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'COX2' or 'Caspase' and 'diabetes'

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https://www.readbyqxmd.com/read/27431618/ameliorative-effect-of-dietary-genistein-on-diabetes-induced-hyper-inflammation-and-oxidative-stress-during-early-stage-of-wound-healing-in-alloxan-induced-diabetic-mice
#1
Hyeyoon Eo, Hea-Ji Lee, Yunsook Lim
Among the diabetic complications, diabetic foot ulcer due to delayed wound healing is one of the most significant clinical problems. Early inflammatory stage is important for better prognosis during wound healing. Thus, regulation of inflammatory response during early stage of wound healing is main target for complete cutaneous recovery. This study investigated the role of genistein supplementation in inflammation and oxidative stress, which are related to NLRP3 inflammasome, NFκB and Nrf2 activation, during cutaneous wound healing in alloxan-induced diabetic mice...
September 23, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25379992/procyanidin-b2-inhibits-inflammasome-mediated-il-1%C3%AE-production-in-lipopolysaccharide-stimulated-macrophages
#2
Neus Martinez-Micaelo, Noemi González-Abuín, Montserrat Pinent, Anna Ardévol, Mayte Blay
SCOPE: Macrophage stimulation with bacterial LPS triggers inflammasome activation, resulting in pro-inflammatory IL-1β cytokine maturation and secretion. IL-1β underlies the pathologies of many diseases, including type-2 diabetes. Thus, the modulation of the inflammatory response through bioactive food compounds, such as procyanidins, is a powerful tool to promote homeostasis. METHODS AND RESULTS: To determine the role of procyanidin B2 in inflammasome activation, LPS-primed THP-1-macrophages were supplemented with or without procyanidin B2 ...
February 2015: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/22169161/antihyperglycemic-potentials-of-a-threatened-plant-helonias-dioica-antioxidative-stress-responses-and-the-signaling-cascade
#3
Debrup Chakraborty, Asmita Samadder, Suman Dutta, Anisur Rahman Khuda-Bukhsh
Helonias dioica (HD) is a threatened species of herb growing in North America. It is used as a traditional medicine for treating various ailments particularly related to reproductive issues. The root is reported to contain approximately 10% of a saponin (chamaelirin; C(36)H(62)O(18)) apart from certain other fatty acids. As saponins are known to have hypoglycemic effects, we suspected its possible antihyperglycemic potentials. We injected intraperitoneally alloxan (ALX) at the dose of 200 mg/kg body weight (bw) to induce hyperglycemia in mice and tested possible hypoglycemic effects of HD in vivo by deploying two doses (100 and 200 mg/kg bw, respectively)...
January 2012: Experimental Biology and Medicine
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