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https://www.readbyqxmd.com/read/30108574/chestnut-honey-and-bacteriophage-application-to-control-pseudomonas-aeruginosa-and-escherichia-coli-biofilms-evaluation-in-an-ex-vivo-wound-model
#1
Ana Oliveira, Jéssica C Sousa, Ana C Silva, Luís D R Melo, Sanna Sillankorva
Chronic skin wounds represent a major burn both economically and socially. Pseudomonas aeruginosa and Escherichia coli are among the most common colonizers of infected wounds and are prolific biofilm formers. Biofilms are a major problem in infections due to their increasingly difficult control and eradication, and tolerance to multiple prescribed drugs. As so, alternative methods are necessary. Bacteriophages (phages) and honey are both seen as a promising approach for biofilm related infections. Phages have specificity toward a bacterial genus, species or even strain, self-replicating nature, and avoid dysbiosis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30082920/control-of-propionibacterium-acnes-by-natural-antimicrobial-substances-role-of-the-bacteriocin-as-48-and-lysozyme
#2
Rubén Cebrián, Sergio Arévalo, Susana Rubiño, Salvador Arias-Santiago, María Dolores Rojo, Manuel Montalbán-López, Manuel Martínez-Bueno, Eva Valdivia, Mercedes Maqueda
We report the high susceptibility of several clinical isolates of Propionibacterium acnes from different sources (skin, bone, wound exudates, abscess or blood contamination) to the head-to-tail cyclized bacteriocin AS-48. This peptide is a feasible candidate for further pharmacological development against this bacterium, due to its physicochemical and biological characteristics, even when it is growing in a biofilm. Thus, the treatment of pre-formed biofilms with AS-48 resulted in a dose- and time-dependent disruption of the biofilm architecture beside the decrease of bacterial viability...
August 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30075292/antibacterial-activity-of-reduced-iron-clay-against-pathogenic-bacteria-associated-with-wound-infections
#3
Katherine M Caflisch, Suzannah M Schmidt-Malan, Jayawant N Mandrekar, Melissa J Karau, Jonathan P Nicklas, Lynda B Williams, Robin Patel
Clay is a substance historically utilized by indigenous cultures for treatment of superficial wound infections. This study evaluated the effects of a clay recently identified by our group, OMT Blue Clay, against staphylococci, streptococci, Enterobacteriaceae and non-fermenting Gram-negative bacilli. The clay and its aqueous leachate were evaluated against the bacteria in biofilm and planktonic states. Time-kill studies were used to assess planktonic activity; biofilms on medical-grade Teflon discs were treated with a hydrated clay suspension or leachate...
July 31, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/30052962/erratum-chronic-pseudomonas-aeruginosa-biofilm-infection-impairs-murine-s100a8-a9-and-neutrophil-effector-cytokines-implications-for-delayed-wound-closure
#4
Hannah Trøstrup, Christian Johann Lerche, Lars Jackie Christophersen, Kim Thomsen, Peter Østrup Jensen, Hans Petter Hougen, Niels Høiby, Claus Moser
No abstract text is available yet for this article.
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/30052024/bottom-up-layer-by-layer-assembling-of-antibacterial-freestanding-nanobiocomposite-films
#5
Antonio Francesko, Kristina Ivanova, Javier Hoyo, Sílvia Pérez-Rafael, Petya Petkova, Margarida M Fernandes, Thomas Heinze, Ernest Mendoza, Tzanko Tzanov
In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions of AgNPs decorated with chitosan (CS) or aminocellulose (AC) were synthesized by applying high intensity ultrasound. These polycationic nanoentities were layer-by-layer assembled with the HA polyanion to generate stable 3D supramolecular constructs, where the biopolymer-capped AgNPs play the dual role of active agent and structural element...
August 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30038509/current-perspectives-on-diagnosis-and-management-of-sternal-wound-infections
#6
REVIEW
Erlangga Yusuf, Monica Chan, Nora Renz, Andrej Trampuz
Deep sternal wound infection (DSWI), also known as mediastinitis, is a serious and potentially fatal condition. The diagnosis and treatment of DSWI are challenging. In this current narrative review, the epidemiology, risk factors, diagnosis, and surgical and antimicrobial management of DSWI are discussed. Ideally, the management of DSWI requires early and sufficient surgical debridement and appropriate antibiotic therapy. When foreign material is present, biofilm-active antibiotic therapy is also needed. Because DSWI is often complex, the management requires the involvement of a multidisciplinary team consisting of cardiothoracic surgeons, plastic surgeons, intensivists, infectious disease specialists, and clinical microbiologists...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/30028372/the-effect-of-vacuum-assisted-closure-therapy-on-methicillin-resistant-staphylococcus-aureus-wound-biofilms
#7
Ivana Ćirković, Dario Jocić, Dragana D Božić, Slobodanka Djukić, Neda Konstantinović, Djordje Radak
Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P < ...
August 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/30019635/urinary-bladder-matrix-protects-host-from-bacterial-induced-lung-infection
#8
Chen Chen, Xiaoping Zhang, Qiao Lin, Nathaniel Remlinger, Thomas W Gilbert, Y Peter Di
The extracellular matrix (ECM) is composed of a complex mixture of structural and functional macromolecules that are important during growth, development, and wound repair. In this study, we seek to determine if an ECM derived from the porcine urinary bladder, specifically urinary bladder matrix (UBM), can act to prevent bacterial infection in the context of lung injury. Here, we examined a digested form of UBM, which prevented bacterial biofilm formed by both Gram-positive bacteria (GPB) such as methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria (GNB) including Pseudomonas aeruginosa (PA) and Klebsiella pneumoniae (KP) in vitro...
July 18, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30018606/a-novel-silver-bioactive-glass-elicits-antimicrobial-efficacy-against-pseudomonas-aeruginosa-and-staphylococcus-aureus-in-an-ex-vivo-skin-wound-biofilm-model
#9
Holly N Wilkinson, Sammi Iveson, Paul Catherall, Matthew J Hardman
Biofilm infection is now understood to be a potent contributor to the recalcitrant nature of chronic wounds. Bacterial biofilms evade the host immune response and show increased resistance to antibiotics. Along with improvements in antibiotic stewardship, effective new anti-biofilm therapies are urgently needed for effective wound management. Previous studies have shown that bioactive glass (Bg) is able to promote healing with moderate bactericidal activity. Here we tested the antimicrobial efficacy of a novel BG incorporating silver (BgAg ), against both planktonic and biofilm forms of the wound-relevant bacteria Pseudomonas aeruginosa and Staphylococcus aureus ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30015553/postoperative-infections-following-cochlear-implant-surgery
#10
Lilian Bostlund Olsen, Sára Larsen, Jens Højberg Wanscher, Christian Emil Faber, Jonas Jeppesen
INTRODUCTION: The aim of this study was to report the frequency and management of postoperative wound infections and to investigate bacteriology and biofilm formation following 653 consecutive cochlear implantations in adults. METHODS: A retrospective file review of 653 consecutive adult cochlear implantations between 1994 and 2015 at the Department of Otorhinolaryngology at Odense University Hospital. A reporting consensus was used to classify infections. RESULTS: The major and minor infection rates were 2% and 8%, respectively...
July 17, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/30013112/the-consequences-of-biofilm-dispersal-on-the-host
#11
Derek Fleming, Kendra Rumbaugh
Chronic infections are often associated with the presence of a biofilm, a community of microorganisms coexisting within a protective matrix of extracellular polymeric substance. Living within a biofilm can make resident microbes significantly more tolerant to antibiotics in comparison to planktonic, free-floating cells. Thus, agents that can degrade biofilms are being pursued for clinical applications. While biofilm degrading and dispersing agents may represent attractive adjunctive therapies for biofilm-associated chronic infections, very little is known about how the host responds to the sudden dispersal of biofilm cells...
July 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30003536/the-role-of-the-microbiome-in-nonhealing-diabetic-wounds
#12
REVIEW
Lindsay R Kalan, Meghan B Brennan
Wound healing is a highly coordinated and complex process, and there can be devastating consequences if it is interrupted. It is believed that, in combination with host factors, microorganisms in a wound bed can not only impair wound healing but can lead to stalled, chronic wounds. It is hypothesized that the wound microbiota persists in chronic wounds as a biofilm, recalcitrant to antibiotic and mechanical intervention. Cultivation-based methods are the gold standard for identification of pathogens residing in wounds...
July 13, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29997579/antimicrobial-photodynamic-therapy-to-control-clinically-relevant-biofilm-infections
#13
REVIEW
Xiaoqing Hu, Ying-Ying Huang, Yuguang Wang, Xiaoyuan Wang, Michael R Hamblin
Biofilm describes a microbially-derived sessile community in which microbial cells are firmly attached to the substratum and embedded in extracellular polymeric matrix. Microbial biofilms account for up to 80% of all bacterial and fungal infections in humans. Biofilm-associated pathogens are particularly resistant to antibiotic treatment, and thus novel antibiofilm approaches needed to be developed. Antimicrobial Photodynamic therapy (aPDT) had been recently proposed to combat clinically relevant biofilms such as dental biofilms, ventilator associated pneumonia, chronic wound infections, oral candidiasis, and chronic rhinosinusitis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29988499/comparison-of-the-antimicrobial-activities-of-four-honeys-from-three-countries-new-zealand-cuba-and-kenya
#14
Gianluca Morroni, José M Alvarez-Suarez, Andrea Brenciani, Serena Simoni, Simona Fioriti, Armanda Pugnaloni, Francesca Giampieri, Luca Mazzoni, Massimiliano Gasparrini, Emanuela Marini, Marina Mingoia, Maurizio Battino, Eleonora Giovanetti
Skin and chronic wound infections are an increasing and urgent health problem worldwide. Their management is difficult and the development of antibiotic resistance by both planktonic and biofilm-associated bacteria necessitates the use of alternative treatments. The purpose of this study was to compare the antimicrobial activity of four honeys from different floral and geographical origins: Melipona beecheii honey (Cuba) and three Apis mellifera honeys [Manuka honey (New Zealand), A. mellifera honey (Cuba), and African honey (Kenya)]...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29984114/fungi-in-the-wound-microbiome
#15
REVIEW
Lindsay Kalan, Elizabeth A Grice
Significance: Culture-independent methods have revealed the diverse and dynamic bacterial communities that colonize chronic wounds. Only recently have studies begun to examine fungal colonization and interactions with the bacterial component of the microbiome, their relationship with the host, and influence on wound outcomes. Recent Advances: Studies using culture-independent sequencing methods reveal that fungi often go undetected in wounds. Candida spp. and Cladosporidium spp. are the most commonly identified fungi in wounds...
July 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29964197/outcome-of-co-infection-with-opportunistic-and-multidrug-resistant-aeromonas-hydrophila-and-a-veronii-in-zebrafish-identification-characterization-pathogenicity-and-immune-responses
#16
H P S U Chandrarathna, Chamilani Nikapitiya, S H S Dananjaya, C U B Wijerathne, S H M P Wimalasena, Hyo Jung Kwun, Gang-Joon Heo, Jehee Lee, Mahanama De Zoysa
Fish can be potentially co-infected by two or more bacterial strains, which can make synergistic influence on the virulence of infection. In this study, two opportunistic and multidrug resistant Aeromonas strains were isolated from wounds of morbid zebrafish with typical deep skin lesions similar to Motile Aeromonas Septicemia. Isolates were genetically identified as A. hydrophila and A. veronii by 16 S rRNA sequencing and phylogenetic analysis. Both isolates were positive for virulent genes (aerA, lip, ser, exu gcaT) and selected phenotypic tests (DNase, protease, gelatinase, lipase, biofilm production and β-haemolysis)...
September 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29963501/development-of-a-high-throughput-ex-vivo-burn-wound-model-using-porcine-skin-and-its-application-to-evaluate-new-approaches-to-control-wound-infection
#17
Diana R Alves, Simon P Booth, Paola Scavone, Pascale Schellenberger, Jonathan Salvage, Cinzia Dedi, Naing-Tun Thet, A Toby A Jenkins, Ryan Waters, Keng W Ng, Andrew D J Overall, Anthony D Metcalfe, Jonathan Nzakizwanayo, Brian V Jones
Biofilm formation in wounds is considered a major barrier to successful treatment, and has been associated with the transition of wounds to a chronic non-healing state. Here, we present a novel laboratory model of wound biofilm formation using ex-vivo porcine skin and a custom burn wound array device. The model supports high-throughput studies of biofilm formation and is compatible with a range of established methods for monitoring bacterial growth, biofilm formation, and gene expression. We demonstrate the use of this model by evaluating the potential for bacteriophage to control biofilm formation by Staphylococcus aureus , and for population density dependant expression of S...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29957118/antimicrobial-peptides-features-action-and-their-resistance-mechanisms-in-bacteria
#18
Hoda Moravej, Zahra Moravej, Maryam Yazdanparast, Mohammad Heiat, Ali Mirhosseini, Mehrdad Moosazadeh Moghaddam, Reza Mirnejad
In recent years, because of increased resistance to conventional antimicrobials, many researchers have started to study the synthesis of new antibiotics to control the disease-causing effects of infectious pathogens. Antimicrobial peptides (AMPs) are among the newest antibiotics; these peptides are integral compounds in all kinds of organisms and play a significant role in microbial ecology, and critically contribute to the innate immunity of organisms by destroying invading microorganisms. Moreover, AMPs may encourage cells to produce chemokines, stimulate angiogenesis, accelerate wound healing, and influence programmed cell death in multicellular organisms...
July 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29956765/application-of-460-nm-visible-light-for-the-elimination-of-candida-albicans-in-vitro-and-in-vivo
#19
Chuan Wang, Zhiyin Yang, Yinbo Peng, Yuanyuan Guo, Min Yao, Jiying Dong
The aim of the present study was to investigate the eradicating effects of 460 nm blue light (BL) on Candida albicans in vitro and in C. albicans‑infected skin wounds in a mouse model. In the present study, the antifungal effects of irradiation with BL on C. albicans in vitro and in vivo were investigated. C. albicans colonies and cell numbers were investigated using the spread plate method and flow cytometry respectively following treatment with BL irradiation. In order to determine whether BL can eradicate C...
August 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29941565/-staphylococcus-aureus-biofilms-release-leukocidins-to-elicit-extracellular-trap-formation-and-evade-neutrophil-mediated-killing
#20
Mohini Bhattacharya, Evelien T M Berends, Rita Chan, Elizabeth Schwab, Sashwati Roy, Chandan K Sen, Victor J Torres, Daniel J Wozniak
Bacterial biofilms efficiently evade immune defenses, greatly complicating the prognosis of chronic infections. How methicillin-resistant Staphylococcus aureus (MRSA) biofilms evade host immune defenses is largely unknown. This study describes some of the major mechanisms required for S. aureus biofilms to evade the innate immune response and provides evidence of key virulence factors required for survival and persistence of bacteria during chronic infections. Neutrophils are the most abundant white blood cells in circulation, playing crucial roles in the control and elimination of bacterial pathogens...
July 10, 2018: Proceedings of the National Academy of Sciences of the United States of America
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