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Daniel Ruhland, Kenneth Chinedu Nwoko, Magali Perez, Joerg Feldmann, Eva M Krupp
The coupling of flow field flow fractionation (FlFFF) with ICP-MS/MS for the fractionation and analysis of natural nanoparticles in environmental samples is becoming more popular. However, the applicability of this technique to non-aqueous samples such as gas condensates from petroleum hydrocarbon samples has not been reported yet. In this study, an asymmetric flow-field flow fractionation (AF4) system coupled with UV and MALS detectors has been optimized to perform the fractionation of natural nanoparticles present in a gas condensate sample, using THF as the carrier liquid...
December 5, 2018: Analytical Chemistry
Pablo Fonda-Pascual, Adrián Alegre-Sánchez, Antonio Harto-Castaño, Oscar M Moreno-Arrones, Bibiana Pérez-García, Maria Luisa González-Morales, Cristina Pindado Ortega, Yolanda Gilaberte-Calzada, José Aguilera, Pedro Jaen Olasolo, Montserrat Fernández-Guarino
BACKGROUND: Daylight photodynamic therapy (dlPDT) is a painless and increasingly cost-effective treatment for actinic keratosis (AK). New protocols avoid incubation minimizing pain and adverse events. However, it is time-consuming and dependent on specific weather conditions. In patients with AK of the scalp, we evaluated the efficacy of indoor photodynamic therapy (PDT) using a wearable low-level light therapy (LLLT) device, without pre-incubation with a photosensitizing agent. METHODS: In this pilot study, 27 patients with thin and moderately thick AK (Olsen Grades I-II) underwent a single 15-minute session of LLLT using a wearable cap-like device immediately after application of methyl-aminolevulinate (MAL) cream, with no prior preparation of the affected area...
November 30, 2018: Photodiagnosis and Photodynamic Therapy
Laura L Pendergast, Barbara A Schaefer, Laura E Murray-Kolb, Erling Svensen, Rita Shrestha, Muneera A Rasheed, Rebecca J Scharf, Margaret Kosek, Angel Orbe Vasquez, Angelina Maphula, Hilda Costa, Zeba A Rasmussen, Aisha Yousafzai, Fahmida Tofail, Jessica C Seidman
The Bayley's Scales of Infant and Toddler Development-Third Edition (Bayley-III) were used to measure the development of 24-month-old children (N = 1,452) in the Interactions of Malnutrition and Enteric Infections: Consequences for Child Health and Development (MAL-ED) study (an international, multisite study on many aspects of child development). This study examined the factor structure and measurement equivalence/invariance of Bayley-III scores across 7 international research sites located in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, and South Africa...
December 2018: School Psychology Quarterly
Wenhui Zhang, Jing Wang, Panpan Guo, Shanshan Dai, Xiaoyue Zhang, Ming Meng, Shigang Shen, Aixia Zhang, Haiyang Dou
In this study, the capacity of asymmetrical flow field-flow fractionation (AF4) coupled with multiangle light scattering (MALS) and differential refractive index (dRI) detectors, to monitor starch retrogradation behavior in situ was evaluated. Meanwhile, the starch samples were characterized by differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FTIR). The effect of the botanical origin, amylose/amylopectin ratio, storage conditions (i.e., temperature and time), and salt on starch retrogradation was systematically investigated...
March 30, 2019: Food Chemistry
Bradley T Gieske, Richard A Stecker, Charles R Smith, Kyle E Witherbee, Patrick S Harty, Robert Wildman, Chad M Kerksick
BACKGROUND: Augmenting fat oxidation is a primary goal of fitness enthusiasts and individuals desiring to improve their body composition. Performing aerobic exercise while fasted continues to be a popular strategy to achieve this outcome, yet little research has examined how nutritional manipulations influence energy expenditure and/or fat oxidation during and after exercise. Initial research has indicated that pre-exercise protein feeding may facilitate fat oxidation while minimizing protein degradation during exercise, but more research is needed to determine if the source of protein further influences such outcomes...
November 29, 2018: Journal of the International Society of Sports Nutrition
Yan-Hong Yong, Ping Wang, Ru-Min Jia, Ravi Gooneratne, Hwa-Chain Robert Wang, Ming Liao, Xiang-Hong Ju
Hyperthermia in pigs induces suppressor of cytokine signaling (SOCS) 3 and SOCS4 expression in intestinal gut and causes disruption of inflammation cytokine production. These changes may affect the development of inflammatory bowel disease in heat-stressed pigs. However, the mechanisms are not well understood. Accordingly, in this study, we examined the roles of SOCS members in regulation of the nuclear factor (NF)-κB pathway and heat shock protein (HSP) 70-mediated cytokine induction in 293T human embryonic kidney cells and IPEC-J2 porcine small intestinal epithelial cells...
November 28, 2018: International Journal of Hyperthermia
Josephine M Canceri, Rachael Brown, Shaun R Watson, Cherylea J Browne
Introduction: Mal de Debarquement Syndrome (MdDS) is a neurological disorder which affects the vestibular system pathways, manifesting as a constant sensation of movement in the form of rocking, bobbing, or swaying. The mechanism of MdDS is poorly understood and there is a lack of awareness amongst medical professionals about the condition. This study aimed to examine treatments and symptom management strategies used by MdDS patients and evaluate their self-reported effectiveness. Method: Motion-Triggered and Spontaneous/Other onset MdDS patients responded to a set of comprehensive questions as a retrospective survey regarding epidemiological details, diagnostic procedures, onset, and symptom triggers, hormonal influences as well as treatments and symptom management strategies used to reduce symptoms...
2018: Frontiers in Neurology
Joshua D Bernstock, Zachary Wright, Asim K Bag, Florian Gessler, G Yancey Gillespie, James M Markert, Gregory K Friedman, James M Johnston
OBJECTIVE: G207, an engineered HSV-1, is a promising therapeutic option for CNS tumors. The first-ever pediatric Phase 1 trial of continuous-infusion delivery of G207 via intratumoral catheters for recurrent/progressive malignant brain tumors is ongoing. Herein, we describe surgical techniques for the accurate placement of catheters in multiple supratentorial locations and perioperative complications associated with such procedures. METHODS: A prospective study of G207 in children with recurrent malignant supratentorial tumors is ongoing...
November 24, 2018: World Neurosurgery
Daisuke Imai, Takashi Maeda, Huanlin Wang, Takahiro Ohmine, Keitaro Edahiro, Makoto Edagawa, Tomoyoshi Takenaka, Shohei Yamaguchi, Kozo Konishi, Shinichi Tsutsui, Hiroyuki Matsuda
BACKGROUND: Median arcuate ligament syndrome (MALS) can cause severe complications after pancreaticoduodenectomy (PD). Most of the reported cases of MALS have been diagnosed perioperatively and can be treated efficiently by interventional radiology or division of the median acute ligament (MAL) fibers. CASE REPORT: A 69-year-old woman underwent PD with resection of the SMV for pancreatic head cancer. Intraoperative exploration showed normal anatomy of the celiac trunk...
November 26, 2018: Surgical Case Reports
Yedu Prasad, Ritesh Kumar, Awanish Kumar Chaudhary, Rajkumar Dhanaraju, Soneya Majumdar, Desirazu N Rao
The bacterium Helicobacter pylori is one of the most common infectious agents found in the human stomach. H. pylori has an unusually large number of DNA methyltransferases (MTases), prompting speculation that they may be involved in the cancerization of epithelial cells. The mod-4a/4b locus, consisting of the hp1369 and hp1370 ORFs, encodes for a truncated and inactive MTase in H. pylori strain 26695. However, slipped-strand synthesis within the phase-variable poly-guanine track in hp1369 results in expression of an active HP1369-1370 fusion N6 -adenine methyltransferase, designated M...
November 26, 2018: Journal of Biological Chemistry
Seyed Morteza Mousavi Naeini, Alireza Khalaj, Ali Abbaszadeh-Kasbi, Seyed Rouhollah Miri
Background  There are several surgical approaches to treat obesity not cured with medical approaches. Each method has its advantages and complications. In here, we have conducted a study to evaluate complications of biliointestinal bypass surgery (BIBP). Methods  A prospective study was conducted in a private hospital from 2002 to 2016. Those patients, not previously operated for morbid obesity, were eligible. Mean follow-up period was 89 months ( ± 54 months; range: 73-108 months). Main outcome measures were weight, BMI (body mass index), concentrations of blood lipids and glucose, liver transaminases, and obesity-related comorbidities and complications...
October 2018: Surgery Journal
John F Jarrell, George A Vilos, Catherine Allaire, Susan Burgess, Claude Fortin, Robert Gerwin, Louise Lapensée, Robert H Lea, Nicholas A Leyland, Paul Martyn, Hassan Shenassa, Paul Taenzer
OBJECTIF: Améliorer La compréhension de la douleur pelvienne chronique (DPC) et fournir des directives cliniques factuelles qui bénéficieront aux fournisseurs de soins de santé primaires, aux obstétriciens-gynécologues et aux spécialistes de la douleur chronique. FARDEAU DE LA SOUFFRANCE: La DPC est une pathologie débilitante courante qui affecte les femmes. Elle est à l'origine d'importantes souffrances personnelles et de dépenses de santé considérables associées aux interventions, dont de multiples consultations et un grand nombre de traitements médicaux et chirurgicaux...
November 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Joon Yeong Park, Seung Hun Park, Mal Geum Kim, Sang-Hyug Park, Tae Hyeon Yoo, Moon Suk Kim
The use of biomimetic scaffolds for bone tissue engineering has been studied for a long time. Biomimetic scaffolds can assist and accelerate bone regeneration that is similar to that of authentic tissue, which represents the environment of cells in a living organism. Currently, numerous biomaterials have been reported for use as a biomimetic scaffold. This review focuses on the design of biomimetic scaffolds, kinds of biomaterials and methods used to fabricate biomimetic scaffolds, growth factors used with biomimetic scaffold for bone regeneration, mobilization of biological agents into biomimetic scaffolds, and studies on (pre)clinical bone regeneration from biomimetic scaffolds...
2018: Advances in Experimental Medicine and Biology
Carmen R M Bria, Farsad Afshinnia, Patrick W Skelly, Thekkelnaycke M Rajendiran, Pradeep Kayampilly, Thommey P Thomas, Victor P Andreev, Subramaniam Pennathur, S Kim Ratanathanawongs Williams
High- and low-density lipoproteins (HDL and LDL) are attractive targets for biomarker discovery. However, ultracentrifugation (UC), the current methodology of choice for isolating HDL and LDL, is tedious, requires large sample volume, results in sample loss, and does not readily provide information on particle size. In this work, human plasma HDL and LDL are separated and collected using semi-preparative asymmetrical flow field-flow fractionation (SP-AF4) and UC. The SP-AF4 and UC separation conditions, sample throughput, and liquid chromatography/mass spectrometry (LC/MS) lipidomic results are compared...
November 23, 2018: Analytical and Bioanalytical Chemistry
R E Adams, J A Brickel, V S Bhat
Dietary supplements are regulated by the U.S. FDA as a subset of foods. Most botanical dietary ingredients do not have pesticide tolerances, resulting in the enforcement of zero tolerance or general maximum residue limits (GMRL), rather than utilizing science-informed tolerances. In the current study, chemical-specific maximum allowable levels (MALs) were derived for 185 pesticides by converting existing, authoritative-body human health effects criteria. MALs were derived for 96% of pesticides using criteria established by the U...
November 20, 2018: Food and Chemical Toxicology
Shreya Bhattacharya, Arundhati Banerjee, Pragati Prasad Sah, Chittabrata Mal, Sujay Ray
Wheat (Triticum aestivum), having high nutritional values is one of the staple food of most of the countries in the world. The productivity of the crop decreases drastically when it encounters various abiotic stresses, most common of which are heat, drought, flood and salinity. There is a crucial role of stress response proteins for the survival of the crops in stress conditions. So the study of wheat stress response proteins is of great importance to raise wheat production in different stress conditions. In this study, we analysed 14-3-3 protein, a stress response protein that is expressed in three major stresses, for example heat, drought and salinity and helps the plants to survive in those conditions...
October 4, 2018: Computational Biology and Chemistry
Jeanne Marie Perotin, Sylvie Leroy, Charles Hugo Marquette, Hervé Mal, Hervé Dutau, Arnaud Bourdin, Jean Michel Vergnon, Christophe Pison, Coralie Barbe, Gaëtan Deslee
Endobronchial coil treatment (ECT) is a minimally invasive procedure developed for palliative care of patients with severe emphysema. ECT has demonstrated a decrease in hyperinflation, an improvement in quality of life, and an acceptable safety profile in randomized controlled trials (RCTs). Because alpha-1 antitrypsin deficiency (AATD) is a classical exclusion criterion in RCTs, there is no available data for ECT in AATD. In this post hoc analysis of the REVOLENS study (Réduction volumique endobronchique par spirales; ClinicalTrials...
2018: International Journal of Chronic Obstructive Pulmonary Disease
David Odoyoh Odatuwa-Omagbemi, Thomas Odafe Adiki, Cornelius Itodo Elachi, Anirejuoritse Bafor
Introduction: Complications arising from the practice of traditional bone setting is a major contributor to the challenges the orthodox orthopaedic practitioner in Nigeria faces. We share our experience at a multi-specialist private health facility in Warri, South-south, Nigeria. Methods: Case notes of patients with musculoskeletal injuries who had prior treatment by traditional bone setters with resulting complications before presenting at our health facility for treatment were reviewed and relevant information extracted and entered in an already prepared proforma...
2018: Pan African Medical Journal
Gerd Krause, Patrick Marcinkowski
No abstract text is available yet for this article.
November 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Esther Mm Van Lieshout, Daan T Van Yperen, Margriet E Van Baar, Suzanne Polinder, Doeke Boersma, Anne Ymvp Cardon, Piet Ar De Rijcke, Marc Guijt, Taco Mal Klem, Koen Ww Lansink, Akkie N Ringburg, Maarten Staarink, Leon Van de Schoot, Alexander H Van der Veen, Floortje C Van Eijck, Percy V Van Eerten, Paul A Vegt, Dagmar I Vos, Marco Waleboer, Michael Hj Verhofstad, Cornelis H Van der Vlies
INTRODUCTION: The Emergency Management of Severe Burns (EMSB) referral criteria have been implemented for optimal triaging of burn patients. Admission to a burn centre is indicated for patients with severe burns or with specific characteristics like older age or comorbidities. Patients not meeting these criteria can also be treated in a hospital without burn centre. Limited information is available about the organisation of care and referral of these patients. The aims of this study are to determine the burn injury characteristics, treatment (costs), quality of life and scar quality of burn patients admitted to a hospital without dedicated burn centre...
November 15, 2018: BMJ Open
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