keyword
https://read.qxmd.com/read/38536832/rapid-resurgence-of-syphilis-in-japan-after-the-covid-19-pandemic-a-descriptive-study
#21
JOURNAL ARTICLE
Akira Komori, Hirotake Mori, Wenke Xie, Simon Valenti, Toshio Naito
Some countries have reported a post-pandemic resurgence in syphilis prevalence, but trend data in the World Health Organization Western Pacific Region (WHO-WPRO), including Japan, are severely lacking. Thus, the present study compares the number of syphilis cases before and after the COVID-19 pandemic in some WHO-WPRO countries. In addition, temporal trends in the number of syphilis cases in Japan pre- and post-pandemic are described. Annual numbers of syphilis cases during the study periods from China, New Zealand, Australia and Japan were compared...
2024: PloS One
https://read.qxmd.com/read/38536820/changes-in-sars-cov-2-viral-load-and-titers-over-time-in-sars-cov-2-infected-human-corpses
#22
JOURNAL ARTICLE
Sayaka Nagasawa, Yuichiro Hirata, Sho Miyamoto, Seiya Ozono, Shun Iida, Harutaka Katano, Shigeki Tsuneya, Kei Kira, Susumu Kobayashi, Makoto Nakajima, Hiroyuki Abe, Masako Ikemura, Isao Yamamoto, Kimiko Nakagawa, Kazumi Kubota, Shinji Akitomi, Iwao Hasegawa, Tetsuo Ushiku, Tadaki Suzuki, Hirotaro Iwase, Yohsuke Makino, Hisako Saitoh
High viral titers of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been detected in human corpses long after death. However, little is known about the kinetics of infectious SARS-CoV-2 in corpses. In this case series study, we investigated the postmortem kinetics of infectious SARS-CoV-2 in human corpses by collecting nasopharyngeal swab samples at multiple time points from six SARS-CoV-2-infected patients after their death. SARS-CoV-2 RNA was detected by quantitative reverse transcription-polymerase chain reaction from nasopharyngeal swab samples collected from all six deceased patients...
2024: PloS One
https://read.qxmd.com/read/38536765/autobench-v1-0-benchmarking-automation-for-electronic-structure-calculations
#23
JOURNAL ARTICLE
Rodrigo A Cormanich, Gabriel D da Silva
This work reports on new software for automatic conformer energy benchmarking calculations for flexible molecules. The software workflow consists of four parts: conformational search, preoptimization, optimization, and frequency calculations at a higher level and last calculations using several theoretical levels. The software was written to be user-friendly and versatile to be used by nonexperts in computational chemistry. Any theoretical levels available in either Gaussian 16 or ORCA 5 may be applied in the benchmarking study...
March 27, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38536716/scratching-beneath-the-surface-an-evaluation-of-the-management-of-scabies-2017-2023
#24
JOURNAL ARTICLE
Bryony Broster, Amanda Clarke, Collins Iwuji, Suneeta Soni
INTRODUCTION: Possible resistance to recommended treatments for scabies has emerged recently. In response to anecdotal reports of a recent increase in treatment failure with permethrin, the British Association for Sexual Health and HIV (BASHH) released a statement alerting members to this. AIMS: To examine attendances and the treatment pathways for scabies cases seen at local sexual health clinics. METHODOLOGY: A case note review of scabies attendances between January 2017 and December 2023 was conducted...
March 27, 2024: International Journal of STD & AIDS
https://read.qxmd.com/read/38536613/identification-of-a-clinical-spirometra-mansoni-plerocercoid-isolate-using-molecular-and-morphological-data
#25
JOURNAL ARTICLE
Si Si Ru, Chi Cheng, Peng Jiang, Xi Zhang
Sparganosis has been a neglected parasitic zoonosis for a long time. The accurate identification of Spirometra tapeworms in clinical practice is poorly understood. A case of breast sparganosis was reported in Henan Province of central China. One plerocercoid approximately 3.5 cm in length was collected from the patient. The clinical isolate was identified as Spirometra mansoni based on the barcoding sequences of mitochondrial cytochrome c oxidase subunit 1 (cox1). Finally, the epidemiology of sparganosis in central China was reviewed...
March 27, 2024: Acta Parasitologica
https://read.qxmd.com/read/38536603/a-case-of-young-male-with-recurrent-acute-pancreatitis-caused-by-an-intrapancreatic-gastric-duplication-cyst
#26
JOURNAL ARTICLE
Sayaka Miyamoto, Yasutaka Ishii, Masahiro Serikawa, Yumiko Tatsukawa, Shinya Nakamura, Juri Ikemoto, Yosuke Tamura, Kenichiro Uemura, Koji Arihiro, Shiro Oka
Gastric duplication cyst (GDC) is a rare gastrointestinal malformation that frequently occurs in the greater curvature of the gastric antrum or corpus. Herein, we reported a case of intrapancreatic GDC found as a result of recurring pancreatitis. A 15-year-old man experienced repeated episodes of acute pancreatitis and was found to have a cystic lesion in the pancreatic tail. Contrast-enhanced computed tomography revealed a 20-mm cystic lesion with an enhanced thick wall. Endoscopic ultrasonography revealed an anechoic cyst with a three-layered wall...
March 27, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38536589/inattentional-blindness-in-medicine
#27
REVIEW
Connor M Hults, Yifan Ding, Geneva G Xie, Rishi Raja, William Johnson, Alexis Lee, Daniel J Simons
People often fail to notice unexpected stimuli when their attention is directed elsewhere. Most studies of this "inattentional blindness" have been conducted using laboratory tasks with little connection to real-world performance. Medical case reports document examples of missed findings in radiographs and CT images, unintentionally retained guidewires following surgery, and additional conditions being overlooked after making initial diagnoses. These cases suggest that inattentional blindness might contribute to medical errors, but relatively few studies have directly examined inattentional blindness in realistic medical contexts...
March 27, 2024: Cognitive Research: Principles and Implications
https://read.qxmd.com/read/38536562/exome-sequencing-identified-mutations-in-the-wnt1-and-col1a2-genes-in-osteogenesis-imperfecta-cases
#28
JOURNAL ARTICLE
Poonam Mehta, Rahul Vishvkarma, Sushil Gupta, Naibedya Chattopadhyay, Singh Rajender
BACKGROUND: Osteogenesis imperfecta (OI) is a heritable connective tissue disorder characterized by bone deformities, fractures and reduced bone mass. OI can be inherited as a dominant, recessive, or X-linked disorder. The mutational spectrum has shown that autosomal dominant mutations in the type I collagen-encoding genes are responsible for OI in 85% of the cases. Apart from collagen genes, mutations in more than 20 other genes, such as CRTAP, CREB3L1, MBTPS2, P4HB, SEC24D, SPARC, FKBP10, LEPRE1, PLOD2, PPIB, SERPINF1, SERPINH1, SP7, WNT1, BMP1, TMEM38B, and IFITM5 have been reported in OI...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536561/exploring-the-causal-relationship-between-takayasu-arteritis-and-inflammatory-bowel-disease-using-mendelian-randomization
#29
JOURNAL ARTICLE
Xiaoli Pang, Huizhong Yang, Chi Wang, Suyan Tian
Takayasu arteritis (TA) and inflammatory bowel disease (IBD) are two distinct diseases; however, previous studies have reported many cases of IBD-TA coexistence. Additionally, the incidence of IBD in patients with TA is estimated to be significantly higher than the incidence in the general population. Therefore, the two diseases are anticipated to be linked. Mendelian randomization (MR) analysis assesses whether an exposure might causally affect an outcome by using genetic variants inherited randomly at conception, thereby reducing the impact of confounding and reverse causality...
March 27, 2024: Immunologic Research
https://read.qxmd.com/read/38536520/expression-profile-of-circulating-exosomal-micrornas-in-leukoplakia-oral-submucous-fibrosis-and-combined-lesions-of-leukoplakia-and-oral-submucous-fibrosis
#30
JOURNAL ARTICLE
Dinesh Yasothkumar, Pratibha Ramani, Selvaraj Jayaraman, Karthikeyan Ramalingam, W M Tilakaratne
OBJECTIVES: This study aims to elucidate the expression of circulating exosomal miRNAs miRNA 21, miRNA 184, and miRNA 145 in the studied groups, including patients with (i) leukoplakia; (ii) oral submucous fibrosis; (iii) oral submucous fibrosis with leukoplakia; (iv) oral squamous cell carcinoma; and (v) healthy individuals. STUDY DESIGN: An observational study was conducted among 54 patients who reported to the outpatient department of Saveetha Dental College and Hospitals...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536499/incidence-of-heterotopic-ossification-following-total-hip-arthroplasty-by-approach-a-systematic-review
#31
JOURNAL ARTICLE
Rex Herzberg, Olivia C Tracey, Shahriar Tahvilian, Nayeem Baksh, Bashir Zikria, Qais Naziri
BACKGROUND: Heterotopic ossification (HO) formation has been increasingly recognized as a complication of major orthopedic surgeries, particularly total hip arthroplasty (THA). Though, the overall incidence of HO following THA has been well-documented, it is often not reported by severity or by surgical approach. QUESTIONS/PURPOSES: (1) What are the demographics of patients with HO? (2) What is the severity of HO following THA using the Brooker classification? (3) What is the incidence and class of HO following different THA approaches (anterior, posterior, posterolateral, anterolateral, superior, lateral, trans-gluteal)? (4) What are the number and training level of surgeons who performed each procedure? METHODS: The PubMed, Embase, and Web of Science databases were queried, and PRISMA guidelines were followed...
March 27, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38536497/large-symptomatic-sacral-tarlov-cyst-in-a-paediatric-patient-case-report-and-technical-note-on-a-new-variation-of-surgical-technique-to-overcome-one-way-check-valve-mechanism
#32
JOURNAL ARTICLE
Sebastian Siller, Jonathan P Funnell, Tim Bishop, Darren Lui, Jason Bernard
PURPOSE: Symptomatic Tarlov cysts in children with a possible underlying one-way check-valve mechanism are very rare. We aim to introduce a new variation of the surgical technique to overcome a check-valve mechanism. METHODS: A 15-years-old girl presented with double incontinence and anogenital numbness due to a large sacral Tarlov-cyst with possibly underlying one-way check valve mechanisms as suggested by preoperative computed tomography myelography. Intraoperatively, one-way check-valve was confirmed and could be eliminated by creating an artificial inner ostium between the Tarlov cyst and thecal sac with blunt perforation...
March 27, 2024: European Spine Journal
https://read.qxmd.com/read/38536431/enhancing-safety-in-tumescent-liposuction-managing-sedation-related-respiratory-issues-and-serious-complications-under-deep-sedation-with-the-propofol-ketamine-protocol
#33
JOURNAL ARTICLE
Eun Ju Kim, Hyunju Kim, Younchan Park
BACKGROUND: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative. METHODS: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536227/patient-education-and-decision-support-for-long-acting-injectable-hiv-antiretroviral-therapy-protocol-for-tool-development-and-pilot-testing-with-ryan-white-hiv-aids-program-medical-case-management-programs-in-new-york
#34
JOURNAL ARTICLE
Mary Kathryn Irvine, Rebecca Zimba, Tigran Avoundjian, Meghan Peterson, Connor Emmert, Sarah G Kulkarni, Morgan M Philbin, Elizabeth A Kelvin, Denis Nash
BACKGROUND: Long-acting injectable (LAI) HIV antiretroviral therapy (ART) presents a major opportunity to facilitate and sustain HIV viral suppression, thus improving health and survival among people living with HIV and reducing the risk of onward transmission. However, realizing the public health potential of LAI ART requires reaching patients who face barriers to daily oral ART adherence and thus can clinically benefit from alternative treatment modalities. Ryan White HIV/AIDS Program Part A medical case management (MCM) programs provide an array of services to address barriers to HIV care and treatment among economically and socially marginalized people living with HIV...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536204/the-impact-of-a-pandemic-on-a-military-oral-and-maxillofacial-pathology-biopsy-service
#35
JOURNAL ARTICLE
Trevor E Miller, Noel E Dickens, Matthew R Rehmel, Bradley E Jones, Nicholas J Hamlin, Quinn C Robbins
INTRODUCTION: Coronavirus disease 2019 (COVID-19) and the resulting societal reaction presented new challenges to the medical community by limiting patient access to care in 2020 and 2021. The Navy Postgraduate Dental School (NPDS) oral and maxillofacial pathology biopsy service is dependent on in-office physician or dentist appointments and patient biopsies. The purpose of this study was to understand the regulatory and societal impacts of COVID-19 restrictions on biopsy service submissions by assessing NPDS biopsy submission quantities and disease distribution...
March 25, 2024: Military Medicine
https://read.qxmd.com/read/38536194/-pregnancy-management-in-a-patient-with-long-qt-syndrome-type-2-lqt2-carrier-of-the-variant-kcnh2-trp100x
#36
JOURNAL ARTICLE
Greta Hametner, Martin Osranek, Corinna Brunckhorst, Argelia Medeiros Domingo
Long QT syndrome (LQTS) is a congenital ion channel disorder causing prolonged ventricular repolarization and presents on surface ECG with a prolonged QTc interval. This condition predisposes to ventricular arrhythmias and also sudden cardiac death. LQTS without appropriate therapy during pregnancy and the postnatal phase poses an additionally increased risk of sudden cardiac death due to physiological changes associated with gestation. We present a case report of a 30-year-old pregnant woman with known long QT syndrome Type 2 (LQT2) and discuss the management in cardiological practice...
February 2024: Praxis
https://read.qxmd.com/read/38536133/superficial-acral-fibromyxoma-on-the-thumb-nail-bed
#37
JOURNAL ARTICLE
Kyra Diehl, Cara Barber, Oliver J Wisco, John Young, Sandra Osswald, Lisa Cohen
Superficial acral fibromyxoma, also known as digital fibromyxoma, is a benign soft tissue tumor. The acral regions, including the palms, soles, fingers, toes, and nail units, are the commonly affected locations. The subungual region of the great toe is the most common site reported in current literature. The tumor is slowly progressive and benign in nature. Histology commonly reveals a fibromyxoid neoplasm with immunoreactivity to CD34 and CD99 markers.1,2,3 We present the case of a 39-year-old female with a nine-year history of repetitive digital trauma presenting with superficial acral fibromyxoma of the thumb-nail bed...
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38536131/brain-abscess-secondary-to-streptococcus-intermedius-following-an-egd-with-biopsy-in-a-patient-with-eosinophilic-esophagitis
#38
JOURNAL ARTICLE
N Begum Ozturk, Tatjana Blazin, Aparna Hariharan, Naveen Reddy
Brain abscess is a rare complication of esophagogastro- duodenoscopy (EGD) with few reported cases in the literature. In this report, we discuss a patient presenting with altered mental status, headache, and dysarthria due to brain abscess caused by S. intermedius shortly after an EGD with an esophageal biopsy showing a new diagnosis of eosinophilic esophagitis. We highlight the rare association of EGD and brain abscess, and discuss the importance of prompt diagnosis and treatment.
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38536105/osteoradionecrosis-in-a-torus-mandibularis-treated-by-antimicrobial-photodynamic-therapy-a-case-report
#39
JOURNAL ARTICLE
Maria Emília Mota, Marcia Martins Marques, Maria Stella Moreira, Nelise Alexandre da Silva Lascane
Background: Osteoradionecrosis (ORN) of the jaws is a late complication after radiotherapy to head and neck cancer. Objective: To describe a rare case of ORN of the torus mandibularis that was successfully managed exclusively with antimicrobial photodynamic therapy (aPDT). Case report: A 72-year-old man presented an exposed necrotic bone observed in the torus mandibularis, extending to the lingual alveolar ridge with no edema nor suppuration. The treatment provided a noninvasive treatment leading to spontaneous sequestrectomy of the torus in 2 weeks with complete mucosal repair in 5 weeks and absence of lesion signs and/or symptoms even after 6 months of follow-up...
March 27, 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38536064/ag-in-zn-s-alloyed-nanocrystals-as-photocatalysts-of-controlled-light-mediated-radical-polymerization
#40
JOURNAL ARTICLE
Patrycja Kowalik, Piotr Bujak, Mateusz Penkala, Anna Iuliano, Ireneusz Wielgus, Karolina Peret, Adam Pron
We report on the first case of the use of nonstoichiometric ternary (Ag-In-Zn-S) semiconductor nanocrystals as photoinitiators and photocatalysts of methyl methacrylate (MMA) polymerization. Two types of nanocrystals were tested, differing in their composition and characterized by red ( λ max = 731 nm) and green ( λ max = 528 nm) photoluminescence, respectively. Exploiting their reducing properties and capability of free radical generation we demonstrate that under ultraviolet (UV) radiation they effectively photoinitiate radical polymerization of MMA whereas under visible light (blue or green) they act as photocatalysts of living radical polymerization...
March 27, 2024: Chemical Communications: Chem Comm
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