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Acetic acid induced colitis

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https://www.readbyqxmd.com/read/30408459/the-possible-ameliorative-effect-of-simvastatin-versus-sulfasalazine-on-acetic-acid-induced-ulcerative-colitis-in-adult-rats
#1
Nema A Soliman, Walaa A Keshk, Fatma H Rizk, Marwa A A Ibrahim
OBJECTIVE: Inflammatory bowel diseases (IBD) are chronic and recurrent disorders of the gastrointestinal tract with unknown etiology and have two major forms, ulcerative colitis (UC) and Crohn diseases. In view of the adverse effects and incomplete efficacy of currently administered drugs, it is essential to investigate new and harmless drugs with more desirable beneficial effects. Statins have many additional pleiotropic effects other than their lipid-lowering effect. This study aims to investigate the role of simvastatin (SIM) at different doses against induced UC in rats...
November 5, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/30345233/protective-effect-of-mumiju-against-acetic-acid-induced-ulcerative-colitis-in-rats
#2
Nadar Shahrokhi, Zakieh Keshavarzi, Mohammad Khaksari Haddad, Fereshteh Amirafzali, Shahriar Dabiri, Nava Shahrokhi
Objective: In this study, we elucidated the ameliorative effect of aqueous extract of leaves of Mumiju against acetic acid-induced experimental colitis in male rats. Materials and Methods: The animals were randomly divided into four groups (n=7) including I: control group, II: vehicle group (injected with 2 ml acetic acid (4%) intra rectally), III and IV: treatment groups which received Mumiju (250 mg/kg) orally or intraperitoneally for 4 consecutive days after ulcer induction...
September 2018: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/30318564/involvement-of-central-opioid-receptors-in-protective-effects-of-methadone-on-experimental-colitis-in-rats
#3
Nahid Fakhraei, Nina Javadian, Reza Rahimian, Fatemeh Nili, Nastaran Rahimi, Shiva Hashemizadeh, Ahmad Reza Dehpour
PURPOSE: There are several lines of evidence on the protective roles of opioids in gastrointestinal inflammatory conditions. This study aims to distinguish the central and peripheral roles of methadone, a non-selective opioid receptor agonist, in an acute model of ulcerative colitis in male rats. METHODS: Ulcerative colitis was induced by intrarectal administration of acetic acid 4%. Methadone was injected subcutaneously (s.c.), 5 and 10 mg/kg, and intracerebroventricular (i...
October 15, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/30166899/anti-ulcerogenic-and-anti-ulcerative-colitis-uc-activities-of-seven-amines-derivatives
#4
Amani S Awaad, Ahmed M Alafeefy, Fatmah A S Alasmary, Reham M El-Meligy, Saleh I Alqasoumi
The Novel target compounds (CP-1-7) were synthesized and tested at doses up to 1000 mg/kg for their entitled activities. They exerted promising results without any behavioral changes and mortality in mice. Therefore, according to the results obtained in our study, it could be categorized as highly safe agents for treating UC since substances possessing LD50 higher than 50 mg/kg are considered nontoxic. They also possessed a potent anti-ulcerogenic activity with different potentials. The most effective compound was CP-4, it produced 97...
December 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30089249/treatment-with-trichilia-catigua-ethyl-acetate-fraction-improves-healing-and-reduces-oxidative-stress-in-tnbs-induced-colitis-in-rats
#5
Fernando Augusto Vicentini, Maiara Morselli Coelho Barbosa, Maísa Carla Fortunato, Ciomar Aparecida Bersani Amado, Jurandir Fernando Comar, Renata Longhini, João Carlos Palazzo de Mello, Maria Raquel Marçal Natali
Beverages containing Trichilia catigua are commonly employed in folk medicine. T. catigua bark extracts possess antioxidant, anti-inflammatory, and bactericidal properties. These properties suggest T. catigua bark extracts as a potential treatment for inflammatory bowel diseases (IBD). Using the 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced model of colitis in rats we evaluated the effect of an ethyl-acetate fraction (EAF) of T. catigua (200 mg/kg) administered by daily oral gavage or intrarectally at different time points after TNBS challenge...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30042998/effects-of-dietary-tryptophan-supplementation-in-the-acetic-acid-induced-colitis-mouse-model
#6
Shuai Chen, Meiwei Wang, Lanmei Yin, Wenkai Ren, Peng Bin, Yaoyao Xia, Gang Liu, Huansheng Yang, Bie Tan, Yulong Yin
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and is strongly associated with intestinal immunity and the microbiome. Tryptophan (Trp) is an inflammatory inhibitor and modulator of the intestinal microflora. We explored the serum profile of amino acids and the effects of diet supplementation with Trp (1.0 g kg-1) on intestinal immunity and microbiota in the acetic acid-induced colitis mouse model. We analyzed the survival rate, colonic morphological parameters, profiles of serum amino acids, microbiota in colonic contents and the relative gene abundance of intestinal proinflammatory cytokines...
August 15, 2018: Food & Function
https://www.readbyqxmd.com/read/30002711/pretreatment-with-obestatin-inhibits-the-development-of-acetic-acid-induced-colitis-in-rats
#7
Aleksandra Matuszyk, Piotr Ceranowicz, Zygmunt Warzecha, Jakub Cieszkowski, Krystyna Gałązka, Joanna Bonior, Jolanta Jaworek, Peter Christopher Konturek, Krzysztof Gil, Artur Dembiński
Introduction: Obestatin is a 23-amino acid peptide derived from proghrelin, a common prohormone for ghrelin and obestatin. Previous studies have shown that obestatin exhibits some protective and therapeutic effects in the pancreas and stomach. The aim of this study was to examine the effect of pretreatment with obestatin on the development of acetic acid-induced colitis. Material and methods: Studies were performed on Wistar rats. Before induction of colitis, rats were treated intraperitoneally with saline or obestatin, administered twice at a dose of 4, 8 or 16 nmol/kg/dose...
June 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29958056/fresh-fruit-juice-of-opuntia-dillenii-haw-attenuates-acetic-acid-induced-ulcerative-colitis-in-rats
#8
S Babitha, K Bindu, Taj Nageena, V P Veerapur
The present study aimed to evaluate the protective effect of fresh fruit juice of Opuntia dillenii Haw. (FJOD) on acetic acid-induced ulcerative colitis in rats. Fresh FJOD (2.5 and 5 ml/kg) and sulfasalazine (100 mg/kg) were given orally for seven consecutive days prior to colitis induction on the eighth day by intrarectal acetic acid (4% v/v) administration. Macroscopic, clinical activity scoring, biochemical, and histopathological examinations of colon were used to assess colonic damage. FJOD and sulfasalazine treatment significantly attenuated the macroscopic damage, clinical activity score, and wet weight of the colon when compared to disease control and further showed significantly reduced levels of myeloperoxidase, malondialdehyde, and serum lactate dehydrogenase and enhanced colonic levels of reduced glutathione...
June 29, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29895146/camellia-oil-camellia-oleifera-abel-modifies-the-composition-of-gut-microbiota-and-alleviates-acetic-acid-induced-colitis-in-rats
#9
Wei-Ting Lee, Yu-Tang Tung, Chun-Ching Wu, Pang-Shuo Tu, Gow-Chin Yen
Ulcerative colitis (UC), one type of chronic inflammatory bowel disease (IBD), is a chronic and recurrent disorder of the gastrointestinal (GI) tract. As camellia oil (CO) is traditionally used to treat GI disorders, this study investigated the role of CO on acetic acid-induced colitis in the rat. The composition of the gut microbial community is related to many diseases; thus, this study also investigated the effects of CO on the composition of the gut microbiota. The rats were fed a dose of 2 mL/kg body weight CO, olive oil (OO), or soybean oil (SO) once a day for 20 days, and the gut microbiota was analyzed using 16S rRNA gene sequencing...
July 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29879761/the-protective-effect-of-melissa-officinalis-l-in-visceral-hypersensitivity-in-rat-using-2-models-of-acid-induced-colitis-and-stress-induced-irritable-bowel-syndrome-a-possible-role-of-nitric-oxide-pathway
#10
Fatemeh Dolatabadi, Amir H Abdolghaffari, Mohammad H Farzaei, Maryam Baeeri, Fatemeh S Ziarani, Majid Eslami, Mohammad Abdollahi, Roja Rahimi
Background/Aims: The aim of present study is to estimate the effects of Melissa officinalis L. (MO) on visceral hypersensitivity (VH), defecation pattern and biochemical factors in 2 experimental models of irritable bowel syndrome (IBS) and the possible role of nitric oxide. Methods: Two individual models of IBS were induced in male Wistar-albino rats. In the acetic acid model, the animals were exposed to rectal distension and abdominal withdrawal reflex, and the defecation patterns were determined...
July 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29736689/protective-effects-of-conventional-and-colon-targeted-lycopene-and-linalool-on-ulcerative-colitis-induced-by-acetic-acid-in-rats
#11
İbrahim Ozan Tekeli, Ahmet Ateşşahin, Fatih Sakin, Abdullah Aslan, Songül Çeribaşı, Mustafa Yipel
OBJECTIVE: To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. METHODS: Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis...
May 7, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29694938/short-chain-fatty-acids-administration-is-protective-in-colitis-associated-colorectal-cancer-development
#12
Yun Tian, Qing Xu, Liqun Sun, Ying Ye, Guozhong Ji
Reduced short-chain fatty acids (SCFAs) have been reported in patients with ulcerative colitis, and increased intake of dietary fiber has shown to be clinically beneficial for colitis. Whether SCFAs suppress tumorigenesis in colitis-associated colorectal cancer remains unknown. The chemopreventive effect of SCFAs in colitis-associated colorectal cancer was evaluated in this study. Model of colitis-associated colorectal cancer in male BALB/c mice was induced by azoxymethane (AOM) and dextran sodium sulfate (DSS)...
July 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29656366/sodium-selenite-ameliorates-both-intestinal-and-extra-intestinal-changes-in-acetic-acid-induced-colitis-in-rats
#13
Samar M Soliman, Walaa Wadie, Samia A Shouman, Afaf A Ainshoka
Selenium and its derivatives including sodium selenite (sod sel) belong to the group of essential trace elements needed for proper health and nutrition. They are fairly safe and possess antioxidant and anti-inflammatory properties. The aim of present investigation was to elucidate the effect of sod sel on experimental colitis model in rats. Colitis was induced by intrarectal instillation of 4% (v/v) acetic acid. Two hours later, sod sel was given to rats on a daily basis for 15 consecutive days. Clinical symptoms, colon mass index, spleen weight inflammatory markers, hematological, biochemical, macroscopic, and histological changes were determined...
June 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29626646/cirrhosis-induced-by-bile-duct-ligation-alleviates-acetic-acid-intestinal-damages-in-rats-involvements-of-nitrergic-and-opioidergic-systems
#14
Nastaran Rahimi, Mahsa Hassanipour, Narges Sistany Allahabadi, Fatemeh Sabbaghziarani, Maryam Yazdanparast, Ahmadreza Dehpour
BACKGROUND: Colitis, a colonic inflammatory condition, showed a linkage with hepatobiliary disorders such as cirrhosis. It has been reported that both endogenous opioids and nitric oxide (NO) play critical roles in colitis pathogenesis. Moreover, opioid and NO levels showed elevation in patients with cirrhosis. The aim of this study was to evaluate the effect of cirrhosis on the experimental model of colitis and the possible involvement of opioidergic/nitrergic systems in rats. METHODS: Colitis was induced by acetic acid 28days after bile duct ligation (BDL)...
June 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29530609/protective-effect-of-sesbania-grandiflora-on-acetic-acid-induced-ulcerative-colitis-in-mice-by-inhibition-of-tnf-%C3%AE-and-il-6
#15
Rohit A Gupta, Meha N Motiwala, Ujawala N Mahajan, Sapna G Sabre
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Sesbania grandiflora (Linn) belonging to the family Fabaceae is commonly known as sesbania, agathi, and katurai. The plant is accredited for alleviating a spectrum of ailments including inflammation, colitis, diarrhea, dysentery, leprosy, gout, rheumatism, jaundice, bronchitis, convulsion and anxiety. It is also used as antitumour, anthelmintic, and laxatives in Ayurveda and Siddha system of Indian traditional medicine. AIM: To reveal protective effect of Sesbania grandiflora in acetic acid induced ulcerative colitis in mice...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29518435/ziziphus-spina-christi-fruit-extract-suppresses-oxidative-stress-and-p38-mapk-expression-in-ulcerative-colitis-in-rats-via-induction-of-nrf2-and-ho-1-expression
#16
Rafa S Almeer, Sahar M Mahmoud, Hatem K Amin, Ahmed E Abdel Moneim
In this study, we aimed to evaluate the anti-inflammatory and protective effects of Ziziphus spina-christi fruit extract (ZFE) against acetic acid (AcOH)-induced colitis in rats. Before a single AcOH instillation, ZFE (100, 200, and 400 mg/kg/day) was administered for 5 days by oral gavage. Pretreatment with ZFE at different doses suppressed the spread of inflammation and inhibited mucosal damage; in addition, it reduced ulcer size and mitigated colitis markers. Administration of ZFE (400 mg/kg) resulted in a greater reduction of inflammatory colonic injury than that after reference drug, mesalazine (MLZ), administration...
May 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29379346/novel-quinazoline-and-acetamide-derivatives-as-safe-anti-ulcerogenic-agent-and-anti-ulcerative-colitis-activity
#17
Fatmah A S Alasmary, Amani S Awaad, Ahmed M Alafeefy, Reham M El-Meligy, Saleh I Alqasoumi
Two novel quinazoline derivatives named as; 3-[(4-hydroxy-3-methoxy-benzylidene)-amino]-2- p- tolyl-3 H -quinazolin-4-one ( 5 ) and 2- p -Tolyl-3-[3,4,5-trimethoxy-benzylidene-amino]-3 H -quinazolin-4-one ( 6 ) in addition to one acetamide derivative named as 2-(2-Hydroxycarbonylphenylamino)- N -(4-aminosulphonylphenyl) 11 were synthesized, and evaluated for their anti-ulcerogenic & Anti-Ulcerative colitis activities. All of the three compounds showed curative activity against acetic acid induced ulcer model at a dose of 50 mg/kg, they produced 65%, 85% & 57...
January 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29279966/betulinic-acid-alleviates-dextran-sulfate-sodium-induced-colitis-and-visceral-pain-in-mice
#18
Jaspreet Kalra, Madhu Cholenahalli Lingaraju, Karikalan Mathesh, Dhirendra Kumar, Subhashree Parida, Thakur Uttam Singh, Anil Kumar Sharma, Dinesh Kumar, Surendra Kumar Tandan
Betulinic acid (BA) exhibits many biological effects including anti-inflammatory and anti-oxidant activities. Free radicals and pro-inflammatory mediators play an important role in the pathology of inflammatory bowel disease (IBD) and associated pain. We, therefore, examined the anti-oxidant, anti-inflammatory, and anti-nociceptive potential of BA in colitis. Colitis was induced with 3% (w/v) dextran sulfate sodium (DSS) in drinking water in mice for 1to7 days. BA (3, 10 and 30 mg/kg) was given orally for 0 to 7 days...
March 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29187079/anti-inflammatory-antioxidant-and-anti-apoptotic-activity-of-diosmin-in-acetic-acid-induced-ulcerative-colitis
#19
A S Shalkami, Mia Hassan, A G Bakr
Ulcerative colitis (UC) is a chronic inflammatory disease affecting colon. The primary symptoms of UC are diarrhoea with blood and mucus and sometimes associated with pain. AIM: This study aimed to evaluate the effects of diosmin (DIO) on UC. METHODS: UC was induced in rats by rectal administration of acetic acid (AA). The degree of mucosal ulceration and damage was determined by evaluating the disease activity index (DAI) and colon damage index scores. Inflammation, oxidative stress and apoptotic responses were determined by measuring the levels of tumour necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-II), malondialdehyde (MDA) and reduced glutathione (GSH) in addition to myeloperoxidase (MPO) activity and caspase-3 expression...
January 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29164668/ameliorative-effects-of-riboflavin-on-acetic-acid-induced-colonic-injury-in-rats
#20
Berna Karakoyun, Büşra Ertaş, Meral Yüksel, Dilek Akakın, Özge Çevik, Göksel Şener
Riboflavin (RF) has been found to be a promising antioxidant and/or anti-inflammatory agent in several studies. However, the effect of RF against acetic acid (AA)-induced colonic injury is currently unknown. This study aimed to investigate the potential antioxidant and protective effects of RF in a rat model of ulcerative colitis. Starting immediately after the colitis induction (AA+RF group) or 1 week before the colitis induction (RF+AA+RF group), the rats were treated with RF (25 mg/kg per day; p.o.) for 3 days...
June 2018: Clinical and Experimental Pharmacology & Physiology
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