keyword
MENU ▼
Read by QxMD icon Read
search

Scorpion snake

keyword
https://www.readbyqxmd.com/read/30084433/receptor-variability-driven-evolution-of-snake-toxins
#1
Xian-Hong Ji, Shang-Fei Zhang, Bin Gao, Shun-Yi Zhu
Three-finger toxins (TFTs) are well-recognized non-enzymatic venom proteins found in snakes. However, although TFTs exhibit accelerated evolution, the drivers of this evolution remain poorly understood. The structural complexes between long-chain α-neurotoxins, a subfamily of TFTs, and their nicotinic acetylcholine receptor targets have been determined in previous research, providing an opportunity to address such questions. In the current study, we observed several previously identified positively selected sites (PSSs) and the highly variable C-terminal loop of these toxins at the toxin/receptor interface...
November 18, 2018: Zoological Research
https://www.readbyqxmd.com/read/30083468/venomix-a-simple-bioinformatic-pipeline-for-identifying-and-characterizing-toxin-gene-candidates-from-transcriptomic-data
#2
Jason Macrander, Jyothirmayi Panda, Daniel Janies, Marymegan Daly, Adam M Reitzel
The advent of next-generation sequencing has resulted in transcriptome-based approaches to investigate functionally significant biological components in a variety of non-model organism. This has resulted in the area of "venomics": a rapidly growing field using combined transcriptomic and proteomic datasets to characterize toxin diversity in a variety of venomous taxa. Ultimately, the transcriptomic portion of these analyses follows very similar pathways after transcriptome assembly often including candidate toxin identification using BLAST, expression level screening, protein sequence alignment, gene tree reconstruction, and characterization of potential toxin function...
2018: PeerJ
https://www.readbyqxmd.com/read/30042318/application-of-metabolomic-tools-for-studying-low-molecular-weight-fraction-of-animal-venoms-and-poisons
#3
REVIEW
Agnieszka Klupczynska, Magdalena Pawlak, Zenon J Kokot, Jan Matysiak
Both venoms and poisonous secretions are complex mixtures that assist in defense, predation, communication, and competition in the animal world. They consist of variable bioactive molecules, such as proteins, peptides, salts and also metabolites. Metabolomics opens up new perspectives for the study of venoms and poisons as it gives an opportunity to investigate their previously unexplored low molecular-weight components. The aim of this article is to summarize the available literature where metabolomic technologies were used for examining the composition of animal venoms and poisons...
July 24, 2018: Toxins
https://www.readbyqxmd.com/read/30028493/antivenom-use-in-bite-and-sting-cases-presenting-to-a-public-hospital
#4
Aynur Şahin, Mualla Aylin Arıcı, Nil Hocaoğlu, Şule Kalkan, Yeşim Tunçok
BACKGROUND: To evaluate the distribution of bite and sting cases presenting to a district public hospital and the use of antivenom in scorpion sting and snake bite cases. METHODS: The demographic characteristics of patients with bites/stings reporting to a public hospital in 2014, the agent involved, the season of reporting, severity of clinical findings during presentation, and use of antivenom in scorpion sting and snake bite cases were evaluated retrospectively...
July 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29956608/hyaluronidases-a-therapeutic-enzyme
#5
Naqab Khan, Zahid Rasul Niazi, Fazlur Rehman, Anam Akhtar, Maryam Muhammad Khan, Samiullah Khan, Sheraz Khan
BACKGROUND: Hyaluronidase is the most important enzyme found in the interstitial matrix, effectively degrading the hyaluronic acid. Hyaluronidases are extensively found in the venom of various animals such as snake, scorpion, spider and others. Up till now five venom hyaluronidases are identified with a defined three-dimensional structure. These enzymes are involved in different biochemical, physiological and pathological conditions like degradation of hyaluronic acid, embryogenesis, transmembrane diffusion of drugs and toxins, inflammatory and allergic response to antigens, healing of wounds, bacterial meningitis, bacteremia and pneumonia...
June 29, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29956606/potential-uses-of-venom-proteins-in-treatment-of-hiv
#6
Bushra Uzair, Rabia Bushra, Barkat Ali Khan, Sarwat Zareen, Fehmida Fasim
BACKGROUND: For about 30 years Human Immunodeficiency Virus (HIV) has been a significant social and health issue. It has been a perilous opponent in the human contest against HIV. At the end of 2015 there were 26.7 million people worldwide who were affected by the Human Immunodeficiency Virus (HIV) and this number is expected to increase. Unfortunately, currently there are no vaccines available for prevention and control of HIV. The global burden of HIV articulates the need for anti-HIV therapeutic factors...
June 28, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921759/evaluating-the-performance-of-de-novo-assembly-methods-for-venom-gland-transcriptomics
#7
Matthew L Holding, Mark J Margres, Andrew J Mason, Christopher L Parkinson, Darin R Rokyta
Venom-gland transcriptomics is a key tool in the study of the evolution, ecology, function, and pharmacology of animal venoms. In particular, gene-expression variation and coding sequences gained through transcriptomics provide key information for explaining functional venom variation over both ecological and evolutionary timescales. The accuracy and usefulness of inferences made through transcriptomics, however, is limited by the accuracy of the transcriptome assembly, which is a bioinformatic problem with several possible solutions...
June 19, 2018: Toxins
https://www.readbyqxmd.com/read/29921195/simulation-studies-and-dynamic-interaction-of-venom-peptides-with-ion-channels
#8
Naqab Khan, Zahid Rasul Niazi, Nauman Rahim Khan, Kifayatullah Shah, Khurram Rehman, Abdul Wahab, Samiullah Khan
BACKGROUND: Arthropods such as scorpion, snake, insects, and spider as well as the marine animals like sea anemone and cone snails are venomous animals producing venoms with a complex mixture of peptide, poly peptides and small proteins. The disulfide rich peptides isolated from these animals are potent substances which specifically and selectively modulate different ion channels. The significant characteristics of these distinctive pharmacologically potent compounds highlights the molecular details of their peptide-ion channels interactions as well as provides the opportunities for the development of novel and natural therapeutic agents to treat various diseases including neurological disorders also...
June 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29894720/ltb-4-and-pge-2-modulate-the-release-of-mip-1%C3%AE-and-il-1%C3%AE-by-cells-stimulated-with-bothrops-snake-venoms
#9
Karina F Zoccal, Giovana Z Ferreira, Morgana K B Prado, Luiz G Gardinassi, Suely V Sampaio, Lúcia H Faccioli
Envenomation by Bothrops snakes promotes the release of inflammatory mediators, whose effects during this context are not well understood. These mediators include chemokines, cytokines and eicosanoids. Indeed, Bothrops snake envenomation results in local and systemic perturbations, including leukocyte recruitment, edema, pain and extensive tissue damage. Recently, our group demonstrated that leukotriene B4 (LTB4 ) and prostaglandin E2 (PGE2 ) regulate macrophage production of interleukin-1β (IL-1β) induced by scorpion venom...
August 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29875536/snake-venom-use-as-a-substitute-for-opioids-a-case-report-and-review-of-literature
#10
Aseem Mehra, Debashish Basu, Sandeep Grover
The mind-altering agents such as tobacco, cannabis, and opium have been widely used since the evolution of human being. These substances have been widely used for recreational purposes. However, derivatives from reptiles such as snakes, reptiles, and scorpions can also be used for recreational purposes and as a substitute for other substances. Their use is rare and related literature is very scanty. In this report, we present a case of snake venom abuse and review the existing literature.
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29751894/potential-effects-of-climate-change-on-the-risk-of-accidents-with-poisonous-species-of-the-genus-tityus-scorpiones-buthidae-in-argentina
#11
Pablo Ariel Martinez, Mayane Alves Andrade, Claudio Juan Bidau
The temporal pattern of co-occurrence of human beings and venomous species (scorpions, spiders, snakes) is changing. Thus, the temporal pattern of areas with risk of accidents with such species tends to become dynamic in time. We analyze the areas of occurrence of species of Tityus in Argentina and assess the impact of global climate change on their area of distribution by the construction of risk maps. Using data of occurrence of the species and climatic variables, we constructed models of species distribution (SMDs) under current and future climatic conditions...
June 2018: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/29733320/harvesting-venom-toxins-from-assassin-bugs-and-other-heteropteran-insects
#12
Andrew Allan Walker, Max Rosenthal, Eivind E A Undheim, Glenn F King
Heteropteran insects such as assassin bugs (Reduviidae) and giant water bugs (Belostomatidae) descended from a common predaceous and venomous ancestor, and the majority of extant heteropterans retain this trophic strategy. Some heteropterans have transitioned to feeding on vertebrate blood (such as the kissing bugs, Triatominae; and bed bugs, Cimicidae) while others have reverted to feeding on plants (most Pentatomomorpha). However, with the exception of saliva used by kissing bugs to facilitate blood-feeding, little is known about heteropteran venoms compared to the venoms of spiders, scorpions and snakes...
April 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29547537/toxins-in-drug-discovery-and-pharmacology
#13
EDITORIAL
Steve Peigneur, Jan Tytgat
Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as a new emerging source of peptide-based therapeutics.
March 16, 2018: Toxins
https://www.readbyqxmd.com/read/29527170/animal-toxins-as-therapeutic-tools-to-treat-neurodegenerative-diseases
#14
REVIEW
Jessica M de Souza, Bruno D C Goncalves, Marcus V Gomez, Luciene B Vieira, Fabiola M Ribeiro
Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for effective drugs an urgent need. Neurodegeneration is triggered by the activation of several cellular processes, including oxidative stress, mitochondrial impairment, neuroinflammation, aging, aggregate formation, glutamatergic excitotoxicity, and apoptosis. Therefore, many research groups aim to identify drugs that may inhibit one or more of these events leading to neuronal cell death...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29302018/injuries-and-envenomation-by-exotic-pets-in-hong-kong
#15
V Ch Ng, A Ch Lit, O F Wong, M L Tse, H T Fung
INTRODUCTION: Exotic pets are increasingly popular in Hong Kong and include fish, amphibians, reptiles, and arthropods. Some of these exotic animals are venomous and may cause injuries to and envenomation of their owners. The clinical experience of emergency physicians in the management of injuries and envenomation by these exotic animals is limited. We reviewed the clinical features and outcomes of injuries and envenomation by exotic pets recorded by the Hong Kong Poison Information Centre...
February 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29021149/the-envenomation-of-general-physiology-throughout-the-last-century
#16
REVIEW
Jon T Sack
Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders. For physiologists, toxins are integral chemical tools that hijack life's fundamental processes with remarkable molecular specificity. Our understanding of electrophysiological phenomena has been transformed time and time again with the help of some terrifying toxins...
November 6, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28790503/mast-cells-and-ige-can-enhance-survival-during-innate-and-acquired-host-responses-to-venoms
#17
REVIEW
Stephen J Galli, Philipp Starkl, Thomas Marichal, Mindy Tsai
Mast cells and immunoglobulin E (IgE) antibodies are thought to promote health by contributing to host responses to certain parasites, but other beneficial functions have remained obscure. Venoms provoke innate inflammatory responses and pathology reflecting the activities of the contained toxins. Venoms also can induce allergic sensitization and development of venom-specific IgE antibodies, which can predispose some subjects to exhibit anaphylaxis upon subsequent exposure to the relevant venom. We found that innate functions of mast cells, including degradation of venom toxins by mast cell-derived proteases, enhanced survival in mice injected with venoms from the honeybee, two species of scorpion, three species of poisonous snakes, or the Gila monster...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28689025/venom-derived-peptide-inhibitors-of-voltage-gated-potassium-channels
#18
REVIEW
Raymond S Norton, K George Chandy
Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade...
December 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28647179/euphorbia-neriifolia-l-review-on-botany-ethnomedicinal-uses-phytochemistry-and-biological-activities
#19
REVIEW
Prashant Y Mali, Shital S Panchal
The present review is intended to provide information on botany, ethnomedicinal uses, phytochemistry and biological activities of various parts of Euphorbia neriifolia (E. neriifolia). E. neriifolia has several ethnomedicinal uses. The latex of E. neriifolia is used as laxative, purgative, rubefacient, carminative and expectorant as well as in treatment of whooping cough, gonorrhoea, leprosy, asthma, dyspepsia, jaundice, enlargement of the spleen, tumours, stone in the bladder, abdominal troubles and leucoderma...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28562767/infrared-thermography-to-diagnose-and-manage-venomous-animal-bites-and-stings
#20
Carlos Roberto de Medeiros, Marcos Leal Brioschi, Solange Nogueira de Souza, Manoel Jacobsen Teixeira
INTRODUCTION: Infrared imaging (IR) is a noninvasive technique that quantifies body surface temperature, producing a digital color image. IR has been used to study diseases in which skin temperature can reflect the presence of inflammation. METHODS: This was an observational pilot study of eight patients envenomed by snakes, spiders, and scorpions. All patients were examined using a thermal camera. RESULTS: In all cases, we obtained infrared images that corroborated clinical findings indicating localized effects of venom, specifically inflammation...
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
keyword
keyword
159314
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"