keyword
https://read.qxmd.com/read/36499761/biologically-active-peptides-from-venoms-applications-in-antibiotic-resistance-cancer-and-beyond
#21
REVIEW
Lucía Ageitos, Marcelo D T Torres, Cesar de la Fuente-Nunez
Peptides are potential therapeutic alternatives against global diseases, such as antimicrobial-resistant infections and cancer. Venoms are a rich source of bioactive peptides that have evolved over time to act on specific targets of the prey. Peptides are one of the main components responsible for the biological activity and toxicity of venoms. South American organisms such as scorpions, snakes, and spiders are important producers of a myriad of peptides with different biological activities. In this review, we report the main venom-derived peptide families produced from South American organisms and their corresponding activities and biological targets...
December 6, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36432033/isolation-characterization-and-anticancer-activity-of-two-bioactive-compounds-from-arisaema-flavum-forssk-schott
#22
JOURNAL ARTICLE
Sobia Nisa, Yamin Bibi, Saadia Masood, Ashraf Ali, Sadia Alam, Maimoona Sabir, Abdul Qayyum, Waqas Ahmed, Sarah Alharthi, Eman Y Santali, Saif A Alharthy, Waleed M Bawazir, Majed N Almashjary
Medicinal plants play important role in the public health sector worldwide. Natural products from medicinal plants are sources of unlimited opportunities for new drug leads because of their unique chemical diversity. Researchers have focused on exploring herbal products as potential sources for the treatment of cancer, cardiac and infectious diseases. Arisaema flavum (Forssk.) is an important medicinal plant found in the northwest Himalayan regions of Pakistan. It is a poisonous plant and is used as a remedy against snake bites and scorpion stings...
November 16, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36351057/temporal-trend-and-epidemiological-profile-of-accidents-involving-venomous-animals-in-brazil-2007-2019
#23
JOURNAL ARTICLE
Tiago Cruz de Souza, Beatrice Emeli Silva Farias, Paulo Sérgio Bernarde, Francisco Chiaravalotti Neto, Djair Durand Ramalho Frade, Andreia Fernandes Brilhante, Leonardo Augusto Kohara Melchior
OBJECTIVE: to analyze the temporal trend of accidents involving venomous animals in Brazil from 2007 to 2019. METHODS: this was a cross-sectional study carried out with data from the Notifiable Health Conditions Information System (SINAN). Prais-Winsten linear regression was used for the temporal analysis. We calculated incidence rates according to sex and age group, relative risk and case fatality ratio. RESULTS: during the study period there were 2,102,657 cases of accidents involving venomous animals...
2022: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://read.qxmd.com/read/36256521/piper-longum-l-a-comprehensive-review-on-traditional-uses-phytochemistry-pharmacology-and-health-promoting-activities
#24
REVIEW
Protha Biswas, Mimosa Ghorai, Tulika Mishra, Abilash Valsala Gopalakrishnan, Debleena Roy, Abhijit Bhagwan Mane, Avinash Mundhra, Neela Das, Vikas Moreshwar Mohture, Manoj Tukaram Patil, Md Habibur Rahman, Niraj Kumar Jha, Gaber El-Saber Batiha, Suchismita Chatterjee Saha, Mahipal S Shekhawat, Radha, Manoj Kumar, Devendra Kumar Pandey, Abhijit Dey
Piper longum (family Piperaceae), commonly known as "long-pepper" or "Pippali" grows as a perennial shrub or as an herbaceous vine. It is native to the Indo-Malaya region and widely distributed in the tropical and subtropical world including the Indian subcontinent, Sri Lanka, Middle-East, and America. The fruits are mostly used as culinary spice and preservatives and are also a potent remedy in various traditional medicinal systems against bronchitis, cough, cold, snakebite, and scorpion-sting and are also used as a contraceptive...
October 18, 2022: Phytotherapy Research: PTR
https://read.qxmd.com/read/36177020/editorial-immune-responses-and-immune-mechanisms-triggered-by-snake-and-scorpion-venoms
#25
EDITORIAL
Manuela B Pucca, Denise V Tambourgi, Wuelton M Monteiro
No abstract text is available yet for this article.
2022: Frontiers in Immunology
https://read.qxmd.com/read/36162498/tako-tsubo-cardiomyopathy-in-clinical-toxinology-a-systematic-review
#26
REVIEW
Jaime Andrés Pereañez, Johan Granados, Raquel Agudelo
Tako-tsubo cardiomyopathy (TTC) is a transient left ventricular dysfunction, normally triggered by emotional or physical stress, although it is also associated with to use of drugs, drug abuse, or some intoxications. In addition, TTC has been reported in some case reports derived from the exposure of patients to animal venoms, toxins or poisons, or bacterial infections. However, to date, a systematic assessment of TTC in clinical toxinology is lacking. Therefore the aim of this study was to collect and integrate the available information about TTC in clinical toxinology...
November 2022: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/36160931/mapping-of-clinical-management-resources-for-snakebites-and-other-animal-envenomings-in-the-brazilian-amazon
#27
JOURNAL ARTICLE
Timothy P Beck, Anna Tupetz, Altair Seabra Farias, Alexandre Silva-Neto, Thiago Rocha, Emily R Smith, Felipe Murta, Flavio Santos Dourado, Deugles Cardoso, Tatyana A Ramos, André Sachett, Thiago Serrão Pinto, Manuela Berto Pucca, Vanderson Sampaio, Flavia Ramos, João Nickenig Vissoci, Jacqueline Sachett, Fan Hui Wen, Catherine A Staton, Charles J Gerardo, Wuelton Monteiro
Snakebite envenomings (SBEs) and other envenomings triggered by venomous animals (VAEs) represent a significant disease burden in Brazil, with 29,152 SBEs reported in 2021 alone with nearly half of those occurring in the remote Brazilian Amazon. In 2021, Brazil recorded 240,294 envenomings from snakes, scorpions, spiders, and caterpillars. Therefore, there is an unequal distribution of SBEs with high morbidity and mortality in the Brazilian Amazon. The severity of SBEs increases when patients require more than 6 h to access antivenom treatment, a common issue for the rural and indigenous populations...
December 2022: Toxicon: X
https://read.qxmd.com/read/36060778/evaluation-of-the-biotechnological-potential-of-peptide-cupiennin-1a-and-analogs
#28
JOURNAL ARTICLE
Rayssa Oliveira Araújo, Michel Lopes Leite, Thais Tavares Baraviera Dutra, Nicolau Brito da Cunha, Taia Maria Berto Rezende, Marcelo Henrique Soller Ramada, Simoni Campos Dias
Antimicrobial peptides (AMPs) are components in the innate immune system of various organisms, and many AMPs can be found in poisons from animals such as spiders, scorpions, and snakes. The peptide Cupiennin-1a is present in the venom of the spider Cupiennius salei and belongs to a group of peptides called cupiennins. The peptide demonstrated high cytotoxic activity against mammalian cells; thus, aiming to solve this problem, seven analogs were designed (R1a, R1b, R2b, R3b, R6b, R8b, and R10b) based on the primary structure of the peptide Cupiennin 1a, reducing its size and substituting some amino acid residues...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/35979070/-skimmia-anquetilia-n-p-taylor-and-airy-shaw-rutaceae-a-critical-appriasal-of-its-ethnobotanical-and-pharmacological-activities
#29
REVIEW
Masarat Nabi, Nahida Tabassum, Bashir Ahmad Ganai
Skimmia anquetilia N.P. Taylor and Airy Shaw (Rutaceae) is a perennial, aromatic, gregarious wild ornamental shrub native to the Western Himalaya. The plant is used in the traditional medicinal system to treat copious health conditions like rheumatism, fever, inflammation, headache, influenza, body-ache, clearing of the nose, diabetes, lowering the body temperature, smallpox, wounds, burns, snake, and scorpion bites. Phytochemical and gas chromatography-mass spectrometer (GC-MS) analysis of S. anquetilia showed the presence of alkanes, alkenes, carboxylic acids, fatty acids, and their esters, simple coumarins, terpenes, phenylpropanoid, and so on...
2022: Frontiers in Plant Science
https://read.qxmd.com/read/35883544/molecular-characterization-of-kunitz-type-protease-inhibitors-from-blister-beetles-coleoptera-meloidae
#30
JOURNAL ARTICLE
Emiliano Fratini, Marianna Nicoletta Rossi, Lucrezia Spagoni, Alessandra Riccieri, Emiliano Mancini, Fabio Polticelli, Marco Alberto Bologna, Paolo Mariottini, Manuela Cervelli
Protease inhibitors are widely studied since the unrestricted activity of proteases can cause extensive organ lesions. In particular, elastase activity is involved in the pathophysiology of acute lung injury, for example during SARS-CoV-2 infection, while serine proteases and thrombin-like proteases are involved in the development and/or pathology of the nervous system. Natural protease inhibitors have the advantage to be reversible and with few side effects and thus are increasingly considered as new drugs...
July 15, 2022: Biomolecules
https://read.qxmd.com/read/35865537/mast-cell-and-basophil-granule-proteases-in-vivo-targets-and-function
#31
REVIEW
Lars Hellman, Srinivas Akula, Zhirong Fu, Sara Wernersson
Proteases are stored in very large amounts within abundant cytoplasmic granules of mast cells (MCs), and in lower amounts in basophils. These proteases are stored in their active form in complex with negatively charged proteoglycans, such as heparin and chondroitin sulfate, ready for rapid release upon MC and basophil activation. The absolute majority of these proteases belong to the large family of chymotrypsin related serine proteases. Three such enzymes are found in human MCs, a chymotryptic enzyme, the chymase, a tryptic enzyme, the tryptase and cathepsin G...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35838213/traditonal-uses-pharmacological-and-phytochemical-studies-of-euphorbia-a-review
#32
JOURNAL ARTICLE
Smail Amtaghri, Mourad Akdad, Miloudia Slaoui, Mohamed Eddouks
ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the genus Euphorbia have long been used as traditional medicine in China, Europe, America, Turkey, India, Africa, Iran, and Pakistan for their great medicinal value and health benefits. Their stems, leaves, roots, latex are widely used to treat respiratory infections, body and skin irritations, digestive disorders, inflammatory infections, body pain, snake or scorpion bites, pregnancy, sensory disturbances, microbial and anti-cancer diseases. OBJECTIVE: This review aimed to provide updated information on the genus Euphorbia, including traditional medicinal uses, valuation and exploitation of medicinal plants, phytochemistry, botanical characterization, pharmacological and toxicological research focused on the medicinal properties of several Euphorbias in particular their antibacterial, anti-tumor, and cell manifestations, in addition to the effect of each isolated bioactive molecule from these species and their pharmacological use including preclinical evaluation of new drugs...
July 13, 2022: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/35830166/trend-in-the-incidence-rates-of-accidents-with-venomous-animals-in-children-and-adolescents-in-brazil-2007-2019
#33
JOURNAL ARTICLE
Thais Cláudia Roma de Oliveira Konstantyner, Camila Bertini Martins, Aécio Flávio Teixeira de Góis, Braian Valério Cassiano de Castro, Tulio Konstantyner
OBJECTIVE: To estimate the temporal trend of the incidence rates of accidents with venomous animals in children and adolescents in Brazil. METHODS: An ecological time-series study was carried out between 2007 and 2019. Data were obtained from the Brazilian Information System on Diseases of Compulsory Declaration (Sistema de Informação de Agravos de Notificação - SINAN). The time series of incidence rates of accidents with venomous animals were stratified by age group (children aged 0 to 9 years and adolescents aged 10 to 19 years), Brazilian macro-regions (North, Northeast, Midwest, Southeast, and South), and type of accident (snake, scorpion, spider, and caterpillar)...
2022: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/35803876/antivenoms-hepatitis-b-vaccine-and-oral-polio-vaccine-can-be-considered-for-storage-and-handling-outside-the-cold-chain-following-the-innovative-controlled-temperature-chain-approach
#34
JOURNAL ARTICLE
Shereen H Mohamed, Osama A Hady, Mona T Kashef, Hamdallah Zedan
Possible applicability of controlled temperature chain (CTC) for selected antisera and vaccines was evaluated. Bivalent oral polio vaccine (OPV), hepatitis B vaccine (HepB vaccine; monovalent and combined) and antisera (lyophilized and liquid scorpion-antivenom and liquid snake-antivenom) were tested. Samples were stored at accelerated (35 ± 5 °C) and freezing (-25 ± 5 °C) conditions for 24 h, one week and one month in addition to recommended storage condition (2-8 °C), except OPV samples that were tested at accelerated and refrigerated (2-8 °C) conditions compared to recommended storage conditions (-25 ± 5 °C)...
July 5, 2022: Biologicals: Journal of the International Association of Biological Standardization
https://read.qxmd.com/read/35723756/animal-venoms-as-a-source-of-antiviral-peptides-active-against-arboviruses-a-systematic-review
#35
REVIEW
William Gustavo Lima, César Quadros Maia, Thayane Santos de Carvalho, Gustavo Oliveira Leite, Júlio César Moreira Brito, Isabella Piassi Dias Godói, Maria Elena de Lima, Jaqueline Maria Siqueira Ferreira
Arthropod-borne viruses (arboviruses), such as Zika virus (ZIKV), chikungunya virus (CHIKV), dengue virus (DENV), yellow fever virus (YFV), and West Nile virus (WNV), are pathogens of global importance. Therefore, there has been an increasing need for new drugs for the treatment of these viral infections. In this context, antimicrobial peptides (AMPs) obtained from animal venoms stand out as promising compounds because they exhibit strong antiviral activity against emerging arboviral pathogens. Thus, we systematically searched and critically analyzed in vitro and in vivo studies that evaluated the anti-arbovirus effect of peptide derivatives from toxins produced by vertebrates and invertebrates...
June 20, 2022: Archives of Virology
https://read.qxmd.com/read/35640874/modern-venomics-current-insights-novel-methods-and-future-perspectives-in-biological-and-applied-animal-venom-research
#36
JOURNAL ARTICLE
Bjoern M von Reumont, Gregor Anderluh, Agostinho Antunes, Naira Ayvazyan, Dimitris Beis, Figen Caliskan, Ana Crnković, Maik Damm, Sebastien Dutertre, Lars Ellgaard, Goran Gajski, Hannah German, Beata Halassy, Benjamin-Florian Hempel, Tim Hucho, Nasit Igci, Maria P Ikonomopoulou, Izhar Karbat, Maria I Klapa, Ivan Koludarov, Jeroen Kool, Tim Lüddecke, Riadh Ben Mansour, Maria Vittoria Modica, Yehu Moran, Ayse Nalbantsoy, María Eugenia Pachón Ibáñez, Alexios Panagiotopoulos, Eitan Reuveny, Javier Sánchez Céspedes, Andy Sombke, Joachim M Surm, Eivind A B Undheim, Aida Verdes, Giulia Zancolli
Venoms have evolved >100 times in all major animal groups, and their components, known as toxins, have been fine-tuned over millions of years into highly effective biochemical weapons. There are many outstanding questions on the evolution of toxin arsenals, such as how venom genes originate, how venom contributes to the fitness of venomous species, and which modifications at the genomic, transcriptomic, and protein level drive their evolution. These questions have received particularly little attention outside of snakes, cone snails, spiders, and scorpions...
May 18, 2022: GigaScience
https://read.qxmd.com/read/35571136/editorial-venoms-and-toxins-functional-omics-and-pharmacological-insights
#37
EDITORIAL
Choo Hock Tan, Kae Yi Tan, Timothy N W Jackson
No abstract text is available yet for this article.
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35538287/comparative-study-of-the-effect-of-snake-venoms-on-the-growth-of-ciliates-tetrahymena-pyriformis-identification-of-venoms-with-high-antiprotozoal-activity
#38
JOURNAL ARTICLE
E G Cheremnykh, A V Osipov, V G Starkov, Nguyen Thi Thuy Trang, Nguyen Cuu Khoa, Hoang Ngoc Anh, Le Tien Dung, V I Tsetlin, Yu N Utkin
To search for compounds with antiprotozoal activity, effects of snake venoms on the ciliates Tetrahymena pyriformis was studied. T. pyriformis from subkingdom of Protozoa, including the protozoal pathogens, was used as a model organism to select the venoms that are the most active against parasitic protozoans. Various concentrations of venoms were added to the cells, and the cells that survived after 24 h were counted. Among the six snake species from the Viperidae family, the venom of the viper Vipera berus, which completely killed the cells at 49 μg/mL, was the most active...
April 2022: Doklady. Biochemistry and Biophysics
https://read.qxmd.com/read/35461625/north-american-envenomation-syndromes
#39
REVIEW
George P Warpinski, Anne-Michelle Ruha
This review discusses the distinct envenomation syndromes produced by North American species of snakes and arthropods, specifically the Crotalinae subfamily of snakes, which includes cottonmouths, copperheads, and rattlesnakes; coral snakes; Latrodectus and Loxosceles species of arachnid; and Centruroides sculpturatus, the only species of North American scorpion capable of producing an envenomation syndrome. The authors discuss the epidemiology, pathophysiology, and presentation of these syndromes and emphasize the varying degrees to which these syndromes can manifest clinically...
May 2022: Emergency Medicine Clinics of North America
https://read.qxmd.com/read/35448857/the-enzymatic-core-of-scorpion-venoms
#40
JOURNAL ARTICLE
Gustavo Delgado-Prudencio, Jimena I Cid-Uribe, J Alejandro Morales, Lourival D Possani, Ernesto Ortiz, Teresa Romero-Gutiérrez
Enzymes are an integral part of animal venoms. Unlike snakes, in which enzymes play a primary role in envenomation, in scorpions, their function appears to be ancillary in most species. Due to this, studies on the diversity of scorpion venom components have focused primarily on the peptides responsible for envenomation (toxins) and a few others (e.g., antimicrobials), while enzymes have been overlooked. In this work, a comprehensive study on enzyme diversity in scorpion venoms was performed by transcriptomic and proteomic techniques...
March 31, 2022: Toxins
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