions and analyzed using a group-level independent component (IC) analysis...
August 11, 2018: Brain Topography
Paul Park, Kai-Ming Fu, Praveen V Mummaneni, Juan S Uribe, Michael Y Wang, Stacie Tran, Adam S Kanter, Pierce D Nunley, David O Okonkwo, Christopher I Shaffrey, Gregory M Mundis, Dean Chou, Robert Eastlack, Neel Anand, Khoi D Than, Joseph M Zavatsky, Richard G Fessler
OBJECTIVE Achieving appropriate spinopelvic alignment in deformity surgery has been correlated with improvement in pain and disability. Minimally invasive surgery (MIS) techniques have been used to treat adult spinal deformity (ASD); however, there is concern for inadequate sagittal plane correction. Because age can influence the degree of sagittal correction required, the purpose of this study was to analyze whether obtaining optimal spinopelvic alignment is required in the elderly to obtain clinical improvement...
August 10, 2018: Journal of Neurosurgery. Spine
Subin Heo, Hye Jin Kim, Bohyun Kim, Jei Hee Lee, Jinoo Kim, Jai Keun Kim
PURPOSE: We aimed to analyze computed tomography (CT) findings and medical records of patients diagnosed with median arcuate ligament syndrome (MALS) and evaluate possible risk factors associated with vascular complications that develop in patients with MALS. METHODS: This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. A total of 37 consecutive patients were diagnosed with MALS using both axial and sagittal CT reconstruction imaging at a single institution over a 7-year period...
July 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Teresa Paula Marques, Alexandra Marques-Pinto, Maria-João Alvarez, Cícero Roberto Pereira
This study aimed to assess the risks and opportunities associated with Facebook usage and to explore the moderating role of psychosocial (mal)adjustment, nationality and age in these relationships. This correlational study involved a sample of 452 Brazilian and 500 Portuguese youths, aged between 14 and 20 years. Results showed that these youths spent a daily average of 61-120 minutes on Facebook, three to four times per week, displaying a positive attitude towards its use. These characteristics were most notable in the Brazilian youths [t(950) = 5...
August 8, 2018: Spanish Journal of Psychology
Peter Kloen, Olivier D R van Wulfften Palthe, Jorn Nützinger, Johanna C E Donders
OBJECTIVE: To describe patients' outcomes after revision of tibial plateau fracture fixation within 12 months of the initial surgical procedure. To assess differences in objective outcome scores (IKDC, SF-36, arthrosis score, physical examination) depending on whether patients were treated for mal-reduction, mal-union, or non-union. DESIGN: Retrospective case series. PATIENTS: Twenty-seven patients who underwent revision within 1 year of primary surgery and with a minimum follow up of 1 year...
July 30, 2018: Journal of Orthopaedic Trauma
Ying Zhou, Haibo Wang, Eric Tse, Hongyan Li, Hongzhe Sun
Arsenic has long been used as therapeutic agents. Understanding the mechanism of action of arsenic-based drugs enables more ef-fective arsenic drugs to be developed. Cell cycle has been known to play a critical role for cell division and growth. Herein, we es-tablish a methodology to evaluate the uptake of two arsenic-based drugs (ATO and ZIO-101) across the cell cycle in single leukemia cells, i.e., NB4 and HL60, using a double thymidine block combined with time-resolved ICP-MS. We show that cells absorb maxi-mal amounts of both ATO and ZIO-101 in G2/M phase and minimum in S phase, and such variation is less apparent for ZIO-101 than ATO (NB4-G2/M: S=2...
August 6, 2018: Analytical Chemistry
Sougata Mallick, Swapna Sindhu Mishra, Subhankar Bedanta
The topic of magnetic antidot lattice (MAL) arrays has drawn attention from both fundamental research as well as from application point of view. MAL arrays are promising candidates for making domain engineering in thin films. For various applications it is necessary to understand the magnetization reversal mechanism as well as the relaxation dynamics. In this context we have studied magnetic antidot lattice (MAL) arrays of Co/Pt with perpendicular anisotropy fabricated by combination of photolithography and sputtering deposition...
August 3, 2018: Scientific Reports
Kajal Mal, Barnali Naskar, Animesh Mondal, Sanchita Goswami, Chandraday Prodhan, Keya Chaudhuri, Chhanda Mukhopadhyay
In this study, a new molecular organic probe has been designed and synthesized by using recyclable, inexpensive and non-toxic polyethylene glycol (PEG-400) as a promoting reaction medium in water under environmentally benevolent conditions. The probe has been explored as a potential chemosensor to detect Al3+ ions using a HEPES buffer (pH = 7.4) solution. Investigations of the fluorescence behaviour of this sensor in DMSO/H2O (2 : 8, v/v) solution displayed a dramatic switch-on response only in the presence of Al3+, while other metal ions, like Li+, Na+, K+, Ag+, Ca2+, Mg2+, Mn2+, Ba2+, Cu2+, Ni2+, Co2+, Fe2+, Zn2+, Cd2+, Hg2+, Pb2+, Sr2+, Fe3+ or Cr3+, have almost no influence on the fluorescence behaviour...
August 3, 2018: Organic & Biomolecular Chemistry
Lu Yang, Wenli Han, Ying Luo, Xiangnan Hu, Ying Xu, Huan Li, Congli Hu, Dan Huang, Jie Ma, Yang Yang, Qi Chen, Yuke Li, Jiahua Zhang, Hui Xia, Zhihao Chen, Hong Wang, Dongzhi Ran, Junqing Yang
Our previous studies indicated that adapentpronitrile, a new adamantane-based dipeptidyl peptidase-IV (DPP-IV) inhibitor, has a hypoglycemic effect and ameliorates rat pancreatic β cell dysfunction in type 2 diabetes mellitus through inhibiting DPP-IV activity. However, the effect of adapentpronitrile on the neurodegenerative diseases has not been studied. In the present study, we first found that adapentpronitrile significantly ameliorated neuronal injury and decreased amyloid precursor protein (APP) and amyloid beta (Aβ) expression in the hippocampus and cortex in the high fat diet/STZ rat model of diabetes...
2018: Frontiers in Cellular Neuroscience
Gustavo Nari, Daniela Mariot, Javier Góngora-Ortega, Santiago López-Ben, Maite Albiol, Joan Figueras
Introducción: Un alto porcentaje de pacientes que reciben una hepatectomía por metástasis de cáncer colorrectal presentarán recidiva hepática, y en algunas será posible una nueva resección. La utilidad de las hepatectomías repetidas continúa siendo discutida. Objetivo: Evaluar los resultados obtenidos a corto y largo plazo. Método: Fueron analizadas 68 rehepatectomías de dos instituciones. Se analizaron datos demográficos y características de la enfermedad metastásica y de las resecciones hepáticas...
2018: Cirugia y Cirujanos
Christopher L Skelly, Colleen Stiles-Shields, Grace Z Mak, Christopher R Speaker, Jonathan Lorenz, Magdalena Anitescu, David M Dickerson, Hope Boyd, Setareh O'Brien, Tina Drossos
OBJECTIVE: Median arcuate ligament syndrome (MALS) is an often overlooked, surgically correctable condition that mimics functional chronic abdominal pain. Patient-reported surgical outcomes are unpredictable in MALS. The objective of this study was to define the psychiatric comorbidities in a cohort of adults undergoing surgery for MALS and to determine whether these comorbidities are predictive of patient-reported quality of life (QOL) outcomes. METHODS: A prospective observational trial was conducted between April 1, 2010, and December 31, 2015, at a single tertiary care hospital...
July 28, 2018: Journal of Vascular Surgery
Aldo A M Lima, Pedro H Q S Medeiros, Alexandre Havt
PURPOSE OF REVIEW: The current review is to update the results on epidemiology, pathobiology, and genes related to virulence, clinical presentation, molecular diagnosis, antimicrobial resistance, and extraintestinal infection of enteroaggregative Escherichia coli (EAEC). RECENT FINDINGS: EAEC subclinical infection was significantly associated with reduced length at 2 years of age and EAEC and coinfections were associated with reduced delta weight-for-length and weight-for-age z-scores in the first 6 months of age in the MAL-ED birth cohort study...
July 30, 2018: Current Opinion in Infectious Diseases
(no author information available yet)
Background: Millions of children in low-income and middle-income countries (LMICs) are at risk of not reaching their full cognitive potential. Malnutrition and enteric infections in early life are implicated as risk factors; however, most studies on these risks and their associations with cognitive development have failed to adequately account for confounding factors or the accumulation of putative insults. Here, we examine the interaction between infections and illness on cognitive development in LMIC community settings...
2018: BMJ Global Health
Chulbul M Ahmed, Michael T Massengill, Emily E Brown, Cristhian J Ildefonso, Howard M Johnson, Alfred S Lewin
We describe an immunosuppressive peptide corresponding to the kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1) that binds to the phospho-tyrosine containing regions of the tyrosine kinases JAK2 and TYK2 and the adaptor protein MAL, and thereby inhibits signaling downstream from these signaling mediators. The peptide, SOCS1-KIR, is thus capable of downregulating overactive JAK/STAT or NF-kB signaling in somatic cells, including those in many compartments of the eye...
July 23, 2018: Experimental Eye Research
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